|
US4551433A
(en)
|
1981-05-18 |
1985-11-05 |
Genentech, Inc. |
Microbial hybrid promoters
|
|
US5702699A
(en)
|
1982-09-23 |
1997-12-30 |
Cetus Corporation |
Process for the recovery of lipophilic proteins
|
|
US4462940A
(en)
|
1982-09-23 |
1984-07-31 |
Cetus Corporation |
Process for the recovery of human β-interferon-like polypeptides
|
|
US5643566A
(en)
|
1982-09-23 |
1997-07-01 |
Cetus Corporation |
Formulation processes for lipophilic proteins
|
|
US4992271A
(en)
|
1982-09-23 |
1991-02-12 |
Cetus Corporation |
Formulation for lipophilic IL-2 proteins
|
|
US4588585A
(en)
|
1982-10-19 |
1986-05-13 |
Cetus Corporation |
Human recombinant cysteine depleted interferon-β muteins
|
|
US4755465A
(en)
|
1983-04-25 |
1988-07-05 |
Genentech, Inc. |
Secretion of correctly processed human growth hormone in E. coli and Pseudomonas
|
|
US5281532A
(en)
|
1983-07-27 |
1994-01-25 |
Mycogen Corporation |
Pseudomas hosts transformed with bacillus endotoxin genes
|
|
US4695455A
(en)
|
1985-01-22 |
1987-09-22 |
Mycogen Corporation |
Cellular encapsulation of pesticides produced by expression of heterologous genes
|
|
US4695462A
(en)
|
1985-06-28 |
1987-09-22 |
Mycogen Corporation |
Cellular encapsulation of biological pesticides
|
|
GB8517071D0
(en)
|
1985-07-05 |
1985-08-14 |
Hoffmann La Roche |
Gram-positive expression control sequence
|
|
US4810643A
(en)
|
1985-08-23 |
1989-03-07 |
Kirin- Amgen Inc. |
Production of pluripotent granulocyte colony-stimulating factor
|
|
US4734362A
(en)
*
|
1986-02-03 |
1988-03-29 |
Cambridge Bioscience Corporation |
Process for purifying recombinant proteins, and products thereof
|
|
DK203187A
(da)
|
1986-04-22 |
1987-10-23 |
Immunex Corp |
Human g-csf proteinekspression
|
|
US5183746A
(en)
|
1986-10-27 |
1993-02-02 |
Schering Aktiengesellschaft |
Formulation processes for pharmaceutical compositions of recombinant β-
|
|
DK174044B1
(da)
|
1986-12-23 |
2002-05-06 |
Kyowa Hakko Kogyo Kk |
Polypeptid afledt fra human granulocytkolonistimulerende faktor, og fremgangsmåde til fremstilling deraf, DNA kodende for nævnte polypeptid, rekombinant plasmid indeholdende nævnte DNA, og mikroorganismer indeholdende nævnte rekombinante plasmid.......
|
|
JP2618618B2
(ja)
|
1988-03-04 |
1997-06-11 |
協和醗酵工業株式会社 |
抗g−csf誘導体、nd28モノクローナル抗体
|
|
US4904584A
(en)
|
1987-12-23 |
1990-02-27 |
Genetics Institute, Inc. |
Site-specific homogeneous modification of polypeptides
|
|
US5128130A
(en)
|
1988-01-22 |
1992-07-07 |
Mycogen Corporation |
Hybrid Bacillus thuringiensis gene, plasmid and transformed Pseudomonas fluorescens
|
|
US5055294A
(en)
|
1988-03-03 |
1991-10-08 |
Mycogen Corporation |
Chimeric bacillus thuringiensis crystal protein gene comprising hd-73 and berliner 1715 toxin genes, transformed and expressed in pseudomonas fluorescens
|
|
CA1340810C
(en)
|
1988-03-31 |
1999-11-02 |
Motoo Yamasaki |
Polypeptide derivatives of human granulocyte colony stimulating factor
|
|
EP0401384B1
(en)
|
1988-12-22 |
1996-03-13 |
Kirin-Amgen, Inc. |
Chemically modified granulocyte colony stimulating factor
|
|
US6372206B1
(en)
|
1989-03-02 |
2002-04-16 |
University Of Florida |
Orally-administered interferon-TAU compositions and methods
|
|
US5166322A
(en)
|
1989-04-21 |
1992-11-24 |
Genetics Institute |
Cysteine added variants of interleukin-3 and chemical modifications thereof
|
|
US5169760A
(en)
|
1989-07-27 |
1992-12-08 |
Mycogen Corporation |
