JP2013533977A5 - - Google Patents
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- Publication number
- JP2013533977A5 JP2013533977A5 JP2013518909A JP2013518909A JP2013533977A5 JP 2013533977 A5 JP2013533977 A5 JP 2013533977A5 JP 2013518909 A JP2013518909 A JP 2013518909A JP 2013518909 A JP2013518909 A JP 2013518909A JP 2013533977 A5 JP2013533977 A5 JP 2013533977A5
- Authority
- JP
- Japan
- Prior art keywords
- biomarkers
- level
- m2pk
- igfbp2
- dkk
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 36
- 239000000090 biomarker Substances 0.000 claims 20
- 206010009944 Colon cancer Diseases 0.000 claims 7
- 102100037985 Dickkopf-related protein 3 Human genes 0.000 claims 7
- 101710099550 Dickkopf-related protein 3 Proteins 0.000 claims 7
- 101001044940 Homo sapiens Insulin-like growth factor-binding protein 2 Proteins 0.000 claims 7
- 102100022710 Insulin-like growth factor-binding protein 2 Human genes 0.000 claims 7
- -1 M2PK Proteins 0.000 claims 7
- 150000001875 compounds Chemical class 0.000 claims 7
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 6
- 102000018651 Epithelial Cell Adhesion Molecule Human genes 0.000 claims 6
- 108010066687 Epithelial Cell Adhesion Molecule Proteins 0.000 claims 6
- 108090001007 Interleukin-8 Proteins 0.000 claims 6
- 230000035945 sensitivity Effects 0.000 claims 6
- 102100040510 Galectin-3-binding protein Human genes 0.000 claims 5
- 101710197901 Galectin-3-binding protein Proteins 0.000 claims 5
- 102000003816 Interleukin-13 Human genes 0.000 claims 5
- 108090000176 Interleukin-13 Proteins 0.000 claims 5
- 102000004890 Interleukin-8 Human genes 0.000 claims 4
- 102000001326 Chemokine CCL4 Human genes 0.000 claims 3
- 108010055165 Chemokine CCL4 Proteins 0.000 claims 3
- 102100039364 Metalloproteinase inhibitor 1 Human genes 0.000 claims 3
- 108010031374 Tissue Inhibitor of Metalloproteinase-1 Proteins 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 238000001514 detection method Methods 0.000 claims 2
- 238000003745 diagnosis Methods 0.000 claims 2
- 102100026802 72 kDa type IV collagenase Human genes 0.000 claims 1
- 101710151806 72 kDa type IV collagenase Proteins 0.000 claims 1
- 102100038778 Amphiregulin Human genes 0.000 claims 1
- 108010033760 Amphiregulin Proteins 0.000 claims 1
- 102100021943 C-C motif chemokine 2 Human genes 0.000 claims 1
- 101710155857 C-C motif chemokine 2 Proteins 0.000 claims 1
- 102100036150 C-X-C motif chemokine 5 Human genes 0.000 claims 1
- 101000947186 Homo sapiens C-X-C motif chemokine 5 Proteins 0.000 claims 1
- 101000808011 Homo sapiens Vascular endothelial growth factor A Proteins 0.000 claims 1
- 101000742599 Homo sapiens Vascular endothelial growth factor D Proteins 0.000 claims 1
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims 1
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 claims 1
- 102000048143 Insulin-Like Growth Factor II Human genes 0.000 claims 1
- 108090001117 Insulin-Like Growth Factor II Proteins 0.000 claims 1
- 102100037850 Interferon gamma Human genes 0.000 claims 1
- 108010074328 Interferon-gamma Proteins 0.000 claims 1
- 102000003814 Interleukin-10 Human genes 0.000 claims 1
- 108090000174 Interleukin-10 Proteins 0.000 claims 1
- 108090000978 Interleukin-4 Proteins 0.000 claims 1
- 108090001005 Interleukin-6 Proteins 0.000 claims 1
- 102100030417 Matrilysin Human genes 0.000 claims 1
- 108090000855 Matrilysin Proteins 0.000 claims 1
