JP2013524170A5 - - Google Patents

Download PDF

Info

Publication number
JP2013524170A5
JP2013524170A5 JP2013501535A JP2013501535A JP2013524170A5 JP 2013524170 A5 JP2013524170 A5 JP 2013524170A5 JP 2013501535 A JP2013501535 A JP 2013501535A JP 2013501535 A JP2013501535 A JP 2013501535A JP 2013524170 A5 JP2013524170 A5 JP 2013524170A5
Authority
JP
Japan
Prior art keywords
inner tube
open end
tube
emulsion
outer tube
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2013501535A
Other languages
English (en)
Japanese (ja)
Other versions
JP6155419B2 (ja
JP2013524170A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2011/030097 external-priority patent/WO2011120020A1/en
Publication of JP2013524170A publication Critical patent/JP2013524170A/ja
Publication of JP2013524170A5 publication Critical patent/JP2013524170A5/ja
Application granted granted Critical
Publication of JP6155419B2 publication Critical patent/JP6155419B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2013501535A 2010-03-25 2011-03-25 検出用の液滴輸送システム Active JP6155419B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US34106510P 2010-03-25 2010-03-25
US61/341,065 2010-03-25
US201161467347P 2011-03-24 2011-03-24
US61/467,347 2011-03-24
PCT/US2011/030097 WO2011120020A1 (en) 2010-03-25 2011-03-25 Droplet transport system for detection

Publications (3)

Publication Number Publication Date
JP2013524170A JP2013524170A (ja) 2013-06-17
JP2013524170A5 true JP2013524170A5 (enExample) 2014-05-15
JP6155419B2 JP6155419B2 (ja) 2017-07-05

Family

ID=44673669

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013501535A Active JP6155419B2 (ja) 2010-03-25 2011-03-25 検出用の液滴輸送システム

Country Status (5)

Country Link
US (1) US9393560B2 (enExample)
EP (1) EP2556170A4 (enExample)
JP (1) JP6155419B2 (enExample)
CA (1) CA2767114A1 (enExample)
WO (1) WO2011120020A1 (enExample)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8709762B2 (en) 2010-03-02 2014-04-29 Bio-Rad Laboratories, Inc. System for hot-start amplification via a multiple emulsion
US9417190B2 (en) 2008-09-23 2016-08-16 Bio-Rad Laboratories, Inc. Calibrations and controls for droplet-based assays
US12162008B2 (en) 2008-09-23 2024-12-10 Bio-Rad Laboratories, Inc. Partition-based method of analysis
US9492797B2 (en) 2008-09-23 2016-11-15 Bio-Rad Laboratories, Inc. System for detection of spaced droplets
US11130128B2 (en) 2008-09-23 2021-09-28 Bio-Rad Laboratories, Inc. Detection method for a target nucleic acid
US9156010B2 (en) 2008-09-23 2015-10-13 Bio-Rad Laboratories, Inc. Droplet-based assay system
US9132394B2 (en) 2008-09-23 2015-09-15 Bio-Rad Laboratories, Inc. System for detection of spaced droplets
US8951939B2 (en) 2011-07-12 2015-02-10 Bio-Rad Laboratories, Inc. Digital assays with multiplexed detection of two or more targets in the same optical channel
CA2738578C (en) 2008-09-23 2021-05-04 Quantalife, Inc. Droplet-based assay system
US8633015B2 (en) 2008-09-23 2014-01-21 Bio-Rad Laboratories, Inc. Flow-based thermocycling system with thermoelectric cooler
US12090480B2 (en) 2008-09-23 2024-09-17 Bio-Rad Laboratories, Inc. Partition-based method of analysis
US10512910B2 (en) 2008-09-23 2019-12-24 Bio-Rad Laboratories, Inc. Droplet-based analysis method
US9764322B2 (en) 2008-09-23 2017-09-19 Bio-Rad Laboratories, Inc. System for generating droplets with pressure monitoring
US9598725B2 (en) 2010-03-02 2017-03-21 Bio-Rad Laboratories, Inc. Emulsion chemistry for encapsulated droplets
CA2767056C (en) 2009-09-02 2018-12-04 Bio-Rad Laboratories, Inc. System for mixing fluids by coalescence of multiple emulsions
CA2767113A1 (en) 2010-03-25 2011-09-29 Bio-Rad Laboratories, Inc. Detection system for droplet-based assays
CA2767182C (en) 2010-03-25 2020-03-24 Bio-Rad Laboratories, Inc. Droplet generation for droplet-based assays
SG190074A1 (en) 2010-11-01 2013-06-28 Bio Rad Laboratories System for forming emulsions
US12097495B2 (en) 2011-02-18 2024-09-24 Bio-Rad Laboratories, Inc. Methods and compositions for detecting genetic material
AU2012231098B2 (en) 2011-03-18 2016-09-29 Bio-Rad Laboratories, Inc. Multiplexed digital assays with combinatorial use of signals
WO2012149042A2 (en) 2011-04-25 2012-11-01 Bio-Rad Laboratories, Inc. Methods and compositions for nucleic acid analysis
WO2013019751A1 (en) 2011-07-29 2013-02-07 Bio-Rad Laboratories, Inc., Library characterization by digital assay
CN106423314B (zh) 2011-09-28 2021-03-02 哈佛学院院长等 用于液滴产生和/或流体操纵的系统和方法
WO2013155531A2 (en) 2012-04-13 2013-10-17 Bio-Rad Laboratories, Inc. Sample holder with a well having a wicking promoter
GB2539836B (en) 2012-08-13 2017-03-29 Univ California Methods for detecting target nucleic acids in sample lysate droplets
US9347056B2 (en) * 2012-10-26 2016-05-24 Seiko Epson Corporation Nucleic acid extraction device, and nucleic acid extraction method, nucleic acid extraction kit, and nucleic acid extraction apparatus, each using the same
WO2014093714A1 (en) 2012-12-14 2014-06-19 Bio-Rad Laboratories, Inc. Methods and compositions for using oils for analysis and detection of molecules
EP2848306B1 (en) * 2013-09-13 2016-04-06 Bruker Daltonik GmbH Dispenser system for mass spectrometric sample preparations
JP2015073485A (ja) * 2013-10-09 2015-04-20 セイコーエプソン株式会社 核酸増幅方法、核酸抽出用デバイス、核酸増幅反応用カートリッジ、及び核酸増幅反応用キット
