|
US4307717A
(en)
|
1977-11-07 |
1981-12-29 |
Lectec Corporation |
Sterile improved bandage containing a medicament
|
|
US4704362A
(en)
|
1977-11-08 |
1987-11-03 |
Genentech, Inc. |
Recombinant cloning vehicle microbial polypeptide expression
|
|
US4352883A
(en)
|
1979-03-28 |
1982-10-05 |
Damon Corporation |
Encapsulation of biological material
|
|
JPS5754588A
(en)
|
1980-09-19 |
1982-04-01 |
Eiji Ichijima |
Alpha-mannosidase
|
|
US4353888A
(en)
|
1980-12-23 |
1982-10-12 |
Sefton Michael V |
Encapsulation of live animal cells
|
|
US4407957A
(en)
|
1981-03-13 |
1983-10-04 |
Damon Corporation |
Reversible microencapsulation of a core material
|
|
US4837148A
(en)
|
1984-10-30 |
1989-06-06 |
Phillips Petroleum Company |
Autonomous replication sequences for yeast strains of the genus pichia
|
|
US4879231A
(en)
|
1984-10-30 |
1989-11-07 |
Phillips Petroleum Company |
Transformation of yeasts of the genus pichia
|
|
US4882279A
(en)
|
1985-10-25 |
1989-11-21 |
Phillips Petroleum Company |
Site selective genomic modification of yeast of the genus pichia
|
|
US4883666A
(en)
|
1987-04-29 |
1989-11-28 |
Massachusetts Institute Of Technology |
Controlled drug delivery system for treatment of neural disorders
|
|
US4929555A
(en)
|
1987-10-19 |
1990-05-29 |
Phillips Petroleum Company |
Pichia transformation
|
|
US5283187A
(en)
|
1987-11-17 |
1994-02-01 |
Brown University Research Foundation |
Cell culture-containing tubular capsule produced by co-extrusion
|
|
US5158881A
(en)
|
1987-11-17 |
1992-10-27 |
Brown University Research Foundation |
Method and system for encapsulating cells in a tubular extrudate in separate cell compartments
|
|
DE3829766A1
(de)
|
1988-09-01 |
1990-03-22 |
Akzo Gmbh |
Verfahren zur herstellung von membranen
|
|
DE3829752A1
(de)
|
1988-09-01 |
1990-03-22 |
Akzo Gmbh |
Integrale asymmetrische polyaethersulfonmembran, verfahren zur herstellung und verwendung zur ultrafiltration und mikrofiltration
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
US5084350A
(en)
|
1990-02-16 |
1992-01-28 |
The Royal Institution For The Advance Of Learning (Mcgill University) |
Method for encapsulating biologically active material including cells
|
|
US5272070A
(en)
|
1991-03-08 |
1993-12-21 |
Board Of Regents, The University Of Texas System |
Method for the preparation of cell lines producing Man3 GlcNac 2 asparagine-linked gylcans and cell lines produced thereby
|
|
CA2109085C
(en)
|
1991-04-25 |
2003-03-11 |
Keith E. Dionne |
Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products
|
|
US5733761A
(en)
|
1991-11-05 |
1998-03-31 |
Transkaryotic Therapies, Inc. |
Protein production and protein delivery
|
|
US6042828A
(en)
|
1992-09-07 |
2000-03-28 |
Kyowa Hakko Kogyo Co., Ltd. |
Humanized antibodies to ganglioside GM2
|
|
ATE218893T1
(de)
|
1993-08-12 |
2002-06-15 |
Neurotech Sa |
Biokompatible immunoisolatorische kapseln, die genetisch veränderte zellen enthalten
|
|
US5589359A
(en)
|
1994-08-05 |
1996-12-31 |
Chiron Corporation |
Chimeric proteins
|
|
US5834251A
(en)
|
1994-12-30 |
1998-11-10 |
Alko Group Ltd. |
Methods of modifying carbohydrate moieties
|
|
WO1997044470A1
(en)
|
1996-05-21 |
1997-11-27 |
Novo Nordisk A/S |
Novel yeast promoters suitable for expression cloning in yeast and heterologous expression of proteins in yeast
|
|
US6699658B1
(en)
|
1996-05-31 |
2004-03-02 |
Board Of Trustees Of The University Of Illinois |
Yeast cell surface display of proteins and uses thereof
|
|
US6300065B1
(en)
|
1996-05-31 |
2001-10-09 |
Board Of Trustees Of The University Of Illinois |
