JP2015524408A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015524408A5 JP2015524408A5 JP2015523158A JP2015523158A JP2015524408A5 JP 2015524408 A5 JP2015524408 A5 JP 2015524408A5 JP 2015523158 A JP2015523158 A JP 2015523158A JP 2015523158 A JP2015523158 A JP 2015523158A JP 2015524408 A5 JP2015524408 A5 JP 2015524408A5
- Authority
- JP
- Japan
- Prior art keywords
- drug
- mammal
- pharmaceutical preparation
- cells
- preparation according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000124008 Mammalia Species 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims 8
- 229940079593 drug Drugs 0.000 claims 8
- 210000004027 cell Anatomy 0.000 claims 7
- 239000000825 pharmaceutical preparation Substances 0.000 claims 7
- 206010011878 Deafness Diseases 0.000 claims 4
- 208000016354 hearing loss disease Diseases 0.000 claims 4
- 231100000888 hearing loss Toxicity 0.000 claims 3
- 230000010370 hearing loss Effects 0.000 claims 3
- 230000003834 intracellular effect Effects 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 claims 1
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 claims 1
- 229930182566 Gentamicin Natural products 0.000 claims 1
- 208000027530 Meniere disease Diseases 0.000 claims 1
- JLEBZPBDRKPWTD-TURQNECASA-O N-ribosylnicotinamide Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](CO)O2)O)=C1 JLEBZPBDRKPWTD-TURQNECASA-O 0.000 claims 1
- 108091005770 SIRT3 Proteins 0.000 claims 1
- 102000000478 Sirtuin 3 Human genes 0.000 claims 1
- 206010070863 Toxicity to various agents Diseases 0.000 claims 1
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 1
- 229960004316 cisplatin Drugs 0.000 claims 1
- 231100000895 deafness Toxicity 0.000 claims 1
- 210000000959 ear middle Anatomy 0.000 claims 1
- 229960002518 gentamicin Drugs 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 210000000067 inner hair cell Anatomy 0.000 claims 1
- 210000002569 neuron Anatomy 0.000 claims 1
- 235000020956 nicotinamide riboside Nutrition 0.000 claims 1
- 239000011618 nicotinamide riboside Substances 0.000 claims 1
- 230000004792 oxidative damage Effects 0.000 claims 1
- 239000011814 protection agent Substances 0.000 claims 1
- 210000004116 schwann cell Anatomy 0.000 claims 1
- 210000001323 spiral ganglion Anatomy 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261672169P | 2012-07-16 | 2012-07-16 | |
| US61/672,169 | 2012-07-16 | ||
| PCT/US2013/050511 WO2014014828A1 (en) | 2012-07-16 | 2013-07-15 | Nicotinamide riboside to treat hearing loss |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015524408A JP2015524408A (ja) | 2015-08-24 |
| JP2015524408A5 true JP2015524408A5 (enExample) | 2016-09-08 |
| JP6289460B2 JP6289460B2 (ja) | 2018-03-07 |
Family
ID=49949192
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015523158A Expired - Fee Related JP6289460B2 (ja) | 2012-07-16 | 2013-07-15 | 難聴を治療するためのニコチンアミドリボシド |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9861651B2 (enExample) |
| EP (1) | EP2872128B1 (enExample) |
| JP (1) | JP6289460B2 (enExample) |
| ES (1) | ES2785303T3 (enExample) |
| WO (1) | WO2014014828A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2670927T3 (es) | 2005-11-18 | 2018-06-04 | Cornell Research Foundation, Inc. | Composiciones de nicotinoil ribósido y métodos de uso |
| US10485814B2 (en) | 2014-06-06 | 2019-11-26 | Glaxosmithkline Intellectual Property (No. 2) Limited | Nicotinamide riboside analogs and pharmaceutical compositions and uses thereof |
| CA2956163C (en) | 2014-07-24 | 2023-01-10 | W.R. Grace & Co.-Conn. | Crystalline form of nicotinamide riboside |
| CN107428791B (zh) | 2015-03-09 | 2024-05-28 | 格雷斯公司 | 烟酰胺核苷的结晶形式 |
| ES2882602T3 (es) | 2015-05-18 | 2021-12-02 | Sensorion | Azasetrón para usar en el tratamiento de la pérdida auditiva |
| US10392414B2 (en) | 2015-07-15 | 2019-08-27 | Cornell University | Syntheses, activities, and methods of use of dihydronicotinamide riboside derivatives |
| US9855289B2 (en) | 2015-08-05 | 2018-01-02 | Metro International Biotech, Llc | Nicotinamide mononucleotide derivatives and their uses |
| GB2542881B (en) | 2015-10-02 | 2020-01-01 | Carr Andrew | Crystal forms of ß-nicotinamide mononucleotide |
| SI3442537T1 (sl) | 2016-04-14 | 2024-05-31 | Sensorion | (+)-azasetron za uporabo pri zdravljenju ušesnih obolenj |
| US10576125B2 (en) | 2016-10-31 | 2020-03-03 | Hough Ear Institute | Methods for enhancing synaptogenesis and neuritogenesis |
| CN120383644A (zh) | 2016-11-11 | 2025-07-29 | 英国贝尔法斯特女王大学 | 烟酰基核苷和还原的烟酰基核苷、其改性衍生物、磷酸化的类似物、腺苷二核苷酸共轭物、以及新颖结晶形式的有效且可规模化的合成 |
| US11071747B2 (en) | 2016-11-29 | 2021-07-27 | University Of Iowa Research Foundation | Use of NAD precursors for breast enhancement |
