JP2013523704A5 - - Google Patents
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- Publication number
- JP2013523704A5 JP2013523704A5 JP2013501930A JP2013501930A JP2013523704A5 JP 2013523704 A5 JP2013523704 A5 JP 2013523704A5 JP 2013501930 A JP2013501930 A JP 2013501930A JP 2013501930 A JP2013501930 A JP 2013501930A JP 2013523704 A5 JP2013523704 A5 JP 2013523704A5
- Authority
- JP
- Japan
- Prior art keywords
- virus
- solution
- additive
- alkyl
- optionally
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 241000700605 Viruses Species 0.000 claims 20
- 239000000243 solution Substances 0.000 claims 19
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 12
- 235000000346 sugar Nutrition 0.000 claims 9
- 239000000654 additive Substances 0.000 claims 8
- 230000000996 additive effect Effects 0.000 claims 8
- 239000007864 aqueous solution Substances 0.000 claims 8
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 239000004471 Glycine Substances 0.000 claims 6
- FFDGPVCHZBVARC-UHFFFAOYSA-N N,N-dimethylglycine Chemical compound CN(C)CC(O)=O FFDGPVCHZBVARC-UHFFFAOYSA-N 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 150000008163 sugars Chemical class 0.000 claims 6
- 239000003125 aqueous solvent Substances 0.000 claims 5
- 150000002148 esters Chemical class 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 229930006000 Sucrose Natural products 0.000 claims 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 3
- 108700003601 dimethylglycine Proteins 0.000 claims 3
- 229940078490 n,n-dimethylglycine Drugs 0.000 claims 3
- 238000007789 sealing Methods 0.000 claims 3
- 239000005720 sucrose Substances 0.000 claims 3
- -1 sulfone compound Chemical class 0.000 claims 3
- 239000003708 ampul Substances 0.000 claims 2
- 239000011521 glass Substances 0.000 claims 2
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims 2
- 241000701242 Adenoviridae Species 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- 241000712079 Measles morbillivirus Species 0.000 claims 1
- 241000712464 Orthomyxoviridae Species 0.000 claims 1
- 241000711504 Paramyxoviridae Species 0.000 claims 1
- 241000701945 Parvoviridae Species 0.000 claims 1
- 241000700625 Poxviridae Species 0.000 claims 1
- MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 claims 1
- MUPFEKGTMRGPLJ-UHFFFAOYSA-N UNPD196149 Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(COC2C(C(O)C(O)C(CO)O2)O)O1 MUPFEKGTMRGPLJ-UHFFFAOYSA-N 0.000 claims 1
- 241000700618 Vaccinia virus Species 0.000 claims 1
- 108700010877 adenoviridae proteins Proteins 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 230000002238 attenuated effect Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229940016409 methylsulfonylmethane Drugs 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 230000002335 preservative effect Effects 0.000 claims 1
- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 239000008174 sterile solution Substances 0.000 claims 1
- 230000001954 sterilising effect Effects 0.000 claims 1
- 150000005846 sugar alcohols Chemical class 0.000 claims 1
- HHVIBTZHLRERCL-UHFFFAOYSA-N sulfonyldimethane Chemical compound CS(C)(=O)=O HHVIBTZHLRERCL-UHFFFAOYSA-N 0.000 claims 1
- 241000701161 unidentified adenovirus Species 0.000 claims 1
- 241000712461 unidentified influenza virus Species 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1005517.6 | 2010-03-31 | ||
| GB1005521.8 | 2010-03-31 | ||
