JP6058529B2 - 血友病ａにおけるインヒビターの発達と関連する遺伝因子 - Google Patents

血友病ａにおけるインヒビターの発達と関連する遺伝因子 Download PDF

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JP6058529B2
JP6058529B2 JP2013505490A JP2013505490A JP6058529B2 JP 6058529 B2 JP6058529 B2 JP 6058529B2 JP 2013505490 A JP2013505490 A JP 2013505490A JP 2013505490 A JP2013505490 A JP 2013505490A JP 6058529 B2 JP6058529 B2 JP 6058529B2
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individual
factor viii
risk
antibody against
another embodiment
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JP2013529071A5 (https=
JP2013529071A (ja
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エリック ベルントルプ，
エリック ベルントルプ，
ヤン アステルマルク，
ヤン アステルマルク，
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2013505490A 2010-04-21 2011-04-21 血友病ａにおけるインヒビターの発達と関連する遺伝因子 Active JP6058529B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32660210P 2010-04-21 2010-04-21
US61/326,602 2010-04-21
PCT/EP2011/056471 WO2011131774A1 (en) 2010-04-21 2011-04-21 Genetic factors associated with inhibitor development in hemophilia a

Related Child Applications (1)

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JP2015183020A Division JP6189904B2 (ja) 2010-04-21 2015-09-16 血友病ａにおけるインヒビターの発達と関連する遺伝因子

Publications (3)

Publication Number Publication Date
JP2013529071A JP2013529071A (ja) 2013-07-18
JP2013529071A5 JP2013529071A5 (https=) 2014-06-05
JP6058529B2 true JP6058529B2 (ja) 2017-01-11

Family

ID=43983253

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2013505490A Active JP6058529B2 (ja) 2010-04-21 2011-04-21 血友病ａにおけるインヒビターの発達と関連する遺伝因子
JP2015183020A Active JP6189904B2 (ja) 2010-04-21 2015-09-16 血友病ａにおけるインヒビターの発達と関連する遺伝因子
JP2017151073A Active JP6568162B2 (ja) 2010-04-21 2017-08-03 血友病ａにおけるインヒビターの発達と関連する遺伝因子
JP2019142337A Withdrawn JP2019180421A (ja) 2010-04-21 2019-08-01 血友病ａにおけるインヒビターの発達と関連する遺伝因子

Family Applications After (3)

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JP2015183020A Active JP6189904B2 (ja) 2010-04-21 2015-09-16 血友病ａにおけるインヒビターの発達と関連する遺伝因子
JP2017151073A Active JP6568162B2 (ja) 2010-04-21 2017-08-03 血友病ａにおけるインヒビターの発達と関連する遺伝因子
JP2019142337A Withdrawn JP2019180421A (ja) 2010-04-21 2019-08-01 血友病ａにおけるインヒビターの発達と関連する遺伝因子

Country Status (7)

Country Link
US (3) US9637789B2 (https=)
EP (2) EP2730663B1 (https=)
JP (4) JP6058529B2 (https=)
AU (1) AU2011244228B2 (https=)
CA (2) CA2796561C (https=)
ES (1) ES2949953T3 (https=)
WO (1) WO2011131774A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2010290131C1 (en) 2009-08-24 2015-12-03 Amunix Operating Inc. Coagulation factor VII compositions and methods of making and using same
AU2011244228B2 (en) * 2010-04-21 2015-07-30 Jan Astermark Genetic factors associated with inhibitor development in hemophilia A
BR112014020694A2 (pt) 2012-02-15 2018-05-08 Amunix Operating Inc. proteína de fusão do fator viii compreendendo polipeptídeo do fator viii fusionado a polipeptí-deo recombinante estendido (xten) e seu método de fabricação, ácido nucleico, vetores, célula hospedeira, bem como composição farmacêutica e seu uso no tratamento de coagulopatia, episódio de hemorragia e hemofilia a
CA2864126A1 (en) 2012-02-15 2013-08-22 Biogen Idec Ma Inc. Recombinant factor viii proteins
US10548953B2 (en) 2013-08-14 2020-02-04 Bioverativ Therapeutics Inc. Factor VIII-XTEN fusions and uses thereof
BR112018002150A2 (pt) 2015-08-03 2018-09-18 Bioverativ Therapeutics Inc proteínas de fusão do fator ix e métodos de fabricação e uso das mesmas
KR101774996B1 (ko) * 2016-06-23 2017-09-19 주식회사 녹십자지놈 혈우병 치료제의 효능 예측 마커 및 이의 용도
IL319473A (en) 2016-12-02 2025-05-01 Bioverativ Therapeutics Inc Methods for treating hemophilic arthritis using chimeric blood clotting factors
BR112020022164A2 (pt) 2018-05-18 2021-02-02 Bioverativ Therapeutics Inc. métodos de tratamento de hemofilia a

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5210015A (en) 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
JP4071277B2 (ja) 1993-11-12 2008-04-02 ピーエイチアールアイ・プロパティーズ・インコーポレーテッド 核酸検出用ハイブリダイゼーションプローブ、共通ステム、方法およびキット
AU710425B2 (en) 1995-12-18 1999-09-23 Washington University Method for nucleic acid analysis using fluorescence resonance energy transfer
WO2008059009A2 (en) * 2006-11-16 2008-05-22 Crucell Holland B.V. Factor v mutants for hemostasis in hemophilia
AU2011244228B2 (en) * 2010-04-21 2015-07-30 Jan Astermark Genetic factors associated with inhibitor development in hemophilia A

Also Published As

Publication number Publication date
US9644239B2 (en) 2017-05-09
CA3050896A1 (en) 2011-10-27
EP2730663A3 (en) 2014-09-10
EP2730663B1 (en) 2023-03-22
JP2019180421A (ja) 2019-10-24
AU2011244228B2 (en) 2015-07-30
US20120065077A1 (en) 2012-03-15
AU2011244228A1 (en) 2012-11-08
CA2796561A1 (en) 2011-10-27
CA3050896C (en) 2023-01-24
ES2949953T3 (es) 2023-10-04
JP2015226551A (ja) 2015-12-17
JP6189904B2 (ja) 2017-08-30
EP2730663A2 (en) 2014-05-14
JP6568162B2 (ja) 2019-08-28
US9637789B2 (en) 2017-05-02
US20180016635A1 (en) 2018-01-18
JP2013529071A (ja) 2013-07-18
JP2017200491A (ja) 2017-11-09
EP2561090A1 (en) 2013-02-27
CA2796561C (en) 2019-09-17
WO2011131774A1 (en) 2011-10-27
US20110312519A1 (en) 2011-12-22

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