JP2013525549A5 - - Google Patents
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- Publication number
- JP2013525549A5 JP2013525549A5 JP2013506252A JP2013506252A JP2013525549A5 JP 2013525549 A5 JP2013525549 A5 JP 2013525549A5 JP 2013506252 A JP2013506252 A JP 2013506252A JP 2013506252 A JP2013506252 A JP 2013506252A JP 2013525549 A5 JP2013525549 A5 JP 2013525549A5
- Authority
- JP
- Japan
- Prior art keywords
- polyunsaturated fatty
- phospholipids
- untreated
- fatty acid
- oil composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000002028 Biomass Substances 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 claims 5
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims 4
- 150000002632 lipids Chemical class 0.000 claims 4
- 230000000813 microbial effect Effects 0.000 claims 4
- 150000003904 phospholipids Chemical class 0.000 claims 4
- 229910002092 carbon dioxide Inorganic materials 0.000 claims 2
- 239000001569 carbon dioxide Substances 0.000 claims 2
- 239000012530 fluid Substances 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- 241000235013 Yarrowia Species 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 239000011203 carbon fibre reinforced carbon Substances 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- 244000005700 microbiome Species 0.000 claims 1
- DCXXMTOCNZCJGO-UHFFFAOYSA-N tristearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 claims 1
Claims (2)
- 方法であって、
ａ）少なくとも１つの多価不飽和脂肪酸を含んでなる油組成物を有する未処理破壊微生物バイオマスを液体または超臨界流体二酸化炭素を含んでなる溶媒で処理して、
（ｉ）実質的にリン脂質を含まない脂質画分を含んでなる抽出物、および
（ii）リン脂質を含んでなる残留バイオマスを得るステップと、
ｂ）ステップ（ａ）パート（ｉ）で得られた抽出物を少なくとも一度分画して、少なくとも１つの多価不飽和脂肪酸を含んでなる精製脂質組成物を得るステップと
を含んでなり、ここで精製脂質組成物が、未処理破壊微生物バイオマスの油組成物と比べてトリアシルグリセロールに富む、上記方法。 - 少なくとも１つの多価不飽和脂肪酸を含んでなる油組成物を有する未処理破壊微生物バイオマスを液体または超臨界流体二酸化炭素を含んでなる溶媒で処理して、
（ｉ）実質的にリン脂質を含まない脂質画分を含んでなる抽出物；および
（ii）リン脂質を含んでなる残留バイオマス；を得るステップを含んでなり、
ここで未処理破壊微生物バイオマスが、その乾燥細胞質量の２５％よりも多くを油として蓄積するヤロウィア（Ｙａｒｒｏｗｉａ）属の油性微生物から得られ；そして
上記少なくとも１つの多価不飽和脂肪酸を含んでなる油組成物が、少なくとも２０個の炭素原子と４つ以上の炭素−炭素二重結合を有する多価不飽和脂肪酸を、総脂肪酸の質量％として測定して、少なくとも２５質量％含んでなる方法。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32679310P | 2010-04-22 | 2010-04-22 | |
| US61/326,793 | 2010-04-22 | ||
| PCT/US2011/033142 WO2011133610A1 (en) | 2010-04-22 | 2011-04-20 | Method for obtaining polyunsaturated fatty acid-containing compositions from microbial biomass |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013525549A JP2013525549A (ja) | 2013-06-20 |
| JP2013525549A5 true JP2013525549A5 (ja) | 2014-05-29 |
Family
ID=44148979
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013506252A Abandoned JP2013525549A (ja) | 2010-04-22 | 2011-04-20 | 微生物バイオマスから多価不飽和脂肪酸含有組成物を得る方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20110263709A1 (ja) |
| EP (1) | EP2561050A1 (ja) |
| JP (1) | JP2013525549A (ja) |
| CN (1) | CN103282474A (ja) |
| AU (1) | AU2011242843A1 (ja) |
| CA (1) | CA2795460A1 (ja) |
| CL (1) | CL2012002897A1 (ja) |
| WO (1) | WO2011133610A1 (ja) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2011261455B2 (en) | 2010-06-01 | 2016-03-24 | Dsm Ip Assets B.V. | Extraction of lipid from cells and products therefrom |
| US20120213905A1 (en) * | 2010-08-11 | 2012-08-23 | E. I. Du Pont De Nemours And Company | Aquaculture feed compositions |
