JP2013520499A5 - - Google Patents
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- Publication number
- JP2013520499A5 JP2013520499A5 JP2012555022A JP2012555022A JP2013520499A5 JP 2013520499 A5 JP2013520499 A5 JP 2013520499A5 JP 2012555022 A JP2012555022 A JP 2012555022A JP 2012555022 A JP2012555022 A JP 2012555022A JP 2013520499 A5 JP2013520499 A5 JP 2013520499A5
- Authority
- JP
- Japan
- Prior art keywords
- fluoro
- vinca alkaloid
- alkaloid compound
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 15
- 229940122803 Vinca alkaloid Drugs 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 7
- 206010025323 Lymphomas Diseases 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 208000032839 leukemia Diseases 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- IENQGDZVEMPBEM-AGJHSZMPSA-N 10'-fluoroanhydrovinblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C=C(C2)CC)N2CCC2=C1NC1=CC=C(F)C=C21 IENQGDZVEMPBEM-AGJHSZMPSA-N 0.000 claims 1
- JQDGXTXFHANTTF-BUCYGOEWSA-N 10'-fluorovinblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=C(F)C=C21 JQDGXTXFHANTTF-BUCYGOEWSA-N 0.000 claims 1
- IBZBZMSKIKKFRY-BUCYGOEWSA-N 10'-fluorovincristine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C=O)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=C(F)C=C21 IBZBZMSKIKKFRY-BUCYGOEWSA-N 0.000 claims 1
- 102000029749 Microtubule Human genes 0.000 claims 1
- 108091022875 Microtubule Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 210000004688 microtubule Anatomy 0.000 claims 1
- 230000011278 mitosis Effects 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30678610P | 2010-02-22 | 2010-02-22 | |
| US61/306,786 | 2010-02-22 | ||
| PCT/US2011/024230 WO2011103007A2 (en) | 2010-02-22 | 2011-02-09 | 10'-fluorinated vinca alkaloids provide enhanced biological activity against mdr cancer cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013520499A JP2013520499A (ja) | 2013-06-06 |
| JP2013520499A5 true JP2013520499A5 (enExample) | 2014-04-03 |
| JP5542972B2 JP5542972B2 (ja) | 2014-07-09 |
Family
ID=44483528
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012555022A Expired - Fee Related JP5542972B2 (ja) | 2010-02-22 | 2011-02-09 | Ｍｄｒがん細胞に対する強化された生物活性を提供する１０’−フッ素化ビンカアルカロイド |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8940754B2 (enExample) |
| EP (1) | EP2539339B1 (enExample) |
| JP (1) | JP5542972B2 (enExample) |
| AU (1) | AU2011218391B2 (enExample) |
| CA (1) | CA2790602C (enExample) |
| WO (1) | WO2011103007A2 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102363622B (zh) * | 2011-11-24 | 2014-01-29 | 四川大学 | 一种化合物及其制备方法和应用 |
| WO2013112757A1 (en) * | 2012-01-25 | 2013-08-01 | Demerx, Inc. | Indole and benzofuran fused isoquinuclidene derivatives and processes for preparing them |
| EP2925760B1 (en) * | 2012-12-03 | 2018-02-21 | The Scripps Research Institute | C20'-substitited urea derivatives of vinca alkaloids |
| HU230462B1 (hu) * | 2013-05-30 | 2016-07-28 | Richter Gedeon Nyrt. | Új bisz-indol alkaloidok mint rákellenes gyógyszerek |
| US9550789B2 (en) | 2014-06-18 | 2017-01-24 | Demerx, Inc. | Halogenated indole and benzofuran derivatives of isoquinuclidene and processes for preparing them |
| EP3464289B1 (en) | 2016-05-31 | 2021-04-21 | The Scripps Research Institute | Ultra-potent vinca alkaloids: added molecular complexity further disrupts the tubulin dimer-dimer interface |
| CN106336419B (zh) * | 2016-08-23 | 2018-10-16 | 江苏豪森药业集团有限公司 | 酒石酸长春瑞滨的制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LU82514A1 (fr) * | 1980-06-10 | 1982-01-20 | Omnium Chimique Sa | Derives n-(vinblastinoyl-23)d'acides amines,leur preparation et leur application therapeutique |
| FR2761990B1 (fr) | 1997-04-10 | 1999-06-25 | Pf Medicament | Derives halogenes antimitotiques d'alcaloides de vinca |
| US6723338B1 (en) | 1999-04-01 | 2004-04-20 | Inex Pharmaceuticals Corporation | Compositions and methods for treating lymphoma |
| NZ547370A (en) * | 2003-12-04 | 2010-09-30 | Amr Technology Inc | Vinca derivatives |
| FR2905949B1 (fr) * | 2006-09-20 | 2008-11-21 | Pierre Fabre Medicament Sa | Derives fluores de catharanthine, leur preparation et leur utilisation comme precurseurs d'alcaloides dimeres de vinca |
-
2011
- 2011-02-09 US US13/580,340 patent/US8940754B2/en active Active
- 2011-02-09 JP JP2012555022A patent/JP5542972B2/ja not_active Expired - Fee Related
- 2011-02-09 EP EP11745058.5A patent/EP2539339B1/en active Active
- 2011-02-09 WO PCT/US2011/024230 patent/WO2011103007A2/en not_active Ceased
- 2011-02-09 CA CA2790602A patent/CA2790602C/en active Active
- 2011-02-09 AU AU2011218391A patent/AU2011218391B2/en not_active Ceased
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