| GBGB1005517.6A GB201005517D0 (en) | 2010-03-31 | 2010-03-31 | Stabilised liquid formulations of polypeptides |
| GBGB1005521.8A GB201005521D0 (en) | 2010-03-31 | 2010-03-31 | Stabilised liquid formulations of virus particles |
| GB1017648.5 | 2010-10-19 | ||
| GBGB1017648.5A GB201017648D0 (en) | 2010-10-19 | 2010-10-19 | Liquid preparation containing stabilised viruses |
| PCT/GB2011/000493 WO2011121301A1 (en) | 2010-03-31 | 2011-03-31 | Excipients for stabilising viral particles, polypeptides or biological material |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016001536A Division JP6053969B2 (ja) | 2010-03-31 | 2016-01-07 | ウイルス粒子、ポリペプチド又は生体材料を安定化させる添加剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013523704A JP2013523704A (ja) | 2013-06-17 |
| JP2013523704A5 true JP2013523704A5 (enExample) | 2014-04-17 |
| JP5869553B2 JP5869553B2 (ja) | 2016-02-24 |
Family
ID=43902836
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013501930A Active JP5869553B2 (ja) | 2010-03-31 | 2011-03-31 | ウイルス粒子、ポリペプチド又は生体材料を安定化させる添加剤 |
| JP2016001536A Active JP6053969B2 (ja) | 2010-03-31 | 2016-01-07 | ウイルス粒子、ポリペプチド又は生体材料を安定化させる添加剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016001536A Active JP6053969B2 (ja) | 2010-03-31 | 2016-01-07 | ウイルス粒子、ポリペプチド又は生体材料を安定化させる添加剤 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US20130164296A1 (enExample) |
| EP (1) | EP2552478B1 (enExample) |
| JP (2) | JP5869553B2 (enExample) |
| KR (2) | KR101884953B1 (enExample) |
| CN (1) | CN102892427A (enExample) |
| AU (2) | AU2011234264B2 (enExample) |
| BR (1) | BR112012025047A2 (enExample) |
| CA (1) | CA2795047C (enExample) |
| DK (1) | DK2552478T3 (enExample) |
| ES (1) | ES2617921T3 (enExample) |
| GB (1) | GB2490644A (enExample) |
| HU (1) | HUE033656T2 (enExample) |
| IL (1) | IL221857A (enExample) |
| WO (1) | WO2011121301A1 (enExample) |
| ZA (1) | ZA201206956B (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2011234264B2 (en) | 2010-03-31 | 2016-02-04 | Stabilitech Ltd | Excipients for stabilising viral particles, polypeptides or biological material |
| US10206960B2 (en) | 2010-03-31 | 2019-02-19 | Stabilitech Biopharma Ltd | Stabilisation of viral particles |
| GB201117233D0 (en) * | 2011-10-05 | 2011-11-16 | Stabilitech Ltd | Stabilisation of polypeptides |
| GB201208293D0 (en) * | 2012-05-11 | 2012-06-20 | Circassia Ltd | Hydrochlorice salt of peptide |
| US9622483B2 (en) | 2014-02-19 | 2017-04-18 | Corning Incorporated | Antimicrobial glass compositions, glasses and polymeric articles incorporating the same |
| US11039620B2 (en) | 2014-02-19 | 2021-06-22 | Corning Incorporated | Antimicrobial glass compositions, glasses and polymeric articles incorporating the same |
| US11039621B2 (en) | 2014-02-19 | 2021-06-22 | Corning Incorporated | Antimicrobial glass compositions, glasses and polymeric articles incorporating the same |
| GB201406569D0 (en) | 2014-04-11 | 2014-05-28 | Stabilitech Ltd | Vaccine compositions |
| GB201513010D0 (en) | 2015-07-23 | 2015-09-09 | Glaxosmithkline Biolog Sa | Novel formulation |
| WO2018115305A1 (en) | 2016-12-22 | 2018-06-28 | Leibniz-Institut für Pflanzengenetik Und Kulturpflanzenforschung (IPK) | Oligomeric vaccines from plants by s-tag-s-protein fusions |
| KR20190104051A (ko) | 2017-01-06 | 2019-09-05 | 스타빌리테크 바이오파마 리미티드 | 바이러스 |
| KR101878599B1 (ko) * | 2017-03-28 | 2018-07-13 | 전북대학교산학협력단 | 메틸설포닐메테인과 만니톨의 흡수촉진 및 고미감소를 위한 공침조성물과 이의 제조방법 |
| GB2562241B (en) * | 2017-05-08 | 2022-04-06 | Stabilitech Biopharma Ltd | Vaccine compositions |