Yeast cell surface display of proteins and uses thereof
|
|
IL127583A0
(en)
|
1996-07-05 |
1999-10-28 |
Novo Nordisk As |
Method for the production of polypeptides
|
|
US6110703A
(en)
|
1996-07-05 |
2000-08-29 |
Novo Nordisk A/S |
Method for the production of polypeptides
|
|
AU3255397A
(en)
|
1996-07-05 |
1998-02-02 |
Novo Nordisk A/S |
Method for the production of precursors of insulin, precursors of insulin analogues, and insulin like peptides
|
|
ATE262041T1
(de)
|
1997-04-23 |
2004-04-15 |
Vlaams Interuniv Inst Biotech |
Regulationssystem für induzierbare expression von gene mit lambda-ähnlichen promotoren
|
|
US7442772B2
(en)
|
1997-12-03 |
2008-10-28 |
Genentech, Inc. |
Antibodies to PRO361 polypeptide
|
|
WO1999037758A2
(en)
|
1998-01-27 |
1999-07-29 |
The Board Of Regents Of The University And Community College System Of Nevada On Behalf Of The University Of Nevada-Reno |
Expression of proteolytically-sensitive peptides
|
|
WO2001042462A2
(en)
|
1999-12-08 |
2001-06-14 |
National University Of Singapore |
Phospholipase a2 inhibitory peptides from python reticulatus
|
|
US20020127219A1
(en)
*
|
1999-12-30 |
2002-09-12 |
Okkels Jens Sigurd |
Lysosomal enzymes and lysosomal enzyme activators
|
|
AU2352201A
(en)
|
1999-12-30 |
2001-07-16 |
Maxygen Aps |
Improved lysosomal enzymes and lysosomal enzyme activators
|
|
DK1283265T3
(da)
|
2000-05-17 |
2009-11-09 |
Mitsubishi Tanabe Pharma Corp |
Fremgangsmåde til fremstilling af protein med reduktion af mannosephosphat i sukkerkæden og glycoprotein fremstillet derved
|
|
US7863020B2
(en)
|
2000-06-28 |
2011-01-04 |
Glycofi, Inc. |
Production of sialylated N-glycans in lower eukaryotes
|
|
US7449308B2
(en)
|
2000-06-28 |
2008-11-11 |
Glycofi, Inc. |
Combinatorial DNA library for producing modified N-glycans in lower eukaryotes
|
|
US7598055B2
(en)
|
2000-06-28 |
2009-10-06 |
Glycofi, Inc. |
N-acetylglucosaminyltransferase III expression in lower eukaryotes
|
|
US7625756B2
(en)
|
2000-06-28 |
2009-12-01 |
GycoFi, Inc. |
Expression of class 2 mannosidase and class III mannosidase in lower eukaryotic cells
|
|
EP2322644A1
(en)
|
2000-06-28 |
2011-05-18 |
GlycoFi, Inc. |
Methods for producing modified glycoproteins
|
|
US7795002B2
(en)
|
2000-06-28 |
2010-09-14 |
Glycofi, Inc. |
Production of galactosylated glycoproteins in lower eukaryotes
|
|
US8697394B2
(en)
|
2000-06-28 |
2014-04-15 |
Glycofi, Inc. |
Production of modified glycoproteins having multiple antennary structures
|
|
EP2267135A3
(en)
|
2000-06-30 |
2011-09-14 |
Vib Vzw |
Protein glycosylation modification in pichia pastoris
|
|
KR100386836B1
(ko)
|
2000-08-31 |
2003-06-09 |
동국제약 주식회사 |
재조합 인체 부갑상선 호르몬을 생산하는 형질전환효모 및재조합 인체 부갑상선 호르몬의 생산방법
|
|
US7001994B2
(en)
|
2001-01-18 |
2006-02-21 |
Genzyme Corporation |
Methods for introducing mannose 6-phosphate and other oligosaccharides onto glycoproteins
|
|
JP4774496B2
(ja)
|
2001-06-14 |
2011-09-14 |
独立行政法人産業技術総合研究所 |
α−マンノシダーゼ
|
|
JP4742191B2
(ja)
|
2001-06-14 |
2011-08-10 |
独立行政法人産業技術総合研究所 |
糖蛋白質およびその製造方法
|
|
DK1438400T3
(da)
|
2001-10-01 |
2009-10-05 |
Dyax Corp |
Flerkædede eukaryote display-vektorer og anvendelser deraf
|
|
US7473680B2
(en)
|
2001-11-28 |
2009-01-06 |
Neose Technologies, Inc. |
Remodeling and glycoconjugation of peptides
|
|
JP4820055B2
(ja)
|
2001-12-27 |
2011-11-24 |
グライコフィ， インコーポレイテッド |
哺乳動物型糖質構造を操作するための方法
|
|
ES2327830T3
(es)
|
2002-03-29 |
2009-11-04 |
Schering Corporation |
Anticuerpos monoclonales humanos anti-interleuquina-5 y metodos y composiciones que los contienen.
