CL2009001061A1 - Microorganismo thraustochytrio aislado que produce acidos grasos que comprenden al menos 40% en peso de acido docosahexaenoico y 0,5% a 6% en peso de ácido n-6 docosapentaenoico en la fraccion de triglicéridos; biomasa y cultivo que comprende dicho microorganismo; aceite microbiano y producto alimenticio; uso del microorganismo en un metodo para producir aceite microbiano, util para tratar la inflamacion. - Google Patents

Microorganismo thraustochytrio aislado que produce acidos grasos que comprenden al menos 40% en peso de acido docosahexaenoico y 0,5% a 6% en peso de ácido n-6 docosapentaenoico en la fraccion de triglicéridos; biomasa y cultivo que comprende dicho microorganismo; aceite microbiano y producto alimenticio; uso del microorganismo en un metodo para producir aceite microbiano, util para tratar la inflamacion.

Info

Publication number
CL2009001061A1
CL2009001061A1 CL2009001061A CL2009001061A CL2009001061A1 CL 2009001061 A1 CL2009001061 A1 CL 2009001061A1 CL 2009001061 A CL2009001061 A CL 2009001061A CL 2009001061 A CL2009001061 A CL 2009001061A CL 2009001061 A1 CL2009001061 A1 CL 2009001061A1
Authority
CL
Chile
Prior art keywords
microorganism
weight
microbial oil
biomass
culture
Prior art date
Application number
CL2009001061A
Other languages
English (en)
Inventor
Kirk E Hansen Jon Milton Behrens Paul Warren Zirkle Ross Stahl Tracey Lynn Pfeifer Joseph W Apt Iii
Original Assignee
Dsm Ip Assets Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42306826&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2009001061(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv
Publication of CL2009001061A1 publication Critical patent/CL2009001061A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/158—Fatty acids; Fats; Products containing oils or fats
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
    • A23D9/00—Other edible oils or fats, e.g. shortenings, cooking oils
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A23L33/12—Fatty acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/02—Algae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9728—Fungi, e.g. yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/12—Unicellular algae; Culture media therefor
    • C12N1/125—Unicellular algae isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C12P7/6432—Eicosapentaenoic acids [EPA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C12P7/6434—Docosahexenoic acids [DHA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C12P7/6445—Glycerides
    • C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K2035/11—Medicinal preparations comprising living procariotic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/89—Algae ; Processes using algae

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Microbiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Food Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Mycology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Birds (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Husbandry (AREA)
  • Nutrition Science (AREA)
  • Botany (AREA)
  • Cell Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Insects & Arthropods (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medical Informatics (AREA)

Abstract

LA PRESENTE INVENCIÓN ESTÁ DIRIGIDA A MICROORGANISMO THRAUSTOCHYTRIDOS AISLADOS ASÍ COMO CEPAS Y MUTANTES DE LO MISMO. LA INVENCIÓN ESTÁ ADEMÁS DIRIGIDA A BIOMASAS, ACEITES MICROBIANOS, COMPOSICIONES, CULTIVOS, MÉTODOS PARA PRODUCIR ACEITES MICROBIANOS, Y MÉTODOS PARA UTILIZAR LAS BIOMASAS Y ACEITES MICROBIANOS AISLADOS DE THRAUSTOCHYTRIDOS.
CL2009001061A 2009-03-19 2009-04-30 Microorganismo thraustochytrio aislado que produce acidos grasos que comprenden al menos 40% en peso de acido docosahexaenoico y 0,5% a 6% en peso de ácido n-6 docosapentaenoico en la fraccion de triglicéridos; biomasa y cultivo que comprende dicho microorganismo; aceite microbiano y producto alimenticio; uso del microorganismo en un metodo para producir aceite microbiano, util para tratar la inflamacion. CL2009001061A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12/407,687 US8207363B2 (en) 2009-03-19 2009-03-19 Thraustochytrids, fatty acid compositions, and methods of making and uses thereof

Publications (1)

Publication Number Publication Date
CL2009001061A1 true CL2009001061A1 (es) 2011-08-12

Family

ID=42306826

Family Applications (2)

Application Number Title Priority Date Filing Date
CL2009001061A CL2009001061A1 (es) 2009-03-19 2009-04-30 Microorganismo thraustochytrio aislado que produce acidos grasos que comprenden al menos 40% en peso de acido docosahexaenoico y 0,5% a 6% en peso de ácido n-6 docosapentaenoico en la fraccion de triglicéridos; biomasa y cultivo que comprende dicho microorganismo; aceite microbiano y producto alimenticio; uso del microorganismo en un metodo para producir aceite microbiano, util para tratar la inflamacion.
CL2013002822A CL2013002822A1 (es) 2009-03-19 2013-09-30 Aceite microbiano que comprende una fraccion de triglicerido de al menos 70% en peso (div. sol. 1061-09).

