JP2013529071A5 - - Google Patents
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- JP2013529071A5 JP2013529071A5 JP2013505490A JP2013505490A JP2013529071A5 JP 2013529071 A5 JP2013529071 A5 JP 2013529071A5 JP 2013505490 A JP2013505490 A JP 2013505490A JP 2013505490 A JP2013505490 A JP 2013505490A JP 2013529071 A5 JP2013529071 A5 JP 2013529071A5
- Authority
- JP
- Japan
- Prior art keywords
- factor viii
- snp
- item
- individual
- risk
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims description 83
- 102000001690 Factor VIII Human genes 0.000 claims description 69
- 108010054218 Factor VIII Proteins 0.000 claims description 69
- 229960000301 factor viii Drugs 0.000 claims description 69
- 238000009007 Diagnostic Kit Methods 0.000 claims description 34
- 108091034117 Oligonucleotide Proteins 0.000 claims description 33
- 239000002773 nucleotide Substances 0.000 claims description 17
- 125000003729 nucleotide group Chemical group 0.000 claims description 17
- 208000031220 Hemophilia Diseases 0.000 claims description 15
- 208000009292 Hemophilia A Diseases 0.000 claims description 15
- 238000002493 microarray Methods 0.000 claims description 14
- 229940030225 antihemorrhagics Drugs 0.000 claims description 12
- 239000002874 hemostatic agent Substances 0.000 claims description 12
- 150000007523 nucleic acids Chemical class 0.000 claims description 8
- 238000012163 sequencing technique Methods 0.000 claims description 8
- 239000012472 biological sample Substances 0.000 claims description 5
- 230000000295 complement effect Effects 0.000 claims description 5
- 238000009396 hybridization Methods 0.000 claims description 5
- 108020004414 DNA Proteins 0.000 claims description 4
- 238000001514 detection method Methods 0.000 claims description 4
- 102000053602 DNA Human genes 0.000 claims description 2
- 102000004190 Enzymes Human genes 0.000 claims description 2
- 108090000790 Enzymes Proteins 0.000 claims description 2
- 238000003556 assay Methods 0.000 claims description 2
- 238000004949 mass spectrometry Methods 0.000 claims description 2
- 238000002844 melting Methods 0.000 claims description 2
- 230000008018 melting Effects 0.000 claims description 2
- 108020004707 nucleic acids Proteins 0.000 claims description 2
- 102000039446 nucleic acids Human genes 0.000 claims description 2
- 238000012175 pyrosequencing Methods 0.000 claims description 2
- 238000003757 reverse transcription PCR Methods 0.000 claims description 2
- 239000007790 solid phase Substances 0.000 claims description 2
- 238000002560 therapeutic procedure Methods 0.000 claims description 2
- 239000000523 sample Substances 0.000 claims 5
- 230000001105 regulatory effect Effects 0.000 claims 3
- 108020005187 Oligonucleotide Probes Proteins 0.000 claims 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 1
- 230000007423 decrease Effects 0.000 claims 1
- 239000002751 oligonucleotide probe Substances 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32660210P | 2010-04-21 | 2010-04-21 | |
| US61/326,602 | 2010-04-21 | ||
| PCT/EP2011/056471 WO2011131774A1 (en) | 2010-04-21 | 2011-04-21 | Genetic factors associated with inhibitor development in hemophilia a |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015183020A Division JP6189904B2 (ja) | 2010-04-21 | 2015-09-16 | 血友病ａにおけるインヒビターの発達と関連する遺伝因子 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013529071A JP2013529071A (ja) | 2013-07-18 |
| JP2013529071A5 true JP2013529071A5 (https=) | 2014-06-05 |
| JP6058529B2 JP6058529B2 (ja) | 2017-01-11 |
Family
ID=43983253
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013505490A Active JP6058529B2 (ja) | 2010-04-21 | 2011-04-21 | 血友病ａにおけるインヒビターの発達と関連する遺伝因子 |
