JP2010254993A5 - - Google Patents
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- Publication number
- JP2010254993A5 JP2010254993A5 JP2010085260A JP2010085260A JP2010254993A5 JP 2010254993 A5 JP2010254993 A5 JP 2010254993A5 JP 2010085260 A JP2010085260 A JP 2010085260A JP 2010085260 A JP2010085260 A JP 2010085260A JP 2010254993 A5 JP2010254993 A5 JP 2010254993A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkoxy
- amino
- sulfonyl
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- -1 amino, hydroxy, sulfonyl Chemical group 0.000 claims 30
- 125000003545 alkoxy group Chemical group 0.000 claims 21
- 125000000217 alkyl group Chemical group 0.000 claims 21
- ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical compound OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 claims 19
- 229910052736 halogen Inorganic materials 0.000 claims 16
- 150000002367 halogens Chemical class 0.000 claims 16
- 125000005499 phosphonyl group Chemical group 0.000 claims 16
- 150000001540 azides Chemical class 0.000 claims 11
- 150000001875 compounds Chemical class 0.000 claims 10
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims 10
- 150000001356 alkyl thiols Chemical class 0.000 claims 8
- 150000001504 aryl thiols Chemical class 0.000 claims 8
- 125000004104 aryloxy group Chemical group 0.000 claims 8
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 8
- 125000001309 chloro group Chemical group Cl* 0.000 claims 8
- 125000001153 fluoro group Chemical group F* 0.000 claims 8
- 229910052739 hydrogen Inorganic materials 0.000 claims 8
- 239000001257 hydrogen Substances 0.000 claims 8
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 8
- 150000003573 thiols Chemical class 0.000 claims 8
- 239000000975 dye Substances 0.000 claims 6
- OAKJQQAXSVQMHS-UHFFFAOYSA-N hydrazine group Chemical group NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims 6
- 229910052760 oxygen Inorganic materials 0.000 claims 6
- 229910052717 sulfur Inorganic materials 0.000 claims 6
- 239000002202 Polyethylene glycol Substances 0.000 claims 5
- 239000002253 acid Substances 0.000 claims 5
- 150000001413 amino acids Chemical class 0.000 claims 5
- 229920000768 polyamine Polymers 0.000 claims 5
- 229920001223 polyethylene glycol Polymers 0.000 claims 5
- 125000004001 thioalkyl group Chemical group 0.000 claims 5
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 4
- NOWKCMXCCJGMRR-UHFFFAOYSA-N Aziridine Chemical compound C1CN1 NOWKCMXCCJGMRR-UHFFFAOYSA-N 0.000 claims 3
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 claims 3
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 claims 3
- 150000001299 aldehydes Chemical class 0.000 claims 3
- 150000001350 alkyl halides Chemical class 0.000 claims 3
- 150000001412 amines Chemical class 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 150000001502 aryl halides Chemical class 0.000 claims 3
- 150000002148 esters Chemical class 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 150000002540 isothiocyanates Chemical class 0.000 claims 3
- 239000000758 substrate Substances 0.000 claims 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims 2
- QPFYXYFORQJZEC-FOCLMDBBSA-N Phenazopyridine Chemical compound NC1=NC(N)=CC=C1\N=N\C1=CC=CC=C1 QPFYXYFORQJZEC-FOCLMDBBSA-N 0.000 claims 2
- 239000012491 analyte Substances 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 238000001514 detection method Methods 0.000 claims 2
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 claims 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 2
- 229940070891 pyridium Drugs 0.000 claims 2
- 125000001273 sulfonato group Chemical group [O-]S(*)(=O)=O 0.000 claims 2
- DHCDFWKWKRSZHF-UHFFFAOYSA-N sulfurothioic S-acid Chemical compound OS(O)(=O)=S DHCDFWKWKRSZHF-UHFFFAOYSA-N 0.000 claims 2
- DWAOUXYZOSPAOH-UHFFFAOYSA-N 4-[2-(diethylamino)ethoxy]furo[3,2-g]chromen-7-one;hydrochloride Chemical compound [Cl-].O1C(=O)C=CC2=C1C=C1OC=CC1=C2OCC[NH+](CC)CC DWAOUXYZOSPAOH-UHFFFAOYSA-N 0.000 claims 1
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims 1
- 150000008064 anhydrides Chemical class 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 229920001222 biopolymer Polymers 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229910052697 platinum Inorganic materials 0.000 claims 1