|
|
US7972809B2
(en)
|
2002-04-26 |
2011-07-05 |
National Institute Of Advanced Industrial Science & Technology |
Methylotrophic yeast producing mammalian type sugar chain
|
|
IL165717A0
(en)
|
2002-06-26 |
2006-01-15 |
Flanders Interuniversity Inst |
A strain of methylotrophic yeast for producing proteins
|
|
DE60334109D1
(de)
|
2002-06-29 |
2010-10-21 |
Leadbio Inc |
Yapsin-mangelmutantenstamm von hansenula polymorpha sowie verfahren zur herstellung rekombinanter proteine damit
|
|
KR100470978B1
(ko)
|
2003-01-02 |
2005-03-10 |
한국생명공학연구원 |
앱신 다중 결손 효모 변이 균주 및 이를 이용한 재조합 단백질의 생산 방법
|
|
RU2407796C2
(ru)
*
|
2003-01-22 |
2010-12-27 |
Гликарт Биотекнолоджи АГ |
КОНСТРУКЦИИ СЛИЯНИЯ И ИХ ПРИМЕНЕНИЕ ДЛЯ ПОЛУЧЕНИЯ АНТИТЕЛ С ПОВЫШЕННЫМИ АФФИННОСТЬЮ СВЯЗЫВАНИЯ Fc-РЕЦЕПТОРА И ЭФФЕКТОРНОЙ ФУНКЦИЕЙ
|
|
AU2012206984B2
(en)
|
2003-02-11 |
2015-07-09 |
Takeda Pharmaceutical Company Limited |
Diagnosis and treatment of multiple sulfatase deficiency and other using a formylglycine generating enzyme (FGE)
|
|
JP4259169B2
(ja)
|
2003-04-16 |
2009-04-30 |
昭和産業株式会社 |
新規α−１，２−マンノシダーゼおよびその遺伝子、ならびに該酵素を用いたα−マンノシル糖化合物の製造方法
|
|
US7259255B2
(en)
|
2003-06-25 |
2007-08-21 |
E. I. Du Pont De Nemours And Company |
Glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate mutase promoters for gene expression in oleaginous yeast
|
|
EP2341128A1
(en)
|
2003-12-24 |
2011-07-06 |
GlycoFi, Inc. |
Methods for eliminating mannosylphosphorylation of glycans in the production of glycoproteins
|
|
CN1922313B
(zh)
|
2004-02-10 |
2011-10-26 |
生物马林医药公司 |
酸性α-糖苷酶及其片段
|
|
US20050265988A1
(en)
|
2004-03-18 |
2005-12-01 |
Byung-Kwon Choi |
Glycosylated glucocerebrosidase expression in fungal hosts
|
|
EP1737969B2
(en)
|
2004-04-15 |
2018-09-12 |
GlycoFi, Inc. |
Production of galactosylated glycoproteins in lower eukaryotes
|
|
CA2501422C
(en)
|
2004-04-29 |
2014-08-12 |
University Of Rochester |
Lymphoid chemokines in the diagnosis, monitoring and treatment of autoimmune disease
|
|
US7465577B2
(en)
|
2004-04-29 |
2008-12-16 |
Glycofi, Inc. |
Methods for reducing or eliminating α-mannosidase resistant glycans for the production of glycoproteins
|
|
US20060014264A1
(en)
|
2004-07-13 |
2006-01-19 |
Stowers Institute For Medical Research |
Cre/lox system with lox sites having an extended spacer region
|
|
US7431927B2
(en)
|
2005-03-24 |
2008-10-07 |
Epitomics, Inc. |
TNFα-neutralizing antibodies
|
|
EP1861505A1
(en)
*
|
2005-03-24 |
2007-12-05 |
DSMIP Assets B.V. |
Process for microbial production of a valuable compound
|
|
CA2604917A1
(en)
|