| AR113996A1 (es) * | 2017-12-22 | 2020-07-08 | Intervet Int Bv | Vacunas líquidas de virus envueltos vivos |
| CA3111273C (en) | 2018-09-06 | 2024-03-26 | Bavarian Nordic A/S | Storage improved poxvirus compositions |
| JP7712284B2 (ja) | 2020-03-12 | 2025-07-23 | バヴァリアン・ノルディック・アクティーゼルスカブ | ポックスウイルスの安定性を改善する組成物 |
| CN114649066B (zh) * | 2020-12-17 | 2025-02-11 | 南开大学 | 一种提升d-氨基酸减缓mbr膜污染效能的智能优化方法 |
| JP7748616B2 (ja) * | 2021-03-24 | 2025-10-03 | 大日本印刷株式会社 | 液体入り組合せ容器、容器セットおよび液体入り容器の製造方法 |
| CN114392237B (zh) * | 2021-12-28 | 2024-02-02 | 上海允英生物医药科技有限公司 | 一种冻干病毒制剂及其制备方法 |
Family Cites Families (92)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3927208A (en) * | 1973-05-14 | 1975-12-16 | Rit Rech Ind Therapeut | Live bovine adenovirus vaccines, preparation thereof and method of vaccination using them |
| US4631189A (en) | 1980-03-10 | 1986-12-23 | Da Vinci Laboratories, a division of FoodScience Corporation | N,N-dimethylglycine and use in immune response |
| JPS6013718A (ja) | 1983-07-05 | 1985-01-24 | Chemo Sero Therapeut Res Inst | Ｂ型肝炎ワクチン |
| JPS60193925A (ja) | 1984-03-13 | 1985-10-02 | Chemo Sero Therapeut Res Inst | 凍結乾燥製剤化ワクチン |
| US4808700A (en) * | 1984-07-09 | 1989-02-28 | Praxis Biologics, Inc. | Immunogenic conjugates of non-toxic E. coli LT-B enterotoxin subunit and capsular polymers |
| JPS61189228A (ja) | 1985-02-19 | 1986-08-22 | Nippon Sekijiyuujishiya | 血液凝固第８因子製剤の製法 |
| US4950596A (en) | 1985-03-04 | 1990-08-21 | The Dow Chemical Company | Stabilization of intracellular enzymes |
| JPS6238173A (ja) * | 1985-08-13 | 1987-02-19 | 三菱レイヨン株式会社 | 抗血液凝固剤 |
| US5169758A (en) | 1986-05-02 | 1992-12-08 | Boehringer Mannheim Gmbh | Stabilized, NAD(P)H-dependent, soluble nitrate reductase, a process for the preparation thereof and a reagent containing it |
| US4816568A (en) | 1986-05-16 | 1989-03-28 | International Minerals & Chemical Corp. | Stabilization of growth hormones |
| NZ221306A (en) | 1986-08-15 | 1990-02-26 | Commw Scient Ind Res Org | 2-component immunoadjuvant comprising a mycobacterial free immunoadjuvant oil and a polycationic polyelectrolyte immunoadjuvant and vaccines thereof |
| US4980277A (en) * | 1987-10-16 | 1990-12-25 | Cultor Ltd. | Cryoprotectant solution and method |
| WO1989011297A1 (en) | 1988-05-27 | 1989-11-30 | Centocor, Inc. | Freeze-dried formulation for antibody products |
| GB8826429D0 (en) | 1988-11-11 | 1988-12-14 | Univ Leeds Ind Service Ltd | Enzyme stabilisation systems |
| EP0487632B1 (en) | 1989-08-15 | 1998-03-04 | Massachusetts Institute Of Technology | Stabilized vaccine compositions |
| CA2051092C (en) | 1990-09-12 | 2002-07-23 | Stephen A. Livesey | Method and apparatus for cryopreparation, dry stabilization and rehydration of biological suspensions |
| WO1993000807A1 (en) | 1991-07-03 | 1993-01-21 | Cryolife, Inc. | Method for stabilization of biomaterials |
| RU2099418C1 (ru) * | 1991-11-21 | 1997-12-20 | Лонца Аг | Фрагмент днк, обеспечивающий использование бетаина, рекомбинантная плазмидная днк с фрагментом днк, обеспечивающим использование бетаина, штамм бактерий rhizobium/agrobacterium, предназначенный для стабильного хранения плазмиды с фрагментом днк, способ получения штамма бактерий |
| ZA936095B (en) | 1992-08-21 | 1994-03-14 | Univ Melbourne | Cytokine applications. |
| FR2698879B1 (fr) | 1992-12-09 | 1995-01-13 | Rhone Poulenc Biochimie | gellules modifiées au niveau du catabolisme de la bétaïne, préparation et utilisations, notamment pour la production de métabolites ou d'enzymes. |
