BR112013007263A2 - desmanosilação de n-glicanos fosforilados - Google Patents
desmanosilação de n-glicanos fosforiladosInfo
- Publication number
- BR112013007263A2 BR112013007263A2 BR112013007263A BR112013007263A BR112013007263A2 BR 112013007263 A2 BR112013007263 A2 BR 112013007263A2 BR 112013007263 A BR112013007263 A BR 112013007263A BR 112013007263 A BR112013007263 A BR 112013007263A BR 112013007263 A2 BR112013007263 A2 BR 112013007263A2
- Authority
- BR
- Brazil
- Prior art keywords
- phosphorylated
- demanosylation
- glycans
- mannose
- hydrolyzing
- Prior art date
Links
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 abstract 1
- 102000003886 Glycoproteins Human genes 0.000 abstract 1
- 108090000288 Glycoproteins Proteins 0.000 abstract 1
- 102000001696 Mannosidases Human genes 0.000 abstract 1
- 108010054377 Mannosidases Proteins 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01113—Mannosyl-oligosaccharide 1,2-alpha-mannosidase (3.2.1.113), i.e. alpha-1,2-mannosidase
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Mycology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38792410P | 2010-09-29 | 2010-09-29 | |
| PCT/IB2011/002780 WO2012042387A2 (en) | 2010-09-29 | 2011-09-29 | De-mannosylation of phosphorylated n-glycans |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112013007263A2 true BR112013007263A2 (pt) | 2016-06-14 |
Family
ID=45478372
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112013007263A BR112013007263A2 (pt) | 2010-09-29 | 2011-09-29 | desmanosilação de n-glicanos fosforilados |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US9689015B2 (https=) |
| EP (1) | EP2622089B1 (https=) |
| JP (1) | JP6131190B2 (https=) |
| KR (1) | KR101979220B1 (https=) |
| CN (1) | CN103261432A (https=) |
| BR (1) | BR112013007263A2 (https=) |
| CA (1) | CA2812872C (https=) |
| SG (1) | SG189110A1 (https=) |
| WO (1) | WO2012042387A2 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008120107A2 (en) | 2007-04-03 | 2008-10-09 | Oxyrane (Uk) Limited | Glycosylation of molecules |
| US9598682B2 (en) | 2009-09-29 | 2017-03-21 | Vib Vzw | Hydrolysis of mannose-1-phospho-6-mannose linkage to phospho-6-mannose |
| US20130053550A1 (en) | 2009-11-19 | 2013-02-28 | Oxyrane Uk Limited | Yeast strains producing mammalian-like complex n-glycans |
| US9347050B2 (en) | 2010-09-29 | 2016-05-24 | Oxyrane Uk Limited | Mannosidases capable of uncapping mannose-1-phospho-6-mannose linkages and demannosylating phosphorylated N-glycans and methods of facilitating mammalian cellular uptake of glycoproteins |
| WO2012042387A2 (en) * | 2010-09-29 | 2012-04-05 | Oxyrane Uk Limited | De-mannosylation of phosphorylated n-glycans |
| EP3628326B1 (en) | 2012-03-15 | 2024-02-28 | Oxyrane UK Limited | Methods and materials for treatment of pompe's disease |
| WO2015013116A1 (en) * | 2013-07-25 | 2015-01-29 | Merck Sharp & Dohme Corp. | Method for reducing the extent of o-mannosylation of glycoproteins |
| EP2997977A1 (en) * | 2014-09-19 | 2016-03-23 | Fundación de la Comunidad Valenciana Centro de Investigación Principe Felipe | Specific mtor inhibitors in the treatment of x-linked adrenoleukodystrophy |
| US11130692B2 (en) * | 2017-06-28 | 2021-09-28 | Uop Llc | Process and apparatus for dosing nutrients to a bioreactor |
| AU2018345303B2 (en) | 2017-10-02 | 2025-09-18 | Denali Therapeutics Inc. | Fusion proteins comprising enzyme replacement therapy enzymes |
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| US20120135461A1 (en) * | 2010-07-30 | 2012-05-31 | William James Cook | Production of glycoproteins with reduced o-glycosylation comprising the use of an alpha-1,2-mannosidase |
| WO2012042387A2 (en) | 2010-09-29 | 2012-04-05 | Oxyrane Uk Limited | De-mannosylation of phosphorylated n-glycans |
| US9347050B2 (en) | 2010-09-29 | 2016-05-24 | Oxyrane Uk Limited | Mannosidases capable of uncapping mannose-1-phospho-6-mannose linkages and demannosylating phosphorylated N-glycans and methods of facilitating mammalian cellular uptake of glycoproteins |
| BR112014015933A2 (pt) | 2011-12-30 | 2019-09-24 | Oxyrane Uk Ltd | métodos e materiais para reduzir a degradação das proteínas recombinantes |
| EP3628326B1 (en) | 2012-03-15 | 2024-02-28 | Oxyrane UK Limited | Methods and materials for treatment of pompe's disease |
-
2011
- 2011-09-29 WO PCT/IB2011/002780 patent/WO2012042387A2/en not_active Ceased
- 2011-09-29 BR BR112013007263A patent/BR112013007263A2/pt not_active Application Discontinuation
- 2011-09-29 CA CA2812872A patent/CA2812872C/en active Active
- 2011-09-29 CN CN2011800574532A patent/CN103261432A/zh active Pending
- 2011-09-29 EP EP11808319.5A patent/EP2622089B1/en active Active
- 2011-09-29 SG SG2013022512A patent/SG189110A1/en unknown
- 2011-09-29 JP JP2013530818A patent/JP6131190B2/ja not_active Expired - Fee Related
- 2011-09-29 KR KR1020137011113A patent/KR101979220B1/ko not_active Expired - Fee Related
- 2011-09-29 US US13/876,730 patent/US9689015B2/en not_active Expired - Fee Related
-
2017
- 2017-05-12 US US15/594,256 patent/US10344310B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| KR101979220B1 (ko) | 2019-05-16 |
| JP6131190B2 (ja) | 2017-05-17 |
| JP2013538581A (ja) | 2013-10-17 |
| CA2812872C (en) | 2021-08-03 |
| US10344310B2 (en) | 2019-07-09 |
| KR20140036124A (ko) | 2014-03-25 |
| EP2622089A2 (en) | 2013-08-07 |
| WO2012042387A3 (en) | 2012-09-07 |
| SG189110A1 (en) | 2013-05-31 |
| EP2622089C0 (en) | 2023-11-01 |
| US20130295603A1 (en) | 2013-11-07 |
| WO2012042387A2 (en) | 2012-04-05 |
| CA2812872A1 (en) | 2012-04-05 |
| CN103261432A (zh) | 2013-08-21 |
| US9689015B2 (en) | 2017-06-27 |
| EP2622089B1 (en) | 2023-11-01 |
| US20170306379A1 (en) | 2017-10-26 |
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