Family Applications After (1)

Application Number Title Priority Date Filing Date
CL2013002822A CL2013002822A1 (es) 2009-03-19 2013-09-30 Aceite microbiano que comprende una fraccion de triglicerido de al menos 70% en peso (div. sol. 1061-09).

Country Status (4)

Country Link
US (7) US8207363B2 (es)
AR (2) AR071493A1 (es)
CL (2) CL2009001061A1 (es)
TW (1) TW201036554A (es)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL356587A1 (en) 2000-01-19 2004-06-28 Omegatech, Inc. Solventless extraction process
EP2401386A4 (en) * 2009-02-25 2013-03-13 Vb Medicare Pvt Ltd IMPROVED METHODS FOR THE FERMENTATIVE MANUFACTURE OF DOCOSAHEXAENIC ACID
ES2732493T3 (es) 2009-09-18 2019-11-22 Phycoil Biotechnology Int Inc Fermentación de microalgas usando iluminación controlada
WO2011082190A1 (en) 2009-12-28 2011-07-07 Martek Biosciences Corporation Recombinant thraustochytrids that grow on sucrose, and compositions, methods of making, and uses thereof
ES2651313T3 (es) * 2009-12-28 2018-01-25 Dsm Ip Assets B.V. Traustoquítridos recombinantes que crecen en xilosa, y composiciones, métodos de preparación y usos de los mismos
CA2787344C (en) 2010-01-19 2018-03-20 Dsm Ip Assets B.V. Eicosapentaenoic acid-producing microorganisms, fatty acid compositions, and methods of making and uses thereof
CN103124791B (zh) 2010-06-01 2016-08-24 帝斯曼知识产权资产管理有限公司 从细胞中提取脂质以及由此获得的产品
US10479969B2 (en) 2010-10-11 2019-11-19 Phycoil Biotechnology International. Inc. Utilization of wastewater for microalgal cultivation
EP3050972B1 (en) * 2011-07-21 2020-11-18 DSM IP Assets B.V. Methods of producing eicosapentaenoic acid in thraustochytrids
US20140323569A1 (en) * 2011-07-21 2014-10-30 Krishna Raman Microbial oils enriched in polyunsaturated fatty acids
CN105410925A (zh) 2011-07-21 2016-03-23 帝斯曼知识产权资产管理有限公司 脂肪酸组合物
PT3401388T (pt) 2012-12-06 2019-08-29 Synthetic Genomics Inc Mutantes de algas com um fenótipo de aclimatação à luminosidade elevada bloqueado
ES2564249B1 (es) * 2013-07-02 2016-12-15 Repsol, S.A. Composiciones y métodos para la producción de biocombustibles
WO2015001141A1 (es) * 2013-07-02 2015-01-08 Repsol, S.A. Composiciones y métodos para la producción de biocombustibles utilizando pseudomonas brassicacearum
EP2826384A1 (de) 2013-07-16 2015-01-21 Evonik Industries AG Verfahren zur Trocknung von Biomasse
SG11201605009RA (en) 2013-12-20 2016-07-28 Dsm Ip Assets Bv Processes for obtaining microbial oil from microbial cells
AR098896A1 (es) 2013-12-20 2016-06-22 Dsm Ip Assets Bv Proceso para obtener aceite microbiano a partir de células microbianas
BR112016014517B1 (pt) 2013-12-20 2022-06-28 Dsm Ip Assets B.V. Processo para a obtenção de um óleo microbiano compreendendo um ou mais ácidos graxos poli-insaturados de uma ou mais células microbianas
KR102435269B1 (ko) 2013-12-20 2022-08-22 디에스엠 아이피 어셋츠 비.브이. 미생물 세포로부터의 미생물 오일의 수득 방법
CA2949711A1 (en) * 2014-05-22 2015-11-26 Synthetic Genomics, Inc. Labyrinthulomycete strains for producing docosahexaenoic acid
