JP2013521297A5 - - Google Patents
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- Publication number
- JP2013521297A5 JP2013521297A5 JP2012556166A JP2012556166A JP2013521297A5 JP 2013521297 A5 JP2013521297 A5 JP 2013521297A5 JP 2012556166 A JP2012556166 A JP 2012556166A JP 2012556166 A JP2012556166 A JP 2012556166A JP 2013521297 A5 JP2013521297 A5 JP 2013521297A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- symptoms
- hormonal
- dextromethorphan
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 22
- 230000003054 hormonal effect Effects 0.000 claims 10
- 208000024891 symptom Diseases 0.000 claims 10
- UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapentin Chemical compound OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 claims 6
- MKXZASYAUGDDCJ-SZMVWBNQSA-N LSM-2525 Chemical compound C1CCC[C@H]2[C@@]3([H])N(C)CC[C@]21C1=CC(OC)=CC=C1C3 MKXZASYAUGDDCJ-SZMVWBNQSA-N 0.000 claims 6
- 229960001985 dextromethorphan Drugs 0.000 claims 6
- 239000012848 Dextrorphan Substances 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- JAQUASYNZVUNQP-PVAVHDDUSA-N dextrorphan Chemical compound C1C2=CC=C(O)C=C2[C@@]23CCN(C)[C@@H]1[C@H]2CCCC3 JAQUASYNZVUNQP-PVAVHDDUSA-N 0.000 claims 4
- 229950006878 dextrorphan Drugs 0.000 claims 4
- 206010029410 night sweats Diseases 0.000 claims 4
- 230000036565 night sweats Effects 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 229960002870 gabapentin Drugs 0.000 claims 3
- 206010016825 Flushing Diseases 0.000 claims 2
- 206010060800 Hot flush Diseases 0.000 claims 2
- 238000013270 controlled release Methods 0.000 claims 2
- 239000002552 dosage form Substances 0.000 claims 2
- 238000013268 sustained release Methods 0.000 claims 2
- 239000012730 sustained-release form Substances 0.000 claims 2
- YKFCISHFRZHKHY-NGQGLHOPSA-N (2s)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid;trihydrate Chemical compound O.O.O.OC(=O)[C@](N)(C)CC1=CC=C(O)C(O)=C1.OC(=O)[C@](N)(C)CC1=CC=C(O)C(O)=C1 YKFCISHFRZHKHY-NGQGLHOPSA-N 0.000 claims 1
- RTHCYVBBDHJXIQ-MRXNPFEDSA-N (R)-fluoxetine Chemical compound O([C@H](CCNC)C=1C=CC=CC=1)C1=CC=C(C(F)(F)F)C=C1 RTHCYVBBDHJXIQ-MRXNPFEDSA-N 0.000 claims 1
- ZEUITGRIYCTCEM-KRWDZBQOSA-N (S)-duloxetine Chemical compound C1([C@@H](OC=2C3=CC=CC=C3C=CC=2)CCNC)=CC=CS1 ZEUITGRIYCTCEM-KRWDZBQOSA-N 0.000 claims 1
- GJSURZIOUXUGAL-UHFFFAOYSA-N Clonidine Chemical compound ClC1=CC=CC(Cl)=C1NC1=NCCN1 GJSURZIOUXUGAL-UHFFFAOYSA-N 0.000 claims 1
- 229940083181 centrally acting adntiadrenergic agent methyldopa Drugs 0.000 claims 1
- 229940035811 conjugated estrogen Drugs 0.000 claims 1
- 229960002866 duloxetine Drugs 0.000 claims 1
- 229960002464 fluoxetine Drugs 0.000 claims 1
- VGKDLMBJGBXTGI-SJCJKPOMSA-N sertraline Chemical compound C1([C@@H]2CC[C@@H](C3=CC=CC=C32)NC)=CC=C(Cl)C(Cl)=C1 VGKDLMBJGBXTGI-SJCJKPOMSA-N 0.000 claims 1
- 229960002073 sertraline Drugs 0.000 claims 1
- PNVNVHUZROJLTJ-UHFFFAOYSA-N venlafaxine Chemical compound C1=CC(OC)=CC=C1C(CN(C)C)C1(O)CCCCC1 PNVNVHUZROJLTJ-UHFFFAOYSA-N 0.000 claims 1
- 229960004688 venlafaxine Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30963810P | 2010-03-02 | 2010-03-02 | |
