JP2013533977A5 - - Google Patents
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- Publication number
- JP2013533977A5 JP2013533977A5 JP2013518909A JP2013518909A JP2013533977A5 JP 2013533977 A5 JP2013533977 A5 JP 2013533977A5 JP 2013518909 A JP2013518909 A JP 2013518909A JP 2013518909 A JP2013518909 A JP 2013518909A JP 2013533977 A5 JP2013533977 A5 JP 2013533977A5
- Authority
- JP
- Japan
- Prior art keywords
- biomarkers
- level
- m2pk
- igfbp2
- dkk
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 36
- 239000000090 biomarker Substances 0.000 claims 20
- 206010009944 Colon cancer Diseases 0.000 claims 7
- 102100037985 Dickkopf-related protein 3 Human genes 0.000 claims 7
- 101710099550 Dickkopf-related protein 3 Proteins 0.000 claims 7
- 101001044940 Homo sapiens Insulin-like growth factor-binding protein 2 Proteins 0.000 claims 7
- 102100022710 Insulin-like growth factor-binding protein 2 Human genes 0.000 claims 7
- -1 M2PK Proteins 0.000 claims 7
- 150000001875 compounds Chemical class 0.000 claims 7
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 6
- 102000018651 Epithelial Cell Adhesion Molecule Human genes 0.000 claims 6
- 108010066687 Epithelial Cell Adhesion Molecule Proteins 0.000 claims 6
- 108090001007 Interleukin-8 Proteins 0.000 claims 6
- 230000035945 sensitivity Effects 0.000 claims 6
- 102100040510 Galectin-3-binding protein Human genes 0.000 claims 5
- 101710197901 Galectin-3-binding protein Proteins 0.000 claims 5
- 102000003816 Interleukin-13 Human genes 0.000 claims 5
- 108090000176 Interleukin-13 Proteins 0.000 claims 5
- 102000004890 Interleukin-8 Human genes 0.000 claims 4
- 102000001326 Chemokine CCL4 Human genes 0.000 claims 3
- 108010055165 Chemokine CCL4 Proteins 0.000 claims 3
- 102100039364 Metalloproteinase inhibitor 1 Human genes 0.000 claims 3
- 108010031374 Tissue Inhibitor of Metalloproteinase-1 Proteins 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 238000001514 detection method Methods 0.000 claims 2
- 238000003745 diagnosis Methods 0.000 claims 2
- 102100026802 72 kDa type IV collagenase Human genes 0.000 claims 1
- 101710151806 72 kDa type IV collagenase Proteins 0.000 claims 1
- 102100038778 Amphiregulin Human genes 0.000 claims 1
- 108010033760 Amphiregulin Proteins 0.000 claims 1
- 102100021943 C-C motif chemokine 2 Human genes 0.000 claims 1
- 101710155857 C-C motif chemokine 2 Proteins 0.000 claims 1
- 102100036150 C-X-C motif chemokine 5 Human genes 0.000 claims 1
- 101000947186 Homo sapiens C-X-C motif chemokine 5 Proteins 0.000 claims 1
- 101000808011 Homo sapiens Vascular endothelial growth factor A Proteins 0.000 claims 1
- 101000742599 Homo sapiens Vascular endothelial growth factor D Proteins 0.000 claims 1
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims 1
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 claims 1
- 102000048143 Insulin-Like Growth Factor II Human genes 0.000 claims 1
- 108090001117 Insulin-Like Growth Factor II Proteins 0.000 claims 1
- 102100037850 Interferon gamma Human genes 0.000 claims 1
- 108010074328 Interferon-gamma Proteins 0.000 claims 1
- 102000003814 Interleukin-10 Human genes 0.000 claims 1
- 108090000174 Interleukin-10 Proteins 0.000 claims 1
- 108090000978 Interleukin-4 Proteins 0.000 claims 1
- 108090001005 Interleukin-6 Proteins 0.000 claims 1
- 102100030417 Matrilysin Human genes 0.000 claims 1
- 108090000855 Matrilysin Proteins 0.000 claims 1
- 102000000380 Matrix Metalloproteinase 1 Human genes 0.000 claims 1
- 108010016113 Matrix Metalloproteinase 1 Proteins 0.000 claims 1
