JP2013526864A5 - - Google Patents

Info

Publication number

JP2013526864A5

JP2013526864A5 JP2013510293A JP2013510293A JP2013526864A5 JP 2013526864 A5 JP2013526864 A5 JP 2013526864A5 JP 2013510293 A JP2013510293 A JP 2013510293A JP 2013510293 A JP2013510293 A JP 2013510293A JP 2013526864 A5 JP2013526864 A5 JP 2013526864A5

Authority

JP

Japan

Prior art keywords

ala

leu

ser

polypeptide

lys

Prior art date

2011-05-12

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 229920001184 polypeptide Polymers 0.000 claims description 42
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 42
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 42
• 150000003839 salts Chemical class 0.000 claims description 16
• 150000001413 amino acids Chemical class 0.000 claims description 14
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 10
• 239000012634 fragment Substances 0.000 claims description 10
• 102000039446 nucleic acids Human genes 0.000 claims description 6
• 108020004707 nucleic acids Proteins 0.000 claims description 6
• 150000007523 nucleic acids Chemical class 0.000 claims description 6
• 239000008194 pharmaceutical composition Substances 0.000 claims description 5
• 238000000034 method Methods 0.000 claims description 4
• 201000010099 disease Diseases 0.000 claims description 3
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 3
• 208000010392 Bone Fractures Diseases 0.000 claims description 2
• 206010017076 Fracture Diseases 0.000 claims description 2
• 101000589873 Homo sapiens Parathyroid hormone/parathyroid hormone-related peptide receptor Proteins 0.000 claims description 2
• 208000000038 Hypoparathyroidism Diseases 0.000 claims description 2
• 208000001132 Osteoporosis Diseases 0.000 claims description 2
• 108090000445 Parathyroid hormone Proteins 0.000 claims description 2
• 108010049264 Teriparatide Proteins 0.000 claims description 2
• 239000007864 aqueous solution Substances 0.000 claims description 2
• 206010003246 arthritis Diseases 0.000 claims description 2
• 239000003937 drug carrier Substances 0.000 claims description 2
• 102000051132 human PTH1R Human genes 0.000 claims description 2
• 201000005991 hyperphosphatemia Diseases 0.000 claims description 2
• 238000001990 intravenous administration Methods 0.000 claims description 2
• 238000004519 manufacturing process Methods 0.000 claims description 2
• 230000007935 neutral effect Effects 0.000 claims description 2
• 208000005368 osteomalacia Diseases 0.000 claims description 2
• 239000000018 receptor agonist Substances 0.000 claims description 2
• 229940044601 receptor agonist Drugs 0.000 claims description 2
• 238000010532 solid phase synthesis reaction Methods 0.000 claims description 2
• 238000007920 subcutaneous administration Methods 0.000 claims description 2
• OGBMKVWORPGQRR-UMXFMPSGSA-N teriparatide Chemical compound C([C@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CNC=N1 OGBMKVWORPGQRR-UMXFMPSGSA-N 0.000 claims description 2
• 206010043554 thrombocytopenia Diseases 0.000 claims description 2
• 239000000203 mixture Substances 0.000 claims 1
• 230000002685 pulmonary effect Effects 0.000 claims 1