JP2015524058A5 - - Google Patents
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- Publication number
- JP2015524058A5 JP2015524058A5 JP2015514156A JP2015514156A JP2015524058A5 JP 2015524058 A5 JP2015524058 A5 JP 2015524058A5 JP 2015514156 A JP2015514156 A JP 2015514156A JP 2015514156 A JP2015514156 A JP 2015514156A JP 2015524058 A5 JP2015524058 A5 JP 2015524058A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- protecting group
- compound
- heterocycle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000623 heterocyclic group Chemical group 0.000 claims 34
- 150000001875 compounds Chemical class 0.000 claims 30
- 229910052739 hydrogen Inorganic materials 0.000 claims 24
- 239000001257 hydrogen Substances 0.000 claims 24
- 125000000217 alkyl group Chemical group 0.000 claims 19
- 125000003342 alkenyl group Chemical group 0.000 claims 17
- 125000000304 alkynyl group Chemical group 0.000 claims 17
- 125000003118 aryl group Chemical group 0.000 claims 17
- 125000004452 carbocyclyl group Chemical group 0.000 claims 17
- 125000001072 heteroaryl group Chemical group 0.000 claims 17
- 150000002431 hydrogen Chemical class 0.000 claims 14
- 238000000034 method Methods 0.000 claims 13
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 10
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 10
- 125000006239 protecting group Chemical group 0.000 claims 10
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 8
- 229910052757 nitrogen Inorganic materials 0.000 claims 8
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 8
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 8
- 125000004430 oxygen atom Chemical group O* 0.000 claims 8
- 150000001450 anions Chemical class 0.000 claims 7
- 239000002207 metabolite Substances 0.000 claims 7
- 102000004190 Enzymes Human genes 0.000 claims 6
- 108090000790 Enzymes Proteins 0.000 claims 6
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 4
- 125000001246 bromo group Chemical group Br* 0.000 claims 4
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- ACFIXJIJDZMPPO-NNYOXOHSSA-N NADPH Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](OP(O)(O)=O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 ACFIXJIJDZMPPO-NNYOXOHSSA-N 0.000 claims 2
- 101150053185 P450 gene Proteins 0.000 claims 2
- 238000001514 detection method Methods 0.000 claims 2
- -1 fluoro compound Chemical class 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 238000004811 liquid chromatography Methods 0.000 claims 2
- 230000003228 microsomal effect Effects 0.000 claims 2
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
- 102000002004 Cytochrome P-450 Enzyme System Human genes 0.000 claims 1
- 108010015742 Cytochrome P-450 Enzyme System Proteins 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 238000002330 electrospray ionisation mass spectrometry Methods 0.000 claims 1
- 238000002101 electrospray ionisation tandem mass spectrometry Methods 0.000 claims 1
- 238000004128 high performance liquid chromatography Methods 0.000 claims 1
- 210000001589 microsome Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261650448P | 2012-05-22 | 2012-05-22 | |
| US61/650,448 | 2012-05-22 | ||
| PCT/US2013/042246 WO2013177293A1 (en) | 2012-05-22 | 2013-05-22 | Trapping reagents for reactive metabolites screening |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015524058A JP2015524058A (ja) | 2015-08-20 |
| JP2015524058A5 true JP2015524058A5 (https=) | 2016-07-14 |
| JP6285917B2 JP6285917B2 (ja) | 2018-02-28 |
Family
ID=48576582
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015514156A Expired - Fee Related JP6285917B2 (ja) | 2012-05-22 | 2013-05-22 | 反応性代謝物質のスクリーニングのための捕獲剤 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US9581605B2 (https=) |
| EP (1) | EP2852678B1 (https=) |
| JP (1) | JP6285917B2 (https=) |
