JP2013540419A5 - - Google Patents

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Publication number

JP2013540419A5

JP2013540419A5 JP2013510816A JP2013510816A JP2013540419A5 JP 2013540419 A5 JP2013540419 A5 JP 2013540419A5 JP 2013510816 A JP2013510816 A JP 2013510816A JP 2013510816 A JP2013510816 A JP 2013510816A JP 2013540419 A5 JP2013540419 A5 JP 2013540419A5

Authority

JP

Japan

Prior art keywords

peptide

amino acid

group

seq

ctl

Prior art date

2011-09-06

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

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• 108090000765 processed proteins & peptides Proteins 0.000 claims description 34
• 150000001413 amino acids Chemical group 0.000 claims description 25
• FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims description 12
• ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims description 12
• 229930182817 methionine Natural products 0.000 claims description 12
• 229940024606 amino acid Drugs 0.000 claims description 11
• ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims description 10
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 10
• COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims description 8
• QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims description 8
• COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims description 8
• QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims description 7
• 125000001433 C-terminal amino-acid group Chemical group 0.000 claims description 6
• 108010013476 HLA-A24 Antigen Proteins 0.000 claims description 5
• AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims description 4
• OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims description 4
• KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims description 4
• 229960000310 isoleucine Drugs 0.000 claims description 4
• AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims description 4
• OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims description 4
• 239000004474 valine Substances 0.000 claims description 4
• 108010074032 HLA-A2 Antigen Proteins 0.000 claims description 3
• 102000025850 HLA-A2 Antigen Human genes 0.000 claims description 3
• KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims description 2
• 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims 10
• 239000002157 polynucleotide Substances 0.000 claims 8
• 102000040430 polynucleotide Human genes 0.000 claims 8
• 108091033319 polynucleotide Proteins 0.000 claims 8
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• 206010028980 Neoplasm Diseases 0.000 claims 2
• 108091008874 T cell receptors Proteins 0.000 claims 2
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• 210000004027 cell Anatomy 0.000 claims 2
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• 238000009007 Diagnostic Kit Methods 0.000 claims 1
• 239000004480 active ingredient Substances 0.000 claims 1
• 231100000433 cytotoxic Toxicity 0.000 claims 1
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• 239000002773 nucleotide Substances 0.000 claims 1
• 125000003729 nucleotide group Chemical group 0.000 claims 1
• 108010091748 peptide A Proteins 0.000 claims 1
• 229920001184 polypeptide Polymers 0.000 claims 1
• 108090000623 proteins and genes Proteins 0.000 claims 1
• 238000001356 surgical procedure Methods 0.000 claims 1
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• 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 description 2
• 125000002987 valine group Chemical group [H]N([H])C([H])(C(*)=O)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 2
• 101000658481 Homo sapiens Tubulin monoglutamylase TTLL4 Proteins 0.000 description 1
• 102100034860 Tubulin monoglutamylase TTLL4 Human genes 0.000 description 1
• 210000004899 c-terminal region Anatomy 0.000 description 1
• 238000006467 substitution reaction Methods 0.000 description 1
• 125000000430 tryptophan group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 0.000 description 1