DK3063291T3 - Multiplex her2 og østrogenreceptor co-farvnings-assays til påvisning af tumorheterogenitet - Google Patents

Multiplex her2 og østrogenreceptor co-farvnings-assays til påvisning af tumorheterogenitet Download PDF

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Publication number
DK3063291T3
DK3063291T3 DK14784425.2T DK14784425T DK3063291T3 DK 3063291 T3 DK3063291 T3 DK 3063291T3 DK 14784425 T DK14784425 T DK 14784425T DK 3063291 T3 DK3063291 T3 DK 3063291T3
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Denmark
Prior art keywords
horogenetic
her2
multiplex
assays
coloring
Prior art date
Application number
DK14784425.2T
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English (en)
Inventor
Hiro Nitta
Brian D Kelly
Eslie Dennis
Shinobu Masuda
Original Assignee
Ventana Med Syst Inc
Nihon Univ School Of Medicine
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Application filed by Ventana Med Syst Inc, Nihon Univ School Of Medicine filed Critical Ventana Med Syst Inc
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Publication of DK3063291T3 publication Critical patent/DK3063291T3/da

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/723—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/82—Translation products from oncogenes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DK14784425.2T 2013-10-11 2014-10-09 Multiplex her2 og østrogenreceptor co-farvnings-assays til påvisning af tumorheterogenitet DK3063291T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361889862P 2013-10-11 2013-10-11
US201461943937P 2014-02-24 2014-02-24
PCT/EP2014/071663 WO2015052287A1 (en) 2013-10-11 2014-10-09 Multiplex her2 and estrogen receptor co-staining assays for detecting tumor heterogeneity

Publications (1)

Publication Number Publication Date
DK3063291T3 true DK3063291T3 (da) 2019-05-06

Family

ID=51730503

Family Applications (1)

Application Number Title Priority Date Filing Date
DK14784425.2T DK3063291T3 (da) 2013-10-11 2014-10-09 Multiplex her2 og østrogenreceptor co-farvnings-assays til påvisning af tumorheterogenitet

Country Status (7)

Country Link
US (2) US20170023579A1 (da)
EP (1) EP3063291B1 (da)
AU (1) AU2014333815B2 (da)
CA (1) CA2942081C (da)
DK (1) DK3063291T3 (da)
ES (1) ES2729638T3 (da)
WO (1) WO2015052287A1 (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9909167B2 (en) 2014-06-23 2018-03-06 The Board Of Trustees Of The Leland Stanford Junior University On-slide staining by primer extension
SG11201700207WA (en) 2014-07-11 2017-02-27 Genentech Inc Anti-pd-l1 antibodies and diagnostic uses thereof
CN116064727A (zh) 2016-07-27 2023-05-05 斯坦福大学托管董事会 高度复用荧光成像
CN116973568A (zh) * 2022-04-22 2023-10-31 中国医学科学院肿瘤医院 受体联合分析对hr+her2+乳腺癌分子亚型及预后的影响
CN114994329A (zh) * 2022-04-28 2022-09-02 杭州广科安德生物科技有限公司 一种检测肿瘤组织中p185蛋白与p95蛋白表达水平的方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2652562C (en) * 2006-05-17 2015-05-12 Cellumen, Inc. Method for automated tissue analysis
EP2444807B1 (en) * 2006-11-01 2014-06-11 Ventana Medical Systems, Inc. Mono- and dinitropyrazole hapten conjugates
US20080299555A1 (en) * 2007-05-30 2008-12-04 Hiroaki Nitta Multicolor chromogenic detection of biomarkers
US20090203015A1 (en) * 2008-02-13 2009-08-13 Celera Corporation Multiplex assays for hormonal and growth factor receptors, and uses thereof
CA2716826C (en) * 2008-02-25 2017-05-09 Prometheus Laboratories Inc. Drug selection for breast cancer therapy using antibody-based arrays
US8445225B2 (en) * 2008-09-05 2013-05-21 The Scripps Research Institute Methods for the detection of circulating tumor cells
CA2779223A1 (en) * 2009-10-27 2011-05-12 Caris Mpi, Inc. Molecular profiling for personalized medicine
ES2606012T3 (es) * 2010-02-26 2017-03-17 Ventana Medical Systems, Inc. Hibridación in situ con sondas PolyTag
AU2011274369A1 (en) * 2010-07-02 2012-12-06 Ventana Medical Systems, Inc. Hapten conjugates for target detection
EP3306321A1 (en) * 2010-07-07 2018-04-11 The Regents of The University of Michigan Diagnosis and treatment of breast cancer
US9740912B2 (en) * 2011-12-20 2017-08-22 Definiens Ag Evaluation of co-registered images of differently stained tissue slices
KR20140120321A (ko) * 2012-02-01 2014-10-13 벤타나 메디컬 시스템즈, 인코포레이티드 조직 샘플들에 있어서의 유전자들을 검출하는 시스템

Also Published As

Publication number Publication date
AU2014333815B2 (en) 2020-07-09
WO2015052287A1 (en) 2015-04-16
EP3063291A1 (en) 2016-09-07
CA2942081C (en) 2021-09-07
US20210011023A1 (en) 2021-01-14
CA2942081A1 (en) 2015-04-16
AU2014333815A1 (en) 2016-10-06
EP3063291B1 (en) 2019-03-20
ES2729638T3 (es) 2019-11-05
US20170023579A1 (en) 2017-01-26

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