ES2900848T3 (es) 2014-10-02 2022-03-18 Evonik Operations Gmbh Procedimiento para la producción de un pienso
WO2016050554A1 (de) 2014-10-02 2016-04-07 Evonik Degussa Gmbh Pufas enthaltendes futtermittel mit hoher abriebfestigkeit und hoher wasserstabilität
US10619175B2 (en) 2014-10-02 2020-04-14 Evonik Operations Gmbh Process for producing a PUFA-containing feedstuff by extruding a PUFA-containing biomass
ES2870093T3 (es) 2014-10-02 2021-10-26 Evonik Operations Gmbh Biomasa que contiene PUFA con estabilidad celular elevada y su empleo para la producción de piensos
CN104263499A (zh) * 2014-10-16 2015-01-07 青岛博之源生物技术有限公司 一种北极甜虾虾油快速提取方法
EP3234136B1 (en) 2014-12-16 2024-08-21 C3J Therapeutics, Inc. Compositions of and methods for in vitro viral genome engineering
US20160264985A1 (en) * 2015-03-12 2016-09-15 Synthetic Genomics, Inc. Microorganisms for fatty acid production using elongase and desaturase enzymes
FR3038914B1 (fr) * 2015-07-17 2020-03-13 Fermentalg Biomasse de thraustochytrides, procede de culture et utilisations
JP2017067510A (ja) * 2015-09-29 2017-04-06 花王株式会社 脂質の質量分析方法
US10851395B2 (en) 2016-06-10 2020-12-01 MARA Renewables Corporation Method of making lipids with improved cold flow properties
CA3043176C (en) * 2016-11-08 2019-12-31 North Carolina State University Encapsulation of nutritional and/or compounds for controlled release and enhancing their bioavailability by limiting chemical or microbial exposure
RU2749188C2 (ru) * 2016-11-11 2021-06-07 Целликс Био Прайвет Лимитед Композиции и способы лечения желудочно-кишечных полипов
CN108424938A (zh) * 2017-09-14 2018-08-21 天津大学 一种破囊壶菌高产脂肪酸的发酵培养基及其应用
WO2019113463A1 (en) 2017-12-08 2019-06-13 Synthetic Genomics, Inc. Improving algal lipid productivity via genetic modification of a tpr domain containing protein
EP3762485A4 (en) * 2018-03-05 2021-12-08 Conagen Inc. ORGANISMS AND PROCESSES FOR THE PRODUCTION OF LOW SULPHATION GLYCOMOLECULES
FR3085962B1 (fr) 2018-09-14 2021-06-18 Fermentalg Procede d'extracton d'une huile riche en pufa
US10842173B2 (en) * 2018-09-21 2020-11-24 Heliae Development, Llc Compositions and methods for introduction of odd-chain fatty acids into poultry eggs
CN110747239B (zh) 2019-11-26 2021-06-22 瞿瀚鹏 富含Sn-2位ARA的微生物油脂及其制备方法和应用
CN111647632A (zh) * 2019-11-28 2020-09-11 天津大学 一种高产脂肪酸的制备方法及破囊壶菌培养基
AU2021362667B2 (en) * 2020-10-14 2024-06-27 Hill's Pet Nutrition, Inc. Pet food compositions
SE2151489A1 (en) * 2021-12-07 2023-06-08 Mycorena Ab A food product or food ingredient comprising fungi biomass with an increased intracellular fat content
EP4198136A3 (en) 2021-12-16 2023-08-30 Indian Oil Corporation Limited Methods and formulations for enhancing high value lipids
WO2023144707A1 (en) 2022-01-25 2023-08-03 Dsm Ip Assets B.V. Media refinement and nutrient feeding approaches to increase polyunsaturated fatty acid production
CN114561434B (zh) * 2022-03-30 2024-03-26 南京师范大学 裂殖壶菌发酵生产epa和dha的方法