- 102100030412 Matrix metalloproteinase-9 Human genes 0.000 claims 1
- 108010015302 Matrix metalloproteinase-9 Proteins 0.000 claims 1
- 102100026262 Metalloproteinase inhibitor 2 Human genes 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 102000013009 Pyruvate Kinase Human genes 0.000 claims 1
- 108020005115 Pyruvate Kinase Proteins 0.000 claims 1
- 108010031372 Tissue Inhibitor of Metalloproteinase-2 Proteins 0.000 claims 1
- 102100039037 Vascular endothelial growth factor A Human genes 0.000 claims 1
- 102100038234 Vascular endothelial growth factor D Human genes 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 210000001772 blood platelet Anatomy 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 210000003593 megakaryocyte Anatomy 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2010903140 | 2010-07-14 | ||
| AU2010903140A AU2010903140A0 (en) | 2010-07-14 | Diagnostic for colorectal cancer | |
| PCT/AU2011/000895 WO2012006681A1 (en) | 2010-07-14 | 2011-07-14 | Diagnostic for colorectal cancer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013533977A JP2013533977A (ja) | 2013-08-29 |
| JP2013533977A5 true JP2013533977A5 (enExample) | 2014-09-18 |
| JP6061344B2 JP6061344B2 (ja) | 2017-01-18 |
Family
ID=45468816
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013518909A Active JP6061344B2 (ja) | 2010-07-14 | 2011-07-14 | 大腸癌の診断 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20130345322A1 (enExample) |
| EP (2) | EP2829881B1 (enExample) |
| JP (1) | JP6061344B2 (enExample) |
| CN (2) | CN103140760B (enExample) |
| AU (1) | AU2011279555B2 (enExample) |
| BR (1) | BR112013000745B1 (enExample) |
| DK (1) | DK2829881T3 (enExample) |
| ES (1) | ES2653646T3 (enExample) |
| IN (1) | IN2013CN01129A (enExample) |
| NO (1) | NO2829881T3 (enExample) |
| PT (1) | PT2829881T (enExample) |
| RU (1) | RU2013103995A (enExample) |
| WO (1) | WO2012006681A1 (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103140760B (zh) | 2010-07-14 | 2016-01-27 | 联邦科学与工业研究组织 | 结肠直肠癌的诊断 |
| US9141756B1 (en) | 2010-07-20 | 2015-09-22 | University Of Southern California | Multi-scale complex systems transdisciplinary analysis of response to therapy |
| MX2013008833A (es) | 2011-02-02 | 2013-12-06 | Amgen Inc | Metodos y composiciones relacionadas con la inhibicion de receptor del factor de crecimiento similar a la insulina 1 (igf-1r). |
| WO2014023820A1 (en) * | 2012-08-09 | 2014-02-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Diagnostic of heart failure |
| GB201218341D0 (en) * | 2012-10-12 | 2012-11-28 | Orign Sciences Ltd | Diagnostic method |
| MX2016012697A (es) * | 2014-03-28 | 2017-05-09 | Applied Proteomics Inc | Perfiles de marcadores biologicos de proteina para detectar tumores colorrectales. |
| EA035674B1 (ru) * | 2014-07-18 | 2020-07-24 | Санофи | Способ определения того, является ли пациент, предположительно страдающий от рака, кандидатом для терапии афлиберцептом |
| CN106191215B (zh) * | 2015-04-29 | 2020-03-24 | 中国科学院上海生命科学研究院 | 肌肉萎缩相关的蛋白质分子标记Dkk-3的筛选及其应用 |
| US10877024B2 (en) * | 2015-05-12 | 2020-12-29 | Superlab Far East Limited | Methods of determining interferon having direct inhibitory effects on tumors and uses thereof |
| CN105219844B (zh) * | 2015-06-08 | 2018-12-14 | 华夏京都医疗投资管理有限公司 | 一种筛查十一种疾病的基因标志物组合、试剂盒以及疾病风险预测模型 |
| CN105021828B (zh) * | 2015-07-20 | 2017-07-28 | 上海交通大学医学院附属新华医院 | 通过检测三期结直肠肿瘤患者血清预测肿瘤患者预后 |
| CN105567846A (zh) * | 2016-02-14 | 2016-05-11 | 上海交通大学医学院附属仁济医院 | 检测粪便中细菌dna的试剂盒及其在大肠癌诊断中的应用 |
| JP6984862B2 (ja) * | 2017-03-15 | 2021-12-22 | 国立大学法人金沢大学 | 血中ケモカインをマーカーとして用いた大腸癌の検出 |