Method, vectors, and host cells for the control of expression of heterologous genes from lac operated promoters
|
|
GB9107846D0
(en)
|
1990-04-30 |
1991-05-29 |
Ici Plc |
Polypeptides
|
|
DE4014750A1
(de)
|
1990-05-08 |
1991-11-14 |
Boehringer Mannheim Gmbh |
Muteine des granulozyten-stimulierenden faktors (g-csf)
|
|
IE912365A1
(en)
|
1990-07-23 |
1992-01-29 |
Zeneca Ltd |
Continuous release pharmaceutical compositions
|
|
CA2069746A1
(en)
|
1990-09-28 |
1992-03-29 |
Jonathan I. Rosen |
Hybrid growth factors
|
|
US5508192A
(en)
|
1990-11-09 |
1996-04-16 |
Board Of Regents, The University Of Texas System |
Bacterial host strains for producing proteolytically sensitive polypeptides
|
|
US5240834A
(en)
*
|
1991-01-22 |
1993-08-31 |
Albert Einstein College Of Medicine Of Yeshiva University |
Solubilization of protein after bacterial expression using sarkosyl
|
|
DE4105480A1
(de)
|
1991-02-21 |
1992-08-27 |
Boehringer Mannheim Gmbh |
Verbesserte aktivierung von rekombinanten proteinen
|
|
US6171824B1
(en)
|
1991-08-30 |
2001-01-09 |
Fred Hutchinson Cancer Research Center |
Hybrid cytokines
|
|
US6057133A
(en)
|
1992-11-24 |
2000-05-02 |
G. D. Searle |
Multivariant human IL-3 fusion proteins and their recombinant production
|
|
ITFI940106A1
(it)
|
1994-05-27 |
1995-11-27 |
Menarini Ricerche Sud Spa |
Molecola ibrida di formula gm-csf-l-epo o epo-l-gm-csf per la stimolaz ione eritropoietica
|
|
US5824784A
(en)
|
1994-10-12 |
1998-10-20 |
Amgen Inc. |
N-terminally chemically modified protein compositions and methods
|
|
RU2098124C1
(ru)
*
|
1994-10-24 |
1997-12-10 |
Общество с ограниченной ответственностью "Ниготек" |
Способ получения интерферона
|
|
US5814485A
(en)
|
1995-06-06 |
1998-09-29 |
Chiron Corporation |
Production of interferon-β (IFN-β) in E. coli
|
|
IT1285405B1
(it)
|
1995-06-06 |
1998-06-03 |
Alza Corp |
Modificazione di farmaci polipeptidici per accrescere il flusso per elettrotrasporto.
|
|
DE69815707T2
(de)
|
1997-11-20 |
2004-07-01 |
Vical, Inc., San Diego |
Behandlung von krebs durch verwendung von zytokin-exprimierender polynukleotiden und zusammensetzungen dafür
|
|
AU751823B2
(en)
|
1998-05-14 |
2002-08-29 |
Merck Patent Gmbh |
Fused protein
|
|
US20030167531A1
(en)
|
1998-07-10 |
2003-09-04 |
Russell Douglas A. |
Expression and purification of bioactive, authentic polypeptides from plants
|
|
NZ513549A
(en)
|
1999-02-18 |
2003-03-28 |
Rmf Dictagene S |
Malaria vaccine
|
|
US7001892B1
(en)
|
1999-06-11 |
2006-02-21 |
Purdue Research Foundation |
Pharmaceutical materials and methods for their preparation and use
|
|
US6531122B1
(en)
|
1999-08-27 |
2003-03-11 |
Maxygen Aps |
Interferon-β variants and conjugates
|
|
KR100358948B1
(ko)
|
2000-03-31 |
2002-10-31 |
한국과학기술원 |
인체 과립성 백혈구의 콜로니 자극인자를 분비하는 대장균
|
|
JP4799803B2
(ja)
|
2000-09-08 |
2011-10-26 |
マサチューセッツ インスティテュート オブ テクノロジー |
G−csfアナログ組成物および方法
|
|
AU3070702A
(en)
|
2000-11-07 |
2002-05-21 |
Chiron Corp |
Stabilized inteferon compositions
|
|
WO2002077034A2
(en)
|
2001-02-06 |
2002-10-03 |
Merk Patent Gmbh |
Modified granulocyte colony stimulating factor (g-csf) with reduced immunogenicity
|
|
US7189830B2
(en)
|
2001-02-19 |
2007-03-13 |
Merck Patent Gmbh |
Anti-KSA/IL-2 fusion proteins with reduced immunogenicity
|
|
MXPA03007316A
(es)
|
2001-02-19 |
2003-12-04 |
Merck Patent Gmbh |
Metodo para la identificacion de epitopes de celulas t y el uso para la preparacion de moleculas con inmunogenicidad reducida.
