JP2013530127A5 - - Google Patents

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JP2013530127A5
JP2013530127A5 JP2013502765A JP2013502765A JP2013530127A5 JP 2013530127 A5 JP2013530127 A5 JP 2013530127A5 JP 2013502765 A JP2013502765 A JP 2013502765A JP 2013502765 A JP2013502765 A JP 2013502765A JP 2013530127 A5 JP2013530127 A5 JP 2013530127A5
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Japan
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pharmaceutical composition
composition according
ttr
dsrna
expression
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JP2013502765A
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JP5860029B2 (ja
JP2013530127A (ja
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Priority claimed from PCT/US2011/030392 external-priority patent/WO2011123468A1/en
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JP2013502765A 2010-03-29 2011-03-29 トランスチレチン(TTR)関連眼アミロイドーシスのためのsiRNA療法 Active JP5860029B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US31870410P 2010-03-29 2010-03-29
US31870210P 2010-03-29 2010-03-29
US61/318,704 2010-03-29
US61/318,702 2010-03-29
PCT/US2011/030392 WO2011123468A1 (en) 2010-03-29 2011-03-29 Sirna therapy for transthyretin (ttr) related ocular amyloidosis

Related Child Applications (1)

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JP2015182463A Division JP2016027814A (ja) 2010-03-29 2015-09-16 トランスチレチン(TTR)関連眼アミロイドーシスのためのsiRNA療法

Publications (3)

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JP2013530127A JP2013530127A (ja) 2013-07-25
JP2013530127A5 true JP2013530127A5 (enExample) 2014-05-08
JP5860029B2 JP5860029B2 (ja) 2016-02-16

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Application Number Title Priority Date Filing Date
JP2013502765A Active JP5860029B2 (ja) 2010-03-29 2011-03-29 トランスチレチン(TTR)関連眼アミロイドーシスのためのsiRNA療法
JP2015182463A Pending JP2016027814A (ja) 2010-03-29 2015-09-16 トランスチレチン(TTR)関連眼アミロイドーシスのためのsiRNA療法
JP2017157474A Pending JP2018012708A (ja) 2010-03-29 2017-08-17 トランスチレチン(TTR)関連眼アミロイドーシスのためのsiRNA療法
JP2019010528A Active JP6669905B2 (ja) 2010-03-29 2019-01-24 トランスチレチン(TTR)関連眼アミロイドーシスのためのsiRNA療法

Family Applications After (3)

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JP2015182463A Pending JP2016027814A (ja) 2010-03-29 2015-09-16 トランスチレチン(TTR)関連眼アミロイドーシスのためのsiRNA療法
JP2017157474A Pending JP2018012708A (ja) 2010-03-29 2017-08-17 トランスチレチン(TTR)関連眼アミロイドーシスのためのsiRNA療法
JP2019010528A Active JP6669905B2 (ja) 2010-03-29 2019-01-24 トランスチレチン(TTR)関連眼アミロイドーシスのためのsiRNA療法

Country Status (7)

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US (5) US20130281510A1 (enExample)
EP (2) EP3329924B1 (enExample)
JP (4) JP5860029B2 (enExample)
AU (1) AU2011235276B2 (enExample)
CA (1) CA2792291A1 (enExample)
ES (1) ES2893199T3 (enExample)
WO (1) WO2011123468A1 (enExample)

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JP6752151B2 (ja) * 2014-03-25 2020-09-09 アークトゥラス・セラピューティクス・インコーポレイテッドArcturus Therapeutics,Inc. 遺伝子サイレンシングにおいて低下したoff−target効果を有するunaオリゴマー
DK3185957T3 (da) 2014-08-29 2022-08-29 Alnylam Pharmaceuticals Inc Patisiran til anvendelse ved behandlingen af transthyretin-medieret amyloidosis
CN104693097A (zh) * 2015-02-13 2015-06-10 佛山市赛维斯医药科技有限公司 一类含双酰肼和烷氧萘基结构的化合物、制备方法及其用途
CN104693095A (zh) * 2015-02-13 2015-06-10 佛山市赛维斯医药科技有限公司 一类双酰肼类FXa抑制剂及其用途
CN104693099A (zh) * 2015-02-13 2015-06-10 佛山市赛维斯医药科技有限公司 一种含双酰肼和萘基结构的化合物及其用途
JP6830441B2 (ja) * 2015-04-01 2021-02-17 アークトゥラス・セラピューティクス・インコーポレイテッドArcturus Therapeutics,Inc. 治療上のunaオリゴマーおよびその使用
WO2017015671A1 (en) 2015-07-23 2017-01-26 Arcturus Therapeutics, Inc. Compositions for treating amyloidosis
ES2842300T3 (es) 2015-07-31 2021-07-13 Alnylam Pharmaceuticals Inc Composiciones de ARNi de transtiretina (TTR) y métodos para su uso para el tratamiento o la prevención de enfermedades asociadas con TTR
WO2017070647A1 (en) 2015-10-23 2017-04-27 The Jackson Laboratory Nicotinamide for use in the treatment and prevention of ocular neurodegenerative disorder (e.g. glaucoma)
US11433089B2 (en) 2016-09-23 2022-09-06 National University Corporation Tokyo Medical And Dental University Blood-brain barrier permeable heteroduplex nucleic acid
CN110177544A (zh) 2016-11-29 2019-08-27 普尔泰克健康有限公司 用于递送治疗剂的外泌体
US11806360B2 (en) 2017-09-19 2023-11-07 Alnylam Pharmaceuticals, Inc. Compositions and methods for treating transthyretin (TTR) mediated amyloidosis
US11851654B2 (en) 2018-03-19 2023-12-26 National University Corporation Tokyo Medical And Dental University Nucleic acid with reduced toxicity
EP3956448A4 (en) * 2019-04-18 2022-10-19 University of Massachusetts Aim2 inhibitors and uses thereof
JP7692829B2 (ja) 2019-07-30 2025-06-16 塩野義製薬株式会社 Murf1を標的とする核酸医薬
WO2021092145A1 (en) * 2019-11-06 2021-05-14 Alnylam Pharmaceuticals, Inc. Transthyretin (ttr) irna composition and methods of use thereof for treating or preventing ttr-associated ocular diseases
WO2021231502A1 (en) * 2020-05-11 2021-11-18 The Board Of Trustees Of The Leland Stanford Junior University Systems and methods for enhancing gene expression
AR126675A1 (es) 2021-08-03 2023-11-01 Alnylam Pharmaceuticals Inc COMPOSICIONES DE ARNi CONTRA LA TRANSTIRRETINA (TTR) Y SUS MÉTODOS DE USO

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