| GB9320782D0 (en) | 1993-10-08 | 1993-12-01 | Univ Leeds Innovations Ltd | Stabilising of proteins on solution |
| WO1995011700A1 (en) | 1993-10-29 | 1995-05-04 | Pharmos Corp. | Submicron emulsions as vaccine adjuvants |
| US5580856A (en) | 1994-07-15 | 1996-12-03 | Prestrelski; Steven J. | Formulation of a reconstituted protein, and method and kit for the production thereof |
| US5965438A (en) * | 1995-06-07 | 1999-10-12 | Phyton, Inc. | Cryopreservation of plant cells |
| MX9800684A (es) | 1995-07-27 | 1998-04-30 | Genentech Inc | Formulacion de proteinas liofilizadas isotonicas estables. |
| GB9521806D0 (en) * | 1995-10-25 | 1996-01-03 | Cortecs Ltd | Preservation methods |
| FR2746109B1 (fr) | 1996-03-12 | 1998-04-17 | Rhone Poulenc Rorer Sa | Milieu pour la conservation de materiel biologique |
| US20070179096A1 (en) | 1996-04-24 | 2007-08-02 | Novo Nordisk A/S | Pharmaceutical Formulation |
| US6037116A (en) | 1996-06-14 | 2000-03-14 | Biostore New Zealand, Ltd. | Compositions comprising betaine, sodium citrate and sodium chloride and methods for the preservation of biological materials |
| AU707186B2 (en) | 1997-07-01 | 1999-07-01 | Transgene S.A. | Compositions useful for transferring therapeutically active substances into a target cell, and their use in gene therapy |
| CA2312233A1 (en) | 1997-11-26 | 1999-06-03 | Universal Preservation Technologies, Inc. | Preservation of sensitive biological samples by vitrification |
| WO2000029024A1 (en) | 1998-11-16 | 2000-05-25 | Introgen Therapeutics, Inc. | Formulation of adenovirus for gene therapy |
| US6689600B1 (en) | 1998-11-16 | 2004-02-10 | Introgen Therapeutics, Inc. | Formulation of adenovirus for gene therapy |
| AUPQ347199A0 (en) * | 1999-10-15 | 1999-11-11 | Csl Limited | Novel polypeptide fragments |
| JP2003535119A (ja) | 2000-06-08 | 2003-11-25 | パウダージェクト ワクチンズ，インコーポレーテッド | 粉末組成物 |
| DE10041515A1 (de) | 2000-08-24 | 2002-03-14 | Gerold Schuler | Verfahren zur Herstellung gebrauchsfertiger, Antigen-beladener oder -unbeladener, kryokonservierter reifer dendritischer Zellen |
| US20040110267A1 (en) | 2000-12-15 | 2004-06-10 | Stratagene | Room temperature stable competent cells |
| AU2002302814A1 (en) | 2001-06-08 | 2002-12-23 | Powderject Vaccines, Inc. | Spray freeze-dried compositions |
| US7101693B2 (en) | 2001-09-07 | 2006-09-05 | Brigham Young University | Plasticized hydrophilic glasses for improved stabilization of biological agents |
| JP4936618B2 (ja) | 2001-09-21 | 2012-05-23 | 株式会社ノエビア | 微細エマルション組成物 |
| US20040161776A1 (en) | 2001-10-23 | 2004-08-19 | Maddon Paul J. | PSMA formulations and uses thereof |
| ATE441666T1 (de) | 2001-12-28 | 2009-09-15 | Kyowa Hakko Kirin Co Ltd | Antikírper gegen den fibroblastenwachstumsfaktor 23 |
| EP3210624A1 (en) | 2002-02-27 | 2017-08-30 | Immunex Corporation | Stabilized tnfr-fc composition comprising arginine |
| JP2003261591A (ja) | 2002-03-08 | 2003-09-19 | Koji Hayade | 凍結乾燥安定剤 |
| EP1539244A1 (en) | 2002-06-27 | 2005-06-15 | Novo Nordisk A/S | Use of dimethyl sulfone as isotonicity agent |
| CA2491805A1 (en) * | 2002-07-10 | 2004-01-22 | Transgene S.A. | Modified adenoviral fiber with ablated binding to cellular receptors |
| WO2004035818A1 (en) | 2002-10-21 | 2004-04-29 | Biotage Ab | Use of osmolytes to heat stabilise luciferase and/or apyrase |
