|
US4307717A
(en)
|
1977-11-07 |
1981-12-29 |
Lectec Corporation |
Sterile improved bandage containing a medicament
|
|
US4704362A
(en)
|
1977-11-08 |
1987-11-03 |
Genentech, Inc. |
Recombinant cloning vehicle microbial polypeptide expression
|
|
US4352883A
(en)
|
1979-03-28 |
1982-10-05 |
Damon Corporation |
Encapsulation of biological material
|
|
JPS5754588A
(en)
|
1980-09-19 |
1982-04-01 |
Eiji Ichijima |
Alpha-mannosidase
|
|
US4353888A
(en)
|
1980-12-23 |
1982-10-12 |
Sefton Michael V |
Encapsulation of live animal cells
|
|
US4407957A
(en)
|
1981-03-13 |
1983-10-04 |
Damon Corporation |
Reversible microencapsulation of a core material
|
|
US4879231A
(en)
|
1984-10-30 |
1989-11-07 |
Phillips Petroleum Company |
Transformation of yeasts of the genus pichia
|
|
US4837148A
(en)
|
1984-10-30 |
1989-06-06 |
Phillips Petroleum Company |
Autonomous replication sequences for yeast strains of the genus pichia
|
|
US4882279A
(en)
|
1985-10-25 |
1989-11-21 |
Phillips Petroleum Company |
Site selective genomic modification of yeast of the genus pichia
|
|
US4883666A
(en)
|
1987-04-29 |
1989-11-28 |
Massachusetts Institute Of Technology |
Controlled drug delivery system for treatment of neural disorders
|
|
US4929555A
(en)
|
1987-10-19 |
1990-05-29 |
Phillips Petroleum Company |
Pichia transformation
|
|
US5158881A
(en)
|
1987-11-17 |
1992-10-27 |
Brown University Research Foundation |
Method and system for encapsulating cells in a tubular extrudate in separate cell compartments
|
|
US5283187A
(en)
|
1987-11-17 |
1994-02-01 |
Brown University Research Foundation |
Cell culture-containing tubular capsule produced by co-extrusion
|
|
DE3829752A1
(de)
|
1988-09-01 |
1990-03-22 |
Akzo Gmbh |
Integrale asymmetrische polyaethersulfonmembran, verfahren zur herstellung und verwendung zur ultrafiltration und mikrofiltration
|
|
DE3829766A1
(de)
|
1988-09-01 |
1990-03-22 |
Akzo Gmbh |
Verfahren zur herstellung von membranen
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
US5084350A
(en)
|
1990-02-16 |
1992-01-28 |
The Royal Institution For The Advance Of Learning (Mcgill University) |
Method for encapsulating biologically active material including cells
|
|
US5272070A
(en)
|
1991-03-08 |
1993-12-21 |
Board Of Regents, The University Of Texas System |
Method for the preparation of cell lines producing Man3 GlcNac 2 asparagine-linked gylcans and cell lines produced thereby
|
|
ATE156344T1
(de)
|
1991-04-25 |
1997-08-15 |
Univ Brown Res Found |
Implantierbare, biokompatible immunisolator- trägersubstanz zum abgeben ausgesuchter, therapeutischer produkte
|
|
US5733761A
(en)
|
1991-11-05 |
1998-03-31 |
Transkaryotic Therapies, Inc. |
Protein production and protein delivery
|
|
US6042828A
(en)
|
1992-09-07 |
2000-03-28 |
Kyowa Hakko Kogyo Co., Ltd. |
Humanized antibodies to ganglioside GM2
|
|
SG48813A1
(en)
|
1993-08-12 |
1998-05-18 |
Cytotherapeutics Inc |
Improved composition and methods for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules
|
|
US5589359A
(en)
|
1994-08-05 |
1996-12-31 |
Chiron Corporation |
Chimeric proteins
|
|
US5834251A
(en)
|
1994-12-30 |
1998-11-10 |
Alko Group Ltd. |
Methods of modifying carbohydrate moieties
|
|
WO1997044470A1
(en)
|
1996-05-21 |