| CN107164535A (zh) * | 2017-07-07 | 2017-09-15 | 沈阳宁沪科技有限公司 | 一种无创高通量甲基化结肠癌诊断、研究和治疗方法 |
| CN110540588B (zh) * | 2018-05-28 | 2022-08-23 | 香港中文大学 | 一种基于肿瘤干细胞标志物EpCAM的抗原表位多肽及其应用 |
| CN108957014A (zh) * | 2018-09-27 | 2018-12-07 | 郑州大学第附属医院 | 结直肠癌血清标志物、表达评估方法、试剂盒及应用 |
| JP2022505676A (ja) * | 2018-10-23 | 2022-01-14 | ブラックソーン セラピューティクス インコーポレイテッド | 患者のスクリーニング、診断、及び層別化のためのシステム及び方法 |
| CN109504778B (zh) * | 2019-01-11 | 2021-11-09 | 复旦大学附属中山医院 | 一种基于表观修饰的5hmC多分子标志物及结直肠癌早期诊断模型 |
| ES2952139T3 (es) * | 2019-03-01 | 2023-10-27 | Advanced Marker Discovery S L | Firma proteica para el diagnóstico de cáncer colorrectal y/o etapa precancerosa del mismo |
| JP7300660B2 (ja) * | 2019-04-03 | 2023-06-30 | 京都府公立大学法人 | 大腸がんの検出方法 |
| JP7032764B2 (ja) * | 2019-04-03 | 2022-03-09 | 京都府公立大学法人 | 大腸がんの検出方法 |
| GB201906199D0 (en) * | 2019-05-02 | 2019-06-19 | Belgian Volition Sprl | Method for the detection of cancer |
| US20220378877A1 (en) * | 2019-11-13 | 2022-12-01 | University Of Virginia Patent Foundation | Treatment of clostridium difficile infections |
| EP3835789A1 (en) | 2019-12-13 | 2021-06-16 | Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts | Biomarker panel for diagnosing colorectal cancer |
| WO2022130597A1 (ja) * | 2020-12-18 | 2022-06-23 | 国立大学法人東北大学 | 推定装置、推定方法、推定プログラム、生成装置、及び、推定システム |
| CA3202255A1 (en) * | 2020-12-21 | 2022-06-30 | Hayley WARSINSKE | Markers for the early detection of colon cell proliferative disorders |
| EP4327100A4 (en) * | 2021-04-20 | 2025-02-26 | Vision Tech Bio Pty Ltd | Biomarkers for colorectal cancer |
| WO2023015354A1 (en) * | 2021-08-11 | 2023-02-16 | Vision Tech Bio Pty Ltd | Method of detecting adenoma |
| WO2023128419A1 (ko) * | 2021-12-31 | 2023-07-06 | 주식회사 이노제닉스 | 대장암 및 대장 용종 또는 진행 선종의 선별 방법 및 그 응용 |
| WO2023128429A1 (ko) * | 2021-12-31 | 2023-07-06 | 주식회사 이노제닉스 | 대장암 및 진행 선종의 선별 검사 방법 및 그 응용 |
| CN114594259B (zh) * | 2022-04-22 | 2022-09-13 | 北京易科拜德科技有限公司 | 一种新型的用于结直肠癌预后预测和诊断的模型及其应用 |
| PL441319A1 (pl) * | 2022-05-31 | 2023-12-04 | Uniwersytet Medyczny Im. Piastów Śląskich We Wrocławiu | Zestaw biomarkerów białkowych i sposób diagnostyki raka jelita grubego in vitro |
| CN116219007A (zh) * | 2022-09-15 | 2023-06-06 | 绍兴积准生物科技有限公司 | 检测结直肠癌的生物标志物组及其应用 |
| WO2026068794A1 (en) | 2024-09-30 | 2026-04-02 | Roche Diagnostics International Ag | Auto-antibodies to anpep for assessing colorectal cancer (crc) or a precancerous condition thereof |
| WO2026068798A1 (en) | 2024-09-30 | 2026-04-02 | Roche Diagnostics International Ag | Sox9 for assessing colorectal cancer (crc) or a precancerous condition thereof |
| WO2026068795A2 (en) | 2024-09-30 | 2026-04-02 | Roche Diagnostics International Ag | Clec3b for assessing colorectal cancer (crc) or a precancerous condition thereof |
| CN119688988A (zh) * | 2024-11-25 | 2025-03-25 | 中国医学科学院肿瘤医院 | Timp1和foxp3作为诊断结直肠癌的生物标志物组合及其应用 |
| CN121186364B (zh) * | 2025-11-25 | 2026-04-14 | 长兴固容生物科技有限公司 | 一种用于胃癌筛查、诊断的标志物组及其用途 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5925517A (en) | 1993-11-12 | 1999-07-20 | The Public Health Research Institute Of The City Of New York, Inc. | Detectably labeled dual conformation oligonucleotide probes, assays and kits |
| JP2004198419A (ja) * | 2002-12-13 | 2004-07-15 | Bayer Healthcare Llc | Ｔｉｍｐ１を用いた検出方法 |
| US20050014165A1 (en) * | 2003-07-18 | 2005-01-20 | California Pacific Medical Center | Biomarker panel for colorectal cancer |
| ATE491953T1 (de) * | 2003-09-15 | 2011-01-15 | Oklahoma Med Res Found | Verfahren zur verwendung von cytokintests zur diagnose, behandlung und beurteilung von ankyloider spondylitis |