- 239000000985 reactive dye Substances 0.000 claims 1
- 150000003461 sulfonyl halides Chemical class 0.000 claims 1
- 0 Cc1c(*)c(*)c(C2=C(*)c3c(*)c(*)c(*)c(*)c3OC2=O)[n]1 Chemical compound Cc1c(*)c(*)c(C2=C(*)c3c(*)c(*)c(*)c(*)c3OC2=O)[n]1 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16586209P | 2009-04-01 | 2009-04-01 | |
| US61/165,862 | 2009-04-01 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010254993A JP2010254993A (ja) | 2010-11-11 |
| JP2010254993A5 true JP2010254993A5 (https=) | 2013-05-02 |
| JP5697886B2 JP5697886B2 (ja) | 2015-04-08 |
Family
ID=42224506
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010085260A Active JP5697886B2 (ja) | 2009-04-01 | 2010-04-01 | 反応性複素環置換７−ヒドロキシクマリンおよびその複合体 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8431416B2 (https=) |
| EP (1) | EP2236508B1 (https=) |
| JP (1) | JP5697886B2 (https=) |
| CN (1) | CN101914093B (https=) |
| ES (1) | ES2548380T3 (https=) |
| SG (1) | SG165300A1 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9400273B1 (en) | 2009-12-09 | 2016-07-26 | Life Technologies Corporation | 7-hydroxycoumarin-based cell-tracking reagents |
| JP6425538B2 (ja) * | 2011-03-30 | 2018-11-21 | スリーエム イノベイティブ プロパティズ カンパニー | 蛍光性化合物又は発蛍光団化合物、並びにこれらの使用法 |
| KR102022483B1 (ko) * | 2012-03-29 | 2019-09-18 | 스미또모 가가꾸 가부시키가이샤 | 염료용 화합물 |
| AU2013334635B2 (en) | 2012-10-24 | 2018-12-06 | Becton, Dickinson And Company | Hydroxamate substituted azaindoline-cyanine dyes and bioconjugates of the same |
| EP3769787A1 (en) * | 2015-06-29 | 2021-01-27 | ImmunoGen, Inc. | Conjugates of cysteine engineered antibodies |
| ITUA20161706A1 (it) | 2016-03-15 | 2017-09-15 | Cyanagen S R L | Nuovi coloranti cumarinici e relativi coniugati |
| EP4610656A3 (en) | 2016-04-15 | 2025-11-19 | Beckman Coulter, Inc. | Photoactive macromolecules and uses thereof |
| JP6821490B2 (ja) * | 2017-04-03 | 2021-01-27 | 日本化薬株式会社 | クマリン化合物又はそれらの塩、並びにこれを含んだ顔料組成物 |
| GB201716931D0 (en) * | 2017-10-16 | 2017-11-29 | Illumina Cambridge Ltd | New fluorescent compounds and their use as biomarkers |
| US20220026434A1 (en) * | 2019-01-21 | 2022-01-27 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V | Advanced methods for automated high-performance identification of carbohydrates and carbohydrate mixture composition patterns and systems therefore as well as methods for calibration of multi wavelength fluorescence detection systems therefore, based on new fluorescent dyes |
| CN109721592B (zh) * | 2019-03-04 | 2022-09-30 | 河南理工大学 | 一种含香豆素的氨基吡嗪酰腙衍生物的荧光探针及其制备方法和应用 |
| EP3747957A1 (en) | 2019-06-07 | 2020-12-09 | Universidade de Évora | Fluorescent vinyl tiophene and bitiophene coumarins dyes and method of synthesis thereof |
| CN115280147A (zh) * | 2020-01-30 | 2022-11-01 | 阿特生物探索公司 | 可紫外激发的基于聚芴的缀合物及其在分析物检测方法中的用途 |
| US11981964B2 (en) * | 2020-07-28 | 2024-05-14 | Illumina Cambridge Limited | Substituted coumarin dyes and uses as fluorescent labels |
| CN112679569B (zh) * | 2020-10-22 | 2022-05-27 | 山西大学 | 一种荧光探针及其制备方法和应用 |
| US20240125773A1 (en) | 2021-02-05 | 2024-04-18 | Beckman Coulter, Inc. | Compositions and methods for preventing non-specific interactions between polymer dyes-antibody conjugates |
| CN113121513B (zh) * | 2021-04-26 | 2023-05-16 | 安徽大学 | 一种咔唑-香豆素基腙类化合物及其制备方法和用途 |
| JP2024517437A (ja) | 2021-05-04 | 2024-04-22 | ベックマン コールター， インコーポレイテッド | Ｕｖ吸収性ポリマー、組成物およびその使用 |
| CN120936679A (zh) | 2023-03-17 | 2025-11-11 | 贝克曼库尔特有限公司 | 苯并噻吩并吡咯花菁染料 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3556959A (en) * | 1968-03-29 | 1971-01-19 | Frank Passal | Nickel plating |
| IT1088554B (it) * | 1977-11-17 | 1985-06-10 | F I D I A Spa | Procedimento sellettivo per la preparazione di derivati della 7-indrossi cumarina |
| US4235781A (en) * | 1979-09-20 | 1980-11-25 | Thomas C. Elder, Inc. | 6 Or 8 Haloallyl substituted 7-hydroxycoumarins |
| US4259233A (en) * | 1979-10-23 | 1981-03-31 | Miles Laboratories, Inc. | β-Galactosyl-umbelliferone-labeled protein and polypeptide conjugates |
| DE3044128A1 (de) | 1980-11-24 | 1982-07-15 | Bayer Ag, 5090 Leverkusen | Cumarine, verfahren zu ihrer herstellung und ihre verwendung |
| US4711955A (en) | 1981-04-17 | 1987-12-08 | Yale University | Modified nucleotides and methods of preparing and using same |