| AU2017367092B2 (en) | 2016-11-29 | 2022-11-03 | University Of Iowa Research Foundation | Use of NAD precursors for improving maternal health and/or offspring health |
| JP7182289B2 (ja) | 2017-04-05 | 2022-12-02 | コーネル ユニヴァーシティー | β－ニコチネートエステルヌクレオチドおよびその調製プロセス |
| CA3086535A1 (en) | 2017-12-22 | 2019-06-27 | Elysium Health, Inc. | Crystalline forms of nicotinamide riboside chloride |
| AU2019214858B2 (en) | 2018-01-30 | 2023-02-02 | Metro International Biotech, Llc | Nicotinamide riboside analogs, pharmaceutical compositions, and uses thereof |
| US11939348B2 (en) | 2019-03-22 | 2024-03-26 | Metro International Biotech, Llc | Compositions comprising a phosphorus derivative of nicotinamide riboside and methods for modulation of nicotinamide adenine dinucleotide |
| US10618927B1 (en) | 2019-03-22 | 2020-04-14 | Metro International Biotech, Llc | Compositions and methods for modulation of nicotinamide adenine dinucleotide |
| EP4471043A3 (en) | 2019-07-19 | 2025-03-05 | Biosynth AG | Method of making nicotinamide ribofuranoside salts, nicotinamide ribofuranoside salts as such, and uses thereof |
| KR20240020716A (ko) | 2021-05-27 | 2024-02-15 | 메트로 인터내셔널 바이오테크 엘엘씨 | 니코틴산 모노뉴클레오타이드 및 이의 에스터의 결정질 고체 및 제조 및 사용 방법 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH695593A5 (de) | 2002-12-17 | 2006-06-30 | Granite Trading Ltd | Vorsatzlinse. |
| US20060063802A1 (en) | 2004-03-29 | 2006-03-23 | Matthieu Guitton | Methods for the treatment of tinnitus induced by cochlear excitotoxicity |
| US20070149466A1 (en) * | 2005-07-07 | 2007-06-28 | Michael Milburn | Methods and related compositions for treating or preventing obesity, insulin resistance disorders, and mitochondrial-associated disorders |
| JP2009500357A (ja) | 2005-07-07 | 2009-01-08 | サートリス ファーマシューティカルズ， インコーポレイテッド | 肥満、インスリン抵抗性障害およびミトコンドリア関連障害を処置または予防するための方法および関連する組成物 |
| EP2278999B1 (en) * | 2008-04-21 | 2025-01-29 | Dompé farmaceutici S.p.A. | Auris formulations for treating otic diseases and conditions |
-
2013
- 2013-07-15 JP JP2015523158A patent/JP6289460B2/ja not_active Expired - Fee Related
- 2013-07-15 EP EP13820653.7A patent/EP2872128B1/en active Active
- 2013-07-15 WO PCT/US2013/050511 patent/WO2014014828A1/en not_active Ceased
- 2013-07-15 US US14/414,924 patent/US9861651B2/en active Active
- 2013-07-15 ES ES13820653T patent/ES2785303T3/es active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2015524408A5 (enExample) | ||
| EA201692257A2 (ru) | Паразитицидные пероральные ветеринарные композиции, включающие системно действующие активные агенты, способы и применение этих композиций и способов | |
| NZ604029A (en) | Methods of treating bladder cancer | |
| MX388278B (es) | Composiciones y metodos para inhibir masp-1 y/o masp-2 y/ o masp-3 para el tratamiento de la hemoglobinuria paroxistica nocturna | |
| RU2012139802A (ru) | Композиции с контролируемым высвобождением на основе кортикостероидов для лечения ушных болезней | |
| EA201190219A1 (ru) | Способы и композиции для лечения ишемических состояний и состояний, связанных с функцией митохондрий | |
| NZ611868A (en) | Gastric and colonic formulations and methods for making and using them | |
| JP2014511892A5 (enExample) | ||
| EA201270221A1 (ru) | Лечение болезни крона с применением лаквинимода | |
| WO2010011609A3 (en) | Controlled release antimicrobial compositions and methods for the treatment of otic disorders | |
| EA200901423A1 (ru) | Бензимидазолы и содержащие их фармацевтические композиции | |
| JP2013530127A5 (enExample) | ||
| WO2009052411A3 (en) | Methods for treatment of thiol-containing compound deficient conditions | |
| EA201490254A1 (ru) | Комбинированное лечение гепатита с | |
| MX2024000828A (es) | Formulaciones de parasiticida de isoxazolina y metodos para el tratamiento de la blefaritis. | |
| Uchida et al. | The adenosine A2A receptor antagonist, istradefylline enhances anti-parkinsonian activity induced by combined treatment with low doses of L-DOPA and dopamine agonists in MPTP-treated common marmosets | |
| JP2020505432A5 (enExample) | ||
| BR112021025701A2 (pt) | Formulações e métodos de parasiticida de isoxazolina para tratar blefarite | |
| EA201270192A1 (ru) | Композиции и способы применения для пострадиационной защиты | |
| BR112014026184A2 (pt) | composições parasiticídicas compreendendo derivados de benzimidazol, métodos e seus usos | |
| Merrick et al. | Does melatonin have therapeutic use in tinnitus | |
| RU2016103098A (ru) | Способ предотвращения и/или лечения хронической травматической энцефалопатии - ii | |
| WO2019004788A3 (ko) | 브라우쏘칼콘 a를 유효성분으로 포함하는 염증성 장질환 예방 또는 치료용 약학 조성물 | |
| AR080048A1 (es) | Tratamiento del tumor del estroma gastrointestinal (gist) con masitinib | |
| FI3442537T3 (fi) | (+)-Atsasetroni käytettäväksi korvaan liittyvien häiriöiden hoitoon |