JP2019532275A5 - - Google Patents
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- JP2019532275A5 JP2019532275A5 JP2019511411A JP2019511411A JP2019532275A5 JP 2019532275 A5 JP2019532275 A5 JP 2019532275A5 JP 2019511411 A JP2019511411 A JP 2019511411A JP 2019511411 A JP2019511411 A JP 2019511411A JP 2019532275 A5 JP2019532275 A5 JP 2019532275A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- hapten
- target
- carbon atoms
- enzyme
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562211590P | 2015-08-28 | 2015-08-28 | |
| US201662301489P | 2016-02-29 | 2016-02-29 | |
| USPCT/US2016/049153 | 2016-08-26 | ||
| PCT/US2016/049153 WO2017040349A1 (en) | 2015-08-28 | 2016-08-26 | Protein proximity assay in formalin fixed paffafin embedded tissue using caged haptens |
| PCT/US2017/048687 WO2018039605A1 (en) | 2015-08-28 | 2017-08-25 | Protein proximity assay in formalin fixed paraffin embedded tissue using caged haptens |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019532275A JP2019532275A (ja) | 2019-11-07 |
| JP2019532275A5 true JP2019532275A5 (https=) | 2020-09-24 |
| JP7033122B2 JP7033122B2 (ja) | 2022-03-09 |
Family
ID=58188142
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018510803A Active JP6880001B2 (ja) | 2015-08-28 | 2016-08-26 | ケージドハプテンを使用するホルマリン固定パラフィン包埋組織におけるタンパク質近接アッセイ |
| JP2019511411A Active JP7033122B2 (ja) | 2015-08-28 | 2017-08-25 | ケージドハプテンを使用するホルマリン固定パラフィン包埋組織におけるタンパク質近接アッセイ |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018510803A Active JP6880001B2 (ja) | 2015-08-28 | 2016-08-26 | ケージドハプテンを使用するホルマリン固定パラフィン包埋組織におけるタンパク質近接アッセイ |
Country Status (7)
| Country | Link |
|---|---|
| US (6) | US11053266B2 (https=) |
| EP (1) | EP3341734B1 (https=) |
| JP (2) | JP6880001B2 (https=) |
| CN (3) | CN107923915B (https=) |
| AU (3) | AU2016316846B2 (https=) |
| CA (1) | CA2996798A1 (https=) |
| WO (2) | WO2017040349A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107923915B (zh) | 2015-08-28 | 2021-05-04 | 文塔纳医疗系统公司 | 使用经掩蔽的半抗原在福尔马林固定石蜡包埋的组织中的蛋白质邻近测定 |
| WO2020121304A1 (en) * | 2018-12-10 | 2020-06-18 | Ariel Scientific Innovations Ltd. | Therapeutic conjugates |
| CN110632040B (zh) * | 2019-05-10 | 2022-03-29 | 长沙理工大学 | 一种血清中前列腺特异性抗原的分析方法 |
| CN114303203A (zh) * | 2019-08-28 | 2022-04-08 | 文塔纳医疗系统公司 | 使用振动光谱法评估抗原修复和靶标修复进展定量 |
| WO2021224293A1 (en) * | 2020-05-07 | 2021-11-11 | Ventana Medical Systems, Inc. | Histochemical systems and methods for evaluating egfr and egfr ligand expression in tumor samples |
| JP2024504944A (ja) * | 2021-01-15 | 2024-02-02 | ヴェンタナ メディカル システムズ， インク． | 保存安定なケージドハプテン |
| CN114994329A (zh) * | 2022-04-28 | 2022-09-02 | 杭州广科安德生物科技有限公司 | 一种检测肿瘤组织中p185蛋白与p95蛋白表达水平的方法 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2730523A (en) * | 1952-08-16 | 1956-01-10 | Eastman Kodak Co | 5-nitrothiazoleazo-n-fluoroalkyl-aniline compounds |
| JP3169216B2 (ja) * | 1988-07-08 | 2001-05-21 | プロメガ・バイオサイエンシーズ・インコーポレイテッド | 蛍光性ベンゾチアゾール誘導体の製法及び用途 |