WO2015200717A2 (en) 2014-06-27 2015-12-30 The Regents Of The University Of California Pcr-activated sorting (pas)
WO2016065056A1 (en) 2014-10-22 2016-04-28 The Regents Of The University Of California High definition microdroplet printer
AU2016215304B2 (en) 2015-02-04 2022-01-27 The Regents Of The University Of California Sequencing of nucleic acids via barcoding in discrete entities
CN105936930A (zh) * 2015-03-04 2016-09-14 松下知识产权经营株式会社 Dna检测方法和dna检测装置
CN105969655A (zh) * 2015-03-10 2016-09-28 松下知识产权经营株式会社 多个核酸靶标的分析方法
GB201509640D0 (en) * 2015-06-03 2015-07-15 Sphere Fluidics Ltd Systems and methods
US10807117B2 (en) * 2015-10-05 2020-10-20 Tokyo Electron Limited Dispense nozzle with a dynamic liquid plug
WO2017117490A1 (en) 2015-12-30 2017-07-06 Bio-Rad Laboratories, Inc. Droplet assay system with automatic calibration
US11142791B2 (en) 2016-08-10 2021-10-12 The Regents Of The University Of California Combined multiple-displacement amplification and PCR in an emulsion microdroplet
CN110462053A (zh) 2016-12-21 2019-11-15 加利福尼亚大学董事会 使用基于水凝胶的液滴进行单细胞基因组测序
US10544413B2 (en) 2017-05-18 2020-01-28 10X Genomics, Inc. Methods and systems for sorting droplets and beads
EP4215616B1 (en) 2017-05-18 2024-09-04 10X Genomics, Inc. Methods and systems for sorting droplets and beads
WO2019006190A1 (en) 2017-06-28 2019-01-03 Bio-Rad Laboratories, Inc. SYSTEM AND METHOD FOR DROPLELET DETECTION
US10357771B2 (en) 2017-08-22 2019-07-23 10X Genomics, Inc. Method of producing emulsions
US10501739B2 (en) 2017-10-18 2019-12-10 Mission Bio, Inc. Method, systems and apparatus for single cell analysis
WO2019083852A1 (en) 2017-10-26 2019-05-02 10X Genomics, Inc. MICROFLUIDIC CHANNEL NETWORKS FOR PARTITIONING
WO2019089979A1 (en) 2017-11-01 2019-05-09 Bio-Rad Laboratories, Inc. Microfluidic system and method for arranging objects
JP2019174167A (ja) * 2018-03-27 2019-10-10 株式会社エンプラス 流体取扱装置
CA3095588A1 (en) * 2018-04-02 2019-10-10 Dropworks, Inc. Systems and methods for serial flow emulsion processes
EP3973074A4 (en) 2019-05-22 2023-09-06 Mission Bio, Inc. METHOD AND DEVICE FOR SIMULTANEOUS TARGETED SEQUENCING OF DNA, RNA AND PROTEIN
US11667954B2 (en) 2019-07-01 2023-06-06 Mission Bio, Inc. Method and apparatus to normalize quantitative readouts in single-cell experiments
WO2022072363A1 (en) * 2020-09-29 2022-04-07 The Regents Of The University Of California Method for rapid and large-scale generation of droplets and droplet libraries
CN115155682B (zh) * 2022-06-30 2024-03-12 中国科学院苏州生物医学工程技术研究所 基于旋转阀的微流控芯片及检测方法

Family Cites Families (276)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3575220A (en) 1968-08-12 1971-04-20 Scientific Industries Apparatus for dispensing liquid sample
BR7500831A (pt) 1974-02-11 1975-12-02 Fmc Corp Aparelho de separacao de bolhas de gas corpo de transmissao de gas para uso no aparelho processo para fabricacao do dito corpo e para difusao de bolhas finas de gas em um corpo de liquido
US4051025A (en) 1976-09-29 1977-09-27 The United States Of America As Represented By The Department Of Health, Education And Welfare Preparative countercurrent chromatography with a slowly rotating helical tube array
US4121466A (en) * 1977-04-19 1978-10-24 Technicon Instruments Corporation Liquid dispenser with an improved probe
JPS6020910B2 (ja) * 1977-07-07 1985-05-24 財団法人半導体研究振興会 静電誘導トランジスタ及び半導体集積回路
US4201691A (en) 1978-01-16 1980-05-06 Exxon Research & Engineering Co. Liquid membrane generator
US4348111A (en) 1978-12-07 1982-09-07 The English Electric Company Limited Optical particle analyzers
US4283262A (en) 1980-07-01 1981-08-11 Instrumentation Laboratory Inc. Analysis system
GB2097692B (en) 1981-01-10 1985-05-22 Shaw Stewart P D Combining chemical reagents
US4399219A (en) 1981-01-29 1983-08-16 Massachusetts Institute Of Technology Process for isolating microbiologically active material
US4636075A (en) 1984-08-22 1987-01-13 Particle Measuring Systems, Inc. Particle measurement utilizing orthogonally polarized components of a laser beam
US4574850A (en) * 1985-01-17 1986-03-11 E. I. Du Pont De Nemours And Company Method of and apparatus for dispensing liquid
US4948961A (en) 1985-08-05 1990-08-14 Biotrack, Inc. Capillary flow device
US5055390A (en) 1988-04-22 1991-10-08 Massachusetts Institute Of Technology Process for chemical manipulation of non-aqueous surrounded microdroplets
US5225332A (en) 1988-04-22 1993-07-06 Massachusetts Institute Of Technology Process for manipulation of non-aqueous surrounded microdroplets
AU639008B2 (en) 1989-06-22 1993-07-15 Alliance Pharmaceutical Corporation Fluorine and phosphorous-containing amphiphilic molecules with surfactant properties
GB8917963D0 (en) 1989-08-05 1989-09-20 Scras Apparatus for repeated automatic execution of a thermal cycle for treatment of biological samples
GB9016163D0 (en) 1990-07-24 1990-09-05 Cemu Bioteknik Chemical method
KR100236506B1 (ko) 1990-11-29 2000-01-15 퍼킨-엘머시터스인스트루먼츠 폴리머라제 연쇄 반응 수행 장치
US5270183A (en) 1991-02-08 1993-12-14 Beckman Research Institute Of The City Of Hope Device and method for the automated cycling of solutions between two or more temperatures
US5994056A (en) 1991-05-02 1999-11-30 Roche Molecular Systems, Inc. Homogeneous methods for nucleic acid amplification and detection
ES2091976T3 (es) 1991-06-20 1996-11-16 Hoffmann La Roche Metodos perfeccionados para la amplificacion del acido nucleico.