| JP2014510166A (ja) * | 2011-02-11 | 2014-04-24 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | 短行程蒸留を使用する微生物源からのトリグリセリド油の精製 |
| US8999663B2 (en) | 2011-02-11 | 2015-04-07 | E L Du Pont De Nemours And Company | Method for obtaining a lipid-containing composition from microbial biomass |
| NZ626699A (en) | 2012-01-06 | 2017-03-31 | Omthera Pharmaceuticals Inc | Dpa-enriched compositions of omega-3 polyunsaturated fatty acids in free acid form |
| KR20150028233A (ko) | 2012-05-07 | 2015-03-13 | 옴테라 파마슈티칼스, 인크. | 스타틴 및 오메가-３ 지방산의 조성물 |
| FR2991337B1 (fr) * | 2012-05-29 | 2016-09-02 | Roquette Freres | Procede continu d'enrichissement en esters ethyliques de dha d'une huile produite par des microalgues |
| US9629820B2 (en) | 2012-12-24 | 2017-04-25 | Qualitas Health, Ltd. | Eicosapentaenoic acid (EPA) formulations |
| US10123986B2 (en) | 2012-12-24 | 2018-11-13 | Qualitas Health, Ltd. | Eicosapentaenoic acid (EPA) formulations |
| US11330817B2 (en) * | 2013-12-04 | 2022-05-17 | Nippon Suisan Kaisha, Ltd. | Microbial oil, production method for microbial oil, concentrated microbial oil, and production method for concentrated microbial oil |
| CA2934491C (en) | 2013-12-20 | 2023-09-26 | Dsm Ip Assets B.V. | Processes for obtaining microbial oil from microbial cells |
| TWI646189B (zh) * | 2013-12-20 | 2019-01-01 | 荷蘭商Ｄｓｍ智慧財產有限公司 | 用於從微生物細胞獲得微生物油之方法（五） |
| EP3083545B1 (en) | 2013-12-20 | 2023-08-02 | DSM IP Assets B.V. | Processes for obtaining microbial oil from microbial cells |
| NZ721417A (en) | 2013-12-20 | 2022-07-01 | Dsm Ip Assets Bv | Processes for obtaining microbial oil from microbial cells |
| MX2016008228A (es) | 2013-12-20 | 2016-11-28 | Dsm Ip Assets Bv | Procedimiento para la obtención de aceite microbiano a partir de células microbianas. |
| US11946017B2 (en) * | 2016-07-13 | 2024-04-02 | Evonik Operations Gmbh | Method of separating lipids from a lysed lipids containing biomass |
| CA3209060A1 (en) * | 2021-02-18 | 2022-08-25 | Jeff NOBBS | Systems and methods of making oil from microorganisms |
Family Cites Families (47)
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|---|---|---|---|---|
| US4675132A (en) | 1985-03-28 | 1987-06-23 | The United States Of America As Represented By The Secretary Of Commerce | Polyunsaturated fatty acids from fish oils |
| US5169968A (en) * | 1985-09-10 | 1992-12-08 | Vitamins, Inc. | Mass separation of liquid or soluble components from solid materials utilizing supercritical fluids |
| EP0252716B1 (en) | 1986-07-08 | 1993-01-07 | Suntory Limited | Process for production of bishomo- gamma-linolenic acid and eicosapentaenoic acid |
| US5246841A (en) | 1986-12-26 | 1993-09-21 | Sagami Chemical Research Center | Microbial process for production of eicosapentaenoic acid |
| JP2582622B2 (ja) | 1987-10-27 | 1997-02-19 | 日東化学工業株式会社 | 糸状菌による高度不飽和脂肪酸の製造法 |
| US5340742A (en) | 1988-09-07 | 1994-08-23 | Omegatech Inc. | Process for growing thraustochytrium and schizochytrium using non-chloride salts to produce a microfloral biomass having omega-3-highly unsaturated fatty acids |
| US5244921A (en) | 1990-03-21 | 1993-09-14 | Martek Corporation | Eicosapentaenoic acids and methods for their production |
| US5658767A (en) | 1991-01-24 | 1997-08-19 | Martek Corporation | Arachidonic acid and methods for the production and use thereof |
