RU2013115434A - Пептиды ttll4 и содержащие их вакцины - Google Patents
Пептиды ttll4 и содержащие их вакцины Download PDFInfo
- Publication number
- RU2013115434A RU2013115434A RU2013115434/10A RU2013115434A RU2013115434A RU 2013115434 A RU2013115434 A RU 2013115434A RU 2013115434/10 A RU2013115434/10 A RU 2013115434/10A RU 2013115434 A RU2013115434 A RU 2013115434A RU 2013115434 A RU2013115434 A RU 2013115434A
- Authority
- RU
- Russia
- Prior art keywords
- peptide
- amino acid
- group
- acid sequence
- seq
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract 46
- 101000658481 Homo sapiens Tubulin monoglutamylase TTLL4 Proteins 0.000 title claims abstract 3
- 102100034860 Tubulin monoglutamylase TTLL4 Human genes 0.000 title claims abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 title claims 7
- 229960005486 vaccine Drugs 0.000 title 1
- 150000001413 amino acids Chemical group 0.000 claims abstract 22
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims abstract 11
- 239000000427 antigen Substances 0.000 claims abstract 8
- 108091007433 antigens Proteins 0.000 claims abstract 8
- 102000036639 antigens Human genes 0.000 claims abstract 8
- 229940024606 amino acid Drugs 0.000 claims abstract 7
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims abstract 6
- 229930182817 methionine Natural products 0.000 claims abstract 6
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims abstract 5
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims abstract 5
- 239000012634 fragment Substances 0.000 claims abstract 5
- 125000001433 C-terminal amino-acid group Chemical group 0.000 claims abstract 4
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims abstract 4
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims abstract 4
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims abstract 4
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims abstract 4
- 108010013476 HLA-A24 Antigen Proteins 0.000 claims abstract 3
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims abstract 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims abstract 2
- 229960000310 isoleucine Drugs 0.000 claims abstract 2
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims abstract 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims abstract 2
- 238000000034 method Methods 0.000 claims 6
- 239000002157 polynucleotide Substances 0.000 claims 6
- 102000040430 polynucleotide Human genes 0.000 claims 6
- 108091033319 polynucleotide Proteins 0.000 claims 6
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- 230000001939 inductive effect Effects 0.000 claims 4
- 210000001744 T-lymphocyte Anatomy 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 238000009007 Diagnostic Kit Methods 0.000 claims 1
- 108010074032 HLA-A2 Antigen Proteins 0.000 claims 1
- 102000025850 HLA-A2 Antigen Human genes 0.000 claims 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 1
- 108091008874 T cell receptors Proteins 0.000 claims 1
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 210000001808 exosome Anatomy 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 230000002980 postoperative effect Effects 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 239000004474 valine Substances 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4202—Receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Toxicology (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38061110P | 2010-09-07 | 2010-09-07 | |
| US61/380,611 | 2010-09-07 | ||
| PCT/JP2011/004987 WO2012032764A1 (en) | 2010-09-07 | 2011-09-06 | Ttll4 peptides and vaccines containing the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2013115434A true RU2013115434A (ru) | 2014-10-20 |
Family
ID=45810374
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2013115434/10A RU2013115434A (ru) | 2010-09-07 | 2011-09-06 | Пептиды ttll4 и содержащие их вакцины |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20130224234A1 (enExample) |
| EP (1) | EP2614146A4 (enExample) |
| JP (1) | JP2013540419A (enExample) |
| KR (1) | KR20130101529A (enExample) |
| CN (1) | CN103189510B (enExample) |
| AU (1) | AU2011300253B2 (enExample) |
| BR (1) | BR112013005448A2 (enExample) |
| CA (1) | CA2810636A1 (enExample) |
| MX (1) | MX2013002303A (enExample) |
| RU (1) | RU2013115434A (enExample) |
| SG (1) | SG187847A1 (enExample) |
| TW (1) | TW201210608A (enExample) |
| WO (1) | WO2012032764A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2015123315A (ru) * | 2012-11-25 | 2017-01-10 | Зе Реджентс Оф Зе Юниверсити Оф Калифорния | Пептиды, стимулирующие подкожный адипогенез |
| WO2015184125A1 (en) | 2014-05-28 | 2015-12-03 | The Regents Of The University Of California | Peptides, compositions, and methods for stimulating subcutaneous adipogenesis |
| CN111041028B (zh) * | 2019-12-20 | 2024-05-17 | 陕西省人民医院 | 人ttll4基因的用途及相关产品 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040142325A1 (en) * | 2001-09-14 | 2004-07-22 | Liat Mintz | Methods and systems for annotating biomolecular sequences |
| AU2003254950A1 (en) * | 2002-08-26 | 2004-03-11 | Kirin Beer Kabushiki Kaisha | Peptides and drugs containing the same |
| WO2004092207A2 (en) * | 2003-04-16 | 2004-10-28 | Algonomics N.V. | Respiratory syncytial virus (rsv) peptides |
| EP2334790A1 (en) * | 2008-08-27 | 2011-06-22 | Oncotherapy Science, Inc. | Pancreatic cancer related gene ttll4 |
-
2011
- 2011-09-06 KR KR1020137008815A patent/KR20130101529A/ko not_active Withdrawn
- 2011-09-06 WO PCT/JP2011/004987 patent/WO2012032764A1/en not_active Ceased
- 2011-09-06 MX MX2013002303A patent/MX2013002303A/es not_active Application Discontinuation
- 2011-09-06 EP EP11823243.8A patent/EP2614146A4/en not_active Withdrawn
- 2011-09-06 CA CA2810636A patent/CA2810636A1/en not_active Abandoned
- 2011-09-06 RU RU2013115434/10A patent/RU2013115434A/ru not_active Application Discontinuation
- 2011-09-06 SG SG2013011077A patent/SG187847A1/en unknown
- 2011-09-06 AU AU2011300253A patent/AU2011300253B2/en not_active Ceased
- 2011-09-06 CN CN201180053599.XA patent/CN103189510B/zh not_active Expired - Fee Related
- 2011-09-06 JP JP2013510816A patent/JP2013540419A/ja not_active Withdrawn
- 2011-09-06 TW TW100132041A patent/TW201210608A/zh unknown
- 2011-09-06 BR BR112013005448A patent/BR112013005448A2/pt not_active IP Right Cessation
- 2011-09-06 US US13/820,736 patent/US20130224234A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2012032764A1 (en) | 2012-03-15 |
| EP2614146A1 (en) | 2013-07-17 |
| AU2011300253A1 (en) | 2013-03-21 |
| AU2011300253B2 (en) | 2015-01-15 |
| CN103189510B (zh) | 2015-05-06 |
| SG187847A1 (en) | 2013-03-28 |
| CN103189510A (zh) | 2013-07-03 |
| EP2614146A4 (en) | 2014-02-12 |
| JP2013540419A (ja) | 2013-11-07 |
| MX2013002303A (es) | 2013-10-28 |
| KR20130101529A (ko) | 2013-09-13 |
| CA2810636A1 (en) | 2012-03-15 |
| BR112013005448A2 (pt) | 2019-09-24 |
| TW201210608A (en) | 2012-03-16 |
| US20130224234A1 (en) | 2013-08-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20151208 |