- 102000000380 Matrix Metalloproteinase 1 Human genes 0.000 claims 1
- 108010016113 Matrix Metalloproteinase 1 Proteins 0.000 claims 1
- 102100030412 Matrix metalloproteinase-9 Human genes 0.000 claims 1
- 108010015302 Matrix metalloproteinase-9 Proteins 0.000 claims 1
- 102100026262 Metalloproteinase inhibitor 2 Human genes 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 102000013009 Pyruvate Kinase Human genes 0.000 claims 1
- 108020005115 Pyruvate Kinase Proteins 0.000 claims 1
- 108010031372 Tissue Inhibitor of Metalloproteinase-2 Proteins 0.000 claims 1
- 102100039037 Vascular endothelial growth factor A Human genes 0.000 claims 1
- 102100038234 Vascular endothelial growth factor D Human genes 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 210000001772 blood platelet Anatomy 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 210000003593 megakaryocyte Anatomy 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2010903140A AU2010903140A0 (en) | 2010-07-14 | Diagnostic for colorectal cancer | |
| AU2010903140 | 2010-07-14 | ||
| PCT/AU2011/000895 WO2012006681A1 (en) | 2010-07-14 | 2011-07-14 | Diagnostic for colorectal cancer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013533977A JP2013533977A (ja) | 2013-08-29 |
| JP2013533977A5 true JP2013533977A5 (enExample) | 2014-09-18 |
| JP6061344B2 JP6061344B2 (ja) | 2017-01-18 |
Family
ID=45468816
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013518909A Active JP6061344B2 (ja) | 2010-07-14 | 2011-07-14 | 大腸癌の診断 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20130345322A1 (enExample) |
| EP (2) | EP2593795A4 (enExample) |
| JP (1) | JP6061344B2 (enExample) |
| CN (2) | CN103140760B (enExample) |
| AU (1) | AU2011279555B2 (enExample) |
| BR (1) | BR112013000745B1 (enExample) |
| DK (1) | DK2829881T3 (enExample) |
| ES (1) | ES2653646T3 (enExample) |
| IN (1) | IN2013CN01129A (enExample) |
| NO (1) | NO2829881T3 (enExample) |
| PT (1) | PT2829881T (enExample) |
| RU (1) | RU2013103995A (enExample) |
| WO (1) | WO2012006681A1 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2011279555B2 (en) | 2010-07-14 | 2016-10-20 | Vision Tech Bio Pty Ltd | Diagnostic for colorectal cancer |
| US9141756B1 (en) | 2010-07-20 | 2015-09-22 | University Of Southern California | Multi-scale complex systems transdisciplinary analysis of response to therapy |
| MX2013008833A (es) | 2011-02-02 | 2013-12-06 | Amgen Inc | Metodos y composiciones relacionadas con la inhibicion de receptor del factor de crecimiento similar a la insulina 1 (igf-1r). |
| PT2883057T (pt) * | 2012-08-09 | 2019-03-06 | Univ Toulouse 3 Paul Sabatier | Diagnóstico de insuficiência cardíaca |
| GB201218341D0 (en) * | 2012-10-12 | 2012-11-28 | Orign Sciences Ltd | Diagnostic method |
| AU2015237229A1 (en) * | 2014-03-28 | 2016-11-10 | Applied Proteomics, Inc. | Protein biomarker profiles for detecting colorectal tumors |
| MX375557B (es) * | 2014-07-18 | 2025-03-06 | Sanofi Sa | Método para predecir el resultado de un tratamiento con aflibercept de un paciente que se sospecha que padece un cáncer. |
| CN106191215B (zh) * | 2015-04-29 | 2020-03-24 | 中国科学院上海生命科学研究院 | 肌肉萎缩相关的蛋白质分子标记Dkk-3的筛选及其应用 |
| EP3294321B1 (en) * | 2015-05-12 | 2024-07-31 | Superlab Far East Limited | Methods of determining interferon having direct inhibitory effects on tumors and uses thereof |