| US5246842A (en) | 1991-10-30 | 1993-09-21 | The United States Of America As Represented By The Secretary Of Agriculture | Production of eicosapentaenoic acid from filamentous fungi utilizing lactose as a primary carbon source |
| JPH05308978A (ja) | 1992-05-11 | 1993-11-22 | Onoda Cement Co Ltd | 藻類によるドコサヘキサエン酸の製造方法 |
| DE4219360C2 (de) * | 1992-06-12 | 1994-07-28 | Milupa Ag | Verfahren zur Gewinnung von Lipiden mit einem hohen Anteil von langkettig-hochungesättigten Fettsäuren |
| EP0823475B1 (en) | 1995-04-17 | 2009-06-17 | National Institute of Advanced Industrial Science and Technology | Novel microorganisms capable of producing highly unsaturated fatty acids and process for producing highly unsaturated fatty acids by using the microorganisms |
| AU731785B2 (en) * | 1996-03-28 | 2001-04-05 | Gist-Brocades B.V. | Preparation of microbial polyunsaturated fatty acid containing oil from pasteurised biomass |
| US6255505B1 (en) | 1996-03-28 | 2001-07-03 | Gist-Brocades, B.V. | Microbial polyunsaturated fatty acid containing oil from pasteurised biomass |
| CA2261231C (en) | 1996-07-23 | 2012-11-27 | Nagase Biochemicals, Ltd. | Process using ulkenia sp. to prepare docosahexaenoic acid and docosapentaenoic acid |
| US5968809A (en) | 1997-04-11 | 1999-10-19 | Abbot Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids |
| KR19990046733A (ko) | 1999-04-20 | 1999-07-05 | 류성구 | 미생물슈도모나스에의한도코사핵사노인산(ｄｈａ)의제조방법 |
| GB2377455A (en) | 2001-02-09 | 2003-01-15 | Univ Hull | Method of culturing crypthecodinium cohnii |
| WO2004009827A2 (en) * | 2002-06-19 | 2004-01-29 | Dsm Ip Assets B.V. | Preparation of microbial oil containing polyunsaturated fatty acids |
| JP4280158B2 (ja) | 2002-12-27 | 2009-06-17 | 富士フイルム株式会社 | ドコサヘキサエン酸生産能を有する微生物及びその利用 |
| US7238482B2 (en) | 2003-05-07 | 2007-07-03 | E. I. Du Pont De Nemours And Company | Production of polyunsaturated fatty acids in oleaginous yeasts |
| US8313911B2 (en) | 2003-05-07 | 2012-11-20 | E I Du Pont De Nemours And Company | Production of polyunsaturated fatty acids in oleaginous yeasts |
| US7214491B2 (en) * | 2003-05-07 | 2007-05-08 | E. I. Du Pont De Nemours And Company | Δ-12 desaturase gene suitable for altering levels of polyunsaturated fatty acids in oleaginous yeasts |
| US7504259B2 (en) * | 2003-11-12 | 2009-03-17 | E. I. Du Pont De Nemours And Company | Δ12 desaturases suitable for altering levels of polyunsaturated fatty acids in oleaginous yeast |
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| AU2005267202B2 (en) | 2004-06-25 | 2011-10-27 | Corteva Agriscience Llc | Delta-8 desaturase and its use in making polyunsaturated fatty acids |
| US7465564B2 (en) | 2004-08-10 | 2008-12-16 | E.I. Du Pont De Nemours And Company | Production of γ-linolenic acid in oleaginous yeast |
| US7588931B2 (en) | 2004-11-04 | 2009-09-15 | E. I. Du Pont De Nemours And Company | High arachidonic acid producing strains of Yarrowia lipolytica |
| US7879591B2 (en) | 2004-11-04 | 2011-02-01 | E.I. Du Pont De Nemours And Company | High eicosapentaenoic acid producing strains of Yarrowia lipolytica |
| JP4849806B2 (ja) * | 2005-02-08 | 2012-01-11 | 日本水産株式会社 | 新規な菌体処理方法を用いた高度不飽和脂肪酸の製造方法 |
| UA94038C2 (ru) | 2005-03-18 | 2011-04-11 | Майкробиа, Инк. | Продуцирование каротиноидов в маслянистых дрожжах и грибах |
