JP2021525783A5 - - Google Patents
Info
- Publication number
- JP2021525783A5 JP2021525783A5 JP2020568258A JP2020568258A JP2021525783A5 JP 2021525783 A5 JP2021525783 A5 JP 2021525783A5 JP 2020568258 A JP2020568258 A JP 2020568258A JP 2020568258 A JP2020568258 A JP 2020568258A JP 2021525783 A5 JP2021525783 A5 JP 2021525783A5
- Authority
- JP
- Japan
- Prior art keywords
- hydroxymethyl
- benzyl
- pyridine
- pyrazine
- fluoro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2018/090385 | 2018-06-08 | ||
| CN2018090385 | 2018-06-08 | ||
| CN2018120975 | 2018-12-13 | ||
| CNPCT/CN2018/120975 | 2018-12-13 | ||
| PCT/CN2019/090221 WO2019233457A1 (zh) | 2018-06-08 | 2019-06-06 | Erk抑制剂及其应用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021525783A JP2021525783A (ja) | 2021-09-27 |
| JP2021525783A5 true JP2021525783A5 (enExample) | 2022-05-16 |
Family
ID=68770778
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020568258A Pending JP2021525783A (ja) | 2018-06-08 | 2019-06-06 | Ｅｒｋ阻害剤及びその使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US11466013B2 (enExample) |
| EP (1) | EP3805217A4 (enExample) |
| JP (1) | JP2021525783A (enExample) |
| KR (1) | KR20210018915A (enExample) |
| CN (1) | CN112204024B (enExample) |
| AU (1) | AU2019280356B2 (enExample) |
| CA (1) | CA3103055A1 (enExample) |
| IL (1) | IL279276A (enExample) |
| SG (1) | SG11202012241RA (enExample) |
| TW (1) | TW202016102A (enExample) |
| WO (1) | WO2019233457A1 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4071155A4 (en) * | 2019-12-06 | 2024-01-17 | D3 Bio (Wuxi) Co., Ltd. | Thiazololactam compound as erk inhibitor and use thereof |
| WO2022253186A1 (zh) * | 2021-06-02 | 2022-12-08 | 南京明德新药研发有限公司 | 一种二甲基取代的噻唑并吡咯酮类化合物的晶型及其制备方法 |
| WO2022268065A1 (en) * | 2021-06-22 | 2022-12-29 | Fochon Biosciences, Ltd. | Compounds as erk inhibitors |
| EP4366733A4 (en) * | 2021-08-11 | 2025-06-25 | Landos Biopharma, Inc. | TETRAHYDROPYRAZOLOPYRIDINE ANALOGUES OF NLRX1 LIGANDS AND THEIR USES |
| WO2024218632A1 (en) * | 2023-04-17 | 2024-10-24 | Array Biopharma Inc. | Erk protein kinase inhibitors |
| KR20260019479A (ko) | 2023-05-04 | 2026-02-10 | 레볼루션 메디슨즈, 인크. | Ras 관련 질환 또는 장애를 위한 병용 요법 |
| CN121889155A (zh) | 2023-08-07 | 2026-04-17 | 锐新医药公司 | 用于治疗ras蛋白相关疾病或病症的rmc-6291 |
| CN117209485A (zh) * | 2023-08-31 | 2023-12-12 | 四川大学华西医院 | 一种具有抗肿瘤活性的嘧啶骨架类化合物及其制备方法和应用 |
| AU2024360465A1 (en) | 2023-10-12 | 2026-04-09 | Revolution Medicines, Inc. | Macrocyclic ras inhibitors |
| WO2025171296A1 (en) | 2024-02-09 | 2025-08-14 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025240847A1 (en) | 2024-05-17 | 2025-11-20 | Revolution Medicines, Inc. | Ras inhibitors |
| US20250375445A1 (en) | 2024-06-07 | 2025-12-11 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| WO2025265060A1 (en) | 2024-06-21 | 2025-12-26 | Revolution Medicines, Inc. | Therapeutic compositions and methods for managing treatment-related effects |
| WO2026006747A1 (en) | 2024-06-28 | 2026-01-02 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026015801A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015790A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015825A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Use of ras inhibitor for treating pancreatic cancer |
| WO2026015796A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026050446A1 (en) | 2024-08-29 | 2026-03-05 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026072904A2 (en) | 2024-09-26 | 2026-04-02 | Revolution Medicines, Inc. | Compositions and methods for treating lung cancer |
| WO2026090116A2 (en) | 2024-10-21 | 2026-04-30 | Revolution Medicines, Inc. | Ras inhibitors |
| US20260108528A1 (en) | 2024-10-22 | 2026-04-23 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| WO2026090245A1 (en) | 2024-10-22 | 2026-04-30 | Revolution Medicines, Inc. | Use of ras inhibitors for treating cancer |
| WO2026106912A1 (en) | 2024-11-12 | 2026-05-21 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026112260A1 (en) | 2024-11-21 | 2026-05-28 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026122764A2 (en) | 2024-12-06 | 2026-06-11 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026128688A2 (en) | 2024-12-13 | 2026-06-18 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026161839A1 (en) | 2025-01-27 | 2026-07-30 | Revolution Medicines, Inc. | Ras inhibitors |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4783532B2 (ja) * | 2000-02-05 | 2011-09-28 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ｅｒｋのインヒビターとして有用なピラゾール組成物 |
| GB0614070D0 (en) * | 2006-07-14 | 2006-08-23 | Glaxo Group Ltd | Compounds |
| CN101796036A (zh) * | 2007-08-02 | 2010-08-04 | 欧加农股份有限公司 | 作为trpv1调节剂的5-苯基异噁唑-3-甲酰胺衍生物 |
| WO2016026078A1 (en) * | 2014-08-19 | 2016-02-25 | Changzhou Jiekai Pharmatech Co., Ltd. | Heterocyclic compounds as erk inhibitors |
| CN107922387B (zh) * | 2015-06-15 | 2024-11-22 | 阿沙纳生物科学公司 | Erk1与erk2的杂环抑制剂及其在癌症治疗中的应用 |
| WO2017080980A1 (en) * | 2015-11-09 | 2017-05-18 | Astrazeneca Ab | Dihydropyrrolopyrazinone derivatives useful in the treatment of cancer |
-
2019
- 2019-06-06 AU AU2019280356A patent/AU2019280356B2/en not_active Expired - Fee Related
- 2019-06-06 KR KR1020217000434A patent/KR20210018915A/ko not_active Ceased
- 2019-06-06 TW TW108119658A patent/TW202016102A/zh unknown
- 2019-06-06 CN CN201980031574.6A patent/CN112204024B/zh not_active Expired - Fee Related
- 2019-06-06 JP JP2020568258A patent/JP2021525783A/ja active Pending
- 2019-06-06 CA CA3103055A patent/CA3103055A1/en active Pending
- 2019-06-06 EP EP19815477.5A patent/EP3805217A4/en not_active Withdrawn
- 2019-06-06 US US16/973,335 patent/US11466013B2/en active Active
- 2019-06-06 SG SG11202012241RA patent/SG11202012241RA/en unknown
- 2019-06-06 WO PCT/CN2019/090221 patent/WO2019233457A1/zh not_active Ceased
-
2020
- 2020-12-08 IL IL279276A patent/IL279276A/en unknown
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