| BRPI0401830A (pt) | 2004-05-25 | 2006-01-17 | Bentonit Uniao Nordeste Sa | Processo de produção de pós granulados secos |
| WO2008005469A2 (en) | 2006-06-30 | 2008-01-10 | Schering Corporation | Igfbp2 biomarker |
| US9060961B2 (en) | 2006-11-09 | 2015-06-23 | University Of Washington | Molecules and methods for treatment and detection of cancer |
| WO2008079269A2 (en) * | 2006-12-19 | 2008-07-03 | Genego, Inc. | Novel methods for functional analysis of high-throughput experimental data and gene groups identified therfrom |
| WO2008100913A2 (en) | 2007-02-12 | 2008-08-21 | The Johns Hopkins University | Early detection and prognosis of colon cancers |
| BRPI0807384A2 (pt) * | 2007-02-27 | 2014-05-20 | Sentoclone Ab | Método de uma etapa para detecção direta ou simultânea de uma célula cancerosa ou elemento de célula cancerosa em uma amostra biológica, kit para uso em um método, base de dados, método para indetificar células cancerosas, e, uso de uma base de dados. |
| WO2008116178A2 (en) * | 2007-03-21 | 2008-09-25 | Vanderbilt University | Systems and methods for diagnosis and prognosis of colorectal cancer |
| CN101680898A (zh) * | 2007-05-10 | 2010-03-24 | 霍夫曼-拉罗奇有限公司 | Timp-1作为结肠直肠癌标志的用途 |
| EP2559771A3 (en) * | 2007-05-17 | 2013-06-12 | Bristol-Myers Squibb Company | Biomarkers and methods for determining sensitivity to insulin growth factor-1 receptor modulators |
| CN101971033A (zh) * | 2007-06-04 | 2011-02-09 | 戴诺普雷克斯公司 | 用于结直肠癌的生物标志物组合 |
| US20090017463A1 (en) * | 2007-07-10 | 2009-01-15 | Vanderbilt University | Methods for predicting prostate cancer recurrence |
| EP2271775A4 (en) * | 2008-04-08 | 2011-09-07 | Nuclea Biomarkers Llc | BIOMARKERGROUP FOR PREDICTING THE REPRESENTATION OF COLORECTAL CARCINOMA |
| US20100111969A1 (en) * | 2008-10-31 | 2010-05-06 | Apogenix Gmbh | Il-4 receptor and il-13 as prognostic markers for colon and pancreas tumors |
| CN102300578A (zh) * | 2008-12-01 | 2011-12-28 | 延寿有限责任公司 | 用于改变健康、安康和寿命的方法和组合物 |
| CN102308212A (zh) * | 2008-12-04 | 2012-01-04 | 加利福尼亚大学董事会 | 用于确定前列腺癌诊断和预后的材料和方法 |
| US9354233B2 (en) * | 2009-02-20 | 2016-05-31 | The Regents Of The University Of California | A+ biomarker assays |
| US20110177525A1 (en) * | 2010-01-19 | 2011-07-21 | Predictive Biosciences, Inc. | Antibodies and methods of diagnosing diseases |
| CN103140760B (zh) * | 2010-07-14 | 2016-01-27 | 联邦科学与工业研究组织 | 结肠直肠癌的诊断 |
-
2011
- 2011-07-14 CN CN201180034158.5A patent/CN103140760B/zh active Active
- 2011-07-14 EP EP14178981.8A patent/EP2829881B1/en active Active
- 2011-07-14 ES ES14178981.8T patent/ES2653646T3/es active Active
- 2011-07-14 WO PCT/AU2011/000895 patent/WO2012006681A1/en not_active Ceased
- 2011-07-14 IN IN1129CHN2013 patent/IN2013CN01129A/en unknown
- 2011-07-14 EP EP11806149.8A patent/EP2593795A4/en not_active Withdrawn
- 2011-07-14 PT PT141789818T patent/PT2829881T/pt unknown
- 2011-07-14 AU AU2011279555A patent/AU2011279555B2/en active Active
- 2011-07-14 RU RU2013103995/15A patent/RU2013103995A/ru not_active Application Discontinuation
- 2011-07-14 BR BR112013000745-1A patent/BR112013000745B1/pt not_active IP Right Cessation
- 2011-07-14 US US13/809,785 patent/US20130345322A1/en not_active Abandoned
- 2011-07-14 NO NO14178981A patent/NO2829881T3/no unknown
- 2011-07-14 DK DK14178981.8T patent/DK2829881T3/en active
- 2011-07-14 CN CN201511009181.5A patent/CN105755112B/zh active Active
- 2011-07-14 JP JP2013518909A patent/JP6061344B2/ja active Active
-
2017
- 2017-03-28 US US15/471,147 patent/US10877039B2/en active Active
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