Family Cites Families (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4485173A (en) * 1981-01-19 1984-11-27 Cpc International Inc. Preparation of fats and oils
ES2052564T3 (es) * 1986-07-08 1994-07-16 Suntory Ltd Procedimiento para la produccion de acido bishomo-gamma-linolenico y acido eicosapanteonico.
US5246841A (en) * 1986-12-26 1993-09-21 Sagami Chemical Research Center Microbial process for production of eicosapentaenoic acid
CA1321767C (en) 1986-12-26 1993-08-31 Noriko Okazaki Process for production of eicosapentaenoic acid
JP2746371B2 (ja) * 1987-12-21 1998-05-06 サントリー株式会社 ビスホモ−γ−リノレン酸及びこれを含有する脂質の製造方法
JP2710344B2 (ja) * 1988-07-13 1998-02-10 サントリー株式会社 高度不飽和脂肪酸及びこれを含有する脂質の製造方法
US6451567B1 (en) * 1988-09-07 2002-09-17 Omegatech, Inc. Fermentation process for producing long chain omega-3 fatty acids with euryhaline microorganisms
US5340742A (en) 1988-09-07 1994-08-23 Omegatech Inc. Process for growing thraustochytrium and schizochytrium using non-chloride salts to produce a microfloral biomass having omega-3-highly unsaturated fatty acids
US5130242A (en) * 1988-09-07 1992-07-14 Phycotech, Inc. Process for the heterotrophic production of microbial products with high concentrations of omega-3 highly unsaturated fatty acids
US5340594A (en) * 1988-09-07 1994-08-23 Omegatech Inc. Food product having high concentrations of omega-3 highly unsaturated fatty acids
US5698244A (en) * 1988-09-07 1997-12-16 Omegatech Inc. Method for raising animals having high concentrations of omega-3 highly unsaturated fatty acids
US5244921A (en) * 1990-03-21 1993-09-14 Martek Corporation Eicosapentaenoic acids and methods for their production
JPH078215A (ja) * 1993-04-30 1995-01-13 Kawasaki Steel Corp ドコサヘキサエン酸含有海洋性微細藻類食品素材およびその製造方法
WO1996033263A1 (fr) 1995-04-17 1996-10-24 JAPAN, represented by DIRECTOR-GENERAL OF AGENCY OF INDUSTRIAL SCIENCE AND TECHNOLOGY Nouveaux micro-organismes capables de produire des acides gras hautement insatures et procede de production d'acides gras hautement insatures utilisant ces micro-organismes
GB9514649D0 (en) * 1995-07-18 1995-09-13 Zeneca Ltd Extraction of triglycerides from microorganisms
ATE328104T1 (de) 1996-03-28 2006-06-15 Dsm Ip Assets Bv Mikrobielles polyungesättigte fettsäure enthaltendes öl und verfahren zur herstellung eines öls aus pasteurisierter und granulierter biomasse
US20030143659A1 (en) * 1996-03-28 2003-07-31 Hendrik Louis Bijl Process for the preparation of a granular microbial biomass and isolation of a compound thereform
US6255505B1 (en) * 1996-03-28 2001-07-03 Gist-Brocades, B.V. Microbial polyunsaturated fatty acid containing oil from pasteurised biomass
CA2261231C (en) * 1996-07-23 2012-11-27 Nagase Biochemicals, Ltd. Process using ulkenia sp. to prepare docosahexaenoic acid and docosapentaenoic acid
EP0960943B1 (en) * 1996-12-27 2014-02-12 Suntory Holdings Limited Media for culturing microorganisms and process for producing unsaturated fatty acids or lipids containing the same
JP2001512029A (ja) * 1997-08-01 2001-08-21 マーテック・バイオサイエンスィズ・コーポレーション Ｄｈａ含有栄養組成物およびそれらの製造方法
DE69825173T2 (de) * 1997-10-30 2005-08-25 Morishita Jintan Co. Ltd. Doppelschichtige kapsel von ungesättigten fettsäuren oder deren derivate und verfahren zu deren herstellung
JP4175698B2 (ja) * 1998-06-19 2008-11-05 サントリー株式会社 新規なトリグリセリド及びそれを含む組成物