|
|
PL371781A1
(en)
|
2001-07-11 |
2005-06-27 |
Maxygen Holdings, Ltd. |
G-csf conjugates
|
|
US20030054435A1
(en)
|
2001-09-10 |
2003-03-20 |
Grabski Anthony C. |
Method for recovering and analyzing a cellular component of cultured cells without having to harvest the cells first
|
|
US20040247562A1
(en)
|
2001-09-28 |
2004-12-09 |
Sang Yup Lee |
Diagnostic method for cancer characterized in the detection of the deletion of g-csf exon 3
|
|
EP2042196B1
(en)
|
2001-10-10 |
2016-07-13 |
ratiopharm GmbH |
Remodelling and glycoconjugation of Granulocyte Colony Stimulating Factor (G-CSF)
|
|
US20080108560A1
(en)
|
2002-03-05 |
2008-05-08 |
Eli Lilly And Company |
Heterologous G-Csf Fusion Proteins
|
|
SI21273A
(sl)
|
2002-07-31 |
2004-02-29 |
LEK farmacevtska dru�ba d.d. |
Priprava inkluzijskih teles z visokim deležem pravilno zvitega prekurzorja heterolognega proteina
|
|
KR100521309B1
(ko)
|
2002-08-31 |
2005-10-14 |
씨제이 주식회사 |
당쇄화된 인간 과립구 형성인자
|
|
US9453251B2
(en)
|
2002-10-08 |
2016-09-27 |
Pfenex Inc. |
Expression of mammalian proteins in Pseudomonas fluorescens
|
|
US8399217B2
(en)
|
2003-03-14 |
2013-03-19 |
Brookhaven Science Associates, Llc |
High density growth of T7 expression strains with auto-induction option
|
|
CA2545610C
(en)
|
2003-11-19 |
2014-03-25 |
Dow Global Technolgies Inc. |
Auxotrophic pseudomonas fluorescens bacteria for recombinant protein expression
|
|
AU2004317306B2
(en)
|
2003-11-21 |
2010-09-02 |
Pelican Technology Holdings, Inc. |
Improved expression systems with Sec-system secretion
|
|
KR100524872B1
(ko)
*
|
2003-12-04 |
2005-11-01 |
씨제이 주식회사 |
인터페론 베타의 정제방법
|
|
ES2663594T3
(es)
|
2004-01-16 |
2018-04-16 |
Pfenex Inc |
Expresión de proteínas de mamífero en Pseudomonas fluorescens
|
|
US8603824B2
(en)
|
2004-07-26 |
2013-12-10 |
Pfenex, Inc. |
Process for improved protein expression by strain engineering
|
|
US7923220B2
(en)
|
2004-12-20 |
2011-04-12 |
Cadila Healthcare Limited |
Process for preparing high levels of interferon beta
|
|
US7790174B2
(en)
|
2004-12-23 |
2010-09-07 |
Merck Serono Sa |
G-CSF polypeptides and uses thereof
|
|
GB0605684D0
(en)
|
2006-03-21 |
2006-05-03 |
Sicor Biotech Uab |
Method For Purifying Granulocyte-Colony Stimulating Factor
|
|
EP2021489A2
(en)
|
2006-05-30 |
2009-02-11 |
Dow Global Technologies Inc. |
Codon optimization method
|
|
EP1939212A1
(en)
|
2006-12-20 |
2008-07-02 |
LEK Pharmaceuticals D.D. |
Organic compounds
|
|
JP5714230B2
(ja)
|
2007-01-31 |
2015-05-07 |
フェネックス インコーポレイテッド |
発現上昇のための細菌リーダー配列
|
|
US9580719B2
(en)
|
2007-04-27 |
2017-02-28 |
Pfenex, Inc. |
Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
|
|
JP5444553B2
(ja)
|
2007-04-27 |
2014-03-19 |
フェネックス インコーポレイテッド |
微生物宿主を迅速にスクリーニングして、異種タンパク質発現の収率および/または質が改善されている特定の株を同定する方法
|
|
US7625555B2
(en)
|
2007-06-18 |
2009-12-01 |
Novagen Holding Corporation |
Recombinant human interferon-like proteins
|
|
US8933197B2
(en)
|
2007-08-15 |
2015-01-13 |
Amunix Operating Inc. |
Compositions comprising modified biologically active polypeptides
|
|
LT3660032T
(lt)
|
2009-06-25 |
2026-02-25 |
Amgen Inc. |
Ne žinduolių sistemoje ekspresuotų baltymų surišamojo gryninimo būdai
|
|
WO2011109556A2
(en)
|
2010-03-04 |
2011-09-09 |
Pfenex Inc. |
Method for producing soluble recombinant interferon protein without denaturing
|
|
NZ603033A
(en)
|
2010-04-01 |
2014-06-27 |
Pfenex Inc |
Methods for g-csf production in a pseudomonas host cell
|