JP2018528425A5 - - Google Patents
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- JP2018528425A5 JP2018528425A5 JP2018510803A JP2018510803A JP2018528425A5 JP 2018528425 A5 JP2018528425 A5 JP 2018528425A5 JP 2018510803 A JP2018510803 A JP 2018510803A JP 2018510803 A JP2018510803 A JP 2018510803A JP 2018528425 A5 JP2018528425 A5 JP 2018528425A5
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- antibody conjugate
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- 229940127121 immunoconjugate Drugs 0.000 claims 19
- 125000004432 carbon atom Chemical group C* 0.000 claims 12
- 102000004190 Enzymes Human genes 0.000 claims 11
- 108090000790 Enzymes Proteins 0.000 claims 11
- 238000000034 method Methods 0.000 claims 11
- 230000000873 masking effect Effects 0.000 claims 9
- 239000000758 substrate Substances 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 125000003368 amide group Chemical group 0.000 claims 4
- 125000004185 ester group Chemical group 0.000 claims 4
- 125000003563 glycoside group Chemical group 0.000 claims 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 4
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims 4
- QAOWNCQODCNURD-UHFFFAOYSA-L sulfate group Chemical group S(=O)(=O)([O-])[O-] QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 4
- XSQUKJJJFZCRTK-UHFFFAOYSA-N urea group Chemical group NC(=O)N XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 4
- 108010074708 B7-H1 Antigen Proteins 0.000 claims 3
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims 3
- 239000003153 chemical reaction reagent Substances 0.000 claims 3
- 238000001514 detection method Methods 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 2
- OXEUETBFKVCRNP-UHFFFAOYSA-N 9-ethyl-3-carbazolamine Chemical compound NC1=CC=C2N(CC)C3=CC=CC=C3C2=C1 OXEUETBFKVCRNP-UHFFFAOYSA-N 0.000 claims 2
- 108010021064 CTLA-4 Antigen Proteins 0.000 claims 2
- 102000008203 CTLA-4 Antigen Human genes 0.000 claims 2
- 229940045513 CTLA4 antagonist Drugs 0.000 claims 2
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 claims 2
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 claims 2
- 125000001931 aliphatic group Chemical group 0.000 claims 2
- 239000003593 chromogenic compound Substances 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 230000004481 post-translational protein modification Effects 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- AWBOSXFRPFZLOP-UHFFFAOYSA-N 2,1,3-benzoxadiazole Chemical compound C1=CC=CC2=NON=C21 AWBOSXFRPFZLOP-UHFFFAOYSA-N 0.000 claims 1
- HSTOKWSFWGCZMH-UHFFFAOYSA-N 3,3'-diaminobenzidine Chemical compound C1=C(N)C(N)=CC=C1C1=CC=C(N)C(N)=C1 HSTOKWSFWGCZMH-UHFFFAOYSA-N 0.000 claims 1
- MZRUFMBFIKGOAL-UHFFFAOYSA-N 5-nitro-1h-pyrazole Chemical compound [O-][N+](=O)C1=CC=NN1 MZRUFMBFIKGOAL-UHFFFAOYSA-N 0.000 claims 1
- 102000002260 Alkaline Phosphatase Human genes 0.000 claims 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 claims 1
- 108700023418 Amidases Proteins 0.000 claims 1
- 101100123850 Caenorhabditis elegans her-1 gene Proteins 0.000 claims 1
- 102100028843 DNA mismatch repair protein Mlh1 Human genes 0.000 claims 1
