JP2017060528A5 - - Google Patents
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- Publication number
- JP2017060528A5 JP2017060528A5 JP2017000348A JP2017000348A JP2017060528A5 JP 2017060528 A5 JP2017060528 A5 JP 2017060528A5 JP 2017000348 A JP2017000348 A JP 2017000348A JP 2017000348 A JP2017000348 A JP 2017000348A JP 2017060528 A5 JP2017060528 A5 JP 2017060528A5
- Authority
- JP
- Japan
- Prior art keywords
- target protein
- alpha
- mannosidase
- modified
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 102000004169 proteins and genes Human genes 0.000 claims 42
- 108090000623 proteins and genes Proteins 0.000 claims 42
- 102100021771 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase Human genes 0.000 claims 20
- 210000004027 cell Anatomy 0.000 claims 20
- 108010009689 mannosyl-oligosaccharide 1,2-alpha-mannosidase Proteins 0.000 claims 20
- 108090000765 processed proteins & peptides Proteins 0.000 claims 19
- 229920001184 polypeptide Polymers 0.000 claims 15
- 102000004196 processed proteins & peptides Human genes 0.000 claims 15
- 238000000034 method Methods 0.000 claims 13
- 210000002472 endoplasmic reticulum Anatomy 0.000 claims 9
- 230000000694 effects Effects 0.000 claims 7
- 101001051674 Homo sapiens Meiosis-specific nuclear structural protein 1 Proteins 0.000 claims 6
- 102100024962 Meiosis-specific nuclear structural protein 1 Human genes 0.000 claims 6
- 241000235015 Yarrowia lipolytica Species 0.000 claims 5
- 108020001507 fusion proteins Proteins 0.000 claims 5
- 102000037865 fusion proteins Human genes 0.000 claims 5
- 102100039371 ER lumen protein-retaining receptor 1 Human genes 0.000 claims 4
- 101000812437 Homo sapiens ER lumen protein-retaining receptor 1 Proteins 0.000 claims 4
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 claims 4
- OVRNDRQMDRJTHS-RTRLPJTCSA-N N-acetyl-D-glucosamine Chemical compound CC(=O)N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-RTRLPJTCSA-N 0.000 claims 4
- MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 claims 4
- 230000014759 maintenance of location Effects 0.000 claims 4
- 241001523626 Arxula Species 0.000 claims 3
- 230000004988 N-glycosylation Effects 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 241000680806 Blastobotrys adeninivorans Species 0.000 claims 2
- 102000019034 Chemokines Human genes 0.000 claims 2
- 108010012236 Chemokines Proteins 0.000 claims 2
- 102000004127 Cytokines Human genes 0.000 claims 2
- 108090000695 Cytokines Proteins 0.000 claims 2
- KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical compound F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 claims 2
- 102000003886 Glycoproteins Human genes 0.000 claims 2
- 108090000288 Glycoproteins Proteins 0.000 claims 2
- 208000015439 Lysosomal storage disease Diseases 0.000 claims 2
- 108010054377 Mannosidases Proteins 0.000 claims 2
- 102000001696 Mannosidases Human genes 0.000 claims 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 2
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims 2
- 241000499912 Trichoderma reesei Species 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108010055059 beta-Mannosidase Proteins 0.000 claims 2
- 239000013592 cell lysate Substances 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 239000003102 growth factor Substances 0.000 claims 2
- 108010045758 lysosomal proteins Proteins 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 244000052769 pathogen Species 0.000 claims 2
- 230000001717 pathogenic effect Effects 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 102100022146 Arylsulfatase A Human genes 0.000 claims 1
- 102100031491 Arylsulfatase B Human genes 0.000 claims 1
- 108010023546 Aspartylglucosylaminase Proteins 0.000 claims 1
- 102100032487 Beta-mannosidase Human genes 0.000 claims 1
- 102000004171 Cathepsin K Human genes 0.000 claims 1
- 108090000625 Cathepsin K Proteins 0.000 claims 1
- 102000004201 Ceramidases Human genes 0.000 claims 1
- 108090000751 Ceramidases Proteins 0.000 claims 1
- 108010036867 Cerebroside-Sulfatase Proteins 0.000 claims 1
- 102100028496 Galactocerebrosidase Human genes 0.000 claims 1
- 108010042681 Galactosylceramidase Proteins 0.000 claims 1
- 102000004366 Glucosidases Human genes 0.000 claims 1
- 108010056771 Glucosidases Proteins 0.000 claims 1
- 102000004547 Glucosylceramidase Human genes 0.000 claims 1
- 108010017544 Glucosylceramidase Proteins 0.000 claims 1
- 108700023372 Glycosyltransferases Proteins 0.000 claims 1
- 102000051366 Glycosyltransferases Human genes 0.000 claims 1
- 108090000144 Human Proteins Proteins 0.000 claims 1
- 102000003839 Human Proteins Human genes 0.000 claims 1
- 108010003272 Hyaluronate lyase Proteins 0.000 claims 1
- 102000009066 Hyaluronoglucosaminidase Human genes 0.000 claims 1
- 102100029199 Iduronate 2-sulfatase Human genes 0.000 claims 1
- 101710096421 Iduronate 2-sulfatase Proteins 0.000 claims 1
- 102000004627 Iduronidase Human genes 0.000 claims 1