US5399497A (en) 1992-02-26 1995-03-21 Miles, Inc. Capsule chemistry sample liquid analysis system and method
US5422277A (en) 1992-03-27 1995-06-06 Ortho Diagnostic Systems Inc. Cell fixative composition and method of staining cells without destroying the cell surface
US5587128A (en) 1992-05-01 1996-12-24 The Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification devices
US5637469A (en) 1992-05-01 1997-06-10 Trustees Of The University Of Pennsylvania Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems
US5639423A (en) 1992-08-31 1997-06-17 The Regents Of The University Of Calfornia Microfabricated reactor
US5408891A (en) * 1992-12-17 1995-04-25 Beckman Instruments, Inc. Fluid probe washing apparatus and method
DE69429038T2 (de) 1993-07-28 2002-03-21 Pe Corporation (Ny), Norwalk Vorrichtung und Verfahren zur Nukleinsäurevervielfältigung
US5538667A (en) 1993-10-28 1996-07-23 Whitehill Oral Technologies, Inc. Ultramulsions
US5538848A (en) 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
JPH07218513A (ja) * 1994-02-01 1995-08-18 Aloka Co Ltd ノズル洗浄方法
US5972716A (en) 1994-04-29 1999-10-26 The Perkin-Elmer Corporation Fluorescence monitoring device with textured optical tube and method for reducing background fluorescence
CA2159830C (en) 1994-04-29 2001-07-03 Applied Biosystems, Llc System for real time detection of nucleic acid amplification products
EP0695941B1 (en) 1994-06-08 2002-07-31 Affymetrix, Inc. Method and apparatus for packaging a chip
US5555191A (en) 1994-10-12 1996-09-10 Trustees Of Columbia University In The City Of New York Automated statistical tracker
FI100859B (sv) 1994-10-14 1998-03-13 Bjarne Holmbom Förfarande och anordning för att utföra on-line flödesextraktion av ex traherbara komponenter i vätskor
US5585069A (en) 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
FR2733766B1 (fr) 1995-05-03 1997-06-06 Rhone Poulenc Rorer Sa Methode de diagnostic de la schizophrenie
US20020022261A1 (en) 1995-06-29 2002-02-21 Anderson Rolfe C. Miniaturized genetic analysis systems and methods
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US6130098A (en) 1995-09-15 2000-10-10 The Regents Of The University Of Michigan Moving microdroplets
US6057149A (en) 1995-09-15 2000-05-02 The University Of Michigan Microscale devices and reactions in microscale devices
US20020068357A1 (en) 1995-09-28 2002-06-06 Mathies Richard A. Miniaturized integrated nucleic acid processing and analysis device and method
US6562605B1 (en) 1995-11-13 2003-05-13 Genencor International, Inc. Extraction of water soluble biomaterials from fluids using a carbon dioxide/surfactant mixture
US5736314A (en) 1995-11-16 1998-04-07 Microfab Technologies, Inc. Inline thermo-cycler
EP0889751B1 (en) 1996-04-03 1999-09-08 The Perkin-Elmer Corporation Device and method for multiple analyte detection
CA2258489C (en) 1996-06-28 2004-01-27 Caliper Technologies Corporation High-throughput screening assay systems in microscale fluidic devices
AU726987B2 (en) 1996-06-28 2000-11-30 Caliper Life Sciences, Inc. Electropipettor and compensation means for electrophoretic bias
US7026468B2 (en) 1996-07-19 2006-04-11 Valentis, Inc. Process and equipment for plasmid purification
US6558916B2 (en) 1996-08-02 2003-05-06 Axiom Biotechnologies, Inc. Cell flow apparatus and method for real-time measurements of patient cellular responses
GB9621357D0 (en) 1996-10-12 1996-12-04 Central Research Lab Ltd Heating apparatus
US7268179B2 (en) 1997-02-03 2007-09-11 Cytonix Corporation Hydrophobic coating compositions, articles coated with said compositions, and processes for manufacturing same
EP1498494A3 (en) 1997-04-01 2007-06-20 Solexa Ltd. Method of nucleic acid sequencing
EP1591541B1 (en) 1997-04-01 2012-02-15 Illumina Cambridge Limited Method of nucleic acid sequencing
US6391622B1 (en) 1997-04-04 2002-05-21 Caliper Technologies Corp. Closed-loop biochemical analyzers
US6143496A (en) 1997-04-17 2000-11-07 Cytonix Corporation Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly
JP2002503336A (ja) 1997-05-16 2002-01-29 アルバータ リサーチ カウンシル 微量流通システムおよびその使用方法
US6664044B1 (en) 1997-06-19 2003-12-16 Toyota Jidosha Kabushiki Kaisha Method for conducting PCR protected from evaporation
US5912945A (en) 1997-06-23 1999-06-15 Regents Of The University Of California X-ray compass for determining device orientation
ES2283936T3 (es) 1997-07-07 2007-11-01 Medical Research Council Procedimiento de clasificacion in vitro.