US8003772B2 (en) 1999-01-14 2011-08-23 Martek Biosciences Corporation Chimeric PUFA polyketide synthase systems and uses thereof
ATE273373T1 (de) * 1999-02-26 2004-08-15 Martek Biosciences Corp Verfahren zum abtrennen von einem docosahexaensäure enthaltenden triglyerid aus einem triglyceridgemisch
DK1166652T4 (en) * 1999-03-04 2016-10-24 Suntory Holdings Ltd The use of material containing 4, 7, 10, 13, 16-docosapentaenoic acid
EP1138757A4 (en) * 1999-09-29 2002-09-18 Micro Gaia Co Ltd METHOD FOR GROWING ALGAE THAT MAKES PHOTOTROPHIC PIGMENTS, HIGH UNSATURATED FATTY ACIDS OR POLYSACCHARIDES IN HIGH CONCENTRATIONS
AU2001232786A1 (en) * 2000-01-11 2001-07-24 Monsanto Company Process for making an enriched mixture of polyunsaturated fatty acid esters
PL356587A1 (en) * 2000-01-19 2004-06-28 Omegatech, Inc. Solventless extraction process
DK1251744T4 (en) * 2000-01-28 2015-11-16 Dsm Ip Assets Bv INCREASED PRODUCTION OF LIPIDS CONTAINING polyenoic fatty acids, AT HØJTÆTHEDSKULTURER eukaryotic microbes in fermentors.
AU3987601A (en) * 2000-02-24 2001-09-03 Thomas Veach Long Process for production of carotenoids, xanthophylls and apo-carotenoids utilizing eukaryotic microorganisms
DE60020271T2 (de) 2000-03-29 2006-03-23 Council Of Scientific And Industrial Research Verfahren zur erhöhung von mehrfachungesättigten fettsäuren in thraustochytriden
JP3425622B2 (ja) * 2000-03-30 2003-07-14 独立行政法人産業技術総合研究所 ラビリンチュラ属菌を用いた高度不飽和脂肪酸含有培養物および高度不飽和脂肪酸含有油脂の製造方法
US6410282B1 (en) * 2000-03-30 2002-06-25 Council Of Scientific And Industrial Research Method for enhancing levels of polyunsaturated fatty acids in thraustochytrid fungi
JP4530311B2 (ja) 2000-07-13 2010-08-25 日本水産株式会社 リパーゼを用いたグリセライドの製造方法
EP1178118A1 (en) * 2000-08-02 2002-02-06 Dsm N.V. Isolation of microbial oils
TWI377253B (en) * 2001-04-16 2012-11-21 Martek Biosciences Corp Product and process for transformation of thraustochytriales microorganisms
JP4995377B2 (ja) * 2001-04-26 2012-08-08 花王株式会社 油脂組成物
US20050129739A1 (en) 2001-05-14 2005-06-16 Gerhard Kohn Production and use of a polar lipid-rich fraction containing omega-3 and/or omega-6 highly unsaturated fatty acids from microbes, genetically modified plant seeds and marine organisms
CA2452401C (en) * 2001-07-02 2013-02-26 Suntory Limited Process for producing fat comprising triglyceride containing highly unsaturated fatty acid
AU2002323409A1 (en) * 2001-08-24 2003-03-10 Martek Biosciences Boulder Corporation Products containing highly unsaturated fatty acids for use by women and their children during stages of preconception, pregnancy and lactation/post-partum
DE10151155A1 (de) * 2001-10-19 2003-05-08 Nutrinova Gmbh Native PUFA-Triglyceridmischungen mit einem hohen Gehalt an mehrfach ungesättigten Fettsäuren sowie Verfahren zu deren Herstellung und deren Verwendung
US6677470B2 (en) * 2001-11-20 2004-01-13 Natural Asa Functional acylglycerides
US20040203120A1 (en) * 2002-03-22 2004-10-14 Council Of Scientific And Industrial Research Method for enhancing levels of polyunsaturated fatty acids in thraustochytrid protists
AU2003237182B2 (en) * 2002-05-03 2008-09-11 Dsm Ip Assets B.V. High-quality lipids and methods for producing by enzymatic liberation from biomass
CA2489982C (en) * 2002-06-19 2019-09-10 Dsm Ip Assets B.V. Preparation of microbial oil-containing polyunsaturated fatty acids