| US5196306A (en) * | 1989-03-29 | 1993-03-23 | E. I. Du Pont De Nemours And Company | Method for the detection or quantitation of an analyte using an analyte dependent enzyme activation system |
| US5182203A (en) * | 1989-03-29 | 1993-01-26 | E. I. Du Pont De Nemours And Company | Bifunctional compounds useful in catalyzed reporter deposition |
| US5180828A (en) * | 1990-02-09 | 1993-01-19 | Molecular Devices Corporation | Chromophoric reagents for incorporation of biotin or other haptens into macromolecules |
| US5595707A (en) | 1990-03-02 | 1997-01-21 | Ventana Medical Systems, Inc. | Automated biological reaction apparatus |
| US5371241A (en) * | 1991-07-19 | 1994-12-06 | Pharmacia P-L Biochemicals Inc. | Fluorescein labelled phosphoramidites |
| GB9517060D0 (en) * | 1995-08-17 | 1995-10-25 | Ciba Geigy Ag | Acylated oligopeptide derivatives |
| US20030235877A1 (en) * | 1996-04-30 | 2003-12-25 | La Region Wallone | Conjugates of haptens to beta-lactam derivatives and their use for detecting and/or quantifying haptens in solution and device for implementation thereof |
| US6582962B1 (en) | 1998-02-27 | 2003-06-24 | Ventana Medical Systems, Inc. | Automated molecular pathology apparatus having independent slide heaters |
| ES2354598T3 (es) | 1998-02-27 | 2011-03-16 | Ventana Medical Systems, Inc. | Aparato de patología molecular automatizado que tiene calefactores de portaobjetos independientes. |
| US20030211630A1 (en) | 1998-02-27 | 2003-11-13 | Ventana Medical Systems, Inc. | Automated molecular pathology apparatus having independent slide heaters |
| US20060040319A1 (en) * | 2000-01-14 | 2006-02-23 | Tom Muir | Multiple sensor-containing active modified polypeptides, preparation and uses thereof |
| WO2003014698A2 (en) * | 2001-08-07 | 2003-02-20 | Merck & Co., Inc. | Biological assay detection method |
| MXPA06010782A (es) * | 2004-03-23 | 2007-03-28 | Complex Biosystems Gmbh | Ligador de profarmaco. |
| US20060246523A1 (en) | 2005-04-28 | 2006-11-02 | Christopher Bieniarz | Antibody conjugates |
| DK2963011T3 (en) | 2005-11-23 | 2018-08-06 | Ventana Med Syst Inc | MOLECULAR CONJUGATE |
| WO2008063378A2 (en) | 2006-11-01 | 2008-05-29 | Ventana Medical Systems, Inc. | Haptens, hapten conjugates, compositions thereof and method for their preparation and use |
| WO2008098100A2 (en) * | 2007-02-07 | 2008-08-14 | Perscitus Biosciences, Llc | Detection of molecule proximity |
| JP2010528285A (ja) | 2007-05-23 | 2010-08-19 | ベンタナ・メデイカル・システムズ・インコーポレーテツド | 免疫組織化学およびｉｎｓｉｔｕハイブリダーゼーションのためのポリマー担体 |
| CA2730565A1 (en) * | 2007-07-27 | 2009-02-05 | Ensemble Discovery Corporation | Detection assays and use thereof |
| WO2010022332A1 (en) | 2008-08-22 | 2010-02-25 | Ventana Medical Systems, Inc. | Method for chromogenic detection of two or more target molecules in a single sample |
| CA2842661C (en) | 2009-10-19 | 2016-02-23 | Ventana Medical Systems, Inc. | Imaging system and techniques |
