CA2996798A1 - Protein proximity assay in formalin fixed paffafin embedded tissue using caged haptens - Google Patents
Protein proximity assay in formalin fixed paffafin embedded tissue using caged haptens Download PDFInfo
- Publication number
- CA2996798A1 CA2996798A1 CA2996798A CA2996798A CA2996798A1 CA 2996798 A1 CA2996798 A1 CA 2996798A1 CA 2996798 A CA2996798 A CA 2996798A CA 2996798 A CA2996798 A CA 2996798A CA 2996798 A1 CA2996798 A1 CA 2996798A1
- Authority
- CA
- Canada
- Prior art keywords
- group
- target
- hapten
- enzyme
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
- G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Organic Chemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562211590P | 2015-08-28 | 2015-08-28 | |
| US62/211,590 | 2015-08-28 | ||
| US201662301489P | 2016-02-29 | 2016-02-29 | |
| US62/301,489 | 2016-02-29 | ||
| PCT/US2016/049153 WO2017040349A1 (en) | 2015-08-28 | 2016-08-26 | Protein proximity assay in formalin fixed paffafin embedded tissue using caged haptens |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2996798A1 true CA2996798A1 (en) | 2017-03-09 |
Family
ID=58188142
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2996798A Pending CA2996798A1 (en) | 2015-08-28 | 2016-08-26 | Protein proximity assay in formalin fixed paffafin embedded tissue using caged haptens |
Country Status (7)
| Country | Link |
|---|---|
| US (6) | US11053266B2 (https=) |
| EP (1) | EP3341734B1 (https=) |
| JP (2) | JP6880001B2 (https=) |
| CN (3) | CN107923915B (https=) |
| AU (3) | AU2016316846B2 (https=) |
| CA (1) | CA2996798A1 (https=) |
| WO (2) | WO2017040349A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2016316846B2 (en) | 2015-08-28 | 2021-07-08 | Ventana Medical Systems, Inc. | Protein proximity assay in formalin fixed paffafin embedded tissue using caged haptens |
| EP3894397A4 (en) * | 2018-12-10 | 2022-09-28 | Ariel Scientific Innovations Ltd. | THERAPEUTIC CONJUGATES |
| CN110632040B (zh) * | 2019-05-10 | 2022-03-29 | 长沙理工大学 | 一种血清中前列腺特异性抗原的分析方法 |
| EP4022624B1 (en) * | 2019-08-28 | 2026-03-11 | Ventana Medical Systems, Inc. | Assessing antigen retrieval and target retrieval progression quantitation with vibrational spectroscopy |
| WO2021224293A1 (en) * | 2020-05-07 | 2021-11-11 | Ventana Medical Systems, Inc. | Histochemical systems and methods for evaluating egfr and egfr ligand expression in tumor samples |
| WO2022152777A1 (en) * | 2021-01-15 | 2022-07-21 | F. Hoffmann-La Roche Ag | Storage stable caged haptens |
| CN114994329A (zh) * | 2022-04-28 | 2022-09-02 | 杭州广科安德生物科技有限公司 | 一种检测肿瘤组织中p185蛋白与p95蛋白表达水平的方法 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2730523A (en) * | 1952-08-16 | 1956-01-10 | Eastman Kodak Co | 5-nitrothiazoleazo-n-fluoroalkyl-aniline compounds |
| WO1990000618A1 (en) | 1988-07-08 | 1990-01-25 | Jbl Scientific, Inc. | Preparation and use of fluorescent benzothiazole derivatives |
| US5196306A (en) | 1989-03-29 | 1993-03-23 | E. I. Du Pont De Nemours And Company | Method for the detection or quantitation of an analyte using an analyte dependent enzyme activation system |
| US5182203A (en) * | 1989-03-29 | 1993-01-26 | E. I. Du Pont De Nemours And Company | Bifunctional compounds useful in catalyzed reporter deposition |
| US5180828A (en) * | 1990-02-09 | 1993-01-19 | Molecular Devices Corporation | Chromophoric reagents for incorporation of biotin or other haptens into macromolecules |
| US5595707A (en) | 1990-03-02 | 1997-01-21 | Ventana Medical Systems, Inc. | Automated biological reaction apparatus |
| US5371241A (en) * | 1991-07-19 | 1994-12-06 | Pharmacia P-L Biochemicals Inc. | Fluorescein labelled phosphoramidites |
| GB9517060D0 (en) * | 1995-08-17 | 1995-10-25 | Ciba Geigy Ag | Acylated oligopeptide derivatives |
