JP2013526554A5 - - Google Patents
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- JP2013526554A5 JP2013526554A5 JP2013510566A JP2013510566A JP2013526554A5 JP 2013526554 A5 JP2013526554 A5 JP 2013526554A5 JP 2013510566 A JP2013510566 A JP 2013510566A JP 2013510566 A JP2013510566 A JP 2013510566A JP 2013526554 A5 JP2013526554 A5 JP 2013526554A5
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- 239000003814 drug Substances 0.000 claims description 24
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 17
- 229940079593 drug Drugs 0.000 claims description 17
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- 208000025966 Neurological disease Diseases 0.000 claims description 6
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- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims description 4
- 201000003883 Cystic fibrosis Diseases 0.000 claims description 4
- 208000007342 Diabetic Nephropathies Diseases 0.000 claims description 4
- 208000006673 asthma Diseases 0.000 claims description 4
- 208000033679 diabetic kidney disease Diseases 0.000 claims description 4
- 210000002345 respiratory system Anatomy 0.000 claims description 3
- 229910052736 halogen Inorganic materials 0.000 claims 7
- 238000004519 manufacturing process Methods 0.000 claims 5
- 150000002367 halogens Chemical class 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 2
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 2
- 150000007513 acids Chemical class 0.000 claims 1
- 125000005647 linker group Chemical group 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 208000002193 Pain Diseases 0.000 description 11
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- 208000020406 Creutzfeldt Jacob disease Diseases 0.000 description 1
- 208000003407 Creutzfeldt-Jakob Syndrome Diseases 0.000 description 1
- 208000010859 Creutzfeldt-Jakob disease Diseases 0.000 description 1
- 206010067889 Dementia with Lewy bodies Diseases 0.000 description 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 description 1
- 102000015554 Dopamine receptor Human genes 0.000 description 1
- 108050004812 Dopamine receptor Proteins 0.000 description 1
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- 208000032225 Proximal spinal muscular atrophy type 1 Diseases 0.000 description 1
- 208000033526 Proximal spinal muscular atrophy type 3 Diseases 0.000 description 1
- 208000037065 Subacute sclerosing leukoencephalitis Diseases 0.000 description 1
- 206010042297 Subacute sclerosing panencephalitis Diseases 0.000 description 1
- 206010043189 Telangiectasia Diseases 0.000 description 1
- 201000008485 Wernicke-Korsakoff syndrome Diseases 0.000 description 1
- 201000007930 alcohol dependence Diseases 0.000 description 1
- 206010053552 allodynia Diseases 0.000 description 1
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- 210000002226 anterior horn cell Anatomy 0.000 description 1
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- 210000004227 basal ganglia Anatomy 0.000 description 1
- 208000003295 carpal tunnel syndrome Diseases 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 230000001054 cortical effect Effects 0.000 description 1
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- 210000000056 organ Anatomy 0.000 description 1
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- 201000002212 progressive supranuclear palsy Diseases 0.000 description 1
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- 230000009885 systemic effect Effects 0.000 description 1
- 208000009056 telangiectasis Diseases 0.000 description 1
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10162919 | 2010-05-17 | ||
| EP10162919.4 | 2010-05-17 | ||
| PCT/EP2011/057539 WO2011144501A1 (en) | 2010-05-17 | 2011-05-10 | Ccr2 antagonists and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013526554A JP2013526554A (ja) | 2013-06-24 |
| JP2013526554A5 true JP2013526554A5 (https=) | 2014-11-06 |