- 102100028849 DNA mismatch repair protein Mlh3 Human genes 0.000 claims 1
- 102100034157 DNA mismatch repair protein Msh2 Human genes 0.000 claims 1
- 102100037700 DNA mismatch repair protein Msh3 Human genes 0.000 claims 1
- 102100021147 DNA mismatch repair protein Msh6 Human genes 0.000 claims 1
- QOSSAOTZNIDXMA-UHFFFAOYSA-N Dicylcohexylcarbodiimide Chemical compound C1CCCCC1N=C=NC1CCCCC1 QOSSAOTZNIDXMA-UHFFFAOYSA-N 0.000 claims 1
- 108090000204 Dipeptidase 1 Proteins 0.000 claims 1
- 102000001301 EGF receptor Human genes 0.000 claims 1
- 108060006698 EGF receptor Proteins 0.000 claims 1
- 101150029707 ERBB2 gene Proteins 0.000 claims 1
- 101000577867 Homo sapiens DNA mismatch repair protein Mlh3 Proteins 0.000 claims 1
- 101001134036 Homo sapiens DNA mismatch repair protein Msh2 Proteins 0.000 claims 1
- 101001027762 Homo sapiens DNA mismatch repair protein Msh3 Proteins 0.000 claims 1
- 101000968658 Homo sapiens DNA mismatch repair protein Msh6 Proteins 0.000 claims 1
- 101000738901 Homo sapiens PMS1 protein homolog 1 Proteins 0.000 claims 1
- 102000004882 Lipase Human genes 0.000 claims 1
- 108090001060 Lipase Proteins 0.000 claims 1
- 239000004367 Lipase Substances 0.000 claims 1
- 229910015837 MSH2 Inorganic materials 0.000 claims 1
- 108010074346 Mismatch Repair Endonuclease PMS2 Proteins 0.000 claims 1
- 102100037480 Mismatch repair endonuclease PMS2 Human genes 0.000 claims 1
- 101100407308 Mus musculus Pdcd1lg2 gene Proteins 0.000 claims 1
- 108010026664 MutL Protein Homolog 1 Proteins 0.000 claims 1
- 102000005348 Neuraminidase Human genes 0.000 claims 1
- 108010006232 Neuraminidase Proteins 0.000 claims 1
- 102000004459 Nitroreductase Human genes 0.000 claims 1
- BZQFBWGGLXLEPQ-UHFFFAOYSA-N O-phosphoryl-L-serine Natural products OC(=O)C(N)COP(O)(O)=O BZQFBWGGLXLEPQ-UHFFFAOYSA-N 0.000 claims 1
- 102100037482 PMS1 protein homolog 1 Human genes 0.000 claims 1
- 108091005804 Peptidases Proteins 0.000 claims 1
- 102000003992 Peroxidases Human genes 0.000 claims 1
- 108700030875 Programmed Cell Death 1 Ligand 2 Proteins 0.000 claims 1
- 102100024213 Programmed cell death 1 ligand 2 Human genes 0.000 claims 1
- 239000004365 Protease Substances 0.000 claims 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 1
- 102000005262 Sulfatase Human genes 0.000 claims 1
- 108010046334 Urease Proteins 0.000 claims 1
- 102000005922 amidase Human genes 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 102000006635 beta-lactamase Human genes 0.000 claims 1
- 229960002685 biotin Drugs 0.000 claims 1
- 235000020958 biotin Nutrition 0.000 claims 1
- 239000011616 biotin Substances 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 229950006137 dexfosfoserine Drugs 0.000 claims 1
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 1
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 229910052740 iodine Inorganic materials 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 238000002372 labelling Methods 0.000 claims 1
- 235000019421 lipase Nutrition 0.000 claims 1
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 1
- 108020001162 nitroreductase Proteins 0.000 claims 1