| US7470532B2 (en) | 2005-10-19 | 2008-12-30 | E.I. Du Pont De Nemours And Company | Mortierella alpina C16/18 fatty acid elongase |
| JP5123861B2 (ja) | 2005-11-23 | 2013-01-23 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | Δ９エロンガーゼおよびそれらの多価不飽和脂肪酸製造における使用 |
| US7695950B2 (en) | 2006-05-17 | 2010-04-13 | E. I. Du Pont De Nemours And Company | Δ5 desaturase and its use in making polyunsaturated fatty acids |
| US7678560B2 (en) | 2006-05-17 | 2010-03-16 | E.I. Du Pont De Nemours And Company | Δ 5 desaturase and its use in making polyunsaturated fatty acids |
| US7556949B2 (en) | 2006-10-30 | 2009-07-07 | E.I. Du Pont De Nemours And Company | Δ17 desaturase and its use in making polyunsaturated fatty acids |
| US7709239B2 (en) | 2006-12-07 | 2010-05-04 | E.I. Du Pont De Nemours And Company | Mutant Δ8 desaturase genes engineered by targeted mutagenesis and their use in making polyunsaturated fatty acids |
| JP2010523113A (ja) | 2007-04-03 | 2010-07-15 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | マルチザイム（ｍｕｌｔｉｚｙｍｅ）および多価不飽和脂肪酸の製造におけるその使用 |
| US7790156B2 (en) | 2007-04-10 | 2010-09-07 | E. I. Du Pont De Nemours And Company | Δ-8 desaturases and their use in making polyunsaturated fatty acids |
| US7794701B2 (en) | 2007-04-16 | 2010-09-14 | E.I. Du Pont De Nemours And Company | Δ-9 elongases and their use in making polyunsaturated fatty acids |
| US7943365B2 (en) | 2007-05-03 | 2011-05-17 | E.I. Du Pont De Nemours And Company | Δ-5 desaturases and their use in making polyunsaturated fatty acids |
| WO2009046231A1 (en) | 2007-10-03 | 2009-04-09 | E. I. Du Pont De Nemours And Company | Optimized strains of yarrowia lipolytica for high eicosapentaenoic acid production |
| US8586104B2 (en) * | 2008-04-10 | 2013-11-19 | U.S. Nutraceuticals, LLC | Plant derived seed extract rich in essentially fatty acids derived from Salvia hispanica L. seed: composition of matter, manufacturing process and use |
| WO2010033753A2 (en) | 2008-09-19 | 2010-03-25 | E. I. Du Pont De Nemours And Company | Mutant delta5 desaturases and their use in making polyunsaturated fatty acids |
| BRPI0917722A2 (pt) | 2008-12-18 | 2017-05-30 | Du Pont | organismo transgênico e método para manipular o teor de malonatos em um organismo transgênico |
| US8637298B2 (en) | 2009-06-16 | 2014-01-28 | E I Du Pont De Nemours And Company | Optimized strains of yarrowia lipolytica for high eicosapentaenoic acid production |
| US8999663B2 (en) * | 2011-02-11 | 2015-04-07 | E L Du Pont De Nemours And Company | Method for obtaining a lipid-containing composition from microbial biomass |
-
2011
- 2011-04-20 CN CN2011800202385A patent/CN103282474A/zh active Pending
- 2011-04-20 AU AU2011242843A patent/AU2011242843A1/en not_active Abandoned
- 2011-04-20 JP JP2013506252A patent/JP2013525549A/ja not_active Abandoned
- 2011-04-20 US US13/090,373 patent/US20110263709A1/en not_active Abandoned
- 2011-04-20 CA CA2795460A patent/CA2795460A1/en not_active Abandoned
- 2011-04-20 WO PCT/US2011/033142 patent/WO2011133610A1/en active Application Filing
- 2011-04-20 EP EP11718570A patent/EP2561050A1/en not_active Withdrawn
-
2012
- 2012-10-17 CL CL2012002897A patent/CL2012002897A1/es unknown
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