KR20050053663A (ko) * 2002-09-13 2005-06-08 산토리 가부시키가이샤 에스테르 교환 유지 또는 트리글리세라이드의 제조 방법
MXPA05003346A (es) 2002-09-27 2005-11-23 Martek Biosciences Corp Control glicemico mejorado para prediabetes y/o diabetes tipo ii utilizando acido docosahexaenoico.
TWI352121B (en) * 2002-10-11 2011-11-11 Nippon Suisan Kaisha Ltd Process for producing a crude oil
JP4280158B2 (ja) * 2002-12-27 2009-06-17 富士フイルム株式会社 ドコサヘキサエン酸生産能を有する微生物及びその利用
MY144341A (en) * 2003-03-27 2011-08-29 Suntory Holdings Ltd Lipid-improving agent and composition containing lipid-improving agent
US20050019880A1 (en) * 2003-03-31 2005-01-27 Council Of Scientific And Industrial Research Method of enhancing levels of polyunsaturated fatty acids in thraustochytrid protists
US6846942B2 (en) * 2003-05-20 2005-01-25 David Rubin Method for preparing pure EPA and pure DHA
US20070015263A1 (en) * 2003-09-01 2007-01-18 Mogens Wumpelmann Method for increasing yield of biomass of and/or components of biomass from marine microorganisms
CA2801065C (en) * 2003-10-02 2020-04-28 Dsm Ip Assets B.V. Production of high levels of dha in microalgae using modified amounts of chloride and potassium
DE10352838A1 (de) * 2003-11-10 2005-07-07 Nutrinova Nutrition Specialties & Food Ingredients Gmbh Verfahren zur Kultivierung von Mikroorganismen der Gattung Thraustochytriales unter Verwendung eines optimierten Niedrigsalzmediums
TWI365716B (en) * 2003-12-02 2012-06-11 Suntory Holdings Ltd Oil or fat and oil compositions containing phospholipids and a long-chain polyunsaturated fatty acid supply compound, and food using same
SE0303513D0 (sv) * 2003-12-19 2003-12-19 Pronova Biocare As Use of a fatty acid composition comprising at least one of epa and dha or any combinations thereof
WO2005063999A1 (en) * 2003-12-30 2005-07-14 Dsm Ip Assets B.V. Deaeration process
GB0403247D0 (en) * 2004-02-13 2004-03-17 Tillotts Pharma Ag A pharmaceutical composition
DE102004022015A1 (de) * 2004-05-03 2005-12-01 Nutrinova Nutrition Specialties & Food Ingredients Gmbh Fischfutter für Aquafarmen auf Basis fermentativ gewonnener mehrfach ungesättigter Fettsäuren
DE102004060340A1 (de) * 2004-07-16 2006-02-09 Basf Plant Science Gmbh Verfahren zur Erhöhung des Gehalts an mehrfach ungesättigten langkettigen Fettsäuren in transgenen Organismen
AU2005272364B2 (en) * 2004-08-12 2010-10-14 Nippon Suisan Kaisha, Ltd. Method for polyunsaturated fatty acid production using novel cell preservation technique
SG155228A1 (en) 2004-08-24 2009-09-30 Suntory Holdings Ltd Process for production of microbial fat/oil containing discretional amount of diacylglycerol and said fat/oil
JP4624040B2 (ja) * 2004-09-06 2011-02-02 日本水産株式会社 菌体培養方法
US7550286B2 (en) * 2004-11-04 2009-06-23 E. I. Du Pont De Nemours And Company Docosahexaenoic acid producing strains of Yarrowia lipolytica
WO2006052664A2 (en) * 2004-11-04 2006-05-18 Monsanto Technology Llc Processes for preparation of oil compositions
CN1264967C (zh) 2004-12-08 2006-07-19 中国海洋大学 海洋真菌裂殖壶菌ouc88的工业应用
US8241868B2 (en) * 2005-02-08 2012-08-14 Nippon Suisan Kaisha, Ltd. Production of polyunsaturated fatty acids using cell treatment method
ES2729976T3 (es) * 2005-06-07 2019-11-07 Dsm Nutritional Products Ag Microorganismos eucariotas para la producción de lípidos y antioxidantes
EP1903883A4 (en) * 2005-07-01 2010-06-23 Martek Biosciences Corp OIL PRODUCT CONTAINING MULTIPLE UNSATURATED FATTY ACIDS AND ITS USES AND MANUFACTURING