US5980936A (en) 1997-08-07 1999-11-09 Alliance Pharmaceutical Corp. Multiple emulsions comprising a hydrophobic continuous phase
EP1538206B1 (en) 1997-09-16 2010-03-24 Centocor, Inc. Method for the complete chemical synthesis and assembly of genes and genomes
US6540895B1 (en) 1997-09-23 2003-04-01 California Institute Of Technology Microfabricated cell sorter for chemical and biological materials
US6833242B2 (en) 1997-09-23 2004-12-21 California Institute Of Technology Methods for detecting and sorting polynucleotides based on size
US6074725A (en) 1997-12-10 2000-06-13 Caliper Technologies Corp. Fabrication of microfluidic circuits by printing techniques
EP1645222B1 (en) 1998-03-04 2014-01-22 Visx, Incorporated Ophthalmologic surgery system
US6384915B1 (en) 1998-03-30 2002-05-07 The Regents Of The University Of California Catheter guided by optical coherence domain reflectometry
JP3081880B2 (ja) 1998-03-30 2000-08-28 農林水産省食品総合研究所長 マイクロスフィアの連続製造装置
US6175669B1 (en) 1998-03-30 2001-01-16 The Regents Of The Universtiy Of California Optical coherence domain reflectometry guidewire
JP3012608B1 (ja) 1998-09-17 2000-02-28 農林水産省食品総合研究所長 マイクロチャネル装置及び同装置を用いたエマルションの製造方法
US6146103A (en) 1998-10-09 2000-11-14 The Regents Of The University Of California Micromachined magnetohydrodynamic actuators and sensors
US6637463B1 (en) 1998-10-13 2003-10-28 Biomicro Systems, Inc. Multi-channel microfluidic system design with balanced fluid flow distribution
US6176609B1 (en) 1998-10-13 2001-01-23 V & P Scientific, Inc. Magnetic tumble stirring method, devices and machines for mixing in vessels
US6413780B1 (en) * 1998-10-14 2002-07-02 Abbott Laboratories Structure and method for performing a determination of an item of interest in a sample
US6086740A (en) 1998-10-29 2000-07-11 Caliper Technologies Corp. Multiplexed microfluidic devices and systems
US6261431B1 (en) 1998-12-28 2001-07-17 Affymetrix, Inc. Process for microfabrication of an integrated PCR-CE device and products produced by the same
GB9900298D0 (en) 1999-01-07 1999-02-24 Medical Res Council Optical sorting method
US6522407B2 (en) 1999-01-22 2003-02-18 The Regents Of The University Of California Optical detection dental disease using polarized light
US6326083B1 (en) 1999-03-08 2001-12-04 Calipher Technologies Corp. Surface coating for microfluidic devices that incorporate a biopolymer resistant moiety
US6303343B1 (en) 1999-04-06 2001-10-16 Caliper Technologies Corp. Inefficient fast PCR
DE60029092T2 (de) 1999-04-09 2007-02-01 Exact Sciences Corp., Marlborough Verfahren zur detektion von nukleinsäuren, welche auf krebs hinweisen
US6357907B1 (en) 1999-06-15 2002-03-19 V & P Scientific, Inc. Magnetic levitation stirring devices and machines for mixing in vessels
AU782726B2 (en) 1999-07-28 2005-08-25 Commissariat A L'energie Atomique Integration of biochemical protocols in a continuous flow microfluidic device
US6977145B2 (en) 1999-07-28 2005-12-20 Serono Genetics Institute S.A. Method for carrying out a biochemical protocol in continuous flow in a microreactor
US6440706B1 (en) 1999-08-02 2002-08-27 Johns Hopkins University Digital amplification
US6524456B1 (en) 1999-08-12 2003-02-25 Ut-Battelle, Llc Microfluidic devices for the controlled manipulation of small volumes
DE19947495C2 (de) 1999-10-01 2003-05-28 Agilent Technologies Inc Mikrofluidischer Mikrochip
DE60043896D1 (de) 1999-12-07 2010-04-08 Exact Sciences Corp Verfahren zum nachweis von lungenneoplasmen in fäkalen proben
US6620625B2 (en) 2000-01-06 2003-09-16 Caliper Technologies Corp. Ultra high throughput sampling and analysis systems and methods
US20020151040A1 (en) 2000-02-18 2002-10-17 Matthew O' Keefe Apparatus and methods for parallel processing of microvolume liquid reactions
JP2003522963A (ja) 2000-02-18 2003-07-29 アクララ バイオサイエンシーズ, インコーポレイテッド 複数部位反応デバイスおよび方法
JP3282619B2 (ja) 2000-03-22 2002-05-20 住友電装株式会社 ワイヤーハーネスの屈曲試験方法及び電線の屈曲試験装置
US20010048900A1 (en) 2000-05-24 2001-12-06 Bardell Ronald L. Jet vortex mixer
US7351376B1 (en) 2000-06-05 2008-04-01 California Institute Of Technology Integrated active flux microfluidic devices and methods
US6466713B2 (en) 2000-08-18 2002-10-15 The Regents Of The University Of California Optical fiber head for providing lateral viewing
US6773566B2 (en) 2000-08-31 2004-08-10 Nanolytics, Inc. Electrostatic actuators for microfluidics and methods for using same
WO2002022878A1 (en) 2000-09-14 2002-03-21 Caliper Technologies Corp. Microfluidic devices and methods for performing temperature mediated reactions
WO2002023163A1 (en) 2000-09-15 2002-03-21 California Institute Of Technology Microfabricated crossflow devices and methods
KR100649342B1 (ko) 2000-10-30 2006-11-27 시쿼넘, 인코포레이티드 기판 상으로 서브마이크로리터 볼륨들을 전달하기 위한 방법 및 장치
KR100435921B1 (ko) 2000-12-29 2004-06-12 주식회사 태평양 동수역학적 이중 안정화에 의한 안정한 수-유-수 다중에멀젼 시스템 및 이의 제조방법
DK1385950T3 (da) 2001-01-19 2008-11-03 Centocor Inc Computerstyret samling af et polynucleotid, som koder for et målpolypeptid
US7567596B2 (en) 2001-01-30 2009-07-28 Board Of Trustees Of Michigan State University Control system and apparatus for use with ultra-fast laser
DE60211857T2 (de) 2001-02-23 2006-12-21 Japan Science And Technology Agency, Kawaguchi Verfahren zur herstellung einer emulsion und vorrichtung dafür
WO2002069016A2 (en) 2001-02-28 2002-09-06 Lightwave Microsystems Corporation Microfluid control for waveguide optical switches, variable attenuators, and other optical devices
US7270786B2 (en) 2001-03-28 2007-09-18 Handylab, Inc. Methods and systems for processing microfluidic samples of particle containing fluids
