JP2013521297A5 - - Google Patents
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- Publication number
- JP2013521297A5 JP2013521297A5 JP2012556166A JP2012556166A JP2013521297A5 JP 2013521297 A5 JP2013521297 A5 JP 2013521297A5 JP 2012556166 A JP2012556166 A JP 2012556166A JP 2012556166 A JP2012556166 A JP 2012556166A JP 2013521297 A5 JP2013521297 A5 JP 2013521297A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- symptoms
- hormonal
- dextromethorphan
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 22
- 230000003054 hormonal Effects 0.000 claims 10
- MKXZASYAUGDDCJ-SZMVWBNQSA-N Dextromethorphan Chemical compound C1CCC[C@H]2[C@@]3([H])N(C)CC[C@]21C1=CC(OC)=CC=C1C3 MKXZASYAUGDDCJ-SZMVWBNQSA-N 0.000 claims 6
- 229960001985 Dextromethorphan Drugs 0.000 claims 6
- JAQUASYNZVUNQP-PVAVHDDUSA-N Dextrorphan Chemical compound C1C2=CC=C(O)C=C2[C@@]23CCN(C)[C@@H]1[C@H]2CCCC3 JAQUASYNZVUNQP-PVAVHDDUSA-N 0.000 claims 4
- 229950006878 Dextrorphan Drugs 0.000 claims 4
- 206010029410 Night sweats Diseases 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- 230000036565 night sweats Effects 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000011780 sodium chloride Substances 0.000 claims 4
- UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapen Chemical compound OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 claims 3
- 229960002870 gabapentin Drugs 0.000 claims 3
- 206010016825 Flushing Diseases 0.000 claims 2
- 206010060800 Hot flush Diseases 0.000 claims 2
- 239000002552 dosage form Substances 0.000 claims 2
- 230000002459 sustained Effects 0.000 claims 2
- GJSURZIOUXUGAL-UHFFFAOYSA-N 2-((2,6-Dichlorophenyl)imino)imidazolidine Chemical compound ClC1=CC=CC(Cl)=C1NC1=NCCN1 GJSURZIOUXUGAL-UHFFFAOYSA-N 0.000 claims 1
- ZEUITGRIYCTCEM-KRWDZBQOSA-N Duloxetine Chemical compound C1([C@@H](OC=2C3=CC=CC=C3C=CC=2)CCNC)=CC=CS1 ZEUITGRIYCTCEM-KRWDZBQOSA-N 0.000 claims 1
- 229960002464 Fluoxetine Drugs 0.000 claims 1
- CJCSPKMFHVPWAR-JTQLQIEISA-N Methyldopa Chemical compound OC(=O)[C@](N)(C)CC1=CC=C(O)C(O)=C1 CJCSPKMFHVPWAR-JTQLQIEISA-N 0.000 claims 1
- 229960000615 Methyldopa Drugs 0.000 claims 1
- RTHCYVBBDHJXIQ-UHFFFAOYSA-N N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine Chemical compound C=1C=CC=CC=1C(CCNC)OC1=CC=C(C(F)(F)F)C=C1 RTHCYVBBDHJXIQ-UHFFFAOYSA-N 0.000 claims 1
- VGKDLMBJGBXTGI-SJCJKPOMSA-N Sertraline Chemical compound C1([C@@H]2CC[C@@H](C3=CC=CC=C32)NC)=CC=C(Cl)C(Cl)=C1 VGKDLMBJGBXTGI-SJCJKPOMSA-N 0.000 claims 1
- 229960002073 Sertraline Drugs 0.000 claims 1
- 229940083181 centrally acting adntiadrenergic agents Methyldopa Drugs 0.000 claims 1
- 229940035811 conjugated estrogens Drugs 0.000 claims 1
- 229960002866 duloxetine Drugs 0.000 claims 1
- PNVNVHUZROJLTJ-UHFFFAOYSA-N venlafaxine Chemical compound C1=CC(OC)=CC=C1C(CN(C)C)C1(O)CCCCC1 PNVNVHUZROJLTJ-UHFFFAOYSA-N 0.000 claims 1
- 229960004688 venlafaxine Drugs 0.000 claims 1
Claims (11)
- 顔面潮紅および寝汗を引き起こす1以上のホルモン変動の症状がある被験者におけるホルモン変動の症状の治療用の、制御放出剤形又は持続性放出剤形の医薬組成物であって、有効量のデキストロメトルファン若しくはデキストロルファン、又はその薬学的に許容可能な塩を含むことを特徴とする医薬組成物。
- 請求項1に記載の医薬組成物において、前記デキストロメトルファンがデキストロメトルファンHBrであることを特徴とする医薬組成物。
- 請求項1に記載の医薬組成物において、前記有効量が1日当たり0.1ないし120mgであることを特徴とする医薬組成物。
- 請求項1に記載の医薬組成物において、前記被験者が女性であることを特徴とする医薬組成物。
- 請求項1に記載の医薬組成物において、前記被験者が男性であることを特徴とする医薬組成物。
- 顔面潮紅および寝汗を引き起こす1以上のホルモン変動の症状がある被験者におけるホルモン変動の症状の治療用の、経皮パッチ形態の医薬組成物であって、有効量のデキストロメトルファン若しくはデキストロルファン、又はその薬学的に許容可能な塩を含むことを特徴とする医薬組成物。