| US61/309,638 | 2010-03-02 | ||
| PCT/US2011/026650 WO2011109367A2 (en) | 2010-03-02 | 2011-03-01 | Methods and compositions for treating or preventing symptoms of hormonal variations |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013521297A JP2013521297A (ja) | 2013-06-10 |
| JP2013521297A5 true JP2013521297A5 (enExample) | 2014-05-15 |
| JP5839362B2 JP5839362B2 (ja) | 2016-01-06 |
Family
ID=44531862
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012556166A Active JP5839362B2 (ja) | 2010-03-02 | 2011-03-01 | ホルモン変動の症状を治療または予防するための方法および組成物 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20110218213A1 (enExample) |
| EP (1) | EP2542241B1 (enExample) |
| JP (1) | JP5839362B2 (enExample) |
| CN (1) | CN102858343B (enExample) |
| AU (3) | AU2011223807B2 (enExample) |
| BR (1) | BR112012022052B1 (enExample) |
| CA (1) | CA2828041C (enExample) |
| EA (1) | EA027350B1 (enExample) |
| ES (1) | ES2574210T3 (enExample) |
| IL (2) | IL221706A (enExample) |
| PL (1) | PL2542241T3 (enExample) |
| WO (1) | WO2011109367A2 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9616123B1 (en) * | 2012-03-05 | 2017-04-11 | Robert L. Knobler | Method and compound for treatment of menopausal symptoms |
| CA2980990A1 (en) * | 2015-04-07 | 2016-10-13 | Meiji Co., Ltd. | Hot flash-suppressing agent |
| US11622948B2 (en) | 2017-11-09 | 2023-04-11 | The Trustees Of Columbia University In The City Of New York | Biomarkers for efficacy of prophylactic treatments against stress-induced affective disorders |
| US11491120B2 (en) | 2017-11-09 | 2022-11-08 | The Trustees Of Columbia University In The City Of New York | Pharmacological prophylactics against stress-induced affective disorders in females |
| JP2022532851A (ja) * | 2019-04-22 | 2022-07-20 | エル クノブラー、ロバート | ホットフラッシュの非ホルモン治療 |
| WO2021108801A2 (en) * | 2019-11-15 | 2021-06-03 | Consegna Pharma, Inc. | Long acting nmda antagonists |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5321012A (en) * | 1993-01-28 | 1994-06-14 | Virginia Commonwealth University Medical College | Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance |
| CA2115792C (en) * | 1993-03-05 | 2005-11-01 | David J. Mayer | Method for the treatment of pain |
| ATE212830T1 (de) * | 1993-11-19 | 2002-02-15 | Alkermes Inc | Herstellung biologisch abbaubarer, einen biologisch aktiven stoff enthaltender, mikropartikel |
| AUPN605795A0 (en) * | 1995-10-19 | 1995-11-09 | F.H. Faulding & Co. Limited | Analgesic pharmaceutical composition |
| PT1202725E (pt) * | 1999-07-22 | 2007-07-11 | Universuty Of Rochester | Método para tratar sintomas de alteração hormonal, incluindo afrontamentos. |
| US20040002482A1 (en) * | 2000-08-30 | 2004-01-01 | Dudley Robert E. | Androgen pharmaceutical composition and method for treating depression |
| US6569471B2 (en) * | 2000-09-01 | 2003-05-27 | Natumin Pharma Ab | Method for the treatment of symptoms related to normal hormonal variations in women |
| US20050129783A1 (en) * | 2001-04-19 | 2005-06-16 | Mccleary Edward L. | Composition and method for treatment of neurophysiological conditions and maintenance of neurophysiological health |
