JP2013523694A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013523694A5 JP2013523694A5 JP2013501854A JP2013501854A JP2013523694A5 JP 2013523694 A5 JP2013523694 A5 JP 2013523694A5 JP 2013501854 A JP2013501854 A JP 2013501854A JP 2013501854 A JP2013501854 A JP 2013501854A JP 2013523694 A5 JP2013523694 A5 JP 2013523694A5
- Authority
- JP
- Japan
- Prior art keywords
- weight
- composition
- composition according
- amount
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 21
- 239000002904 solvent Substances 0.000 claims 5
- 239000003589 local anesthetic agent Substances 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 150000004671 saturated fatty acids Chemical class 0.000 claims 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 4
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 claims 3
- 235000021122 unsaturated fatty acids Nutrition 0.000 claims 3
- 150000004670 unsaturated fatty acids Chemical class 0.000 claims 3
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims 2
- ZKMNUMMKYBVTFN-HNNXBMFYSA-N (S)-ropivacaine Chemical compound CCCN1CCCC[C@H]1C(=O)NC1=C(C)C=CC=C1C ZKMNUMMKYBVTFN-HNNXBMFYSA-N 0.000 claims 2
- RZRNAYUHWVFMIP-KTKRTIGZSA-N 1-oleoylglycerol Chemical group CCCCCCCC\C=C/CCCCCCCC(=O)OCC(O)CO RZRNAYUHWVFMIP-KTKRTIGZSA-N 0.000 claims 2
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims 2
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims 2
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims 2
- 239000005642 Oleic acid Substances 0.000 claims 2
- 206010000210 abortion Diseases 0.000 claims 2
- 231100000176 abortion Toxicity 0.000 claims 2
- RZRNAYUHWVFMIP-HXUWFJFHSA-N glycerol monolinoleate Natural products CCCCCCCCC=CCCCCCCCC(=O)OC[C@H](O)CO RZRNAYUHWVFMIP-HXUWFJFHSA-N 0.000 claims 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims 2
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims 2
- 150000004668 long chain fatty acids Chemical class 0.000 claims 2
- 235000021281 monounsaturated fatty acids Nutrition 0.000 claims 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 2
- WBHHMMIMDMUBKC-XLNAKTSKSA-N ricinelaidic acid Chemical compound CCCCCC[C@@H](O)C\C=C\CCCCCCCC(O)=O WBHHMMIMDMUBKC-XLNAKTSKSA-N 0.000 claims 2
- 229960003656 ricinoleic acid Drugs 0.000 claims 2
- FEUQNCSVHBHROZ-UHFFFAOYSA-N ricinoleic acid Natural products CCCCCCC(O[Si](C)(C)C)CC=CCCCCCCCC(=O)OC FEUQNCSVHBHROZ-UHFFFAOYSA-N 0.000 claims 2
- 229960001549 ropivacaine Drugs 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 235000003441 saturated fatty acids Nutrition 0.000 claims 2
- LEBVLXFERQHONN-UHFFFAOYSA-N 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Chemical compound CCCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-UHFFFAOYSA-N 0.000 claims 1
- 206010000234 Abortion spontaneous Diseases 0.000 claims 1
- 235000021314 Palmitic acid Nutrition 0.000 claims 1
- 235000021355 Stearic acid Nutrition 0.000 claims 1
- OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical class CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 claims 1
- 229960003150 bupivacaine Drugs 0.000 claims 1
- 239000004359 castor oil Substances 0.000 claims 1
- 235000019438 castor oil Nutrition 0.000 claims 1
- 210000003679 cervix uteri Anatomy 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000004720 fertilization Effects 0.000 claims 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 229960004288 levobupivacaine Drugs 0.000 claims 1
- LEBVLXFERQHONN-INIZCTEOSA-N levobupivacaine Chemical compound CCCCN1CCCC[C@H]1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-INIZCTEOSA-N 0.000 claims 1
- 229960005015 local anesthetics Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims 1
- 239000012074 organic phase Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229950008882 polysorbate Drugs 0.000 claims 1
- 229920000136 polysorbate Polymers 0.000 claims 1
- 208000000995 spontaneous abortion Diseases 0.000 claims 1
- 239000008117 stearic acid Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE1050322 | 2010-04-01 | ||
| SE1050322-5 | 2010-04-01 | ||
| US32542510P | 2010-04-19 | 2010-04-19 | |
| US61/325,425 | 2010-04-19 | ||