- 顔面潮紅および寝汗を引き起こす1以上のホルモン変動の症状がある被験者におけるホルモン変動の症状の治療用の、制御放出剤形又は持続性放出剤形の医薬組成物であって、有効量のデキストロメトルファン若しくはデキストロルファン、又はその薬学的に許容可能な塩と、前記ホルモン変動の症状を軽減することが知られている別の化合物とを含むことを特徴とする医薬組成物。
- 請求項7に記載の医薬組成物において、前記別の化合物が、結合型エストロゲン、ブプロピアン、ベンラファキシン、フルオキセチン、デュロキセチン、セルトラリン、クロニジン、クロニジン塩酸塩、メチルドパ、及びガバペンチンからなる群から選択されることを特徴とする医薬組成物。
- 請求項8に記載の医薬組成物において、前記別の化合物がガバペンチンであることを特徴とする医薬組成物。
- 請求項9に記載の医薬組成物において、前記有効量が1日当たり0.1ないし120mgであり、前記ガバペンチンの量が1日当たり1mgないし900mgであることを特徴とする医薬組成物。
- 顔面潮紅および寝汗を引き起こす1以上のホルモン変動の症状がある被験者におけるホルモン変動の症状の治療用の、経皮パッチ形態の医薬組成物であって、有効量のデキストロメトルファン若しくはデキストロルファン、又はその薬学的に許容可能な塩と、前記ホルモン変動の症状を軽減することが知られている別の化合物とを含むことを特徴とする医薬組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30963810P | 2010-03-02 | 2010-03-02 | |
US61/309,638 | 2010-03-02 | ||
PCT/US2011/026650 WO2011109367A2 (en) | 2010-03-02 | 2011-03-01 | Methods and compositions for treating or preventing symptoms of hormonal variations |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2013521297A JP2013521297A (ja) | 2013-06-10 |
JP2013521297A5 true JP2013521297A5 (ja) | 2014-05-15 |
JP5839362B2 JP5839362B2 (ja) | 2016-01-06 |
Family
ID=44531862
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2012556166A Active JP5839362B2 (ja) | 2010-03-02 | 2011-03-01 | ホルモン変動の症状を治療または予防するための方法および組成物 |
Country Status (12)
Country | Link |
---|---|
US (1) | US20110218213A1 (ja) |
EP (1) | EP2542241B1 (ja) |
JP (1) | JP5839362B2 (ja) |
CN (1) | CN102858343B (ja) |
AU (3) | AU2011223807B2 (ja) |
BR (1) | BR112012022052B1 (ja) |
CA (1) | CA2828041C (ja) |
EA (1) | EA027350B1 (ja) |
ES (1) | ES2574210T3 (ja) |
IL (2) | IL221706A (ja) |
PL (1) | PL2542241T3 (ja) |
WO (1) | WO2011109367A2 (ja) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9616123B1 (en) * | 2012-03-05 | 2017-04-11 | Robert L. Knobler | Method and compound for treatment of menopausal symptoms |
SG11201708162UA (en) * | 2015-04-07 | 2017-11-29 | Meiji Co Ltd | Hot flash-suppressing agent |
WO2019094757A1 (en) * | 2017-11-09 | 2019-05-16 | The Trustees Of Columbia University In The City Of New York | Pharmacological prophylactics against stress-induced affective disorders in females |
WO2019094596A1 (en) | 2017-11-09 | 2019-05-16 | The Trustees Of Columbia University In The City Of New York | Biomarkers for efficacy of prophylactic treatments against stress-induced affective disorders |
SG11202112822VA (en) * | 2019-04-22 | 2021-12-30 | Robert Knobler | Non-hormonal treatment of hot flashes |
WO2021108801A2 (en) * | 2019-11-15 | 2021-06-03 | Consegna Pharma, Inc. | Long acting nmda antagonists |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5321012A (en) * | 1993-01-28 | 1994-06-14 | Virginia Commonwealth University Medical College | Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance |
CA2115792C (en) * | 1993-03-05 | 2005-11-01 | David J. Mayer | Method for the treatment of pain |
WO1995013799A1 (en) * | 1993-11-19 | 1995-05-26 | Alkermes Controlled Therapeutics Inc. Ii | Preparation of biodegradable microparticles containing a biologically active agent |
AUPN605795A0 (en) * | 1995-10-19 | 1995-11-09 | F.H. Faulding & Co. Limited | Analgesic pharmaceutical composition |
WO2001007037A1 (en) * | 1999-07-22 | 2001-02-01 | University Of Rochester | Method of treating symptoms of hormonal variation, including hot flashes |