| JP2015183020A Active JP6189904B2 (ja) | 2010-04-21 | 2015-09-16 | 血友病ａにおけるインヒビターの発達と関連する遺伝因子 |
| JP2017151073A Active JP6568162B2 (ja) | 2010-04-21 | 2017-08-03 | 血友病ａにおけるインヒビターの発達と関連する遺伝因子 |
| JP2019142337A Withdrawn JP2019180421A (ja) | 2010-04-21 | 2019-08-01 | 血友病ａにおけるインヒビターの発達と関連する遺伝因子 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015183020A Active JP6189904B2 (ja) | 2010-04-21 | 2015-09-16 | 血友病ａにおけるインヒビターの発達と関連する遺伝因子 |
| JP2017151073A Active JP6568162B2 (ja) | 2010-04-21 | 2017-08-03 | 血友病ａにおけるインヒビターの発達と関連する遺伝因子 |
| JP2019142337A Withdrawn JP2019180421A (ja) | 2010-04-21 | 2019-08-01 | 血友病ａにおけるインヒビターの発達と関連する遺伝因子 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US9637789B2 (https=) |
| EP (2) | EP2730663B1 (https=) |
| JP (4) | JP6058529B2 (https=) |
| AU (1) | AU2011244228B2 (https=) |
| CA (2) | CA3050896C (https=) |
| ES (1) | ES2949953T3 (https=) |
| WO (1) | WO2011131774A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2771999A1 (en) | 2009-08-24 | 2011-03-10 | Amunix Operating Inc. | Coagulation factor vii compositions and methods of making and using same |
| JP6058529B2 (ja) * | 2010-04-21 | 2017-01-11 | エリック ベルントルプ， | 血友病ａにおけるインヒビターの発達と関連する遺伝因子 |
| EP2822577B1 (en) | 2012-02-15 | 2019-02-06 | Bioverativ Therapeutics Inc. | Recombinant factor viii proteins |
| JP6256882B2 (ja) | 2012-02-15 | 2018-01-10 | アムニクス オペレーティング インコーポレイテッド | 第ｖｉｉｉ因子組成物、ならびに組成物の作製方法および用途 |
| TW202003554A (zh) | 2013-08-14 | 2020-01-16 | 美商百歐維拉提夫治療公司 | 因子ｖｉｉｉ－ｘｔｅｎ融合物及其用途 |
| EA201890423A1 (ru) | 2015-08-03 | 2018-07-31 | Биовератив Терапьютикс Инк. | Слитые белки фактора ix, способы их получения и применения |
| KR101774996B1 (ko) * | 2016-06-23 | 2017-09-19 | 주식회사 녹십자지놈 | 혈우병 치료제의 효능 예측 마커 및 이의 용도 |
| MX2019006444A (es) | 2016-12-02 | 2019-10-30 | Bioverativ Therapeutics Inc | Métodos de tratamiento de artropatía hemofílica utilizando factores de coagulación quiméricos. |
| PL3793588T3 (pl) | 2018-05-18 | 2025-09-01 | Bioverativ Therapeutics Inc. | Sposoby leczenia hemofilii a |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5210015A (en) | 1990-08-06 | 1993-05-11 | Hoffman-La Roche Inc. | Homogeneous assay system using the nuclease activity of a nucleic acid polymerase |
| DK1921169T3 (da) | 1993-11-12 | 2012-06-04 | Phri Properties Inc | Hybridiseringssonder til nukleinsyredetektion, universelle stamceller, fremgangsmåder og kits |
| CA2240667A1 (en) | 1995-12-18 | 1997-06-26 | Washington University | Method for nucleic acid analysis using fluorescence resonance energy transfer |
| WO2008059009A2 (en) * | 2006-11-16 | 2008-05-22 | Crucell Holland B.V. | Factor v mutants for hemostasis in hemophilia |
| JP6058529B2 (ja) * | 2010-04-21 | 2017-01-11 | エリック ベルントルプ， | 血友病ａにおけるインヒビターの発達と関連する遺伝因子 |
-
2011
- 2011-04-21 JP JP2013505490A patent/JP6058529B2/ja active Active
- 2011-04-21 EP EP14154482.5A patent/EP2730663B1/en active Active
- 2011-04-21 ES ES14154482T patent/ES2949953T3/es active Active
- 2011-04-21 US US13/091,968 patent/US9637789B2/en active Active
- 2011-04-21 CA CA3050896A patent/CA3050896C/en active Active
- 2011-04-21 AU AU2011244228A patent/AU2011244228B2/en active Active
- 2011-04-21 EP EP11715562A patent/EP2561090A1/en not_active Withdrawn
- 2011-04-21 CA CA2796561A patent/CA2796561C/en active Active
- 2011-04-21 WO PCT/EP2011/056471 patent/WO2011131774A1/en not_active Ceased
- 2011-08-10 US US13/207,286 patent/US9644239B2/en active Active
-
2015
- 2015-09-16 JP JP2015183020A patent/JP6189904B2/ja active Active
-
2017
- 2017-03-14 US US15/458,878 patent/US20180016635A1/en not_active Abandoned
- 2017-08-03 JP JP2017151073A patent/JP6568162B2/ja active Active
-
2019
- 2019-08-01 JP JP2019142337A patent/JP2019180421A/ja not_active Withdrawn
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