US6575188B2 (en) 2001-07-26 2003-06-10 Handylab, Inc. Methods and systems for fluid control in microfluidic devices
US7010391B2 (en) 2001-03-28 2006-03-07 Handylab, Inc. Methods and systems for control of microfluidic devices
US7192557B2 (en) 2001-03-28 2007-03-20 Handylab, Inc. Methods and systems for releasing intracellular material from cells within microfluidic samples of fluids
EP1384022A4 (en) 2001-04-06 2004-08-04 California Inst Of Techn NUCLEIC ACID AMPLIFICATION USING MICROFLUID DEVICES
US6793723B2 (en) 2001-05-10 2004-09-21 Pitney Bowes Inc. Homogeneous photosensitive optically variable ink compositions for ink jet printing
US20030049659A1 (en) 2001-05-29 2003-03-13 Lapidus Stanley N. Devices and methods for isolating samples into subsamples for analysis
US20030013680A1 (en) 2001-06-12 2003-01-16 Keryx Methods using glycosaminoglycans for the treatment of nephropathy
US6905885B2 (en) 2001-06-12 2005-06-14 The Regents Of The University Of California Portable pathogen detection system
US6808683B2 (en) 2001-09-25 2004-10-26 Cytonome, Inc. Droplet dispensing system
CA2451614C (en) 2001-06-25 2011-01-04 Georgia Tech Research Corporation Dual resonance energy transfer nucleic acid probes
US6797257B2 (en) 2001-06-26 2004-09-28 The Board Of Trustees Of The University Of Illinois Paramagnetic polymerized protein microspheres and methods of preparation thereof
US6573490B2 (en) 2001-06-28 2003-06-03 Valeo Electrical Systems, Inc. Interleaved mosaic imaging rain sensor
US20030032172A1 (en) 2001-07-06 2003-02-13 The Regents Of The University Of California Automated nucleic acid assay system
US7297778B2 (en) 2001-07-25 2007-11-20 Affymetrix, Inc. Complexity management of genomic DNA
US20030027150A1 (en) 2001-08-03 2003-02-06 Katz David A. Method of haplotyping and kit therefor
AUPR707101A0 (en) 2001-08-16 2001-09-06 Corbett Research Pty Ltd Continuous flow thermal device
US7094379B2 (en) 2001-10-24 2006-08-22 Commissariat A L'energie Atomique Device for parallel and synchronous injection for sequential injection of different reagents
KR100442836B1 (ko) 2001-11-10 2004-08-02 삼성전자주식회사 생화학 유체를 온도가 다른 폐쇄된 챔버 구간을 따라 회전이동시키는 폐쇄 유체 회로 시스템
GB0127564D0 (en) 2001-11-16 2002-01-09 Medical Res Council Emulsion compositions
WO2003048295A1 (en) 2001-11-30 2003-06-12 Fluidigm Corporation Microfluidic device and methods of using same
US7198897B2 (en) 2001-12-19 2007-04-03 Brandeis University Late-PCR
US20030170698A1 (en) 2002-01-04 2003-09-11 Peter Gascoyne Droplet-based microfluidic oligonucleotide synthesis engine
US20030180765A1 (en) 2002-02-01 2003-09-25 The Johns Hopkins University Digital amplification for detection of mismatch repair deficient tumor cells
DE60303504T2 (de) 2002-02-22 2006-10-12 Biodot, Inc., Irvine Verfahren und vorrichtung zur kontaktlosen tröpfchenabgabe unterhalb einer fluidischen oberfläche
EP1488006B1 (en) 2002-03-20 2008-05-28 InnovativeBio.Biz Microcapsules with controlable permeability encapsulating a nucleic acid amplification reaction mixture and their use as reaction compartments for parallels reactions
US7312085B2 (en) 2002-04-01 2007-12-25 Fluidigm Corporation Microfluidic particle-analysis systems
US7993266B2 (en) 2002-04-26 2011-08-09 Lawrence Livermore National Security, Llc Early detection of contagious diseases
US7129091B2 (en) 2002-05-09 2006-10-31 University Of Chicago Device and method for pressure-driven plug transport and reaction
FR2841063B1 (fr) 2002-06-18 2004-09-17 Commissariat Energie Atomique Dispositif de deplacement de petits volumes de liquide le long d'un micro-catenaire par des forces electrostatiques
JP2006507921A (ja) 2002-06-28 2006-03-09 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 流体分散のための方法および装置
US6794671B2 (en) 2002-07-17 2004-09-21 Particle Sizing Systems, Inc. Sensors and methods for high-sensitivity optical particle counting and sizing
US20040038385A1 (en) 2002-08-26 2004-02-26 Langlois Richard G. System for autonomous monitoring of bioagents
US7188731B2 (en) 2002-08-26 2007-03-13 The Regents Of The University Of California Variable flexure-based fluid filter
US8871446B2 (en) 2002-10-02 2014-10-28 California Institute Of Technology Microfluidic nucleic acid analysis
WO2004074818A2 (en) 2002-12-20 2004-09-02 Biotrove, Inc. Assay apparatus and method using microfluidic arrays
EP1587940A4 (en) 2002-12-20 2006-06-07 Caliper Life Sciences Inc SINGLE MOLECULAR AMPLIFICATION AND DNA PROOF
US20060094108A1 (en) 2002-12-20 2006-05-04 Karl Yoder Thermal cycler for microfluidic array assays
US20050042639A1 (en) 2002-12-20 2005-02-24 Caliper Life Sciences, Inc. Single molecule amplification and detection of DNA length
CA2513889A1 (en) 2003-01-29 2004-08-19 454 Corporation Double ended sequencing
US7595195B2 (en) 2003-02-11 2009-09-29 The Regents Of The University Of California Microfluidic devices for controlled viscous shearing and formation of amphiphilic vesicles
US7041481B2 (en) 2003-03-14 2006-05-09 The Regents Of The University Of California Chemical amplification based on fluid partitioning
DK2959774T3 (da) 2003-03-28 2019-05-13 Inguran Llc Fremgangsmåde til kryokonservering af sædceller
US8828663B2 (en) 2005-03-18 2014-09-09 Fluidigm Corporation Thermal reaction device and method for using the same
US7604965B2 (en) 2003-04-03 2009-10-20 Fluidigm Corporation Thermal reaction device and method for using the same
DE10315640A1 (de) 2003-04-04 2004-10-14 Ignatov, Konstantin Verfahren zur kontrollierten Freisetzung von Komponenten in eine Lösung
EP1685282A2 (en) 2003-04-17 2006-08-02 Fluidigm Corporation Crystal growth devices and systems, and methods for using same