| AU2003297833A1 (en) | 2002-12-10 | 2004-06-30 | Schering-Plough Ltd. | Canine rankl and methods for preparing and using the same |
| PL1633391T3 (pl) | 2003-06-03 | 2012-03-30 | Novo Nordisk As | Stabilizowane farmaceutycznie kompozycje peptydowe |
| EP2292642A1 (en) | 2003-06-10 | 2011-03-09 | Opal Therapeutics Pty Ltd | Immunomodulating compositions, uses therefor and processes for their production |
| US20060247167A1 (en) | 2003-09-01 | 2006-11-02 | Novo Nordisk A/S | Stable formulations of peptides |
| US7642077B2 (en) | 2003-12-08 | 2010-01-05 | Genencor International, Inc. | Biocomposite comprising co-precipitate of enzyme, silicate and polyamine |
| EP1711619A4 (en) | 2003-12-30 | 2007-04-11 | Virumar Pituach Tarkivin Ltd | INTEGRATED VIRUS COMPLEXES, METHOD FOR THE MANUFACTURE THEREOF, VACCINES CONTAINING THEM AND METHOD FOR THE USE THEREOF |
| AU2005251676B2 (en) | 2004-03-03 | 2011-09-29 | Revance Therapeutics, Inc. | Compositions and methods for topical diagnostic and therapeutic transport |
| US20060058238A1 (en) | 2004-09-15 | 2006-03-16 | Lee Laurent-Applegate | Fetal skin cell protein compositions for the treatment of skin conditions, disorders or diseases and methods of making and using the same |
| WO2006039336A2 (en) | 2004-10-01 | 2006-04-13 | Ramscor, Inc. | Conveniently implantable sustained release drug compositions |
| US8173148B2 (en) | 2004-11-10 | 2012-05-08 | Tolmar Therapeutics, Inc. | Stabilized polymeric delivery system comprising a water-insoluble polymer and an organic liquid |
| CA2595380A1 (en) | 2005-01-28 | 2006-08-03 | Wyeth | Stabilized liquid polypeptide formulations |
| GB0502661D0 (en) | 2005-02-09 | 2005-03-16 | Stabilitech Ltd | A desiccated product |
| TWI398272B (zh) * | 2005-03-08 | 2013-06-11 | Intervet Int Bv | 化學定義的安定劑 |
| JP5020935B2 (ja) | 2005-04-08 | 2012-09-05 | アルゴス セラピューティクス，インコーポレイティド | 樹状細胞組成物および方法 |
| SI1954308T1 (sl) | 2005-09-16 | 2011-12-30 | Merial Ltd | Stabilizatorji za liofilizirana cepiva |
| RU2008117396A (ru) | 2005-10-04 | 2009-11-10 | Альк-Абелло А/С (Dk) | Твердая вакцинная композиция |
| AU2006315026B2 (en) | 2005-11-21 | 2012-11-22 | Sanofi Pasteur Limited | Stabilizing formulations for recombinant viruses |
| RU2424247C2 (ru) | 2005-11-30 | 2011-07-20 | Интернэшнл Инститьют Оф Кэнсер Иммьюнолоджи, Инк. | Пептид, индуцирующий цитотоксические т-клетки (цтл), способ индукции цтл, антитело, связывающееся с этим пептидом, применение пептида в фармацевтической композиции и для лечения или предупреждения рака, антигенпредставляющая клетка |
| CA2631714C (en) | 2005-12-02 | 2014-09-16 | Novartis Ag | Nanoparticles for use in immunogenic compositions |
| CN101495136A (zh) | 2006-02-15 | 2009-07-29 | 英克隆系统公司 | 抗体配制品 |
| US8021659B2 (en) | 2006-04-28 | 2011-09-20 | Naidu Lp | Coenzyme Q10, lactoferrin and angiogenin compositions and uses thereof |
| ES2286951B1 (es) | 2006-05-26 | 2008-10-01 | Instituto Cientifico Y Tecnologico De Navarra, S.A | Nanoparticulas bioadhesivas para la administracion de moleculas biologicamente activas. |
| US20090053197A1 (en) | 2006-06-14 | 2009-02-26 | Ramaekers Joseph C | Transfer Factor Compositions and Methods |
| CA2668417A1 (en) * | 2006-11-03 | 2008-05-15 | Alphavax, Inc. | Alphavirus and alphavirus replicon particle formulations and methods |
| GB0705245D0 (en) * | 2007-03-19 | 2007-04-25 | Stabilitech Ltd | Stable biological products |