| PCT/EP2011/055025 WO2011121082A1 (en) | 2010-04-01 | 2011-03-31 | Bioadhesive compositions of local anaesthetics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013523694A JP2013523694A (ja) | 2013-06-17 |
| JP2013523694A5 true JP2013523694A5 (enExample) | 2014-05-22 |
Family
ID=44278867
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013501854A Pending JP2013523694A (ja) | 2010-04-01 | 2011-03-31 | 局所麻酔薬の生体接着性組成物 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20130079371A1 (enExample) |
| EP (1) | EP2552409A1 (enExample) |
| JP (1) | JP2013523694A (enExample) |
| KR (1) | KR20130080435A (enExample) |
| CN (1) | CN102869344A (enExample) |
| AU (1) | AU2011234415C1 (enExample) |
| BR (1) | BR112012024885A2 (enExample) |
| CA (1) | CA2794280A1 (enExample) |
| CL (1) | CL2012002705A1 (enExample) |
| EA (1) | EA201290790A1 (enExample) |
| IL (1) | IL222225A0 (enExample) |
| MX (1) | MX2012011261A (enExample) |
| NZ (1) | NZ602540A (enExample) |
| PH (1) | PH12012501887A1 (enExample) |
| SG (1) | SG184072A1 (enExample) |
| WO (1) | WO2011121082A1 (enExample) |
| ZA (1) | ZA201206989B (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9642912B2 (en) | 2006-03-06 | 2017-05-09 | Crescita Therapeutics Inc. | Topical formulations for treating skin conditions |
| US9308181B2 (en) | 2006-03-06 | 2016-04-12 | Nuvo Research Inc. | Topical formulations, systems and methods |
| US20110229565A1 (en) | 2008-09-17 | 2011-09-22 | Karp Jeffrey M | Drug Delivery Composition Comprising a Self-Assembled Gelator |
| JP2013540757A (ja) | 2010-09-24 | 2013-11-07 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド | カプセル化された作用物質の放出を制御する能力を有するナノ構造ゲル |
| US10220093B2 (en) | 2013-02-28 | 2019-03-05 | Mira Pharma Corporation | Long-acting semi-solid lipid formulations |
| EP2961380B1 (en) * | 2013-02-28 | 2020-04-08 | Mira Pharma Corporation | Injectable long-acting local anesthetic semi-solid formulations and its compositions |
| GB201317718D0 (en) | 2013-10-07 | 2013-11-20 | Buzzz Pharmaceuticals Ltd | Novel formulation |
| JP6678946B2 (ja) | 2015-03-25 | 2020-04-15 | テルモ株式会社 | ゲル状局所麻酔剤およびそれを用いたゲル状局所麻酔製剤 |
| EP3375456B1 (en) | 2015-11-12 | 2023-05-03 | Terumo Kabushiki Kaisha | Sustained-release topically administered agent |
| WO2018144991A1 (en) | 2017-02-03 | 2018-08-09 | The Brigham And Women's Hospital, Inc. | Self-assembled gels formed with anti-retroviral drugs, prodrugs thereof, and pharmaceutical uses thereof |
| US10881745B2 (en) * | 2017-05-08 | 2021-01-05 | Alivio Therapeutics, Inc. | Formulation of nanostructured gels for increased agent loading and adhesion |
| US10561606B2 (en) | 2017-12-06 | 2020-02-18 | Mira Pharma Corporation | Injectable long-acting local anesthetic semi-solid gel formulations |
| US11426418B2 (en) | 2017-12-06 | 2022-08-30 | Mira Pharma Corporation | Injectable long-acting semi-solid gel formulations |
| JP7046396B2 (ja) | 2017-12-06 | 2022-04-04 | 湖州惠中濟世生物科技有限公司 | 注射可能な長時間作用性局所麻酔薬半固形製剤 |
| US11839605B2 (en) | 2018-10-11 | 2023-12-12 | Alivio Therapeutics, Inc. | Non-injectable hydrogel formulations for smart release |
| EP4284272A4 (en) * | 2021-01-29 | 2024-12-25 | Insitu Biologics, Inc. | COMPOSITIONS AND METHODS OF SUSTAINED TREATMENT OF PAIN |
| CN118697692B (zh) * | 2024-06-27 | 2024-11-26 | 山东中医药大学附属医院 | 一种防苦麻醉胶浆剂、方法及应用 |
| CN119587525B (zh) * | 2024-11-07 | 2025-09-05 | 海南三帝制药有限公司 | 一种二甲卡因复合制剂及其制备方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5045553A (en) * | 1987-06-24 | 1991-09-03 | Fujisawa Pharmaceutical Company, Ltd. | Pharmaceutical composition for percutaneous drug absorption and percutaneous drug absorption promoter |
| WO1995026715A2 (en) * | 1994-03-30 | 1995-10-12 | Dumex-Alpharma A/S | Use of fatty acid esters as bioadhesive substances |
| SE9601421D0 (sv) | 1996-04-12 | 1996-04-12 | Astra Ab | New composition |
| ATE214599T1 (de) * | 1996-10-14 | 2002-04-15 | Kowa Co | Lokalanästhetikum zur aüsserlichen anwendung |
| US20040001889A1 (en) * | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
| WO2004071398A2 (en) * | 2003-02-17 | 2004-08-26 | Cipla Ltd | Pharmaceutical patch |
| US20050084508A1 (en) | 2003-07-22 | 2005-04-21 | Vancaillie Thierry G. | Topical anesthesia formulation for bodily cavities |
