JP2013521297A5 - - Google Patents
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- Publication number
- JP2013521297A5 JP2013521297A5 JP2012556166A JP2012556166A JP2013521297A5 JP 2013521297 A5 JP2013521297 A5 JP 2013521297A5 JP 2012556166 A JP2012556166 A JP 2012556166A JP 2012556166 A JP2012556166 A JP 2012556166A JP 2013521297 A5 JP2013521297 A5 JP 2013521297A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- symptoms
- hormonal
- dextromethorphan
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 22
- 230000003054 hormonal effect Effects 0.000 claims 10
- 208000024891 symptom Diseases 0.000 claims 10
- UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapentin Chemical compound OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 claims 6
- MKXZASYAUGDDCJ-SZMVWBNQSA-N LSM-2525 Chemical compound C1CCC[C@H]2[C@@]3([H])N(C)CC[C@]21C1=CC(OC)=CC=C1C3 MKXZASYAUGDDCJ-SZMVWBNQSA-N 0.000 claims 6
- 229960001985 dextromethorphan Drugs 0.000 claims 6
- 239000012848 Dextrorphan Substances 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- JAQUASYNZVUNQP-PVAVHDDUSA-N dextrorphan Chemical compound C1C2=CC=C(O)C=C2[C@@]23CCN(C)[C@@H]1[C@H]2CCCC3 JAQUASYNZVUNQP-PVAVHDDUSA-N 0.000 claims 4
- 229950006878 dextrorphan Drugs 0.000 claims 4
- 206010029410 night sweats Diseases 0.000 claims 4
- 230000036565 night sweats Effects 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 229960002870 gabapentin Drugs 0.000 claims 3
- 206010016825 Flushing Diseases 0.000 claims 2
- 206010060800 Hot flush Diseases 0.000 claims 2
- 238000013270 controlled release Methods 0.000 claims 2
- 239000002552 dosage form Substances 0.000 claims 2
- 238000013268 sustained release Methods 0.000 claims 2
- 239000012730 sustained-release form Substances 0.000 claims 2
- YKFCISHFRZHKHY-NGQGLHOPSA-N (2s)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid;trihydrate Chemical compound O.O.O.OC(=O)[C@](N)(C)CC1=CC=C(O)C(O)=C1.OC(=O)[C@](N)(C)CC1=CC=C(O)C(O)=C1 YKFCISHFRZHKHY-NGQGLHOPSA-N 0.000 claims 1
- RTHCYVBBDHJXIQ-MRXNPFEDSA-N (R)-fluoxetine Chemical compound O([C@H](CCNC)C=1C=CC=CC=1)C1=CC=C(C(F)(F)F)C=C1 RTHCYVBBDHJXIQ-MRXNPFEDSA-N 0.000 claims 1
- ZEUITGRIYCTCEM-KRWDZBQOSA-N (S)-duloxetine Chemical compound C1([C@@H](OC=2C3=CC=CC=C3C=CC=2)CCNC)=CC=CS1 ZEUITGRIYCTCEM-KRWDZBQOSA-N 0.000 claims 1
- GJSURZIOUXUGAL-UHFFFAOYSA-N Clonidine Chemical compound ClC1=CC=CC(Cl)=C1NC1=NCCN1 GJSURZIOUXUGAL-UHFFFAOYSA-N 0.000 claims 1
- 229940083181 centrally acting adntiadrenergic agent methyldopa Drugs 0.000 claims 1
- 229940035811 conjugated estrogen Drugs 0.000 claims 1
- 229960002866 duloxetine Drugs 0.000 claims 1
- 229960002464 fluoxetine Drugs 0.000 claims 1
- VGKDLMBJGBXTGI-SJCJKPOMSA-N sertraline Chemical compound C1([C@@H]2CC[C@@H](C3=CC=CC=C32)NC)=CC=C(Cl)C(Cl)=C1 VGKDLMBJGBXTGI-SJCJKPOMSA-N 0.000 claims 1
- 229960002073 sertraline Drugs 0.000 claims 1
- PNVNVHUZROJLTJ-UHFFFAOYSA-N venlafaxine Chemical compound C1=CC(OC)=CC=C1C(CN(C)C)C1(O)CCCCC1 PNVNVHUZROJLTJ-UHFFFAOYSA-N 0.000 claims 1
- 229960004688 venlafaxine Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30963810P | 2010-03-02 | 2010-03-02 | |