| AU2008231072B2 (en) | 2007-03-22 | 2013-08-01 | The Regents Of The University Of Colorado | Method of preparing an immunologically-active adjuvant-bound dried vaccine composition |
| EP2150537A4 (en) | 2007-06-01 | 2010-09-22 | Acologix Inc | STABLE PEPTIDE FORMULATION AT HIGH TEMPERATURE |
| WO2009006097A1 (en) | 2007-06-29 | 2009-01-08 | Johnson & Johnson Regenerative Therapeutics, Llc | Liquid protein formulations comprising gdf-5 for use at elevated temperatures |
| CN101835479A (zh) | 2007-07-25 | 2010-09-15 | 佰欧益有限公司 | 多系祖细胞分化为软骨细胞 |
| US20090123436A1 (en) | 2007-11-08 | 2009-05-14 | Surmodics, Inc. | Cryopreservative compositions and methods |
| BRPI0911048A2 (pt) | 2008-04-14 | 2015-12-29 | Atrm Llc | formulações líquidas tamponadas de gdf-5 |
| EP2278997B1 (en) | 2008-04-21 | 2016-08-10 | Nanobio Corporation | Nanoemulsion influenza vaccine |
| US20110212127A1 (en) * | 2008-09-24 | 2011-09-01 | Stabilitech Ltd. | Method for Preserving Polypeptides Using a Sugar and Polyethyleneimine |
| GB2479069B (en) | 2008-09-24 | 2012-07-25 | Stabilitech Ltd | Method for preserving polypeptides using a sugar and polyethyleneimine |
| BRPI0915696B8 (pt) | 2008-11-07 | 2021-05-25 | Serum Institute Of India Ltd | composição de vacina de rotavírus liofilizada e método de preparar a referida composição |
| WO2010132508A2 (en) | 2009-05-11 | 2010-11-18 | Biomatrica, Inc. | Compositions and methods for biological sample storage |
| CN101670104A (zh) | 2009-09-24 | 2010-03-17 | 浙江大学 | 一种含人参皂甙的油佐剂及其制备方法 |
| US20130171128A1 (en) | 2010-03-02 | 2013-07-04 | Amgen Inc. | Reducing viscosity of pharmaceutical formulations |
| HUE042330T2 (hu) | 2010-03-31 | 2019-06-28 | Stabilitech Biopharma Ltd | Módszer alumínium adjuvánsok és alumíniummal adjuvált vakcinák megóvására |
| AU2011234264B2 (en) | 2010-03-31 | 2016-02-04 | Stabilitech Ltd | Excipients for stabilising viral particles, polypeptides or biological material |
| US10206960B2 (en) | 2010-03-31 | 2019-02-19 | Stabilitech Biopharma Ltd | Stabilisation of viral particles |
| GB201117233D0 (en) | 2011-10-05 | 2011-11-16 | Stabilitech Ltd | Stabilisation of polypeptides |
| GB201406569D0 (en) * | 2014-04-11 | 2014-05-28 | Stabilitech Ltd | Vaccine compositions |
| KR20190104051A (ko) | 2017-01-06 | 2019-09-05 | 스타빌리테크 바이오파마 리미티드 | 바이러스 |
| GB2562241B (en) | 2017-05-08 | 2022-04-06 | Stabilitech Biopharma Ltd | Vaccine compositions |
-
2011
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- 2011-03-31 EP EP11714594.6A patent/EP2552478B1/en active Active
- 2011-03-31 CN CN2011800181285A patent/CN102892427A/zh active Pending
- 2011-03-31 KR KR1020127028704A patent/KR101884953B1/ko not_active Expired - Fee Related
- 2011-03-31 GB GB1216473.7A patent/GB2490644A/en not_active Withdrawn
- 2011-03-31 WO PCT/GB2011/000493 patent/WO2011121301A1/en not_active Ceased
- 2011-03-31 US US13/637,913 patent/US20130164296A1/en not_active Abandoned
- 2011-03-31 ES ES11714594.6T patent/ES2617921T3/es active Active
- 2011-03-31 JP JP2013501930A patent/JP5869553B2/ja active Active
- 2011-03-31 DK DK11714594.6T patent/DK2552478T3/en active
- 2011-03-31 KR KR1020177022631A patent/KR101943429B1/ko not_active Expired - Fee Related
- 2011-03-31 CA CA2795047A patent/CA2795047C/en active Active
- 2011-03-31 BR BR112012025047A patent/BR112012025047A2/pt not_active Application Discontinuation
- 2011-03-31 HU HUE11714594A patent/HUE033656T2/en unknown
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2012
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