JP2013531801A5 - - Google Patents
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- Publication number
- JP2013531801A5 JP2013531801A5 JP2013518768A JP2013518768A JP2013531801A5 JP 2013531801 A5 JP2013531801 A5 JP 2013531801A5 JP 2013518768 A JP2013518768 A JP 2013518768A JP 2013518768 A JP2013518768 A JP 2013518768A JP 2013531801 A5 JP2013531801 A5 JP 2013531801A5
- Authority
- JP
- Japan
- Prior art keywords
- hapten
- peroxidase
- sample
- conjugate
- subsequent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000003992 Peroxidases Human genes 0.000 claims 13
- 108040007629 peroxidase activity proteins Proteins 0.000 claims 13
- DZGWFCGJZKJUFP-UHFFFAOYSA-N tyramine Chemical compound NCCC1=CC=C(O)C=C1 DZGWFCGJZKJUFP-UHFFFAOYSA-N 0.000 claims 9
- 125000003118 aryl group Chemical group 0.000 claims 5
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 4
- 229940127121 immunoconjugate Drugs 0.000 claims 4
- 150000002978 peroxides Chemical class 0.000 claims 4
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 claims 4
- 230000003100 immobilizing effect Effects 0.000 claims 3
- 229960003732 tyramine Drugs 0.000 claims 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 2
- 125000001931 aliphatic group Chemical group 0.000 claims 2
- 150000001412 amines Chemical class 0.000 claims 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- -1 dinitrophenyl Chemical group 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 239000001301 oxygen Substances 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 239000011593 sulfur Substances 0.000 claims 2
- SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 claims 1
- AWBOSXFRPFZLOP-UHFFFAOYSA-N 2,1,3-benzoxadiazole Chemical compound C1=CC=CC2=NON=C21 AWBOSXFRPFZLOP-UHFFFAOYSA-N 0.000 claims 1
- 125000001894 2,4,6-trinitrophenyl group Chemical group [H]C1=C(C(*)=C(C([H])=C1[N+]([O-])=O)[N+]([O-])=O)[N+]([O-])=O 0.000 claims 1
- WHCPTFFIERCDSB-UHFFFAOYSA-N 7-(diethylamino)-2-oxochromene-3-carboxylic acid Chemical compound C1=C(C(O)=O)C(=O)OC2=CC(N(CC)CC)=CC=C21 WHCPTFFIERCDSB-UHFFFAOYSA-N 0.000 claims 1
- 102000002260 Alkaline Phosphatase Human genes 0.000 claims 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 claims 1
- SHIBSTMRCDJXLN-UHFFFAOYSA-N Digoxigenin Natural products C1CC(C2C(C3(C)CCC(O)CC3CC2)CC2O)(O)C2(C)C1C1=CC(=O)OC1 SHIBSTMRCDJXLN-UHFFFAOYSA-N 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 108010001336 Horseradish Peroxidase Proteins 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 claims 1
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 claims 1
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000002877 alkyl aryl group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 229940049706 benzodiazepine Drugs 0.000 claims 1
- 239000004202 carbamide Substances 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- QONQRTHLHBTMGP-UHFFFAOYSA-N digitoxigenin Natural products CC12CCC(C3(CCC(O)CC3CC3)C)C3C11OC1CC2C1=CC(=O)OC1 QONQRTHLHBTMGP-UHFFFAOYSA-N 0.000 claims 1