- 108010003381 Iduronidase Proteins 0.000 claims 1
- 102000004882 Lipase Human genes 0.000 claims 1
- 108090001060 Lipase Proteins 0.000 claims 1
- 108010013563 Lipoprotein Lipase Proteins 0.000 claims 1
- 102100022119 Lipoprotein lipase Human genes 0.000 claims 1
- 102100021003 N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase Human genes 0.000 claims 1
- 108010027520 N-Acetylgalactosamine-4-Sulfatase Proteins 0.000 claims 1
- 101000652829 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) Exo-alpha-sialidase Proteins 0.000 claims 1
- 108090001050 Phosphoric Diester Hydrolases Proteins 0.000 claims 1
- 102000004861 Phosphoric Diester Hydrolases Human genes 0.000 claims 1
- 108091000080 Phosphotransferase Proteins 0.000 claims 1
- 102000011971 Sphingomyelin Phosphodiesterase Human genes 0.000 claims 1
- 108010061312 Sphingomyelin Phosphodiesterase Proteins 0.000 claims 1
- 102000005488 Thioesterase Human genes 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 108010030291 alpha-Galactosidase Proteins 0.000 claims 1
- 102000005840 alpha-Galactosidase Human genes 0.000 claims 1
- 102000012086 alpha-L-Fucosidase Human genes 0.000 claims 1
- 108010061314 alpha-L-Fucosidase Proteins 0.000 claims 1
- -1 alpha-L-mannosidase Proteins 0.000 claims 1
- 102000002014 alpha-N-Acetylgalactosaminidase Human genes 0.000 claims 1
- 108010015684 alpha-N-Acetylgalactosaminidase Proteins 0.000 claims 1
- 108010005774 beta-Galactosidase Proteins 0.000 claims 1
- 102000005936 beta-Galactosidase Human genes 0.000 claims 1
- 102000006995 beta-Glucosidase Human genes 0.000 claims 1
- 108010047754 beta-Glucosidase Proteins 0.000 claims 1
- 102000007478 beta-N-Acetylhexosaminidases Human genes 0.000 claims 1
- 108010085377 beta-N-Acetylhexosaminidases Proteins 0.000 claims 1
- 230000002255 enzymatic effect Effects 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 229960002773 hyaluronidase Drugs 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 230000026731 phosphorylation Effects 0.000 claims 1
- 238000006366 phosphorylation reaction Methods 0.000 claims 1
- 102000020233 phosphotransferase Human genes 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 108020002982 thioesterase Proteins 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90990407P | 2007-04-03 | 2007-04-03 | |
| US60/909,904 | 2007-04-03 | ||
| US94021207P | 2007-05-25 | 2007-05-25 | |
| US60/940,212 | 2007-05-25 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014205471A Division JP6228096B2 (ja) | 2007-04-03 | 2014-10-06 | 分子のグリコシル化 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017060528A JP2017060528A (ja) | 2017-03-30 |
| JP2017060528A5 true JP2017060528A5 (https=) | 2017-11-30 |
| JP6511476B2 JP6511476B2 (ja) | 2019-05-15 |
Family
ID=39808762
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010501617A Expired - Fee Related JP5967861B2 (ja) | 2007-04-03 | 2008-04-03 | 分子のグリコシル化 |
| JP2014205471A Expired - Fee Related JP6228096B2 (ja) | 2007-04-03 | 2014-10-06 | 分子のグリコシル化 |
| JP2017000348A Expired - Fee Related JP6511476B2 (ja) | 2007-04-03 | 2017-01-05 | 分子のグリコシル化 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010501617A Expired - Fee Related JP5967861B2 (ja) | 2007-04-03 | 2008-04-03 | 分子のグリコシル化 |
| JP2014205471A Expired - Fee Related JP6228096B2 (ja) | 2007-04-03 | 2014-10-06 | 分子のグリコシル化 |
Country Status (9)
| Country | Link |
|---|---|
| US (5) | US8026083B2 (https=) |
| EP (4) | EP2508612B1 (https=) |
| JP (3) | JP5967861B2 (https=) |
| KR (3) | KR101812400B1 (https=) |
| CN (2) | CN101680014B (https=) |
| CA (3) | CA2682578C (https=) |
| DK (2) | DK2508612T3 (https=) |
| SG (1) | SG177941A1 (https=) |
| WO (1) | WO2008120107A2 (https=) |
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| AU2009202778B2 (en) * | 2008-07-11 | 2014-05-08 | Commonwealth of Australia as represented by and acting through the Department of Climate Change, Energy, the Environment and Water | Improved baiting method and composition |
| MX2011004201A (es) | 2008-10-20 | 2011-05-24 | Abbott Lab | Desactivacion viral durante purificacion de anticuerpos. |
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| US20120121630A1 (en) * | 2009-07-24 | 2012-05-17 | Bryan Janine T | Recombinant ectodomain expression of herpes simplex virus glycoproteins in yeast |
| US9598682B2 (en) | 2009-09-29 | 2017-03-21 | Vib Vzw | Hydrolysis of mannose-1-phospho-6-mannose linkage to phospho-6-mannose |
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| BR112012020882A2 (pt) * | 2010-02-24 | 2015-11-03 | Merck Sharp & Dohme | métodos para produzir uma glicoproteína heteróloga e para produzir uma composição de glicoproteína, célula hospedeira, composição de glicoproteína, e, uso da pichia pastoris recombinante. |
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| PL2991683T3 (pl) | 2013-05-02 | 2020-03-31 | Glykos Finland Oy | Koniugaty glikoproteiny lub glikanu z toksycznym ładunkiem |
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