| US20030235877A1 (en) * | 1996-04-30 | 2003-12-25 | La Region Wallone | Conjugates of haptens to beta-lactam derivatives and their use for detecting and/or quantifying haptens in solution and device for implementation thereof |
| JP3847559B2 (ja) | 1998-02-27 | 2006-11-22 | ベンタナ・メデイカル・システムズ・インコーポレーテツド | 独立スライド加熱器を有する自動化分子病理学装置 |
| US20030211630A1 (en) | 1998-02-27 | 2003-11-13 | Ventana Medical Systems, Inc. | Automated molecular pathology apparatus having independent slide heaters |
| US6582962B1 (en) | 1998-02-27 | 2003-06-24 | Ventana Medical Systems, Inc. | Automated molecular pathology apparatus having independent slide heaters |
| US20060040319A1 (en) * | 2000-01-14 | 2006-02-23 | Tom Muir | Multiple sensor-containing active modified polypeptides, preparation and uses thereof |
| WO2003014698A2 (en) * | 2001-08-07 | 2003-02-20 | Merck & Co., Inc. | Biological assay detection method |
| CA2940803A1 (en) * | 2004-03-23 | 2005-10-27 | Ascendis Pharma Gmbh | Prodrug linker |
| CA2609702C (en) | 2005-04-28 | 2013-05-28 | Ventana Medical Systems, Inc. | Antibody conjugates via heterobifunctional peg linkers |
| US20070117153A1 (en) | 2005-11-23 | 2007-05-24 | Christopher Bieniarz | Molecular conjugate |
| DK2444807T3 (da) * | 2006-11-01 | 2014-08-11 | Ventana Med Syst Inc | Mono- og dinitropyrazolhaptenkonjugater |
| WO2008098100A2 (en) * | 2007-02-07 | 2008-08-14 | Perscitus Biosciences, Llc | Detection of molecule proximity |
| EP2167963B1 (en) | 2007-05-23 | 2019-04-17 | Ventana Medical Systems, Inc. | Polymeric carriers for immunohistochemistry and in situ hybridization |
| CN101952719A (zh) * | 2007-07-27 | 2011-01-19 | 通信改革公司 | 检测测定法及其用途 |
| EP2334827B1 (en) | 2008-08-22 | 2015-03-11 | Ventana Medical Systems, Inc. | Method for chromogenic detection of two or more target molecules in a single sample |
| CA2842661C (en) | 2009-10-19 | 2016-02-23 | Ventana Medical Systems, Inc. | Imaging system and techniques |
| CA2782009C (en) | 2009-11-27 | 2017-10-03 | Ecole Polytechnique Federale De Lausanne (Epfl) | Nanofluidic biosensor and its use for rapid measurement of biomolecular interactions in solution and methods |
| SG190892A1 (en) | 2010-12-30 | 2013-07-31 | Ventana Med Syst Inc | Enhanced deposition of chromogens utilizing pyrimidine analogs |
| US8852599B2 (en) * | 2011-05-26 | 2014-10-07 | Bristol-Myers Squibb Company | Immunoconjugates, compositions for making them, and methods of making and use |
| CN105204152B (zh) | 2011-09-09 | 2018-10-26 | 文塔纳医疗系统公司 | 成像系统、盒和使用其的方法 |
| ES2678211T3 (es) | 2012-03-27 | 2018-08-09 | Ventana Medical Systems, Inc. | Conjugados de señalización y procedimientos de uso |
| CA2901513C (en) * | 2013-03-12 | 2020-12-29 | Ventana Medical Systems, Inc. | Proximity assay for in situ detection of targets |
| CN103513039B (zh) * | 2013-07-10 | 2015-12-23 | 广州美格生物科技有限公司 | 一种利用定向肽库检测蛋白质与其他分子相互作用的方法 |
| US10241115B2 (en) * | 2013-12-10 | 2019-03-26 | Merck Sharp & Dohme Corp. | Immunohistochemical proximity assay for PD-1 positive cells and PD-ligand positive cells in tumor tissue |
| CA2940439C (en) * | 2014-02-24 | 2024-03-19 | Ventana Medical Systems, Inc. | Quinone methide analog signal amplification |
| US10550190B2 (en) * | 2014-04-04 | 2020-02-04 | Merck Sharp & Dohme Corp. | Phosphate based linkers for intracellular delivery of drug conjugates |
| CN107003323B (zh) * | 2014-11-25 | 2019-06-04 | 文塔纳医疗系统公司 | 使用化学连接和半抗原转移的邻近测定法 |
| EP3037820A1 (en) | 2014-12-27 | 2016-06-29 | Miltenyi Biotec GmbH | Cell detection methods and reagents having a releasable labelling moiety |
| AU2016316846B2 (en) * | 2015-08-28 | 2021-07-08 | Ventana Medical Systems, Inc. | Protein proximity assay in formalin fixed paffafin embedded tissue using caged haptens |
-
2016