1997-11-27 |
Novo Nordisk A/S |
Novel yeast promoters suitable for expression cloning in yeast and heterologous expression of proteins in yeast
|
|
US6300065B1
(en)
|
1996-05-31 |
2001-10-09 |
Board Of Trustees Of The University Of Illinois |
Yeast cell surface display of proteins and uses thereof
|
|
US6699658B1
(en)
|
1996-05-31 |
2004-03-02 |
Board Of Trustees Of The University Of Illinois |
Yeast cell surface display of proteins and uses thereof
|
|
US6110703A
(en)
|
1996-07-05 |
2000-08-29 |
Novo Nordisk A/S |
Method for the production of polypeptides
|
|
CA2258307C
(en)
|
1996-07-05 |
2008-02-12 |
Novo Nordisk A/S |
Method of producing heterologous short chain polypeptides by yeast with impaired yap3 protease
|
|
AU3255397A
(en)
|
1996-07-05 |
1998-02-02 |
Novo Nordisk A/S |
Method for the production of precursors of insulin, precursors of insulin analogues, and insulin like peptides
|
|
PT975775E
(pt)
|
1997-04-23 |
2004-07-30 |
Vlaams Interuniv Inst Biotech |
Sistema regulador para a expressao induzivel de genes com promotores lambdoides
|
|
US7442772B2
(en)
|
1997-12-03 |
2008-10-28 |
Genentech, Inc. |
Antibodies to PRO361 polypeptide
|
|
WO1999037758A2
(en)
|
1998-01-27 |
1999-07-29 |
The Board Of Regents Of The University And Community College System Of Nevada On Behalf Of The University Of Nevada-Reno |
Expression of proteolytically-sensitive peptides
|
|
WO2001042462A2
(en)
|
1999-12-08 |
2001-06-14 |
National University Of Singapore |
Phospholipase a2 inhibitory peptides from python reticulatus
|
|
AU2352201A
(en)
|
1999-12-30 |
2001-07-16 |
Maxygen Aps |
Improved lysosomal enzymes and lysosomal enzyme activators
|
|
US20020127219A1
(en)
|
1999-12-30 |
2002-09-12 |
Okkels Jens Sigurd |
Lysosomal enzymes and lysosomal enzyme activators
|
|
EP1283265B1
(en)
|
2000-05-17 |
2009-08-05 |
Mitsubishi Tanabe Pharma Corporation |
Process for producing protein with reduction of mannose phosphate in the sugar chain and glycoprotein produced thereby
|
|
US7598055B2
(en)
|
2000-06-28 |
2009-10-06 |
Glycofi, Inc. |
N-acetylglucosaminyltransferase III expression in lower eukaryotes
|
|
US7449308B2
(en)
|
2000-06-28 |
2008-11-11 |
Glycofi, Inc. |
Combinatorial DNA library for producing modified N-glycans in lower eukaryotes
|
|
US7795002B2
(en)
|
2000-06-28 |
2010-09-14 |
Glycofi, Inc. |
Production of galactosylated glycoproteins in lower eukaryotes
|
|
US7625756B2
(en)
*
|
2000-06-28 |
2009-12-01 |
GycoFi, Inc. |
Expression of class 2 mannosidase and class III mannosidase in lower eukaryotic cells
|
|
US7863020B2
(en)
|
2000-06-28 |
2011-01-04 |
Glycofi, Inc. |
Production of sialylated N-glycans in lower eukaryotes
|
|
ES2252261T3
(es)
|
2000-06-28 |
2006-05-16 |
Glycofi, Inc. |
Metodos para producir glicoproteinas modificadas.
|
|
US8697394B2
(en)
|
2000-06-28 |
2014-04-15 |
Glycofi, Inc. |
Production of modified glycoproteins having multiple antennary structures
|
|
EP1294910B1
(en)
|
2000-06-30 |
2008-11-19 |
VIB vzw |
Protein glycosylation modification in pichia pastoris
|
|
ES2258371B1
(es)
|
2000-08-31 |
2007-05-16 |
Dong Kook Pharmaceutical Co. Ltd. |
Levadura transformante productora de hormona paratiroidea humana y procedimiento para producir la hormona.