| US61/309,638 | 2010-03-02 | ||
| PCT/US2011/026650 WO2011109367A2 (en) | 2010-03-02 | 2011-03-01 | Methods and compositions for treating or preventing symptoms of hormonal variations |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013521297A JP2013521297A (ja) | 2013-06-10 |
| JP2013521297A5 true JP2013521297A5 (enExample) | 2014-05-15 |
| JP5839362B2 JP5839362B2 (ja) | 2016-01-06 |
Family
ID=44531862
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012556166A Active JP5839362B2 (ja) | 2010-03-02 | 2011-03-01 | ホルモン変動の症状を治療または予防するための方法および組成物 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20110218213A1 (enExample) |
| EP (1) | EP2542241B1 (enExample) |
| JP (1) | JP5839362B2 (enExample) |
| CN (1) | CN102858343B (enExample) |
| AU (3) | AU2011223807B2 (enExample) |
| BR (1) | BR112012022052B1 (enExample) |
| CA (1) | CA2828041C (enExample) |
| EA (1) | EA027350B1 (enExample) |
| ES (1) | ES2574210T3 (enExample) |
| IL (2) | IL221706A (enExample) |
| PL (1) | PL2542241T3 (enExample) |
| WO (1) | WO2011109367A2 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9616123B1 (en) * | 2012-03-05 | 2017-04-11 | Robert L. Knobler | Method and compound for treatment of menopausal symptoms |
| JP6038416B1 (ja) * | 2015-04-07 | 2016-12-07 | 株式会社明治 | 火照り抑制剤 |
| WO2019094596A1 (en) | 2017-11-09 | 2019-05-16 | The Trustees Of Columbia University In The City Of New York | Biomarkers for efficacy of prophylactic treatments against stress-induced affective disorders |
| US11491120B2 (en) | 2017-11-09 | 2022-11-08 | The Trustees Of Columbia University In The City Of New York | Pharmacological prophylactics against stress-induced affective disorders in females |
| EP3958862A4 (en) * | 2019-04-22 | 2023-01-25 | Robert L. Knobler | NON-HORMONIC HOT FLASH TREATMENT |
| US20220401366A1 (en) * | 2019-11-15 | 2022-12-22 | Consegna Pharma, Inc. | Long acting nmda antagonists |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5321012A (en) * | 1993-01-28 | 1994-06-14 | Virginia Commonwealth University Medical College | Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance |
| CA2115792C (en) * | 1993-03-05 | 2005-11-01 | David J. Mayer | Method for the treatment of pain |
| EP2283821A1 (en) * | 1993-11-19 | 2011-02-16 | Alkermes, Inc. | Preparation of biodegradable microparticles containing a biologically active agent |
| AUPN605795A0 (en) * | 1995-10-19 | 1995-11-09 | F.H. Faulding & Co. Limited | Analgesic pharmaceutical composition |
| NZ517044A (en) * | 1999-07-22 | 2004-02-27 | Univ Rochester | Gamma-aminobutyric acid analogues, e.g. gabapentin and pregabalin, to treat symptoms of hormonal variation, including hot flushes, nausea, emesis and fever |
| US20040002482A1 (en) * | 2000-08-30 | 2004-01-01 | Dudley Robert E. | Androgen pharmaceutical composition and method for treating depression |
| US6569471B2 (en) * | 2000-09-01 | 2003-05-27 | Natumin Pharma Ab | Method for the treatment of symptoms related to normal hormonal variations in women |