- 2016-08-26 AU AU2016316846A patent/AU2016316846B2/en active Active
- 2016-08-26 CA CA2996798A patent/CA2996798A1/en active Pending
- 2016-08-26 JP JP2018510803A patent/JP6880001B2/ja active Active
- 2016-08-26 CN CN201680049897.4A patent/CN107923915B/zh active Active
- 2016-08-26 EP EP16842723.5A patent/EP3341734B1/en active Active
- 2016-08-26 WO PCT/US2016/049153 patent/WO2017040349A1/en not_active Ceased
-
2017
- 2017-08-25 CN CN201780060757.1A patent/CN109791144B/zh active Active
- 2017-08-25 CN CN202310341013.4A patent/CN116338167A/zh active Pending
- 2017-08-25 JP JP2019511411A patent/JP7033122B2/ja active Active
- 2017-08-25 WO PCT/US2017/048687 patent/WO2018039605A1/en not_active Ceased
-
2018
- 2018-02-28 US US15/907,479 patent/US11053266B2/en active Active
-
2019
- 2019-02-25 US US16/284,098 patent/US11345719B2/en active Active
-
2021
- 2021-01-15 US US17/149,911 patent/US12559511B2/en active Active
- 2021-06-11 US US17/345,072 patent/US12173019B2/en active Active
- 2021-08-19 AU AU2021218128A patent/AU2021218128B2/en active Active
- 2021-10-16 US US17/503,303 patent/US12577266B2/en active Active
-
2023
- 2023-03-17 AU AU2023201682A patent/AU2023201682B2/en active Active
-
2024
- 2024-11-13 US US18/945,898 patent/US20250066397A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2021218128B2 (en) | 2022-12-22 |
| US20210221833A1 (en) | 2021-07-22 |
| US12559511B2 (en) | 2026-02-24 |
| JP6880001B2 (ja) | 2021-06-02 |
| AU2016316846B2 (en) | 2021-07-08 |
| WO2018039605A1 (en) | 2018-03-01 |
| US20220089622A1 (en) | 2022-03-24 |
| JP2019532275A (ja) | 2019-11-07 |
| AU2016316846A1 (en) | 2018-02-22 |
| EP3341734B1 (en) | 2024-08-07 |
| EP3341734A1 (en) | 2018-07-04 |
| CN109791144B (zh) | 2023-04-18 |
| EP3341734A4 (en) | 2019-02-06 |
| JP2018528425A (ja) | 2018-09-27 |
| US11345719B2 (en) | 2022-05-31 |
| US20180186821A1 (en) | 2018-07-05 |
| US20190233447A1 (en) | 2019-08-01 |
| AU2021218128A1 (en) | 2021-09-09 |
| CN109791144A (zh) | 2019-05-21 |
| US12577266B2 (en) | 2026-03-17 |
| CN116338167A (zh) | 2023-06-27 |
| AU2023201682B2 (en) | 2023-12-07 |
| JP7033122B2 (ja) | 2022-03-09 |
| AU2023201682A1 (en) | 2023-04-13 |
| US12173019B2 (en) | 2024-12-24 |
| CN107923915A (zh) | 2018-04-17 |
| US20210309680A1 (en) | 2021-10-07 |
| WO2017040349A1 (en) | 2017-03-09 |
| CN107923915B (zh) | 2021-05-04 |
| US11053266B2 (en) | 2021-07-06 |
| US20250066397A1 (en) | 2025-02-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20190722 |
|
| MFA | Maintenance fee for application paid |
Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 8TH ANNIV.) - STANDARD Year of fee payment: 8 |
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| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20240726 |
|
| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT DETERMINED COMPLIANT Effective date: 20241217 Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL Effective date: 20241217 |
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| D15 | Examination report completed |
Free format text: ST27 STATUS EVENT CODE: A-2-2-D10-D15-D126 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: EXAMINER'S REPORT Effective date: 20250220 |
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| W00 | Other event occurred |
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| P13 | Application amended |
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| MFA | Maintenance fee for application paid |
Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 9TH ANNIV.) - STANDARD Year of fee payment: 9 |
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| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20250724 |
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| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL Effective date: 20250724 |