|
|
US7001994B2
(en)
|
2001-01-18 |
2006-02-21 |
Genzyme Corporation |
Methods for introducing mannose 6-phosphate and other oligosaccharides onto glycoproteins
|
|
JP4774496B2
(ja)
*
|
2001-06-14 |
2011-09-14 |
独立行政法人産業技術総合研究所 |
α−マンノシダーゼ
|
|
JP4742191B2
(ja)
|
2001-06-14 |
2011-08-10 |
独立行政法人産業技術総合研究所 |
糖蛋白質およびその製造方法
|
|
DK2093286T3
(da)
|
2001-10-01 |
2013-05-13 |
Dyax Corp |
Flerkædede, eukaryote displayvektorer og anvendelser deraf
|
|
US7473680B2
(en)
|
2001-11-28 |
2009-01-06 |
Neose Technologies, Inc. |
Remodeling and glycoconjugation of peptides
|
|
CA2471551C
(en)
|
2001-12-27 |
2014-09-30 |
Glycofi, Inc. |
Methods to engineer mammalian-type carbohydrate structures
|
|
PT1527100E
(pt)
|
2002-03-29 |
2009-08-25 |
Schering Corp |
Anticorpos monoclonais humanos para interleucina-5 e métodos e composições compreendendo os mesmos
|
|
US7972809B2
(en)
|
2002-04-26 |
2011-07-05 |
National Institute Of Advanced Industrial Science & Technology |
Methylotrophic yeast producing mammalian type sugar chain
|
|
IL165717A0
(en)
|
2002-06-26 |
2006-01-15 |
Flanders Interuniversity Inst |
A strain of methylotrophic yeast for producing proteins
|
|
EP1534835B1
(en)
|
2002-06-29 |
2010-09-08 |
Korea Research Institute of Bioscience and Biotechnology |
Hansenula polymorpha yapsin deficient mutant strain and process for the preparation of recombinant proteins using the same
|
|
KR100470978B1
(ko)
|
2003-01-02 |
2005-03-10 |
한국생명공학연구원 |
앱신 다중 결손 효모 변이 균주 및 이를 이용한 재조합 단백질의 생산 방법
|
|
AU2012206984B2
(en)
|
2003-02-11 |
2015-07-09 |
Takeda Pharmaceutical Company Limited |
Diagnosis and treatment of multiple sulfatase deficiency and other using a formylglycine generating enzyme (FGE)
|
|
JP4259169B2
(ja)
|
2003-04-16 |
2009-04-30 |
昭和産業株式会社 |
新規α−１，２−マンノシダーゼおよびその遺伝子、ならびに該酵素を用いたα−マンノシル糖化合物の製造方法
|
|
US7259255B2
(en)
|
2003-06-25 |
2007-08-21 |
E. I. Du Pont De Nemours And Company |
Glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate mutase promoters for gene expression in oleaginous yeast
|
|
CA2551484C
(en)
|
2003-12-24 |
2015-03-31 |
Glycofi, Inc. |
Methods for eliminating mannosylphosphorylation of glycans in the production of glycoproteins
|
|
CA2553955C
(en)
|
2004-02-10 |
2012-08-28 |
Zystor Therapeutics, Inc. |
Acid alpha-glucosidase and fragments thereof
|
|
WO2005089047A2
(en)
|
2004-03-18 |
2005-09-29 |
Glycofi, Inc. |
Glycosylated glucocerebrosidase expression in fungal hosts
|
|
AU2005233387B2
(en)
|
2004-04-15 |
2011-05-26 |
Glycofi, Inc. |
Production of galactosylated glycoproteins in lower eukaryotes
|
|
CN101084233B
(zh)
|
2004-04-29 |
2012-08-15 |
格利科菲公司 |
用于在糖蛋白产生中减少或消除α-甘露糖苷酶抗性聚糖的方法
|
|
CA2501422C
(en)
|
2004-04-29 |
2014-08-12 |
University Of Rochester |
Lymphoid chemokines in the diagnosis, monitoring and treatment of autoimmune disease
