JP2013523694A - 局所麻酔薬の生体接着性組成物 - Google Patents

局所麻酔薬の生体接着性組成物 Download PDF

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JP2013523694A
JP2013523694A JP2013501854A JP2013501854A JP2013523694A JP 2013523694 A JP2013523694 A JP 2013523694A JP 2013501854 A JP2013501854 A JP 2013501854A JP 2013501854 A JP2013501854 A JP 2013501854A JP 2013523694 A JP2013523694 A JP 2013523694A
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pharmaceutical composition
weight
composition according
amount
local anesthetic
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JP2013501854A
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Japanese (ja)
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JP2013523694A5 (enExample
Inventor
スンドベリ，マルク
ブローディン，アルネ
グスタヴソン，ヨナス
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ファーマネスト・エイビイ
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0023—Heat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Anesthesiology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Biochemistry (AREA)
  • Emergency Medicine (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2013501854A 2010-04-01 2011-03-31 局所麻酔薬の生体接着性組成物 Pending JP2013523694A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
SE1050322 2010-04-01
SE1050322-5 2010-04-01
US32542510P 2010-04-19 2010-04-19
US61/325,425 2010-04-19
PCT/EP2011/055025 WO2011121082A1 (en) 2010-04-01 2011-03-31 Bioadhesive compositions of local anaesthetics

Publications (2)

Publication Number Publication Date
JP2013523694A true JP2013523694A (ja) 2013-06-17
JP2013523694A5 JP2013523694A5 (enExample) 2014-05-22

Family

ID=44278867

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013501854A Pending JP2013523694A (ja) 2010-04-01 2011-03-31 局所麻酔薬の生体接着性組成物

Country Status (17)

Country Link
US (1) US20130079371A1 (enExample)
EP (1) EP2552409A1 (enExample)
JP (1) JP2013523694A (enExample)
KR (1) KR20130080435A (enExample)
CN (1) CN102869344A (enExample)
AU (1) AU2011234415C1 (enExample)
BR (1) BR112012024885A2 (enExample)
CA (1) CA2794280A1 (enExample)
CL (1) CL2012002705A1 (enExample)
EA (1) EA201290790A1 (enExample)
IL (1) IL222225A0 (enExample)
MX (1) MX2012011261A (enExample)
NZ (1) NZ602540A (enExample)
PH (1) PH12012501887A1 (enExample)
SG (1) SG184072A1 (enExample)
WO (1) WO2011121082A1 (enExample)
ZA (1) ZA201206989B (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017082121A1 (ja) 2015-11-12 2017-05-18 テルモ株式会社 徐放性局所投与剤
US10517859B2 (en) 2015-03-25 2019-12-31 Terumo Kabushiki Kaisha Gel local anesthetic agent and gel local anesthetic preparation using same
JP2020519635A (ja) * 2017-05-08 2020-07-02 アリヴィオ セラピューティクス， インコーポレイテッド 増大した薬剤負荷および接着のためのナノ構造化ゲルの製剤

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9642912B2 (en) 2006-03-06 2017-05-09 Crescita Therapeutics Inc. Topical formulations for treating skin conditions
US9308181B2 (en) 2006-03-06 2016-04-12 Nuvo Research Inc. Topical formulations, systems and methods
US20110229565A1 (en) 2008-09-17 2011-09-22 Karp Jeffrey M Drug Delivery Composition Comprising a Self-Assembled Gelator
JP2013540757A (ja) 2010-09-24 2013-11-07 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド カプセル化された作用物質の放出を制御する能力を有するナノ構造ゲル
US10220093B2 (en) 2013-02-28 2019-03-05 Mira Pharma Corporation Long-acting semi-solid lipid formulations
EP2961380B1 (en) * 2013-02-28 2020-04-08 Mira Pharma Corporation Injectable long-acting local anesthetic semi-solid formulations and its compositions
GB201317718D0 (en) 2013-10-07 2013-11-20 Buzzz Pharmaceuticals Ltd Novel formulation
WO2018144991A1 (en) 2017-02-03 2018-08-09 The Brigham And Women's Hospital, Inc. Self-assembled gels formed with anti-retroviral drugs, prodrugs thereof, and pharmaceutical uses thereof
US10561606B2 (en) 2017-12-06 2020-02-18 Mira Pharma Corporation Injectable long-acting local anesthetic semi-solid gel formulations
US11426418B2 (en) 2017-12-06 2022-08-30 Mira Pharma Corporation Injectable long-acting semi-solid gel formulations
JP7046396B2 (ja) 2017-12-06 2022-04-04 湖州惠中濟世生物科技有限公司 注射可能な長時間作用性局所麻酔薬半固形製剤
US11839605B2 (en) 2018-10-11 2023-12-12 Alivio Therapeutics, Inc. Non-injectable hydrogel formulations for smart release
EP4284272A4 (en) * 2021-01-29 2024-12-25 Insitu Biologics, Inc. COMPOSITIONS AND METHODS OF SUSTAINED TREATMENT OF PAIN
CN118697692B (zh) * 2024-06-27 2024-11-26 山东中医药大学附属医院 一种防苦麻醉胶浆剂、方法及应用
CN119587525B (zh) * 2024-11-07 2025-09-05 海南三帝制药有限公司 一种二甲卡因复合制剂及其制备方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01156919A (ja) * 1987-06-24 1989-06-20 Fujisawa Pharmaceut Co Ltd 経皮吸収用製剤
JPH09510980A (ja) * 1994-03-30 1997-11-04 デュメックス―アルファルマ エイ／エス 生物付着性物質としての脂肪酸エステルの使用
JP2008100939A (ja) * 2006-10-18 2008-05-01 Nichiban Co Ltd 皮膚刺激の少ない経皮吸収型製剤
JP2008526934A (ja) * 2005-01-14 2008-07-24 カムルス エービー ＧｎＲＨ類似体製剤
JP2009518374A (ja) * 2005-12-07 2009-05-07 ファーマコデックス リミテッド 活性薬剤、特にジクロフェナクの経皮投与
JP2009537513A (ja) * 2006-05-16 2009-10-29 マクニール アーベー トロメタモールを緩衝性作用物質として含有する、ニコチンの口腔内送り込み用薬用製品