WO2004102204A1 (en) * 2003-05-16 2004-11-25 Global Technologies (Nz) Ltd Method and apparatus for mixing sample and reagent in a suspension fluid
US7629123B2 (en) 2003-07-03 2009-12-08 University Of Medicine And Dentistry Of New Jersey Compositions and methods for diagnosing autism
EP1649061B1 (en) 2003-07-03 2010-08-25 University Of Medicine And Dentistry Of New Jersey Genes as diagnostic tools for autism
CA2531105C (en) 2003-07-05 2015-03-17 The Johns Hopkins University Method and compositions for detection and enumeration of genetic variations
EP1654527A4 (en) 2003-08-01 2012-01-04 Ge Healthcare Bio Sciences Ab OPTICAL RESONANCE ANALYSIS UNIT
CN104069784B (zh) 2003-08-27 2017-01-11 哈佛大学 流体物种的电子控制
EP1664077B1 (en) 2003-09-05 2016-04-13 Trustees of Boston University Method for non-invasive prenatal diagnosis
US20050277125A1 (en) 2003-10-27 2005-12-15 Massachusetts Institute Of Technology High-density reaction chambers and methods of use
US7141537B2 (en) 2003-10-30 2006-11-28 3M Innovative Properties Company Mixture of fluorinated polyethers and use thereof as surfactant
WO2005055807A2 (en) 2003-12-05 2005-06-23 Beatrice And Samuel A. Seaver Foundation Methods and compositions for autism risk assessment background
US8293471B2 (en) 2004-01-28 2012-10-23 Marshall University Research Corporation Apparatus and method for a continuous rapid thermal cycle system
ES2432040T3 (es) 2004-01-28 2013-11-29 454 Life Sciences Corporation Amplificación de ácido nucleico con emulsión de flujo continuo
CA2555081A1 (en) 2004-02-03 2005-08-18 Postech Foundation High throughput device for performing continuous-flow reactions
KR100552706B1 (ko) 2004-03-12 2006-02-20 삼성전자주식회사 핵산 증폭 방법 및 장치
EP1757357B1 (en) 2004-03-23 2013-04-24 Japan Science and Technology Agency Method and device for producing micro-droplets
US7432106B2 (en) 2004-03-24 2008-10-07 Applied Biosystems Inc. Liquid processing device including gas trap, and system and method
EP3611273A1 (en) 2004-03-31 2020-02-19 The General Hospital Corporation Method to determine responsiveness of cancer to epidermal growth factor receptor targeting treatments
US20050221279A1 (en) 2004-04-05 2005-10-06 The Regents Of The University Of California Method for creating chemical sensors using contact-based microdispensing technology
HU227246B1 (en) 2004-04-30 2010-12-28 Szegedi Biolog Koezpont Use of genes as molecular markers in diagnosis of schizophrenia and diagnostic kit
WO2005110395A1 (en) 2004-05-19 2005-11-24 University Of South Carolina System and device for magnetic drug targeting with magnetic drug carrier particles
US8652851B2 (en) 2004-06-17 2014-02-18 University Of Florida Research Foundation, Inc. Multi-acceptor molecular probes and applications thereof
EP1612279B1 (en) 2004-06-29 2009-03-11 Roche Diagnostics GmbH Association of single nucleotide polymorphisms in PPAR gamma with osteoporosis
WO2006023719A2 (en) 2004-08-20 2006-03-02 Enh Research Institute Identification of snp’s associated with schizophrenia, schizoaffective disorder and bipolar disorder
CN101052468B (zh) 2004-09-09 2012-02-01 居里研究所 采用共线电场的微流控装置
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
US9109256B2 (en) 2004-10-27 2015-08-18 Esoterix Genetic Laboratories, Llc Method for monitoring disease progression or recurrence
WO2006052822A2 (en) * 2004-11-05 2006-05-18 Cytolution, Inc. Methods and devices for screening cervical cancer
US20090098044A1 (en) 2004-11-15 2009-04-16 Australian Nuclear Science And Technology Organisation Solid particles from controlled destabilisation of microemulsions
US20060166223A1 (en) 2005-01-26 2006-07-27 Reed Michael W DNA purification and analysis on nanoengineered surfaces
US7423751B2 (en) 2005-02-08 2008-09-09 Northrop Grumman Corporation Systems and methods for use in detecting harmful aerosol particles
EP2505591A1 (en) 2005-02-11 2012-10-03 Memorial Sloan-Kettering Cancer Center Methods and compositions for detecting a drug resistant EGFR mutant
US9039273B2 (en) 2005-03-04 2015-05-26 President And Fellows Of Harvard College Method and apparatus for forming multiple emulsions
KR20100099333A (ko) 2005-03-05 2010-09-10 주식회사 씨젠 이중 특이성 올리고뉴클레오타이드를 사용한 방법 및 이중 특이성 올리고뉴클레오타이드
US20060269934A1 (en) 2005-03-16 2006-11-30 Applera Corporation Compositions and methods for clonal amplification and analysis of polynucleotides
US20070048756A1 (en) 2005-04-18 2007-03-01 Affymetrix, Inc. Methods for whole genome association studies
JP4968815B2 (ja) * 2005-05-24 2012-07-04 エムエス機器株式会社 エマルジョンの自動分離方法
DE102005037401B4 (de) 2005-08-08 2007-09-27 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Bildung einer Emulsion in einem fluidischen Mikrosystem
WO2007038670A2 (en) 2005-09-30 2007-04-05 Perlegen Sciences, Inc. Methods and compositions for screening and treatment of disorders of blood glucose regulation
EP2363205A3 (en) 2006-01-11 2014-06-04 Raindance Technologies, Inc. Microfluidic Devices And Methods Of Use In The Formation And Control Of Nanoreactors
US7976795B2 (en) 2006-01-19 2011-07-12 Rheonix, Inc. Microfluidic systems
WO2007089541A2 (en) 2006-01-27 2007-08-09 President And Fellows Of Harvard College Fluidic droplet coalescence
HUE030215T2 (en) 2006-02-02 2017-04-28 Univ Leland Stanford Junior Non-invasive fetal genetic screening by digital analysis
EP1991357B1 (en) 2006-02-07 2016-09-14 Stokes Bio Limited A microfluidic analysis system
US20100304446A1 (en) 2006-02-07 2010-12-02 Stokes Bio Limited Devices, systems, and methods for amplifying nucleic acids
EP2298438A1 (en) 2006-02-07 2011-03-23 Stokes Bio Limited A microfluidic droplet queuing network