- SHIBSTMRCDJXLN-KCZCNTNESA-N digoxigenin Chemical compound C1([C@@H]2[C@@]3([C@@](CC2)(O)[C@H]2[C@@H]([C@@]4(C)CC[C@H](O)C[C@H]4CC2)C[C@H]3O)C)=CC(=O)OC1 SHIBSTMRCDJXLN-KCZCNTNESA-N 0.000 claims 1
- 239000007850 fluorescent dye Substances 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 150000005363 heterobiaryls Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 230000000415 inactivating effect Effects 0.000 claims 1
- 125000004999 nitroaryl group Chemical group 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 239000002096 quantum dot Substances 0.000 claims 1
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 claims 1
- JUVIOZPCNVVQFO-HBGVWJBISA-N rotenone Chemical compound O([C@H](CC1=C2O3)C(C)=C)C1=CC=C2C(=O)[C@@H]1[C@H]3COC2=C1C=C(OC)C(OC)=C2 JUVIOZPCNVVQFO-HBGVWJBISA-N 0.000 claims 1
- 125000004962 sulfoxyl group Chemical group 0.000 claims 1
- 150000003648 triterpenes Chemical class 0.000 claims 1
- 0 CC(C1)C(CCNC(C(C)(C)CCOC(C)(C)CNC(C#*)=*)=S)=C*=C1O Chemical compound CC(C1)C(CCNC(C(C)(C)CCOC(C)(C)CNC(C#*)=*)=S)=C*=C1O 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39894610P | 2010-07-02 | 2010-07-02 | |
| US61/398,946 | 2010-07-02 | ||
| US201161464216P | 2011-02-28 | 2011-02-28 | |
| US61/464,216 | 2011-02-28 | ||
| PCT/US2011/042849 WO2012003476A2 (en) | 2010-07-02 | 2011-07-01 | Hapten conjugates for target detection |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013531801A JP2013531801A (ja) | 2013-08-08 |
| JP2013531801A5 true JP2013531801A5 (https=) | 2014-07-17 |
Family
ID=44583735
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013518768A Pending JP2013531801A (ja) | 2010-07-02 | 2011-07-01 | 標的検出のためのハプテンコンジュゲート |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20130109019A1 (https=) |
| EP (1) | EP2588443A2 (https=) |
| JP (1) | JP2013531801A (https=) |
| AU (1) | AU2011274369A1 (https=) |
| CA (1) | CA2800936A1 (https=) |
| WO (1) | WO2012003476A2 (https=) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10539487B2 (en) | 2010-03-04 | 2020-01-21 | Ventana Medical Systems, Inc. | Systems and methods for monitoring tissue sample processing |
| WO2011109769A1 (en) | 2010-03-04 | 2011-09-09 | Ventana Medical Systems, Inc. | Processing system for processing specimens using acoustic energy |
| US10126216B2 (en) | 2011-02-17 | 2018-11-13 | Ventana Medical Systems, Inc. | Method for tissue sample fixation |
| ES2676183T3 (es) | 2010-07-02 | 2018-07-17 | Ventana Medical Systems, Inc. | Detección de dianas usando marcas de masa y espectrometría de masas |
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| WO2013167387A1 (en) | 2012-05-10 | 2013-11-14 | Ventana Medical Systems, Inc. | Uniquely specific probes for pten, pik3ca, met, top2a, and mdm2 |
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| US10778913B2 (en) | 2013-03-12 | 2020-09-15 | Ventana Medical Systems, Inc. | Digitally enhanced microscopy for multiplexed histology |
| CA2901513C (en) * | 2013-03-12 | 2020-12-29 | Ventana Medical Systems, Inc. | Proximity assay for in situ detection of targets |