US8426338B2 (en) 2005-07-12 2013-04-23 Adelaide Research And Innovation Pty Ltd Chelating agents for micronutrient fertilisers
AU2005339110A1 (en) 2005-12-16 2007-06-21 Avestha Gengraine Technologies Pvt.Ltd. Docosahexaenoic acid (DHA) producing thraustochytrid strain - SC1
CN101346138B (zh) * 2005-12-21 2013-03-13 布鲁迪科技有限公司 Dha、epa或dha衍生的epa用于治疗细胞氧化损伤相关疾病的用途
DE602006015701D1 (de) * 2005-12-29 2010-09-02 Abl Biotechnologies Ltd Neuer schizochytrium-limacinum-stamm, der sich für die produktion von lipiden und extrazellulären polysacchariden eignet, sowie verfahren hierfür
WO2007149577A2 (en) * 2006-06-23 2007-12-27 The Procter & Gamble Company Concentrated and odorless omega 3 fatty acids
US20090304784A1 (en) * 2006-07-28 2009-12-10 V. Mane Fils Seamless capsules containing high amounts of polyunsaturated fatty acids and a flavouring component
ES2572833T3 (es) * 2006-08-01 2016-06-02 Dsm Nutritional Products Ag Proceso de producción de aceite microbiano que contiene ácidos grasos poliinsaturados
MX2009002285A (es) 2006-08-29 2011-10-11 Market Biosciences Corp Uso de aceites dpa(n-6) en formulas para infantes.
US20100086979A1 (en) 2006-10-27 2010-04-08 Thomas Kiy Production of omega-3 fatty acids in microflora of thraustochytriales using modified media
EP2099924B1 (en) 2006-12-05 2015-07-15 Biomass Research & Refining Pty Ltd Production of biodiesel
JP5101894B2 (ja) * 2007-01-15 2012-12-19 サントリーホールディングス株式会社 高度不飽和脂肪酸及びこれを含有する脂質の製造方法
US20080234377A1 (en) * 2007-03-23 2008-09-25 Martek Biosciences Corporation Polyunsaturated fatty acids for treatment of dementia and pre-dementia-related conditions
EP1992233A1 (en) * 2007-05-11 2008-11-19 DSMIP Assets B.V. Stabilized marine oils and process of making them
CA2692394A1 (en) * 2007-07-06 2009-01-15 Seth J. Baum Fatty acid compositions and methods of use
CN103120225A (zh) 2007-08-31 2013-05-29 马太克生物科学公司 含多不饱和脂肪酸的固体脂肪组合物及其制备与应用
US20090099261A1 (en) * 2007-09-25 2009-04-16 Isi Brands Inc. Omega-3 mixtures
WO2009046231A1 (en) * 2007-10-03 2009-04-09 E. I. Du Pont De Nemours And Company Optimized strains of yarrowia lipolytica for high eicosapentaenoic acid production
US8343753B2 (en) * 2007-11-01 2013-01-01 Wake Forest University School Of Medicine Compositions, methods, and kits for polyunsaturated fatty acids from microalgae
US20100178369A1 (en) * 2009-01-15 2010-07-15 Nicole Lee Arledge Antioxidant-stabilized concentrated fish oil
WO2010088700A1 (en) 2009-02-02 2010-08-05 Martek Biosciences Corporation Methods for improving cognitive function and decreasing heart rate
EP2401386A4 (en) 2009-02-25 2013-03-13 Vb Medicare Pvt Ltd IMPROVED METHODS FOR THE FERMENTATIVE MANUFACTURE OF DOCOSAHEXAENIC ACID
KR101841756B1 (ko) 2009-03-09 2018-03-23 프로노바 바이오파마 너지 에이에스 지방산 오일 혼합물 및 계면활성제를 포함하는 조성물 및 이의 방법 및 사용
MX356532B (es) 2009-03-19 2018-06-01 Martek Biosciences Corp Traustoquitridos, composiciones de acidos grasos y metodos de produccion y uso de los mismos.
ES2623610T3 (es) * 2009-03-19 2017-07-11 Dsm Ip Assets B.V. Moléculas de ácido nucleico de ácido graso poliinsaturado sintasas, y polipéptidos, composiciones y métodos de preparación y usos de los mismos
CA2787344C (en) * 2010-01-19 2018-03-20 Dsm Ip Assets B.V. Eicosapentaenoic acid-producing microorganisms, fatty acid compositions, and methods of making and uses thereof