US20070258083A1 (en) 2006-04-11 2007-11-08 Optiscan Biomedical Corporation Noise reduction for analyte detection systems
US8492168B2 (en) 2006-04-18 2013-07-23 Advanced Liquid Logic Inc. Droplet-based affinity assays
US7816121B2 (en) * 2006-04-18 2010-10-19 Advanced Liquid Logic, Inc. Droplet actuation system and method
US7815871B2 (en) 2006-04-18 2010-10-19 Advanced Liquid Logic, Inc. Droplet microactuator system
WO2009140373A2 (en) 2008-05-13 2009-11-19 Advanced Liquid Logic, Inc. Droplet actuator devices, systems, and methods
EP2530168B1 (en) 2006-05-11 2015-09-16 Raindance Technologies, Inc. Microfluidic Devices
US7608399B2 (en) * 2006-06-26 2009-10-27 Blood Cell Storage, Inc. Device and method for extraction and analysis of nucleic acids from biological samples
EP1881079A1 (en) 2006-07-20 2008-01-23 Pangaea Biotech, S.A. Method for the detection of EGFR mutations in blood samples
EP2077912B1 (en) 2006-08-07 2019-03-27 The President and Fellows of Harvard College Fluorocarbon emulsion stabilizing surfactants
WO2008024114A1 (en) 2006-08-24 2008-02-28 Genizon Biosciences Inc. Genemap of the human genes associated with schizophrenia
EP1912067A1 (en) 2006-10-12 2008-04-16 Eppendorf Array Technologies S.A. Method for quantification of a target compound obtained from a biological sample upon chips
US8841116B2 (en) * 2006-10-25 2014-09-23 The Regents Of The University Of California Inline-injection microdevice and microfabricated integrated DNA analysis system using same
WO2008070074A2 (en) 2006-12-04 2008-06-12 Pgxhealth Llc Genetic markers of schizophrenia
EP2140027B1 (en) 2006-12-07 2012-07-18 Novartis AG Non-invasive prenatal genetic screen
US8262900B2 (en) 2006-12-14 2012-09-11 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US8338166B2 (en) 2007-01-04 2012-12-25 Lawrence Livermore National Security, Llc Sorting, amplification, detection, and identification of nucleic acid subsequences in a complex mixture
WO2008089244A2 (en) 2007-01-17 2008-07-24 University Of Rochester Frequency-addressable apparatus and methods for actuation of liquids
US9029085B2 (en) 2007-03-07 2015-05-12 President And Fellows Of Harvard College Assays and other reactions involving droplets
WO2008109878A2 (en) 2007-03-07 2008-09-12 California Institute Of Technology Testing device
US20100144538A1 (en) 2007-03-08 2010-06-10 Genizon Biosciences Inc. Genemap of the human genes associated with schizophrenia
EP2136786B8 (en) 2007-03-28 2012-11-14 President and Fellows of Harvard College Apparatus for forming droplets
JP5666763B2 (ja) 2007-04-11 2015-02-12 味の素株式会社 油中水型乳化組成物
US8951732B2 (en) 2007-06-22 2015-02-10 Advanced Liquid Logic, Inc. Droplet-based nucleic acid amplification in a temperature gradient
WO2009011808A1 (en) * 2007-07-13 2009-01-22 President And Fellows Of Harvard College Droplet-based selection
CA2694820C (en) 2007-07-30 2015-06-16 F. Hoffman-La Roche Ag Methods of identification using methylation of cpg
JP2009031174A (ja) * 2007-07-30 2009-02-12 Hitachi High-Technologies Corp 自動分析装置
US20090053719A1 (en) 2007-08-03 2009-02-26 The Chinese University Of Hong Kong Analysis of nucleic acids by digital pcr
JP5707132B2 (ja) 2007-09-07 2015-04-22 フルイダイム コーポレイション コピー数変動の決定、方法およびシステム
WO2009049889A1 (en) 2007-10-16 2009-04-23 Roche Diagnostics Gmbh High resolution, high throughput hla genotyping by clonal sequencing
US7807920B2 (en) 2007-10-30 2010-10-05 Opel, Inc. Concentrated solar photovoltaic module
WO2009085246A1 (en) 2007-12-20 2009-07-09 University Of Massachusetts Cross-linked biopolymers, related compositions and methods of use
JP5224801B2 (ja) 2007-12-21 2013-07-03 キヤノン株式会社 核酸増幅装置
US8367370B2 (en) 2008-02-11 2013-02-05 Wheeler Aaron R Droplet-based cell culture and cell assays using digital microfluidics
US20090220434A1 (en) 2008-02-29 2009-09-03 Florida State University Research Foundation Nanoparticles that facilitate imaging of biological tissue and methods of forming the same
US8062903B2 (en) 2008-03-03 2011-11-22 University Of Washington Droplet compartmentalization for chemical separation and on-line sampling
US9487822B2 (en) 2008-03-19 2016-11-08 Fluidigm Corporation Method and apparatus for determining copy number variation using digital PCR
US9011777B2 (en) 2008-03-21 2015-04-21 Lawrence Livermore National Security, Llc Monodisperse microdroplet generation and stopping without coalescence
WO2010001419A2 (en) 2008-07-04 2010-01-07 Decode Genetics Ehf Copy number variations predictive of risk of schizophrenia
WO2010009365A1 (en) 2008-07-18 2010-01-21 Raindance Technologies, Inc. Droplet libraries
US8256931B2 (en) 2008-07-24 2012-09-04 Seward George H Achromatic homogenizer and collimator for LEDs
PL3663411T3 (pl) 2008-08-12 2022-02-07 Stokes Bio Limited Sposoby do cyfrowego pcr
US9180453B2 (en) 2008-08-15 2015-11-10 University Of Washington Method and apparatus for the discretization and manipulation of sample volumes
WO2010021936A1 (en) 2008-08-16 2010-02-25 The Board Of Trustees Of The Leland Stanford Junior University Digital pcr calibration for high throughput sequencing
US8383345B2 (en) 2008-09-12 2013-02-26 University Of Washington Sequence tag directed subassembly of short sequencing reads into long sequencing reads
US20110218123A1 (en) 2008-09-19 2011-09-08 President And Fellows Of Harvard College Creation of libraries of droplets and related species
US20130084572A1 (en) 2011-09-30 2013-04-04 Quantalife, Inc. Calibrations and controls for droplet-based assays