2005-04-14 |
2007-01-25 |
Csir |
Recombinant yeasts for synthesizing epoxide hydrolases
|
|
CA2623197A1
(en)
|
2005-09-22 |
2007-03-29 |
Prosci Incorporated |
Glycosylated polypeptides produced in yeast mutants and methods of use thereof
|
|
US20080081035A1
(en)
*
|
2006-10-03 |
2008-04-03 |
National Enzyme Company |
Therapeutic protease compositions
|
|
US20110076752A1
(en)
|
2007-02-09 |
2011-03-31 |
Medimmune, Llc |
Antibody library display by yeast cell plasma membrane
|
|
WO2008120107A2
(en)
|
2007-04-03 |
2008-10-09 |
Oxyrane (Uk) Limited |
Glycosylation of molecules
|
|
EP2166093B1
(en)
|
2007-05-18 |
2015-09-16 |
Tokyo Metropolitan Institute of Medical Science |
Pharmaceutical composition for enzyme replacement therapy
|
|
CN105274072A
(zh)
|
2008-01-18 |
2016-01-27 |
生物马林药物股份有限公司 |
制备活性高度磷酸化人溶酶体硫酸酯酶及其应用
|
|
EP2245151B1
(en)
|
2008-02-20 |
2014-12-24 |
GlycoFi, Inc. |
Vectors and yeast strains for protein production
|
|
HRP20170698T1
(hr)
*
|
2008-05-07 |
2017-09-22 |
Biomarin Pharmaceutical Inc. |
Lizosomski usmjereni peptidi i njihove uporabe
|
|
EP2401357B1
(en)
|
2009-02-26 |
2015-03-25 |
GlaxoSmithKline LLC |
Host cells and methods of use
|
|
US9598682B2
(en)
|
2009-09-29 |
2017-03-21 |
Vib Vzw |
Hydrolysis of mannose-1-phospho-6-mannose linkage to phospho-6-mannose
|
|
US20130053550A1
(en)
|
2009-11-19 |
2013-02-28 |
Oxyrane Uk Limited |
Yeast strains producing mammalian-like complex n-glycans
|
|
FR2954349A1
(fr)
|
2009-12-22 |
2011-06-24 |
Agronomique Inst Nat Rech |
Sulfatase modifiant selectivement les glycosaminoglycanes
|
|
US20130096281A1
(en)
|
2010-01-21 |
2013-04-18 |
Oxyrane Uk Limited |
Methods and compositions for displaying a polypeptide on a yeast cell surface
|
|
US20120135461A1
(en)
|
2010-07-30 |
2012-05-31 |
William James Cook |
Production of glycoproteins with reduced o-glycosylation comprising the use of an alpha-1,2-mannosidase
|
|
WO2012042387A2
(en)
*
|
2010-09-29 |
2012-04-05 |
Oxyrane Uk Limited |
De-mannosylation of phosphorylated n-glycans
|
|
US9347050B2
(en)
|
2010-09-29 |
2016-05-24 |
Oxyrane Uk Limited |
Mannosidases capable of uncapping mannose-1-phospho-6-mannose linkages and demannosylating phosphorylated N-glycans and methods of facilitating mammalian cellular uptake of glycoproteins
|
|
BR112014015933A2
(pt)
|
2011-12-30 |
2019-09-24 |
Oxyrane Uk Ltd |
métodos e materiais para reduzir a degradação das proteínas recombinantes
|
|
EP3628326B1
(en)
|
2012-03-15 |
2024-02-28 |
Oxyrane UK Limited |
Methods and materials for treatment of pompe's disease
|