| WO (1) | WO2013177293A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2852678B1 (en) | 2012-05-22 | 2017-08-23 | Biogen MA Inc. | Trapping reagents for reactive metabolites screening |
| WO2017214297A1 (en) * | 2016-06-09 | 2017-12-14 | Oregon State University | Compounds for delivering glutathione to a target and methods of making and using the same |
| US11084897B2 (en) | 2017-12-12 | 2021-08-10 | International Business Machines Corporation | Chemical compounds with perfluoroaryl groups that can facilitate post-synthesis functionalization |
| US11118008B2 (en) | 2018-07-06 | 2021-09-14 | International Business Machines Corporation | Ring-opening polymerizations using a flow reactor |
| WO2021233997A1 (en) * | 2020-05-20 | 2021-11-25 | F. Hoffmann-La Roche Ag | Reagent for mass spectrometry |
| JP7808465B2 (ja) * | 2021-12-20 | 2026-01-29 | 花王株式会社 | 有機化合物、試薬、及び分析方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5478723A (en) | 1993-09-27 | 1995-12-26 | Parkinson; Andrew | Method and apparatus for determining the role of cytochrome P450 and related enzymes in the metabolism of drugs and other chemicals |
| US5891696A (en) | 1996-08-02 | 1999-04-06 | Panvera Corporation | Compositions for cytochrome P450 biotransformation reactions |
| US6830897B2 (en) * | 2000-04-26 | 2004-12-14 | Pfizer Inc. | High throughput screen for reducing drug candidate attrition |
| PT1425586E (pt) * | 2001-09-14 | 2007-12-31 | Electrophoretics Ltd | Marcadores de massa |
| AU2002952747A0 (en) | 2002-11-18 | 2002-12-05 | Ludwig Institute For Cancer Research | Method for analysing peptides |
| WO2004109279A2 (en) | 2003-06-09 | 2004-12-16 | Pfizer Products Inc. | Sensitive and selective in vitro assay for the detection of reactive drug intermediates |
| US7169576B2 (en) | 2004-01-08 | 2007-01-30 | Bristol-Myers Squibb Company | Method for identifying drug metabolites with dansylated glutathione |
| JP4566604B2 (ja) * | 2004-03-31 | 2010-10-20 | 塩野義製薬株式会社 | 糖鎖標識試薬 |
| WO2006012154A1 (en) * | 2004-06-28 | 2006-02-02 | Janssen Pharmaceutica, N.V. | A method for detecting reactive metabolites using stable-isotope trapping and mass spectroscopy |
| WO2006080210A1 (ja) * | 2005-01-27 | 2006-08-03 | National University Corporation Hokkaido University | イオン化効率を向上させるための試薬、方法およびキット、並びにその利用 |
| WO2008042634A2 (en) * | 2006-09-29 | 2008-04-10 | Janssen Pharmaceutica, N.V. | Isotopically labeled trapping agent and method for identifying reactive metabolites |
| US8268865B2 (en) | 2007-05-11 | 2012-09-18 | Rempex Pharmaceuticals, Inc. | Quaternary alkyl ammonium bacterial efflux pump inhibitors and therapeutic uses thereof |
| HRP20160569T1 (hr) | 2007-12-03 | 2016-07-29 | Obe Therapy Biotechnology | Boropeptidni inhibitori enteropeptidaze i njihove uporabe u liječenju pretilosti, pretjerane tjelesne težine i/ili bolesti povezane s abnormalnim metabolizmom masti |
| WO2010122673A1 (en) * | 2009-04-23 | 2010-10-28 | Eisai R&D Management Co., Ltd. | Trapping compounds and method for identifying reactive metabolites |
| EP2470900B1 (en) | 2009-08-25 | 2014-12-03 | Antec Leyden B.V. | A method of screening agents for their impact on nucleic acid oxidation reactions |
| WO2011159685A2 (en) | 2010-06-16 | 2011-12-22 | The Regents Of The University Of Michigan | Inhibition of wdr5 interaction with its binding partners and therapeutic methods |
| EP2852678B1 (en) | 2012-05-22 | 2017-08-23 | Biogen MA Inc. | Trapping reagents for reactive metabolites screening |
-
2013
- 2013-05-22 EP EP13726990.8A patent/EP2852678B1/en active Active
- 2013-05-22 JP JP2015514156A patent/JP6285917B2/ja not_active Expired - Fee Related
- 2013-05-22 US US14/402,818 patent/US9581605B2/en not_active Expired - Fee Related
- 2013-05-22 WO PCT/US2013/042246 patent/WO2013177293A1/en not_active Ceased
-
2017
- 2017-01-03 US US15/397,523 patent/US10100081B2/en active Active
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