US20130017551A1 (en) 2011-07-13 2013-01-17 Bio-Rad Laboratories, Inc. Computation of real-world error using meta-analysis of replicates
US8709762B2 (en) 2010-03-02 2014-04-29 Bio-Rad Laboratories, Inc. System for hot-start amplification via a multiple emulsion
CA2738578C (en) * 2008-09-23 2021-05-04 Quantalife, Inc. Droplet-based assay system
US9132394B2 (en) 2008-09-23 2015-09-15 Bio-Rad Laboratories, Inc. System for detection of spaced droplets
US9598725B2 (en) 2010-03-02 2017-03-21 Bio-Rad Laboratories, Inc. Emulsion chemistry for encapsulated droplets
US20130059754A1 (en) 2011-09-01 2013-03-07 Bio-Rad Laboratories, Inc. Digital assays with reduced measurement uncertainty
US20120171683A1 (en) 2010-03-02 2012-07-05 Ness Kevin D Analysis of fragmented genomic dna in droplets
US8633015B2 (en) 2008-09-23 2014-01-21 Bio-Rad Laboratories, Inc. Flow-based thermocycling system with thermoelectric cooler
US8951939B2 (en) 2011-07-12 2015-02-10 Bio-Rad Laboratories, Inc. Digital assays with multiplexed detection of two or more targets in the same optical channel
US9156010B2 (en) 2008-09-23 2015-10-13 Bio-Rad Laboratories, Inc. Droplet-based assay system
EP2389455A4 (en) 2009-01-26 2012-12-05 Verinata Health Inc METHODS AND COMPOSITIONS FOR IDENTIFYING A FETAL CELL
US8528589B2 (en) 2009-03-23 2013-09-10 Raindance Technologies, Inc. Manipulation of microfluidic droplets
WO2010117461A2 (en) 2009-04-08 2010-10-14 Applied Biosystems, Llc System and method for preparing and using bulk emulsion
CA2767056C (en) 2009-09-02 2018-12-04 Bio-Rad Laboratories, Inc. System for mixing fluids by coalescence of multiple emulsions
IN2012DN03431A (enExample) 2009-09-21 2015-10-23 Akonni Biosystems
US10520500B2 (en) 2009-10-09 2019-12-31 Abdeslam El Harrak Labelled silica-based nanomaterial with enhanced properties and uses thereof
EP2957641B1 (en) 2009-10-15 2017-05-17 Ibis Biosciences, Inc. Multiple displacement amplification
US8835358B2 (en) 2009-12-15 2014-09-16 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse labels
EP2517025B1 (en) 2009-12-23 2019-11-27 Bio-Rad Laboratories, Inc. Methods for reducing the exchange of molecules between droplets
JP5934657B2 (ja) 2010-02-12 2016-06-15 レインダンス テクノロジーズ, インコーポレイテッド デジタル検体分析
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
CA2767182C (en) 2010-03-25 2020-03-24 Bio-Rad Laboratories, Inc. Droplet generation for droplet-based assays
CA2767113A1 (en) 2010-03-25 2011-09-29 Bio-Rad Laboratories, Inc. Detection system for droplet-based assays
WO2012045012A2 (en) 2010-09-30 2012-04-05 Raindance Technologies, Inc. Sandwich assays in droplets
SG190074A1 (en) 2010-11-01 2013-06-28 Bio Rad Laboratories System for forming emulsions
EP2673382B1 (en) 2011-02-11 2020-05-06 Bio-Rad Laboratories, Inc. Thermocycling device for nucleic acid amplification and methods of use
EP3859011A1 (en) 2011-02-11 2021-08-04 Bio-Rad Laboratories, Inc. Methods for forming mixed droplets
EP2675819B1 (en) 2011-02-18 2020-04-08 Bio-Rad Laboratories, Inc. Compositions and methods for molecular labeling
AU2012231098B2 (en) 2011-03-18 2016-09-29 Bio-Rad Laboratories, Inc. Multiplexed digital assays with combinatorial use of signals
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
DE202012013668U1 (de) 2011-06-02 2019-04-18 Raindance Technologies, Inc. Enzymquantifizierung
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
WO2013019751A1 (en) 2011-07-29 2013-02-07 Bio-Rad Laboratories, Inc., Library characterization by digital assay

Similar Documents

Publication Publication Date Title
JP2014502209A5 (enExample)
WO2013186672A3 (en) Optical detection system for liquid samples
EP2400306A3 (en) Sample analyzer and liquid aspirating method
JP2015014506A5 (enExample)
ES2526106B1 (es) Dispositivo para probar líquidos de cigarrillos electrónicos
EP4521094A3 (en) Detector inlet and sampling method
JP2010103576A5 (ja) 露光装置、及び液体検出方法
JP2013525762A5 (enExample)
WO2011159537A3 (en) Method and device for analyte detection
EP3023755A3 (en) Optical impedance modulation for fuel quantity measurement
MX2016007350A (es) Dispositivo de analisis.
CL2014001659A1 (es) Dispositivo para detectar depósitos en un área de reflexión dentro de un sistema que contiene liquido, comprende un transductor ultrasónico para emitir una señal hacia el área de reflexión y un medio de detección de la señal obtenida por la reflexión de la señal; método para detectar depósitos de sedimentos y/o de incrustaciones en una área de reflexión.
WO2013190326A3 (en) Particle characterization
BR112013030616A2 (pt) aparelho de teste para coletar uma ou mais amostras de fluido de fundo de poço a partir de um furo de poço, e método para capturar uma amostra a partir de um furo de poço.
WO2013079927A3 (en) Air sampling device
BR112013005062A2 (pt) conjunto detector de gota, método de detecção de ejeções de gotas de fluido em um dispositivo ejetor de fluido e sistema detector de gotas
WO2010078465A3 (en) Capillary flow solid phase assay
WO2015066468A3 (en) Grease gun with sensing capability
WO2014058615A3 (en) Apparatus and method for analyte extraction
EP2803971A3 (en) Particle detecting device and particle detecting method
EP2682727A3 (en) Leakage Detection Device Using Siphon Principle
IL273447B1 (en) Microfluidic system and method for the recovery of particles
EP2940437A4 (en) DEVICE FOR DETERMINING THE FLUID LEVEL
FR2977317B1 (fr) Procede de detection d'anomalies lors du remplissage d'un dispositif de dosage de liquide et dispositif de dosage de liquide
FR2943785B1 (fr) Procede de detection et de quantification d'analytes d'interet dans un liquide et dispositif de mise en oeuvre.