| CN105219844B (zh) * | 2015-06-08 | 2018-12-14 | 华夏京都医疗投资管理有限公司 | 一种筛查十一种疾病的基因标志物组合、试剂盒以及疾病风险预测模型 |
| CN105021828B (zh) * | 2015-07-20 | 2017-07-28 | 上海交通大学医学院附属新华医院 | 通过检测三期结直肠肿瘤患者血清预测肿瘤患者预后 |
| CN105567846A (zh) * | 2016-02-14 | 2016-05-11 | 上海交通大学医学院附属仁济医院 | 检测粪便中细菌dna的试剂盒及其在大肠癌诊断中的应用 |
| JP6984862B2 (ja) * | 2017-03-15 | 2021-12-22 | 国立大学法人金沢大学 | 血中ケモカインをマーカーとして用いた大腸癌の検出 |
| CN107164535A (zh) * | 2017-07-07 | 2017-09-15 | 沈阳宁沪科技有限公司 | 一种无创高通量甲基化结肠癌诊断、研究和治疗方法 |
| CN110540588B (zh) * | 2018-05-28 | 2022-08-23 | 香港中文大学 | 一种基于肿瘤干细胞标志物EpCAM的抗原表位多肽及其应用 |
| CN108957014A (zh) * | 2018-09-27 | 2018-12-07 | 郑州大学第附属医院 | 结直肠癌血清标志物、表达评估方法、试剂盒及应用 |
| EP3870030A4 (en) * | 2018-10-23 | 2022-08-03 | Blackthorn Therapeutics, Inc. | SYSTEMS AND METHODS FOR SCREENING, DIAGNOSIS AND STRATIFICATION OF PATIENTS |
| CN109504778B (zh) * | 2019-01-11 | 2021-11-09 | 复旦大学附属中山医院 | 一种基于表观修饰的5hmC多分子标志物及结直肠癌早期诊断模型 |
| JP2022522803A (ja) * | 2019-03-01 | 2022-04-20 | アドバンスド マーカー ディスカバリー エセ． エレ． | 結腸直腸癌及び／又はその前癌段階の診断用タンパク質シグネチャー |
| JP7300660B2 (ja) * | 2019-04-03 | 2023-06-30 | 京都府公立大学法人 | 大腸がんの検出方法 |
| JP7032764B2 (ja) * | 2019-04-03 | 2022-03-09 | 京都府公立大学法人 | 大腸がんの検出方法 |
| GB201906199D0 (en) * | 2019-05-02 | 2019-06-19 | Belgian Volition Sprl | Method for the detection of cancer |
| US20220378877A1 (en) * | 2019-11-13 | 2022-12-01 | University Of Virginia Patent Foundation | Treatment of clostridium difficile infections |
| EP3835789A1 (en) | 2019-12-13 | 2021-06-16 | Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts | Biomarker panel for diagnosing colorectal cancer |
| WO2022130597A1 (ja) * | 2020-12-18 | 2022-06-23 | 国立大学法人東北大学 | 推定装置、推定方法、推定プログラム、生成装置、及び、推定システム |
| CN117083525A (zh) * | 2020-12-21 | 2023-11-17 | 福瑞诺姆控股公司 | 用于结肠细胞增殖性病症的早期检测的标志物 |
| AU2022259871A1 (en) * | 2021-04-20 | 2023-11-23 | Vision Tech Bio Pty Ltd | Biomarkers for colorectal cancer |
| CA3228665A1 (en) * | 2021-08-11 | 2023-02-16 | Trevor Lockett | Method of detecting adenoma |
| WO2023128429A1 (ko) * | 2021-12-31 | 2023-07-06 | 주식회사 이노제닉스 | 대장암 및 진행 선종의 선별 검사 방법 및 그 응용 |
| WO2023128419A1 (ko) * | 2021-12-31 | 2023-07-06 | 주식회사 이노제닉스 | 대장암 및 대장 용종 또는 진행 선종의 선별 방법 및 그 응용 |
| CN114594259B (zh) * | 2022-04-22 | 2022-09-13 | 北京易科拜德科技有限公司 | 一种新型的用于结直肠癌预后预测和诊断的模型及其应用 |
| PL441319A1 (pl) * | 2022-05-31 | 2023-12-04 | Uniwersytet Medyczny Im. Piastów Śląskich We Wrocławiu | Zestaw biomarkerów białkowych i sposób diagnostyki raka jelita grubego in vitro |
| CN116219007A (zh) * | 2022-09-15 | 2023-06-06 | 绍兴积准生物科技有限公司 | 检测结直肠癌的生物标志物组及其应用 |
| CN119688988A (zh) * | 2024-11-25 | 2025-03-25 | 中国医学科学院肿瘤医院 | Timp1和foxp3作为诊断结直肠癌的生物标志物组合及其应用 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5925517A (en) | 1993-11-12 | 1999-07-20 | The Public Health Research Institute Of The City Of New York, Inc. | Detectably labeled dual conformation oligonucleotide probes, assays and kits |
| JP2004198419A (ja) * | 2002-12-13 | 2004-07-15 | Bayer Healthcare Llc | Ｔｉｍｐ１を用いた検出方法 |
| US20050014165A1 (en) * | 2003-07-18 | 2005-01-20 | California Pacific Medical Center | Biomarker panel for colorectal cancer |
| EP2280285A1 (en) * | 2003-09-15 | 2011-02-02 | Oklahoma Medical Research Foundation | Method of using cytokine assays to diagnose, treat, and evaluate inflammatory and autoimmune diseases |
| BRPI0401830A (pt) | 2004-05-25 | 2006-01-17 | Bentonit Uniao Nordeste Sa | Processo de produção de pós granulados secos |
| US20080112888A1 (en) * | 2006-06-30 | 2008-05-15 | Schering Corporation | Igfbp2 biomarker |