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9601421D0 (sv) 1996-04-12 1996-04-12 Astra Ab New composition
ATE214599T1 (de) * 1996-10-14 2002-04-15 Kowa Co Lokalanästhetikum zur aüsserlichen anwendung
US20040001889A1 (en) * 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
WO2004071398A2 (en) * 2003-02-17 2004-08-26 Cipla Ltd Pharmaceutical patch
US20050084508A1 (en) 2003-07-22 2005-04-21 Vancaillie Thierry G. Topical anesthesia formulation for bodily cavities
JP4931369B2 (ja) 2005-05-31 2012-05-16 ポーラ化成工業株式会社 リポソームおよびそれを含む処置用の組成物
CA2623561C (en) * 2005-09-27 2015-04-28 Efrat Biopolymers Ltd. Gelling hydrophobic injectable polymer compositions
US20070280972A1 (en) * 2006-04-25 2007-12-06 Zars, Inc. Adhesive solid gel-forming formulations for dermal drug delivery
US9918934B2 (en) 2006-12-12 2018-03-20 Edgar Joel Acosta-Zara Linker-based lecithin microemulsion delivery vehicles
US20090247494A1 (en) 2008-04-01 2009-10-01 Phillip Mark Kofsky Omega-3 essential fatty acid composition and method for treatment of anal and colon-rectal disorders

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01156919A (ja) * 1987-06-24 1989-06-20 Fujisawa Pharmaceut Co Ltd 経皮吸収用製剤
JPH09510980A (ja) * 1994-03-30 1997-11-04 デュメックス―アルファルマ エイ／エス 生物付着性物質としての脂肪酸エステルの使用
JP2008526934A (ja) * 2005-01-14 2008-07-24 カムルス エービー ＧｎＲＨ類似体製剤
JP2009518374A (ja) * 2005-12-07 2009-05-07 ファーマコデックス リミテッド 活性薬剤、特にジクロフェナクの経皮投与
JP2009537513A (ja) * 2006-05-16 2009-10-29 マクニール アーベー トロメタモールを緩衝性作用物質として含有する、ニコチンの口腔内送り込み用薬用製品
JP2008100939A (ja) * 2006-10-18 2008-05-01 Nichiban Co Ltd 皮膚刺激の少ない経皮吸収型製剤

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10517859B2 (en) 2015-03-25 2019-12-31 Terumo Kabushiki Kaisha Gel local anesthetic agent and gel local anesthetic preparation using same
WO2017082121A1 (ja) 2015-11-12 2017-05-18 テルモ株式会社 徐放性局所投与剤
JP2020519635A (ja) * 2017-05-08 2020-07-02 アリヴィオ セラピューティクス， インコーポレイテッド 増大した薬剤負荷および接着のためのナノ構造化ゲルの製剤
JP2022103299A (ja) * 2017-05-08 2022-07-07 アリヴィオ セラピューティクス， インコーポレイテッド 増大した薬剤負荷および接着のためのナノ構造化ゲルの製剤
JP7211974B2 (ja) 2017-05-08 2023-01-24 アリヴィオ セラピューティクス， インコーポレイテッド 増大した薬剤負荷および接着のためのナノ構造化ゲルの製剤
JP2023041861A (ja) * 2017-05-08 2023-03-24 アリヴィオ セラピューティクス， インコーポレイテッド 増大した薬剤負荷および接着のためのナノ構造化ゲルの製剤

Also Published As

Publication number Publication date
US20130079371A1 (en) 2013-03-28
SG184072A1 (en) 2012-10-30
AU2011234415A1 (en) 2012-10-18
CA2794280A1 (en) 2011-10-06
MX2012011261A (es) 2012-12-05
WO2011121082A1 (en) 2011-10-06
EP2552409A1 (en) 2013-02-06
EA201290790A1 (ru) 2013-04-30
AU2011234415B2 (en) 2014-04-10
CN102869344A (zh) 2013-01-09
CL2012002705A1 (es) 2013-02-01
AU2011234415C1 (en) 2014-07-10
NZ602540A (en) 2014-05-30
PH12012501887A1 (en) 2012-12-17
BR112012024885A2 (pt) 2016-06-21
KR20130080435A (ko) 2013-07-12
IL222225A0 (en) 2012-12-31
ZA201206989B (en) 2014-04-30

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