| US20050129783A1 (en) * | 2001-04-19 | 2005-06-16 | Mccleary Edward L. | Composition and method for treatment of neurophysiological conditions and maintenance of neurophysiological health |
| WO2003037334A1 (en) * | 2001-10-31 | 2003-05-08 | Merck & Co., Inc. | Method for treating or preventing symptoms of hormonal variation including hot flashes |
| EP1534258A2 (en) * | 2002-08-15 | 2005-06-01 | Wyeth | AGONISM OF THE 5HT 2a RECEPTOR FOR TREATMENT OF THERMOREGULATORY DYSFUNCTION |
| HUP0303313A2 (hu) * | 2003-10-09 | 2005-07-28 | Richter Gedeon Vegyészeti Gyár Rt. | Transzdermális gyógyszerkészítmények |
| US7855195B2 (en) * | 2003-12-02 | 2010-12-21 | Pharmaneuroboost N.V. | Method of treating mental disorders using D4 and 5-HT2A antagonists, inverse agonists or partial agonists |
| EP1753460A2 (en) * | 2004-05-11 | 2007-02-21 | Pfizer Products Inc. | Combination of atypical antipsychotics and 5-ht1b receptor antagonists |
| CA2569411A1 (en) * | 2004-06-04 | 2005-12-22 | Mood Management Sciences, Llc | Methods and compositions for treating mood disorder |
| EP1827450A4 (en) * | 2004-11-17 | 2009-04-22 | Cypress Bioscience Inc | METHOD FOR REDUCING THE SIDE EFFECTS OF TREATMENT WITH MIRTAZAPINE |
| MX2008000248A (es) * | 2005-07-06 | 2008-03-19 | Sepracor Inc | Combinaciones de eszopiclona y un antidepresivo y metodos de tratamiento contra la menopausia y trastornos del estado de animo, la ansiedad y trastornos cognitivos. |
| JP5528705B2 (ja) * | 2005-12-13 | 2014-06-25 | トリニティ ラボラトリーズ インコーポレイテッド | ヒトにおける早漏を治療するための方法 |
| JP2009525343A (ja) * | 2006-02-03 | 2009-07-09 | アバニール・ファーマシューティカルズ | 鬱病、不安および神経変性疾患を治療するためのデキストロメトルファンおよびキニジンを含む薬剤組成物 |
| US7645750B2 (en) * | 2006-12-13 | 2010-01-12 | Yung Shin Pharmaceutical Ind. Co., Ltd. | Method of treating symptoms of hormonal variations |
| ES2423485T3 (es) * | 2007-03-19 | 2013-09-20 | Acadia Pharmaceuticals Inc. | Asociaciones de agonistas y antagonistas inversos 5-HT2A con antipsicóticos |
| CN102223893B (zh) * | 2008-07-22 | 2014-07-16 | 曼诺吉尼克斯公司 | 治疗与绝经、激素改变和关节炎相关的症状的组合物和方法 |
-
2011
- 2011-03-01 ES ES11751180.8T patent/ES2574210T3/es active Active
- 2011-03-01 WO PCT/US2011/026650 patent/WO2011109367A2/en not_active Ceased
- 2011-03-01 EA EA201290851A patent/EA027350B1/ru unknown
- 2011-03-01 US US13/037,728 patent/US20110218213A1/en not_active Abandoned
- 2011-03-01 AU AU2011223807A patent/AU2011223807B2/en active Active
- 2011-03-01 CN CN201180020427.2A patent/CN102858343B/zh active Active
- 2011-03-01 JP JP2012556166A patent/JP5839362B2/ja active Active
- 2011-03-01 EP EP11751180.8A patent/EP2542241B1/en active Active
- 2011-03-01 PL PL11751180.8T patent/PL2542241T3/pl unknown
- 2011-03-01 CA CA2828041A patent/CA2828041C/en active Active
- 2011-03-01 BR BR112012022052-7A patent/BR112012022052B1/pt active IP Right Grant
-
2012
- 2012-08-30 IL IL221706A patent/IL221706A/en active IP Right Grant
-
2016
- 2016-08-10 AU AU2016213776A patent/AU2016213776B2/en active Active
-
2017
- 2017-08-06 IL IL253853A patent/IL253853B/en active IP Right Grant
-
2018
- 2018-07-12 AU AU2018205147A patent/AU2018205147A1/en not_active Abandoned
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