| US9060961B2 (en) | 2006-11-09 | 2015-06-23 | University Of Washington | Molecules and methods for treatment and detection of cancer |
| US9353415B2 (en) * | 2006-12-19 | 2016-05-31 | Thomson Reuters (Scientific) Llc | Methods for functional analysis of high-throughput experimental data and gene groups identified therefrom |
| JP2010517582A (ja) | 2007-02-12 | 2010-05-27 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 結腸癌の早期検出および予後診断の方法 |
| HUE028487T2 (en) * | 2007-02-27 | 2016-12-28 | Sentoclone Int Ab | Detection of tumor cell multiplex using panel of agents associated with extracellular markers |
| WO2008116178A2 (en) * | 2007-03-21 | 2008-09-25 | Vanderbilt University | Systems and methods for diagnosis and prognosis of colorectal cancer |
| CA2684024A1 (en) * | 2007-05-10 | 2008-11-20 | F. Hoffmann-La Roche Ag | Use of timp-1 as a marker for colorectal cancer |
| WO2008144345A2 (en) * | 2007-05-17 | 2008-11-27 | Bristol-Myers Squibb Company | Biomarkers and methods for determining sensitivity to insulin growth factor-1 receptor modulators |
| WO2009037572A2 (en) * | 2007-06-04 | 2009-03-26 | Diagnoplex | Biomarker combinations for colorectal cancer |
| US20090017463A1 (en) * | 2007-07-10 | 2009-01-15 | Vanderbilt University | Methods for predicting prostate cancer recurrence |
| WO2009126543A1 (en) * | 2008-04-08 | 2009-10-15 | Nuclea Biomarkers, Llc | Biomarker panel for prediction of recurrent colorectal cancer |
| US20100111969A1 (en) * | 2008-10-31 | 2010-05-06 | Apogenix Gmbh | Il-4 receptor and il-13 as prognostic markers for colon and pancreas tumors |
| CN102300578A (zh) * | 2008-12-01 | 2011-12-28 | 延寿有限责任公司 | 用于改变健康、安康和寿命的方法和组合物 |
| WO2010065940A1 (en) * | 2008-12-04 | 2010-06-10 | The Regents Of The University Of California | Materials and methods for determining diagnosis and prognosis of prostate cancer |
| CN102326080B (zh) * | 2009-02-20 | 2015-08-05 | 加利福尼亚大学董事会 | A+生物标志物的试验 |
| US20110177525A1 (en) * | 2010-01-19 | 2011-07-21 | Predictive Biosciences, Inc. | Antibodies and methods of diagnosing diseases |
| AU2011279555B2 (en) * | 2010-07-14 | 2016-10-20 | Vision Tech Bio Pty Ltd | Diagnostic for colorectal cancer |
-
2011
- 2011-07-14 AU AU2011279555A patent/AU2011279555B2/en active Active
- 2011-07-14 DK DK14178981.8T patent/DK2829881T3/en active
- 2011-07-14 EP EP11806149.8A patent/EP2593795A4/en not_active Withdrawn
- 2011-07-14 CN CN201180034158.5A patent/CN103140760B/zh active Active
- 2011-07-14 US US13/809,785 patent/US20130345322A1/en not_active Abandoned
- 2011-07-14 EP EP14178981.8A patent/EP2829881B1/en active Active
- 2011-07-14 IN IN1129CHN2013 patent/IN2013CN01129A/en unknown
- 2011-07-14 NO NO14178981A patent/NO2829881T3/no unknown
- 2011-07-14 PT PT141789818T patent/PT2829881T/pt unknown
- 2011-07-14 BR BR112013000745-1A patent/BR112013000745B1/pt not_active IP Right Cessation
- 2011-07-14 JP JP2013518909A patent/JP6061344B2/ja active Active
- 2011-07-14 RU RU2013103995/15A patent/RU2013103995A/ru not_active Application Discontinuation
- 2011-07-14 WO PCT/AU2011/000895 patent/WO2012006681A1/en not_active Ceased
- 2011-07-14 ES ES14178981.8T patent/ES2653646T3/es active Active
- 2011-07-14 CN CN201511009181.5A patent/CN105755112B/zh active Active
-
2017
- 2017-03-28 US US15/471,147 patent/US10877039B2/en active Active
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