Also Published As

Publication number Publication date
US20100239533A1 (en) 2010-09-23
AR071493A1 (es) 2010-06-23
US20180064138A1 (en) 2018-03-08
CL2013002822A1 (es) 2014-01-24
US20240081376A1 (en) 2024-03-14
US20120088831A1 (en) 2012-04-12
US9414612B2 (en) 2016-08-16
US20190000114A1 (en) 2019-01-03
US10757959B2 (en) 2020-09-01
US8207363B2 (en) 2012-06-26
US20200390126A1 (en) 2020-12-17
TW201036554A (en) 2010-10-16
US20160309748A1 (en) 2016-10-27
US10085465B2 (en) 2018-10-02
US10362794B2 (en) 2019-07-30
AR111298A2 (es) 2019-06-26

Similar Documents

Publication Publication Date Title
CL2009001061A1 (es) Microorganismo thraustochytrio aislado que produce acidos grasos que comprenden al menos 40% en peso de acido docosahexaenoico y 0,5% a 6% en peso de ácido n-6 docosapentaenoico en la fraccion de triglicéridos; biomasa y cultivo que comprende dicho microorganismo; aceite microbiano y producto alimenticio; uso del microorganismo en un metodo para producir aceite microbiano, util para tratar la inflamacion.
AR087944A1 (es) Microorganismos productores de acido eicosapentaenoico, composiciones de acidos grasos, y metodos de elaboracion y usos de los mismos
BRPI0923968B1 (pt) composição, produto alimentício e alimento animal compreendendo óleo microbiano
BR112012017831B8 (pt) óleo microbiano, alimento animal e biomassa compreendendo o referido óleo microbiano
EA201600471A1 (ru) Экстрагированный растительный липид, содержащий длинноцепочечные полиненасыщенные жирные кислоты
CL2013003791A1 (es) Proceso para fabricar una biomasa algal que comprende al menos 67% de grasa total que incluye cultivar un alga bajo condiciones de cultivo suficientes para proporcionar una biomasa algal que comprende 67% o mas de grasa total; biomasa; composicion de lipidos; y producto alimenticio.
BRPI0712205A2 (pt) Microorganismo, geneticamente modificado e métodos para produção melhorada de ácidos graxos, alcoís graxos, ésteres e cera de ácidos graxos usados em composições biocombustíveis, método para se obter um derivado de ácido graxo, composições biocombustíveis e biocombustiveis
AR074364A1 (es) Enzimas y metodo para producir acidos grasos omega -3
Hong et al. Biodiesel production from Vietnam heterotrophic marine microalga Schizochytrium mangrovei PQ6
CL2012002897A1 (es) Metodo que comprende procesar biomasa microbiana interrumpida no tratada que tiene una composicion de aceite y fraccionar el extracto obtenido para obtener una composicion lipidica de al menos un acido graso poliinsaturado.
Yang et al. Extracting lipids from several species of wet microalgae using ethanol at room temperature
IN2014DN05640A (es)
MY171747A (en) Method to recover free fatty acids from fats and oils
Yang et al. Bio-based chemicals from biorefining: Lipid and wax conversion and utilization
MX2010002798A (es) Metodos y composiciones para controlar la densidad a granel de carbon mineral para coquizado.
BRPI0911286A8 (pt) Método aperfeiçoado de produção de biodisel
CL2011003162A1 (es) Celula huesped recombinante de yarrowia sp. que produce un aceite que comprende al menos 50% en peso de acido eicosapentaenoico (epa) y tiene una relacion epa: acido linoleico de al menos 3,1:1; y metodo para elaborar un aceite microbiano que comprende epa.
BR112020019053B8 (pt) Microalgas, método de produção de uma biomassa, e, método de produção de um bio-óleo
JP6406978B2 (ja) 脂肪酸混合物
Mohan et al. Biomass and lipid production of marine diatom Amphiprora paludosa W. Smith at different nutrient concentrations
WO2010043013A3 (en) A method for the production of biodiesel fuel
PE20212375A1 (es) Composiciones de acidos grasos poliinsaturados enriquecidos con dha
AR127746A1 (es) Nueva cepa de schizochytrium sp. fácil de extraer aceite de una célula y método para producir aceite que contiene omega-3 utilizando la misma
CO6450690A2 (es) Traustoquítridos, composiciones de ácidos grasos, y métodos de producción y usos de los mismos
MX2024005590A (es) Nueva cepa de schizochytrium sp. con facil extraccion de aceite intracelular y metodo para producir aceite que contiene omega-3 utilizando la misma.