| EP1848403B8 (en) * | 2005-01-14 | 2010-05-19 | Camurus Ab | Topical bioadhesive formulations |
| JP4931369B2 (ja) | 2005-05-31 | 2012-05-16 | ポーラ化成工業株式会社 | リポソームおよびそれを含む処置用の組成物 |
| CA2623561C (en) * | 2005-09-27 | 2015-04-28 | Efrat Biopolymers Ltd. | Gelling hydrophobic injectable polymer compositions |
| GB0524958D0 (en) * | 2005-12-07 | 2006-01-18 | Pharmakodex Ltd | Transdermal administration of active agents |
| US20070280972A1 (en) * | 2006-04-25 | 2007-12-06 | Zars, Inc. | Adhesive solid gel-forming formulations for dermal drug delivery |
| US20070269386A1 (en) * | 2006-05-16 | 2007-11-22 | Per Steen | New product and use and manufacture thereof |
| JP5181320B2 (ja) * | 2006-10-18 | 2013-04-10 | ニチバン株式会社 | 皮膚刺激の少ない経皮吸収型製剤 |
| US9918934B2 (en) | 2006-12-12 | 2018-03-20 | Edgar Joel Acosta-Zara | Linker-based lecithin microemulsion delivery vehicles |
| US20090247494A1 (en) | 2008-04-01 | 2009-10-01 | Phillip Mark Kofsky | Omega-3 essential fatty acid composition and method for treatment of anal and colon-rectal disorders |
-
2011
- 2011-03-31 SG SG2012068250A patent/SG184072A1/en unknown
- 2011-03-31 CA CA2794280A patent/CA2794280A1/en not_active Abandoned
- 2011-03-31 PH PH1/2012/501887A patent/PH12012501887A1/en unknown
- 2011-03-31 JP JP2013501854A patent/JP2013523694A/ja active Pending
- 2011-03-31 CN CN2011800166567A patent/CN102869344A/zh active Pending
- 2011-03-31 BR BR112012024885A patent/BR112012024885A2/pt not_active IP Right Cessation
- 2011-03-31 NZ NZ602540A patent/NZ602540A/en not_active IP Right Cessation
- 2011-03-31 EP EP11711566A patent/EP2552409A1/en not_active Withdrawn
- 2011-03-31 KR KR1020127028642A patent/KR20130080435A/ko not_active Withdrawn
- 2011-03-31 EA EA201290790A patent/EA201290790A1/ru unknown
- 2011-03-31 US US13/638,519 patent/US20130079371A1/en not_active Abandoned
- 2011-03-31 MX MX2012011261A patent/MX2012011261A/es not_active Application Discontinuation
- 2011-03-31 AU AU2011234415A patent/AU2011234415C1/en not_active Ceased
- 2011-03-31 WO PCT/EP2011/055025 patent/WO2011121082A1/en not_active Ceased
-
2012
- 2012-09-18 ZA ZA2012/06989A patent/ZA201206989B/en unknown
- 2012-09-27 IL IL222225A patent/IL222225A0/en unknown
- 2012-09-27 CL CL2012002705A patent/CL2012002705A1/es unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2013523694A5 (enExample) | ||
| NZ602540A (en) | Bioadhesive compositions of local anaesthetics | |
| CN104968368B (zh) | 固溶体组合物及其在剧痛中的用途 | |
| AU2014363599B2 (en) | Orally disintegrating solid dosage unit containing an estetrol component | |
| JP2011510984A5 (enExample) | ||
| RU2013124514A (ru) | Воспалительное заболевание | |
| JP2015520237A5 (enExample) | ||
| FI3360575T3 (fi) | Ihon kautta annosteltavat farmaseuttiset koostumukset, jotka käsittävät vaikuttavia aineita | |
| JP2016510041A5 (enExample) | ||
| JP2008540394A5 (enExample) | ||
| JP2007523049A5 (enExample) | ||
| JP2013522230A5 (enExample) | ||
| HRP20171319T1 (hr) | Monolitni intravaginalni prsten koji sadrži progesteron i metode njegove izrade i uporabe | |
| BR112012019374A2 (pt) | composição farmacêutica, pellet de liberação prolongada, composição farmacêutica oral, método para tratamento de uma doença neurodegenerativa ou um dano ao sistema nervoso em um indivíduo necessitado do mesmo e método para preparação de uma formulação de liberação prolongada de um agente ativo | |
| IL251413B2 (en) | Composition of injectable buprenorphine | |
| NZ596946A (en) | Solid compositions comprising 5-aminolevulinic acid | |
| JP2018526351A (ja) | Ｎｓａｉｄのための固溶体組成物 | |
| CN102892408A (zh) | 适于局部麻醉剂的无水药物组合物 | |
| JP2015522649A5 (enExample) | ||
| TW201444553A (zh) | 外用醫藥組成物 | |
| BR112012017476A2 (pt) | composto, composição, método para preparar uma composição, uso de um composto, e, métodos para tratar doenças, para inibir um alérgico peptidase do ácaro da poeira, para exterminar ácaros, para controlar uma população de ácaros | |
| UA109642C2 (uk) | Композиція для лікування захворювань сітківки із застосуванням інтраокулярної тампонади | |
| JP2017529377A5 (enExample) | ||
| JP2020182497A5 (enExample) | ||
| JP2020526507A (ja) | ホットフラッシュの新規処置法 |