JP6131190B2 - リン酸化ｎ−グリカンの脱マンノシル化 - Google Patents

リン酸化ｎ−グリカンの脱マンノシル化 Download PDF

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JP6131190B2
JP6131190B2 JP2013530818A JP2013530818A JP6131190B2 JP 6131190 B2 JP6131190 B2 JP 6131190B2 JP 2013530818 A JP2013530818 A JP 2013530818A JP 2013530818 A JP2013530818 A JP 2013530818A JP 6131190 B2 JP6131190 B2 JP 6131190B2
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disease
aspergillus
mannosidase
polypeptide
culture
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JP2013538581A5 (https=
JP2013538581A (ja
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カトレーン カミラ テレスポレ アリダ マリア ピーンス，
カトレーン カミラ テレスポレ アリダ マリア ピーンス，
ヴァウテル フェルフェケン，
ヴァウテル フェルフェケン，
Original Assignee
オキシレイン ユーケー リミテッド
オキシレイン ユーケー リミテッド
フェーイーベー フェーゼットヴェー
フェーイーベー フェーゼットヴェー
ユニフェルシテイト ヘント
ユニフェルシテイト ヘント
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01113—Mannosyl-oligosaccharide 1,2-alpha-mannosidase (3.2.1.113), i.e. alpha-1,2-mannosidase
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

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  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
JP2013530818A 2010-09-29 2011-09-29 リン酸化ｎ−グリカンの脱マンノシル化 Expired - Fee Related JP6131190B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38792410P 2010-09-29 2010-09-29
US61/387,924 2010-09-29
PCT/IB2011/002780 WO2012042387A2 (en) 2010-09-29 2011-09-29 De-mannosylation of phosphorylated n-glycans

Publications (3)

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JP2013538581A JP2013538581A (ja) 2013-10-17
JP2013538581A5 JP2013538581A5 (https=) 2014-11-13
JP6131190B2 true JP6131190B2 (ja) 2017-05-17

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US (2) US9689015B2 (https=)
EP (1) EP2622089B1 (https=)
JP (1) JP6131190B2 (https=)
KR (1) KR101979220B1 (https=)
CN (1) CN103261432A (https=)
BR (1) BR112013007263A2 (https=)
CA (1) CA2812872C (https=)
SG (1) SG189110A1 (https=)
WO (1) WO2012042387A2 (https=)

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* Cited by examiner, † Cited by third party
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US9347050B2 (en) 2010-09-29 2016-05-24 Oxyrane Uk Limited Mannosidases capable of uncapping mannose-1-phospho-6-mannose linkages and demannosylating phosphorylated N-glycans and methods of facilitating mammalian cellular uptake of glycoproteins
WO2012042387A2 (en) * 2010-09-29 2012-04-05 Oxyrane Uk Limited De-mannosylation of phosphorylated n-glycans
EP3628326B1 (en) 2012-03-15 2024-02-28 Oxyrane UK Limited Methods and materials for treatment of pompe's disease
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AU2018345303B2 (en) 2017-10-02 2025-09-18 Denali Therapeutics Inc. Fusion proteins comprising enzyme replacement therapy enzymes

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Publication number Publication date
KR101979220B1 (ko) 2019-05-16
JP2013538581A (ja) 2013-10-17
CA2812872C (en) 2021-08-03
US10344310B2 (en) 2019-07-09
KR20140036124A (ko) 2014-03-25
EP2622089A2 (en) 2013-08-07
WO2012042387A3 (en) 2012-09-07
SG189110A1 (en) 2013-05-31
EP2622089C0 (en) 2023-11-01
US20130295603A1 (en) 2013-11-07
WO2012042387A2 (en) 2012-04-05
CA2812872A1 (en) 2012-04-05
CN103261432A (zh) 2013-08-21
US9689015B2 (en) 2017-06-27
EP2622089B1 (en) 2023-11-01
US20170306379A1 (en) 2017-10-26
BR112013007263A2 (pt) 2016-06-14

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