| BR112015023120A2 (pt) | 2013-03-15 | 2017-11-21 | Genentech Inc | método para identificar um indivíduo com uma doença ou disfunção, método para prever a responsividade de um indivíduo com uma doença ou disfunção, método para determinar a probabilidade de que um indivíduo com uma doença ou disfunção exibirá benefício do tratamento, método para selecionar uma terapia, usos de um antagonista de ligação do eixo pd-l1, ensaio para identificar um indivíduo com uma doença, kit de diagnóstico, método para avaliar uma resposta ao tratamento e método para monitorar a resposta de um indivíduo tratado |
| JP6416135B2 (ja) * | 2013-03-15 | 2018-10-31 | ベンタナ メディカル システムズ， インコーポレイテッド | スペクトル・アンミキシング |
| CA2907493A1 (en) | 2013-04-30 | 2014-11-13 | California Institute Of Technology | Multiplex labeling of molecules by sequential hybridization barcoding |
| DK3063291T3 (da) * | 2013-10-11 | 2019-05-06 | Ventana Med Syst Inc | Multiplex her2 og østrogenreceptor co-farvnings-assays til påvisning af tumorheterogenitet |
| EP3110966A1 (en) | 2014-02-24 | 2017-01-04 | Ventana Medical Systems, Inc. | Automated rna detection using labeled 2'-o-methyl rna oligonucleotide probes and signal amplification systems |
| JP6666905B2 (ja) | 2014-05-29 | 2020-03-18 | スプリング バイオサイエンス コーポレーション | Ｐｄ−ｌ１抗体及びその使用 |
| RU2715038C2 (ru) | 2014-07-11 | 2020-02-21 | Дженентек, Инк. | Антитела анти-pd-l1 и способы их диагностического применения |
| ES2791950T3 (es) | 2015-02-03 | 2020-11-06 | Ventana Med Syst Inc | Ensayo histoquímico para evaluar la expresión del ligando de muerte programada 1 (PD-L1) |
| CN107430121B (zh) * | 2015-03-13 | 2020-06-23 | 希森美康株式会社 | 受试物质的检测方法及在该方法中使用的试剂盒 |
| EP3371594A1 (en) | 2015-11-06 | 2018-09-12 | Ventana Medical Systems, Inc. | Representative diagnostics |
| WO2017085307A1 (en) * | 2015-11-22 | 2017-05-26 | Ventana Medical Systems, Inc. | Methods of identifying immune cells in pd-l1 positive tumor tissue |
| WO2017132276A1 (en) | 2016-01-26 | 2017-08-03 | Ventana Medical Systems, Inc. | Predictive diagnostic workflow for tumors usnig automated dissection, next generation sequencing, and automated slide stainers |
| WO2017155996A1 (en) | 2016-03-08 | 2017-09-14 | Ventana Medical Systems, Inc. | Multiplexed immunohistochemistry using recombinant antibodies with epitope tags |
| JP6736921B2 (ja) * | 2016-03-10 | 2020-08-05 | コニカミノルタ株式会社 | Ｆｉｓｈ染色方法 |
| WO2017175523A1 (ja) * | 2016-04-06 | 2017-10-12 | コニカミノルタ株式会社 | 蛍光免疫染色法 |
| WO2018002015A1 (en) * | 2016-06-28 | 2018-01-04 | Ventana Medical Systems, Inc. | New colors for chromogenic ihc and ish staining with multi-dye quinone methide and tyramide conjugates |
| EP3516397A1 (en) | 2016-09-23 | 2019-07-31 | Ventana Medical Systems, Inc. | Methods and systems for scoring extracellular matrix biomarkers in tumor samples |
| WO2018118786A1 (en) * | 2016-12-19 | 2018-06-28 | Ventana Medical Systems, Inc. | Methods and systems for quantitative immunohistochemistry |
| EP3659110A1 (en) | 2017-07-24 | 2020-06-03 | Ventana Medical Systems, Inc. | Methods and systems for evaluation of immune cell infiltrate in tumor samples |
| CN111656179B (zh) | 2017-11-13 | 2023-11-03 | 豪夫迈·罗氏有限公司 | 用于使用表位电泳进行样品分析的装置 |