- 108040007629 peroxidase activity proteins Proteins 0.000 claims 1
- FDIKHVQUPVCJFA-UHFFFAOYSA-N phosphohistidine Chemical compound OP(=O)(O)NC(C(=O)O)CC1=CN=CN1 FDIKHVQUPVCJFA-UHFFFAOYSA-N 0.000 claims 1
- BZQFBWGGLXLEPQ-REOHCLBHSA-N phosphoserine Chemical compound OC(=O)[C@@H](N)COP(O)(O)=O BZQFBWGGLXLEPQ-REOHCLBHSA-N 0.000 claims 1
- USRGIUJOYOXOQJ-GBXIJSLDSA-N phosphothreonine Chemical compound OP(=O)(O)O[C@H](C)[C@H](N)C(O)=O USRGIUJOYOXOQJ-GBXIJSLDSA-N 0.000 claims 1
- FFRYUAVNPBUEIC-UHFFFAOYSA-N quinoxalin-2-ol Chemical compound C1=CC=CC2=NC(O)=CN=C21 FFRYUAVNPBUEIC-UHFFFAOYSA-N 0.000 claims 1
- 229910052709 silver Inorganic materials 0.000 claims 1
- 239000004332 silver Substances 0.000 claims 1
- 108060007951 sulfatase Proteins 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- -1 thiazolesulfonamide Chemical compound 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562211590P | 2015-08-28 | 2015-08-28 | |
| US62/211,590 | 2015-08-28 | ||
| US201662301489P | 2016-02-29 | 2016-02-29 | |
| US62/301,489 | 2016-02-29 | ||
| PCT/US2016/049153 WO2017040349A1 (en) | 2015-08-28 | 2016-08-26 | Protein proximity assay in formalin fixed paffafin embedded tissue using caged haptens |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018528425A JP2018528425A (ja) | 2018-09-27 |
| JP2018528425A5 true JP2018528425A5 (https=) | 2019-10-03 |
| JP6880001B2 JP6880001B2 (ja) | 2021-06-02 |
Family
ID=58188142
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018510803A Active JP6880001B2 (ja) | 2015-08-28 | 2016-08-26 | ケージドハプテンを使用するホルマリン固定パラフィン包埋組織におけるタンパク質近接アッセイ |
| JP2019511411A Active JP7033122B2 (ja) | 2015-08-28 | 2017-08-25 | ケージドハプテンを使用するホルマリン固定パラフィン包埋組織におけるタンパク質近接アッセイ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019511411A Active JP7033122B2 (ja) | 2015-08-28 | 2017-08-25 | ケージドハプテンを使用するホルマリン固定パラフィン包埋組織におけるタンパク質近接アッセイ |
Country Status (7)
| Country | Link |
|---|---|
| US (6) | US11053266B2 (https=) |
| EP (1) | EP3341734B1 (https=) |
| JP (2) | JP6880001B2 (https=) |
| CN (3) | CN107923915B (https=) |
| AU (3) | AU2016316846B2 (https=) |
| CA (1) | CA2996798A1 (https=) |
| WO (2) | WO2017040349A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2016316846B2 (en) | 2015-08-28 | 2021-07-08 | Ventana Medical Systems, Inc. | Protein proximity assay in formalin fixed paffafin embedded tissue using caged haptens |
| EP3894397A4 (en) * | 2018-12-10 | 2022-09-28 | Ariel Scientific Innovations Ltd. | THERAPEUTIC CONJUGATES |
| CN110632040B (zh) * | 2019-05-10 | 2022-03-29 | 长沙理工大学 | 一种血清中前列腺特异性抗原的分析方法 |
| EP4022624B1 (en) * | 2019-08-28 | 2026-03-11 | Ventana Medical Systems, Inc. | Assessing antigen retrieval and target retrieval progression quantitation with vibrational spectroscopy |
| WO2021224293A1 (en) * | 2020-05-07 | 2021-11-11 | Ventana Medical Systems, Inc. | Histochemical systems and methods for evaluating egfr and egfr ligand expression in tumor samples |
| WO2022152777A1 (en) * | 2021-01-15 | 2022-07-21 | F. Hoffmann-La Roche Ag | Storage stable caged haptens |