| US20040259850A1 (en) * | 2001-10-31 | 2004-12-23 | Alves Stephen E. | Method for treating or preventing symptoms of hormonal variation including hot flashes |
| RU2340333C2 (ru) * | 2002-08-15 | 2008-12-10 | Вайет | Агонизм 5нт2a -рецептора для лечения нарушения функции терморегуляции |
| HUP0303313A2 (hu) * | 2003-10-09 | 2005-07-28 | Richter Gedeon Vegyészeti Gyár Rt. | Transzdermális gyógyszerkészítmények |
| US7855195B2 (en) * | 2003-12-02 | 2010-12-21 | Pharmaneuroboost N.V. | Method of treating mental disorders using D4 and 5-HT2A antagonists, inverse agonists or partial agonists |
| WO2005107808A2 (en) * | 2004-05-11 | 2005-11-17 | Pfizer Products Inc. | Combination of atypical antipsychotics and 5-ht1b receptor antagonists |
| EP1758600A4 (en) * | 2004-06-04 | 2008-03-05 | Mood Man Sciences Llc | METHOD AND COMPOSITIONS FOR TREATING MUTUAL DISORDER |
| US20060122127A1 (en) * | 2004-11-17 | 2006-06-08 | Cypress Bioscience, Inc. | Methods for reducing the side effects associated with mirtzapine treatment |
| CN101257907A (zh) * | 2005-07-06 | 2008-09-03 | 塞普拉科公司 | 左旋佐匹克隆和抗抑郁剂的组合 |
| EP1969117A4 (en) * | 2005-12-13 | 2008-12-17 | Trinity Lab Inc | A method to treat premature ejaculation in humans |
| WO2007092329A2 (en) * | 2006-02-03 | 2007-08-16 | Avanir Pharmaceuticals | Pharmaceutical compositions for treating depression, anxiety and neurodegenerative disorders |
| US7645750B2 (en) * | 2006-12-13 | 2010-01-12 | Yung Shin Pharmaceutical Ind. Co., Ltd. | Method of treating symptoms of hormonal variations |
| WO2008116024A2 (en) * | 2007-03-19 | 2008-09-25 | Acadia Pharmaceuticals Inc. | Combinations of 5-ht2a inverse agonists and antagonists with antipsychotics |
| EP2323688B1 (en) * | 2008-07-22 | 2018-10-17 | MenoGeniX, Inc. | Compositions and methods for treating symptoms associated with menopause, hormonal variations and arthritis |
-
2011
- 2011-03-01 CN CN201180020427.2A patent/CN102858343B/zh active Active
- 2011-03-01 CA CA2828041A patent/CA2828041C/en active Active
- 2011-03-01 BR BR112012022052-7A patent/BR112012022052B1/pt active IP Right Grant
- 2011-03-01 EP EP11751180.8A patent/EP2542241B1/en active Active
- 2011-03-01 EA EA201290851A patent/EA027350B1/ru unknown
- 2011-03-01 JP JP2012556166A patent/JP5839362B2/ja active Active
- 2011-03-01 WO PCT/US2011/026650 patent/WO2011109367A2/en not_active Ceased
- 2011-03-01 AU AU2011223807A patent/AU2011223807B2/en active Active
- 2011-03-01 US US13/037,728 patent/US20110218213A1/en not_active Abandoned
- 2011-03-01 ES ES11751180.8T patent/ES2574210T3/es active Active
- 2011-03-01 PL PL11751180.8T patent/PL2542241T3/pl unknown
-
2012
- 2012-08-30 IL IL221706A patent/IL221706A/en active IP Right Grant
-
2016
- 2016-08-10 AU AU2016213776A patent/AU2016213776B2/en active Active
-
2017
- 2017-08-06 IL IL253853A patent/IL253853B/en active IP Right Grant
-
2018
- 2018-07-12 AU AU2018205147A patent/AU2018205147A1/en not_active Abandoned
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