| ES2965647T3 (es) | 2018-01-31 | 2024-04-16 | Ventana Med Syst Inc | Procedimientos y sistemas para la evaluación de infiltrado de células inmunitarias en cáncer colorrectal en estadio III |
| EP3797296B1 (en) | 2018-05-21 | 2024-09-04 | Genentech, Inc. | Her2 heterogeneity as a biomarker in cancer |
| CN108957017A (zh) * | 2018-05-29 | 2018-12-07 | 郑州左安检测科技有限公司 | 一种检测苯二氮卓的试纸条及其制备方法和应用方法 |
| CN108918896A (zh) * | 2018-05-29 | 2018-11-30 | 郑州左安检测科技有限公司 | 一种检测苯二氮卓的fitc试纸条及其制备方法和应用方法 |
| WO2020016266A1 (en) | 2018-07-17 | 2020-01-23 | Ventana Medical Systems, Inc. | Materials and methods for detecting fusion proteins |
| WO2020053376A1 (en) | 2018-09-13 | 2020-03-19 | Ventana Medical Systems, Inc. | Histochemical and cytochemical methods for detecting ntrk fusion proteins |
| JP7455816B2 (ja) * | 2018-09-20 | 2024-03-26 | ヴェンタナ メディカル システムズ， インク． | クマリン系架橋試薬 |
| CN112789684B (zh) | 2018-10-01 | 2025-05-09 | 文塔纳医疗系统公司 | 用于预测对pd-1轴导向疗法的应答的方法和系统 |
| WO2020074742A1 (en) | 2018-10-12 | 2020-04-16 | F. Hoffmann-La Roche Ag | Detection methods for epitachophoresis workflow automation |
| CN113348356A (zh) | 2018-11-20 | 2021-09-03 | 文塔纳医疗系统公司 | 用于针对形态学特征和生物标志物表达而制备和分析细胞样品的方法和系统 |
| WO2020161125A1 (en) | 2019-02-05 | 2020-08-13 | Ventana Medical Systems, Inc. | Methods and systems for evaluation of immune cell infiltrate in stage iv colorectal cancer |
| JP7441243B2 (ja) | 2019-05-14 | 2024-02-29 | エフ． ホフマン－ラ ロシュ アーゲー | 試料分析のための装置および方法 |
| WO2021041874A1 (en) | 2019-08-29 | 2021-03-04 | Martin David C | Biofunctional thiophene monomers |
| WO2021224293A1 (en) | 2020-05-07 | 2021-11-11 | Ventana Medical Systems, Inc. | Histochemical systems and methods for evaluating egfr and egfr ligand expression in tumor samples |
| WO2022043491A2 (en) * | 2020-08-28 | 2022-03-03 | Ventana Medical Systems, Inc. | Conjugates including a detectable moiety |
| WO2022063787A1 (en) | 2020-09-22 | 2022-03-31 | Roche Diagnostics Gmbh | Antibodies specific for alpha-1,6-core-fucosylated psa and fucosylated fragments thereof |
| CN113552362B (zh) * | 2021-07-23 | 2024-08-09 | 湖北百奥斯生物科技有限公司 | 一种新型信号放大的免疫荧光试剂盒 |
| WO2023058624A1 (ja) * | 2021-10-08 | 2023-04-13 | コニカミノルタ株式会社 | 染色方法、評価方法および標本 |
| CN116444424B (zh) * | 2023-06-16 | 2023-09-08 | 广东省大湾区华南理工大学聚集诱导发光高等研究院 | 一种基于聚集诱导发光的酪酰胺荧光材料、免疫组化染色试剂盒及其应用 |
| WO2025014787A1 (en) | 2023-07-07 | 2025-01-16 | Ventana Medical Systems, Inc. | Brightfield triplex immunohistochemistry assay for evaluating the colocalization of the er, pr, and ki-67 biomarkers in cells |
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-
2011
- 2011-07-01 AU AU2011274369A patent/AU2011274369A1/en not_active Abandoned
- 2011-07-01 WO PCT/US2011/042849 patent/WO2012003476A2/en not_active Ceased
- 2011-07-01 US US13/805,978 patent/US20130109019A1/en not_active Abandoned
- 2011-07-01 EP EP11738526.0A patent/EP2588443A2/en not_active Withdrawn
- 2011-07-01 JP JP2013518768A patent/JP2013531801A/ja active Pending
- 2011-07-01 CA CA2800936A patent/CA2800936A1/en not_active Abandoned
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