| SE8505716D0 (sv) | 1985-12-03 | 1985-12-03 | Biocarb Ab | Novel compounds and conjugates thereof |
| US5047519A (en) | 1986-07-02 | 1991-09-10 | E. I. Du Pont De Nemours And Company | Alkynylamino-nucleotides |
| US5049673A (en) | 1987-10-30 | 1991-09-17 | The Regents Of The University Of California | Fluorescent indicator dyes for calcium working at long wavelengths |
| US5516629A (en) | 1990-04-16 | 1996-05-14 | Cryopharm Corporation | Photoinactivation of viral and bacterial blood contaminants using halogenated coumarins |
| US5648270A (en) | 1995-02-06 | 1997-07-15 | Molecular Probes, Inc. | Methods of sensing with fluorescent conjugates of metal-chelating nitrogen heterocycles |
| US5405975A (en) | 1993-03-29 | 1995-04-11 | Molecular Probes, Inc. | Fluorescent ion-selective diaryldiaza crown ether conjugates |
| US5453517A (en) | 1992-02-25 | 1995-09-26 | Molecular Probes, Inc. | Reactive derivatives of bapta used to make ion-selective chelators |
| NL9001639A (nl) | 1990-07-19 | 1992-02-17 | Amc Amsterdam | Pt-houdende verbinding, werkwijze voor de bereiding ervan, alsmede toepassing van dergelijke verbindingen. |
| US5714327A (en) | 1990-07-19 | 1998-02-03 | Kreatech Diagnostics | Platinum-containing compounds, methods for their preparation and applications thereof |
| US5208148A (en) | 1990-12-07 | 1993-05-04 | Molecular Probes, Inc. | Lipophilic fluorescent glycosidase substrates |
| YU187991A (sh) | 1990-12-11 | 1994-09-09 | Hoechst Aktiengesellschaft | 3-(2)-amino-ali tiol-modifikovani, s fluorescentnom bojom vezani nukleozidi, nukleotidi i oligonukleotidi, postupak za njihovo dobijanje i njihova upotreba |
| US5539082A (en) | 1993-04-26 | 1996-07-23 | Nielsen; Peter E. | Peptide nucleic acids |
| US5516911A (en) | 1993-12-30 | 1996-05-14 | The United States Of America As Represented By The Department Of Health And Human Services | Fluorescent intracellular calcium indicators |
| US6150510A (en) | 1995-11-06 | 2000-11-21 | Aventis Pharma Deutschland Gmbh | Modified oligonucleotides, their preparation and their use |
| US5741657A (en) | 1995-03-20 | 1998-04-21 | The Regents Of The University Of California | Fluorogenic substrates for β-lactamase and methods of use |
| US6342379B1 (en) * | 1995-06-07 | 2002-01-29 | The Regents Of The University Of California | Detection of transmembrane potentials by optical methods |
| US5684142A (en) | 1995-06-07 | 1997-11-04 | Oncor, Inc. | Modified nucleotides for nucleic acid labeling |
| US5668268A (en) | 1995-11-27 | 1997-09-16 | Hybridon, Inc. | Passivated polymer supports for nucleic acid synthesis |
| US5955604A (en) | 1996-10-15 | 1999-09-21 | The Regents Of The University Of California | Substrates for β-lactamase and uses thereof |
| US5830912A (en) * | 1996-11-15 | 1998-11-03 | Molecular Probes, Inc. | Derivatives of 6,8-difluoro-7-hydroxycoumarin |
| US5696157A (en) * | 1996-11-15 | 1997-12-09 | Molecular Probes, Inc. | Sulfonated derivatives of 7-aminocoumarin |
| US6221612B1 (en) * | 1997-08-01 | 2001-04-24 | Aurora Biosciences Corporation | Photon reducing agents for use in fluorescence assays |
| US6372895B1 (en) | 2000-07-07 | 2002-04-16 | 3M Innovative Properties Company | Fluorogenic compounds |
| US6207404B1 (en) | 1999-09-30 | 2001-03-27 | Gentest Corporation | Coumarin-based CYP3A fluorescent assay reagents |
| US7304168B2 (en) * | 2003-08-14 | 2007-12-04 | Board Of Regents, University Of Texas System | Photo-caged fluorescent molecules |
| US7674924B2 (en) * | 2006-05-22 | 2010-03-09 | Third Wave Technologies, Inc. | Compositions, probes, and conjugates and uses thereof |
| US20100029017A1 (en) * | 2008-07-29 | 2010-02-04 | Becton, Dickinson And Company | Mono-chlorinated hydroxycoumarin conjugates |
-
2010
- 2010-03-17 US US12/726,267 patent/US8431416B2/en active Active
- 2010-03-30 EP EP10158457.1A patent/EP2236508B1/en active Active
- 2010-03-30 ES ES10158457.1T patent/ES2548380T3/es active Active
- 2010-03-31 SG SG201002257-2A patent/SG165300A1/en unknown
- 2010-04-01 JP JP2010085260A patent/JP5697886B2/ja active Active
- 2010-04-01 CN CN201010228953.5A patent/CN101914093B/zh active Active
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