| CN114994329A (zh) * | 2022-04-28 | 2022-09-02 | 杭州广科安德生物科技有限公司 | 一种检测肿瘤组织中p185蛋白与p95蛋白表达水平的方法 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2730523A (en) * | 1952-08-16 | 1956-01-10 | Eastman Kodak Co | 5-nitrothiazoleazo-n-fluoroalkyl-aniline compounds |
| WO1990000618A1 (en) | 1988-07-08 | 1990-01-25 | Jbl Scientific, Inc. | Preparation and use of fluorescent benzothiazole derivatives |
| US5196306A (en) | 1989-03-29 | 1993-03-23 | E. I. Du Pont De Nemours And Company | Method for the detection or quantitation of an analyte using an analyte dependent enzyme activation system |
| US5182203A (en) * | 1989-03-29 | 1993-01-26 | E. I. Du Pont De Nemours And Company | Bifunctional compounds useful in catalyzed reporter deposition |
| US5180828A (en) * | 1990-02-09 | 1993-01-19 | Molecular Devices Corporation | Chromophoric reagents for incorporation of biotin or other haptens into macromolecules |
| US5595707A (en) | 1990-03-02 | 1997-01-21 | Ventana Medical Systems, Inc. | Automated biological reaction apparatus |
| US5371241A (en) * | 1991-07-19 | 1994-12-06 | Pharmacia P-L Biochemicals Inc. | Fluorescein labelled phosphoramidites |
| GB9517060D0 (en) * | 1995-08-17 | 1995-10-25 | Ciba Geigy Ag | Acylated oligopeptide derivatives |
| US20030235877A1 (en) * | 1996-04-30 | 2003-12-25 | La Region Wallone | Conjugates of haptens to beta-lactam derivatives and their use for detecting and/or quantifying haptens in solution and device for implementation thereof |
| JP3847559B2 (ja) | 1998-02-27 | 2006-11-22 | ベンタナ・メデイカル・システムズ・インコーポレーテツド | 独立スライド加熱器を有する自動化分子病理学装置 |
| US20030211630A1 (en) | 1998-02-27 | 2003-11-13 | Ventana Medical Systems, Inc. | Automated molecular pathology apparatus having independent slide heaters |
| US6582962B1 (en) | 1998-02-27 | 2003-06-24 | Ventana Medical Systems, Inc. | Automated molecular pathology apparatus having independent slide heaters |
| US20060040319A1 (en) * | 2000-01-14 | 2006-02-23 | Tom Muir | Multiple sensor-containing active modified polypeptides, preparation and uses thereof |
| WO2003014698A2 (en) * | 2001-08-07 | 2003-02-20 | Merck & Co., Inc. | Biological assay detection method |
| CA2940803A1 (en) * | 2004-03-23 | 2005-10-27 | Ascendis Pharma Gmbh | Prodrug linker |
| CA2609702C (en) | 2005-04-28 | 2013-05-28 | Ventana Medical Systems, Inc. | Antibody conjugates via heterobifunctional peg linkers |
| US20070117153A1 (en) | 2005-11-23 | 2007-05-24 | Christopher Bieniarz | Molecular conjugate |
| DK2444807T3 (da) * | 2006-11-01 | 2014-08-11 | Ventana Med Syst Inc | Mono- og dinitropyrazolhaptenkonjugater |
| WO2008098100A2 (en) * | 2007-02-07 | 2008-08-14 | Perscitus Biosciences, Llc | Detection of molecule proximity |
| EP2167963B1 (en) | 2007-05-23 | 2019-04-17 | Ventana Medical Systems, Inc. | Polymeric carriers for immunohistochemistry and in situ hybridization |
| CN101952719A (zh) * | 2007-07-27 | 2011-01-19 | 通信改革公司 | 检测测定法及其用途 |
| EP2334827B1 (en) | 2008-08-22 | 2015-03-11 | Ventana Medical Systems, Inc. | Method for chromogenic detection of two or more target molecules in a single sample |
| CA2842661C (en) | 2009-10-19 | 2016-02-23 | Ventana Medical Systems, Inc. | Imaging system and techniques |