| BR112012012787B1 (pt) * | 2009-11-27 | 2019-12-17 | Ecole Polytechnique Fed Lausanne Epfl | biossensor para a detecção de difusão de biomoléculas fluorescentes, arranjo, conjunto e método para a detecção e medição de difusão de biomoléculas fluorescentes |
| ES2689593T3 (es) | 2010-12-30 | 2018-11-14 | Ventana Medical Systems, Inc. | Depósito potenciado de cromógenos que utilizan análogos de piridina |
| US8852599B2 (en) * | 2011-05-26 | 2014-10-07 | Bristol-Myers Squibb Company | Immunoconjugates, compositions for making them, and methods of making and use |
| JP5898318B2 (ja) | 2011-09-09 | 2016-04-06 | ベンタナ メディカル システムズ， インコーポレイテッド | イメージングシステム、カセッテ、およびこれを使用する方法 |
| EP2831587B1 (en) | 2012-03-27 | 2018-05-16 | Ventana Medical Systems, Inc. | Signaling conjugates and methods of use |
| DK2971064T3 (da) * | 2013-03-12 | 2019-12-16 | Ventana Med Syst Inc | Nærhedsassay til in situ-påvisning af mål |
| CN103513039B (zh) * | 2013-07-10 | 2015-12-23 | 广州美格生物科技有限公司 | 一种利用定向肽库检测蛋白质与其他分子相互作用的方法 |
| EP3079772B1 (en) * | 2013-12-10 | 2020-02-05 | Merck Sharp & Dohme Corp. | Immunohistochemical proximity assay for pd-1 positive cells and pd-ligand positive cells in tumor tissue |
| WO2015124703A1 (en) * | 2014-02-24 | 2015-08-27 | Ventana Medical Systems, Inc. | Quinone methide analog signal amplification |
| EP3125943B1 (en) * | 2014-04-04 | 2026-04-22 | Merck Sharp & Dohme LLC | Phosphate based linkers for intracellular delivery of drug conjugates |
| CN107003323B (zh) * | 2014-11-25 | 2019-06-04 | 文塔纳医疗系统公司 | 使用化学连接和半抗原转移的邻近测定法 |
| EP3037820A1 (en) | 2014-12-27 | 2016-06-29 | Miltenyi Biotec GmbH | Cell detection methods and reagents having a releasable labelling moiety |
| CN107923915B (zh) * | 2015-08-28 | 2021-05-04 | 文塔纳医疗系统公司 | 使用经掩蔽的半抗原在福尔马林固定石蜡包埋的组织中的蛋白质邻近测定 |
-
2016
- 2016-08-26 CN CN201680049897.4A patent/CN107923915B/zh active Active
- 2016-08-26 EP EP16842723.5A patent/EP3341734B1/en active Active
- 2016-08-26 WO PCT/US2016/049153 patent/WO2017040349A1/en not_active Ceased
- 2016-08-26 CA CA2996798A patent/CA2996798A1/en active Pending
- 2016-08-26 AU AU2016316846A patent/AU2016316846B2/en active Active
- 2016-08-26 JP JP2018510803A patent/JP6880001B2/ja active Active
-
2017
- 2017-08-25 WO PCT/US2017/048687 patent/WO2018039605A1/en not_active Ceased
- 2017-08-25 CN CN201780060757.1A patent/CN109791144B/zh active Active
- 2017-08-25 CN CN202310341013.4A patent/CN116338167A/zh active Pending
- 2017-08-25 JP JP2019511411A patent/JP7033122B2/ja active Active
-
2018
- 2018-02-28 US US15/907,479 patent/US11053266B2/en active Active
-
2019
- 2019-02-25 US US16/284,098 patent/US11345719B2/en active Active
-
2021
- 2021-01-15 US US17/149,911 patent/US12559511B2/en active Active
- 2021-06-11 US US17/345,072 patent/US12173019B2/en active Active
- 2021-08-19 AU AU2021218128A patent/AU2021218128B2/en active Active
- 2021-10-16 US US17/503,303 patent/US12577266B2/en active Active
-
2023
- 2023-03-17 AU AU2023201682A patent/AU2023201682B2/en active Active
-
2024
- 2024-11-13 US US18/945,898 patent/US20250066397A1/en active Pending
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