JP2013534902A5 - - Google Patents

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Publication number
JP2013534902A5
JP2013534902A5 JP2013501421A JP2013501421A JP2013534902A5 JP 2013534902 A5 JP2013534902 A5 JP 2013534902A5 JP 2013501421 A JP2013501421 A JP 2013501421A JP 2013501421 A JP2013501421 A JP 2013501421A JP 2013534902 A5 JP2013534902 A5 JP 2013534902A5
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JP
Japan
Prior art keywords
indol
dihydro
amine
acetyl
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2013501421A
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English (en)
Japanese (ja)
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JP2013534902A (ja
JP5876031B2 (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2011/029511 external-priority patent/WO2011119663A1/en
Publication of JP2013534902A publication Critical patent/JP2013534902A/ja
Publication of JP2013534902A5 publication Critical patent/JP2013534902A5/ja
Application granted granted Critical
Publication of JP5876031B2 publication Critical patent/JP5876031B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2013501421A 2010-03-25 2011-03-23 化合物 Expired - Fee Related JP5876031B2 (ja)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US31747610P 2010-03-25 2010-03-25
US61/317,476 2010-03-25
US35286310P 2010-06-09 2010-06-09
US61/352,863 2010-06-09
US38148010P 2010-09-10 2010-09-10
US61/381,480 2010-09-10
US38815110P 2010-09-30 2010-09-30
US61/388,151 2010-09-30
US41906810P 2010-12-02 2010-12-02
US61/419,068 2010-12-02
PCT/US2011/029511 WO2011119663A1 (en) 2010-03-25 2011-03-23 Chemical compounds

Publications (3)

Publication Number Publication Date
JP2013534902A JP2013534902A (ja) 2013-09-09
JP2013534902A5 true JP2013534902A5 (enExample) 2014-05-08
JP5876031B2 JP5876031B2 (ja) 2016-03-02

Family

ID=46160738

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013501421A Expired - Fee Related JP5876031B2 (ja) 2010-03-25 2011-03-23 化合物

Country Status (15)

Country Link
US (1) US20120077828A1 (enExample)
EP (1) EP2549868B1 (enExample)
JP (1) JP5876031B2 (enExample)
KR (1) KR101676077B1 (enExample)
CN (1) CN102917588B (enExample)
AR (1) AR080792A1 (enExample)
AU (1) AU2011232516B2 (enExample)
EA (1) EA022325B1 (enExample)
ES (1) ES2530955T3 (enExample)
IL (1) IL222120A (enExample)
MX (1) MX2012011045A (enExample)
SG (1) SG183954A1 (enExample)
TW (1) TW201202241A (enExample)
UY (1) UY33288A (enExample)
WO (1) WO2011119663A1 (enExample)

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WO2015056180A1 (en) * 2013-10-15 2015-04-23 Glaxosmithkline Intellectual Property (No.2) Limited Indoline derivatives as inhibitors of perk
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RS62713B1 (sr) 2014-08-11 2022-01-31 Acerta Pharma Bv Terapeutske kombinacije btk inhibitora i bcl-2 inhibitora
AR102426A1 (es) 2014-10-24 2017-03-01 Bristol Myers Squibb Co Compuestos de indolcarboxamida como inhibidores de btk
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WO2016126026A2 (ko) * 2015-02-04 2016-08-11 서울대학교병원 당뇨병 치료 조성물 및 이의 용도
RU2018103913A (ru) 2015-07-02 2019-08-02 Асерта Фарма Б.В. Твердые формы и композиции (s)-4-(8-амино-3-(1-(бут-2- иноил)пирролидин-2-ил)имидазо[1,5-a]пиразин-1-ил)-n-(пиридин-2-ил)бензамида
TW201722957A (zh) * 2015-09-15 2017-07-01 葛蘭素史克智慧財產(第二)有限公司 化學化合物
WO2017046739A1 (en) * 2015-09-15 2017-03-23 Glaxosmithkline Intellectual Property (No.2) Limited Imidazolidinone derivatives as inhibitors of perk
CN113549110B (zh) * 2016-04-07 2024-08-16 葛兰素史密斯克莱知识产权发展有限公司 用作蛋白质调节剂的杂环酰胺
EP3442980B1 (en) * 2016-04-15 2021-06-09 Cancer Research Technology Limited Heterocyclic compounds as ret kinase inhibitors
US11026945B2 (en) * 2016-04-29 2021-06-08 The Trustees Of The University Of Pennsylvania Protein kinase RNA-like endoplasmic reticulum kinase (PERK) inhibitors for prevention and/or treatment of lung injury and/or inflammation
US10723706B2 (en) 2016-06-13 2020-07-28 Ramot At Tel-Aviv University Ltd. Perk inhibitors and uses thereof in treating diseases associated with aggregation-prone proteins
MX388660B (es) 2016-06-21 2025-03-20 Nerviano Medical Sciences Srl DERIVADOS DE N-(SUSTITUIDA-FENIL)-SULFONAMIDA COMO INHIBIDORES DE QUINASA N-(sustituida-fenil)-sulfonamida.
AU2017300123A1 (en) * 2016-07-20 2019-01-31 Glaxosmithkline Intellectual Property Development Limited Isoquinoline derivatives as PERK inhibitors
CN109982693A (zh) * 2016-09-22 2019-07-05 香港大学 细胞异常分化和isr相关疾病的预防和治疗方法
WO2018138358A1 (en) 2017-01-30 2018-08-02 Université de Liège Perk and ire-1a inhibitors against neurodevelopmental disorders
CN106974910B (zh) * 2017-03-02 2019-11-12 深圳大学 含索拉非尼和gsk2656157的药物组合物及用途
CN106963769B (zh) * 2017-03-03 2019-10-25 深圳大学 含pi3k抑制剂和perk抑制剂的药物组合物及其应用
HUE069999T2 (hu) 2017-03-06 2025-04-28 Tsubota Lab Inc Kompozíció miópia megelõzésében vagy szuppressziójában történõ alkalmazásra
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CN111213632B (zh) * 2019-11-19 2022-03-01 长春中医药大学 动物药环氧树脂标本制作方法
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