| CA2782009C (en) | 2009-11-27 | 2017-10-03 | Ecole Polytechnique Federale De Lausanne (Epfl) | Nanofluidic biosensor and its use for rapid measurement of biomolecular interactions in solution and methods |
| SG190892A1 (en) | 2010-12-30 | 2013-07-31 | Ventana Med Syst Inc | Enhanced deposition of chromogens utilizing pyrimidine analogs |
| US8852599B2 (en) * | 2011-05-26 | 2014-10-07 | Bristol-Myers Squibb Company | Immunoconjugates, compositions for making them, and methods of making and use |
| CN105204152B (zh) | 2011-09-09 | 2018-10-26 | 文塔纳医疗系统公司 | 成像系统、盒和使用其的方法 |
| ES2678211T3 (es) | 2012-03-27 | 2018-08-09 | Ventana Medical Systems, Inc. | Conjugados de señalización y procedimientos de uso |
| CA2901513C (en) * | 2013-03-12 | 2020-12-29 | Ventana Medical Systems, Inc. | Proximity assay for in situ detection of targets |
| CN103513039B (zh) * | 2013-07-10 | 2015-12-23 | 广州美格生物科技有限公司 | 一种利用定向肽库检测蛋白质与其他分子相互作用的方法 |
| US10241115B2 (en) * | 2013-12-10 | 2019-03-26 | Merck Sharp & Dohme Corp. | Immunohistochemical proximity assay for PD-1 positive cells and PD-ligand positive cells in tumor tissue |
| CA2940439C (en) * | 2014-02-24 | 2024-03-19 | Ventana Medical Systems, Inc. | Quinone methide analog signal amplification |
| US10550190B2 (en) * | 2014-04-04 | 2020-02-04 | Merck Sharp & Dohme Corp. | Phosphate based linkers for intracellular delivery of drug conjugates |
| CN107003323B (zh) * | 2014-11-25 | 2019-06-04 | 文塔纳医疗系统公司 | 使用化学连接和半抗原转移的邻近测定法 |
| EP3037820A1 (en) | 2014-12-27 | 2016-06-29 | Miltenyi Biotec GmbH | Cell detection methods and reagents having a releasable labelling moiety |
| AU2016316846B2 (en) * | 2015-08-28 | 2021-07-08 | Ventana Medical Systems, Inc. | Protein proximity assay in formalin fixed paffafin embedded tissue using caged haptens |
-
2016
- 2016-08-26 AU AU2016316846A patent/AU2016316846B2/en active Active
- 2016-08-26 CA CA2996798A patent/CA2996798A1/en active Pending
- 2016-08-26 JP JP2018510803A patent/JP6880001B2/ja active Active
- 2016-08-26 CN CN201680049897.4A patent/CN107923915B/zh active Active
- 2016-08-26 EP EP16842723.5A patent/EP3341734B1/en active Active
- 2016-08-26 WO PCT/US2016/049153 patent/WO2017040349A1/en not_active Ceased
-
2017
- 2017-08-25 CN CN201780060757.1A patent/CN109791144B/zh active Active
- 2017-08-25 CN CN202310341013.4A patent/CN116338167A/zh active Pending
- 2017-08-25 JP JP2019511411A patent/JP7033122B2/ja active Active
- 2017-08-25 WO PCT/US2017/048687 patent/WO2018039605A1/en not_active Ceased
-
2018
- 2018-02-28 US US15/907,479 patent/US11053266B2/en active Active
-
2019
- 2019-02-25 US US16/284,098 patent/US11345719B2/en active Active
-
2021
- 2021-01-15 US US17/149,911 patent/US12559511B2/en active Active
- 2021-06-11 US US17/345,072 patent/US12173019B2/en active Active
- 2021-08-19 AU AU2021218128A patent/AU2021218128B2/en active Active
- 2021-10-16 US US17/503,303 patent/US12577266B2/en active Active
-
2023
- 2023-03-17 AU AU2023201682A patent/AU2023201682B2/en active Active
-
2024
- 2024-11-13 US US18/945,898 patent/US20250066397A1/en active Pending
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