US20040002482A1 (en) * | 2000-08-30 | 2004-01-01 | Dudley Robert E. | Androgen pharmaceutical composition and method for treating depression |
US6569471B2 (en) * | 2000-09-01 | 2003-05-27 | Natumin Pharma Ab | Method for the treatment of symptoms related to normal hormonal variations in women |
US20050129783A1 (en) * | 2001-04-19 | 2005-06-16 | Mccleary Edward L. | Composition and method for treatment of neurophysiological conditions and maintenance of neurophysiological health |
US20040259850A1 (en) * | 2001-10-31 | 2004-12-23 | Alves Stephen E. | Method for treating or preventing symptoms of hormonal variation including hot flashes |
CA2494687A1 (en) * | 2002-08-15 | 2004-02-26 | Wyeth | Agonism of the 5ht2a receptor for treatment of thermoregulatory dysfunction |
HUP0303313A2 (hu) * | 2003-10-09 | 2005-07-28 | Richter Gedeon Vegyészeti Gyár Rt. | Transzdermális gyógyszerkészítmények |
US7855195B2 (en) * | 2003-12-02 | 2010-12-21 | Pharmaneuroboost N.V. | Method of treating mental disorders using D4 and 5-HT2A antagonists, inverse agonists or partial agonists |
JP2007537232A (ja) * | 2004-05-11 | 2007-12-20 | ファイザー・プロダクツ・インク | 非定型抗精神病薬と5−ht1b受容体拮抗薬の組合せ |
US20070264358A1 (en) * | 2004-06-04 | 2007-11-15 | Wittlin William A | Methods and Compositions for Treating Mood Disorder |
WO2006055854A2 (en) * | 2004-11-17 | 2006-05-26 | Cypress Bioscience, Inc. | Methods for reducing the side effects associated with mirtazapine treatment |
CN101257907A (zh) * | 2005-07-06 | 2008-09-03 | 塞普拉科公司 | 左旋佐匹克隆和抗抑郁剂的组合 |
WO2007070779A2 (en) * | 2005-12-13 | 2007-06-21 | Trinity Laboratories, Inc. | A method to treat premature ejaculation in humans |
KR20080097443A (ko) * | 2006-02-03 | 2008-11-05 | 아바니르 파마슈티컬스 | 덱스트로메토판 및 퀴니딘을 포함하는, 우울, 불안 및 신경퇴행성 장애 치료용 약제학적 조성물 |
US7645750B2 (en) * | 2006-12-13 | 2010-01-12 | Yung Shin Pharmaceutical Ind. Co., Ltd. | Method of treating symptoms of hormonal variations |
WO2008116024A2 (en) * | 2007-03-19 | 2008-09-25 | Acadia Pharmaceuticals Inc. | Combinations of 5-ht2a inverse agonists and antagonists with antipsychotics |
AU2009274022B2 (en) * | 2008-07-22 | 2016-06-02 | Menogenix, Inc. | Compositions and methods for treating symptoms associated with menopause, hormonal variations and arthritis |
-
2011
- 2011-03-01 CN CN201180020427.2A patent/CN102858343B/zh active Active
- 2011-03-01 WO PCT/US2011/026650 patent/WO2011109367A2/en active Application Filing
- 2011-03-01 PL PL11751180.8T patent/PL2542241T3/pl unknown
- 2011-03-01 US US13/037,728 patent/US20110218213A1/en not_active Abandoned
- 2011-03-01 BR BR112012022052-7A patent/BR112012022052B1/pt active IP Right Grant
- 2011-03-01 JP JP2012556166A patent/JP5839362B2/ja active Active
- 2011-03-01 AU AU2011223807A patent/AU2011223807B2/en active Active
- 2011-03-01 ES ES11751180.8T patent/ES2574210T3/es active Active
- 2011-03-01 CA CA2828041A patent/CA2828041C/en active Active
- 2011-03-01 EA EA201290851A patent/EA027350B1/ru unknown
- 2011-03-01 EP EP11751180.8A patent/EP2542241B1/en active Active
-
2012
- 2012-08-30 IL IL221706A patent/IL221706A/en active IP Right Grant
-
2016
- 2016-08-10 AU AU2016213776A patent/AU2016213776B2/en active Active
-
2017
- 2017-08-06 IL IL253853A patent/IL253853B/en active IP Right Grant
-
2018
- 2018-07-12 AU AU2018205147A patent/AU2018205147A1/en not_active Abandoned
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