|
|
US20060014264A1
(en)
|
2004-07-13 |
2006-01-19 |
Stowers Institute For Medical Research |
Cre/lox system with lox sites having an extended spacer region
|
|
US7431927B2
(en)
|
2005-03-24 |
2008-10-07 |
Epitomics, Inc. |
TNFα-neutralizing antibodies
|
|
EP1910514A4
(en)
|
2005-04-14 |
2010-03-03 |
Oxyrane Uk Ltd |
RECOMBINANT HEEDS FOR SYNTHETIZING EPOXY HYDROLASES
|
|
EP1934605B1
(en)
|
2005-09-22 |
2014-03-26 |
Prosci Incorporated |
Glycosylated polypeptides produced in yeast mutants and methods of use thereof
|
|
US20080081035A1
(en)
|
2006-10-03 |
2008-04-03 |
National Enzyme Company |
Therapeutic protease compositions
|
|
JP2010517577A
(ja)
|
2007-02-09 |
2010-05-27 |
メディミューン，エルエルシー |
酵母細胞原形質膜による抗体ライブラリー提示
|
|
CA2887752C
(en)
*
|
2007-04-03 |
2020-03-24 |
Vib Vzw |
Glycosylation of molecules
|
|
WO2008143354A1
(ja)
|
2007-05-18 |
2008-11-27 |
Tokyo Metropolitan Organization For Medical Research |
酵素補充療法用医薬組成物
|
|
CA2711590C
(en)
|
2008-01-18 |
2021-03-23 |
Biomarin Pharmaceutical Inc. |
Manufacture of active highly phosphorylated human lysosomal sulfatase enzymes and uses thereof
|
|
US20100311122A1
(en)
|
2008-02-20 |
2010-12-09 |
Glycofi, Inc |
Vectors and yeast strains for protein production
|
|
JP5627571B2
(ja)
|
2008-05-07 |
2014-11-19 |
バイオマリン ファーマシューティカル インコーポレイテッド |
リソソーム標的化ペプチドおよびその使用
|
|
WO2010099195A1
(en)
|
2009-02-26 |
2010-09-02 |
Glaxosmithkline Llc. |
Host cells and methods of use
|
|
KR102000383B1
(ko)
*
|
2009-09-29 |
2019-07-15 |
유니버시테이트 젠트 |
만노스-1-포스포-6-만노스 결합의 포스포-6-만노스로의 가수분해
|
|
WO2011061629A2
(en)
|
2009-11-19 |
2011-05-26 |
Oxyrane Uk Limited |
Yeast strains producing mammalian-like complex n-glycans
|
|
FR2954349A1
(fr)
|
2009-12-22 |
2011-06-24 |
Agronomique Inst Nat Rech |
Sulfatase modifiant selectivement les glycosaminoglycanes
|
|
JP2013517761A
(ja)
|
2010-01-21 |
2013-05-20 |
オキシレイン ユーケー リミテッド |
酵母細胞の表面上にポリペプチドをディスプレイするための方法および組成物
|
|
US20120135461A1
(en)
*
|
2010-07-30 |
2012-05-31 |
William James Cook |
Production of glycoproteins with reduced o-glycosylation comprising the use of an alpha-1,2-mannosidase
|
|
CA2812872C
(en)
|
2010-09-29 |
2021-08-03 |
Oxyrane Uk Limited |
De-mannosylation of phosphorylated n-glycans
|
|
US9347050B2
(en)
|
2010-09-29 |
2016-05-24 |
Oxyrane Uk Limited |
Mannosidases capable of uncapping mannose-1-phospho-6-mannose linkages and demannosylating phosphorylated N-glycans and methods of facilitating mammalian cellular uptake of glycoproteins
|
|
US20150031081A1
(en)
|
2011-12-30 |
2015-01-29 |
Oxyrane Uk Limited |
Methods and materials for reducing degradation of recombinant proteins
|
|
EP3628326B1
(en)
|
2012-03-15 |
2024-02-28 |
Oxyrane UK Limited |
Methods and materials for treatment of pompe's disease
|