| JP5647339B2 JP5647339B2 (ja) | 2014-12-24 |
Family
ID=42732650
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013510566A Active JP5647339B2 (ja) | 2010-05-17 | 2011-05-10 | Ｃｃｒ２アンタゴニスト及びこれらの使用 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US8841313B2 (https=) |
| EP (1) | EP2571870B1 (https=) |
| JP (1) | JP5647339B2 (https=) |
| WO (1) | WO2011144501A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2687931C (en) | 2007-05-31 | 2016-05-24 | Boehringer Ingelheim International Gmbh | Ccr2 receptor antagonists and uses thereof |
| HUE025547T2 (en) | 2008-12-19 | 2016-02-29 | Boehringer Ingelheim Int | Cyclic pyrimidine-4-carboxamides as CCR2 receptor antagonists for the treatment of inflammation, asthma and COPD |
| ES2674275T3 (es) | 2009-12-17 | 2018-06-28 | Centrexion Therapeutics Corporation | Antagonistas del receptor CCR2 y usos de los mismos |
| EP2569298B1 (en) | 2010-05-12 | 2015-11-25 | Boehringer Ingelheim International GmbH | Novel ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments |
| WO2011141477A1 (en) | 2010-05-12 | 2011-11-17 | Boehringer Ingelheim International Gmbh | New ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments |
| WO2011144501A1 (en) | 2010-05-17 | 2011-11-24 | Boehringer Ingelheim International Gmbh | Ccr2 antagonists and uses thereof |
| EP2576542B1 (en) | 2010-05-25 | 2015-04-22 | Boehringer Ingelheim International GmbH | Cyclic amide derivatives of pyridazine-3-carboxylic acids and their use in the treatment of pulmonary, pain, immune related and cardiovascular diseases |
| EP2576538B1 (en) | 2010-06-01 | 2015-10-28 | Boehringer Ingelheim International GmbH | New CCR2 antagonists |
| EP2731941B1 (en) | 2011-07-15 | 2019-05-08 | Boehringer Ingelheim International GmbH | Novel and selective ccr2 antagonists |
| US9630896B2 (en) | 2013-11-22 | 2017-04-25 | Tansna Therapeutics, Inc. | 2,5-dialkyl-4-H/halo/ether-phenol compounds |
| MX383744B (es) | 2015-07-02 | 2025-03-14 | Centrexion Therapeutics Corp | Citrato de (4-((3r,4r)-3-metoxitetrahidro-piran-4-ilamino)piperidin-1-il) (5-metil-6-(((2r, 6s)-6-(p-tolil)tetrahidro-2h-piran-2-il) metilamino) pirimidin-4-il) metanona. |
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| US20130143905A1 (en) | 2009-12-17 | 2013-06-06 | Boehringer Ingelheim International Gmbh | Novel antagonists for ccr2 and uses thereof |
| ES2674275T3 (es) | 2009-12-17 | 2018-06-28 | Centrexion Therapeutics Corporation | Antagonistas del receptor CCR2 y usos de los mismos |
| WO2011141477A1 (en) | 2010-05-12 | 2011-11-17 | Boehringer Ingelheim International Gmbh | New ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments |
| EP2569298B1 (en) | 2010-05-12 | 2015-11-25 | Boehringer Ingelheim International GmbH | Novel ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments |
| WO2011144501A1 (en) | 2010-05-17 | 2011-11-24 | Boehringer Ingelheim International Gmbh | Ccr2 antagonists and uses thereof |
| EP2576542B1 (en) | 2010-05-25 | 2015-04-22 | Boehringer Ingelheim International GmbH | Cyclic amide derivatives of pyridazine-3-carboxylic acids and their use in the treatment of pulmonary, pain, immune related and cardiovascular diseases |
| EP2576538B1 (en) | 2010-06-01 | 2015-10-28 | Boehringer Ingelheim International GmbH | New CCR2 antagonists |
| JP5786257B2 (ja) | 2011-06-16 | 2015-09-30 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規の選択的ｃｃｒ２拮抗薬 |
| EP2731941B1 (en) | 2011-07-15 | 2019-05-08 | Boehringer Ingelheim International GmbH | Novel and selective ccr2 antagonists |
-
2011
- 2011-05-10 WO PCT/EP2011/057539 patent/WO2011144501A1/en not_active Ceased
- 2011-05-10 JP JP2013510566A patent/JP5647339B2/ja active Active
- 2011-05-10 US US13/698,065 patent/US8841313B2/en active Active
- 2011-05-10 EP EP11718996.9A patent/EP2571870B1/en active Active
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