JP2013520466A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013520466A5 JP2013520466A5 JP2012554332A JP2012554332A JP2013520466A5 JP 2013520466 A5 JP2013520466 A5 JP 2013520466A5 JP 2012554332 A JP2012554332 A JP 2012554332A JP 2012554332 A JP2012554332 A JP 2012554332A JP 2013520466 A5 JP2013520466 A5 JP 2013520466A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkylene
- pyrrolidin
- pyridin
- oxo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30811410P | 2010-02-25 | 2010-02-25 | |
| US61/308,114 | 2010-02-25 | ||
| US33392710P | 2010-05-12 | 2010-05-12 | |
| US61/333,927 | 2010-05-12 | ||
| US38841010P | 2010-09-30 | 2010-09-30 | |
| US61/388,410 | 2010-09-30 | ||
| PCT/EP2011/052662 WO2011104266A1 (en) | 2010-02-25 | 2011-02-23 | Dimeric iap inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013520466A JP2013520466A (ja) | 2013-06-06 |
| JP2013520466A5 true JP2013520466A5 (cg-RX-API-DMAC7.html) | 2014-03-20 |
Family
ID=44476672
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012554332A Pending JP2013520466A (ja) | 2010-02-25 | 2011-02-23 | 二量体ｉａｐ阻害剤 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8445440B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2539333A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2013520466A (cg-RX-API-DMAC7.html) |
| KR (1) | KR20130010894A (cg-RX-API-DMAC7.html) |
| CN (1) | CN102834389A (cg-RX-API-DMAC7.html) |
| AR (1) | AR080253A1 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112012021291A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2790302A1 (cg-RX-API-DMAC7.html) |
| EA (1) | EA201201177A1 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2012009894A (cg-RX-API-DMAC7.html) |
| TW (1) | TW201141846A (cg-RX-API-DMAC7.html) |
| UY (1) | UY33236A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2011104266A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100317593A1 (en) * | 2009-06-12 | 2010-12-16 | Astrazeneca Ab | 2,3-dihydro-1h-indene compounds |
| UY33794A (es) * | 2010-12-13 | 2012-07-31 | Novartis Ag | Inhibidores diméricos de las iap |
| US20140243276A1 (en) | 2011-09-30 | 2014-08-28 | Tetralogic Pharmaceuticals Corporation | Smac mimetic (birinapant) for use in the treatment of proliferative diseases (cancer) |
| US9453048B2 (en) | 2012-08-09 | 2016-09-27 | Bristol-Myers Squibb Company | IAP antagonists |
| CA2930030A1 (en) * | 2012-11-09 | 2014-05-15 | Ensemble Therapeutics Corporation | Macrocyclic compounds for inhibition of inhibitors of apoptosis |
| KR20160030099A (ko) | 2013-06-25 | 2016-03-16 | 더 월터 앤드 엘리자 홀 인스티튜트 오브 메디컬 리서치 | 세포내 감염의 치료 방법 |
| WO2016079527A1 (en) | 2014-11-19 | 2016-05-26 | Tetralogic Birinapant Uk Ltd | Combination therapy |
| WO2016097773A1 (en) | 2014-12-19 | 2016-06-23 | Children's Cancer Institute | Therapeutic iap antagonists for treating proliferative disorders |
| CN109705191B (zh) * | 2017-10-25 | 2022-04-29 | 广东东阳光药业有限公司 | Iap抑制剂及其在药物中的应用 |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6041077B2 (ja) | 1976-09-06 | 1985-09-13 | 喜徳 喜谷 | １，２‐ジアミノシクロヘキサン異性体のシス白金（２）錯体 |
| US5281620A (en) | 1986-12-23 | 1994-01-25 | Cancer Research Campaign Technology Limited | Compounds having antitumor and antibacterial properties |
| PE20010306A1 (es) | 1999-07-02 | 2001-03-29 | Agouron Pharma | Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa |
| GB0018891D0 (en) | 2000-08-01 | 2000-09-20 | Novartis Ag | Organic compounds |
| JP2002037626A (ja) | 2000-07-27 | 2002-02-06 | Internatl Superconductivity Technology Center | ビスマス系高温超電導体の製造方法。 |
| PE20020354A1 (es) | 2000-09-01 | 2002-06-12 | Novartis Ag | Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda) |
| US6995162B2 (en) | 2001-01-12 | 2006-02-07 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
| TWI275390B (en) | 2002-04-30 | 2007-03-11 | Wyeth Corp | Process for the preparation of 7-substituted-3- quinolinecarbonitriles |
| KR20090046973A (ko) | 2002-11-27 | 2009-05-11 | 아이알엠 엘엘씨 | 암세포에서 세포자멸사를 유도하기 위한 방법 및 조성물 |
| JP2007524596A (ja) | 2003-02-28 | 2007-08-30 | トランスフォーム・ファーマシューティカルズ・インコーポレイテッド | 共結晶医薬組成物 |
| CN1953744A (zh) | 2004-02-05 | 2007-04-25 | 诺瓦提斯公司 | Dna拓扑异构酶抑制剂和iap抑制剂的组合 |
| WO2005084317A2 (en) | 2004-03-01 | 2005-09-15 | Board Of Regents, The University Of Texas System | Dimeric small molecule potentiators of apoptosis |
| ES2475207T3 (es) | 2004-07-15 | 2014-07-10 | Tetralogic Pharmaceuticals Corporation | Compuestos de unión a IAP |
| MX2007010371A (es) | 2005-02-25 | 2008-01-11 | Tetralogic Pharmaceuticals | Inhibidores dimericos iap. |
| JP4954983B2 (ja) | 2005-05-18 | 2012-06-20 | ファーマサイエンス・インコーポレイテッド | Ｂｉｒドメイン結合化合物 |
| GB0510390D0 (en) | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
| CA2617642A1 (en) | 2005-08-09 | 2007-02-22 | Tetralogic Pharmaceuticals Corporation | Treatment of proliferative disorders |
| WO2007048224A1 (en) * | 2005-10-25 | 2007-05-03 | Aegera Therapeutics Inc. | Iap bir domain binding compounds |
| KR20080080131A (ko) | 2005-12-20 | 2008-09-02 | 노파르티스 아게 | Ｉａｐ-억제제와 탁산의 조합물 |
| TWI504597B (zh) | 2006-03-16 | 2015-10-21 | Pharmascience Inc | 結合於細胞凋亡抑制蛋白（ｉａｐ）之桿狀病毒ｉａｐ重複序列（ｂｉｒ）區域之化合物 |
| US7807699B2 (en) | 2006-03-21 | 2010-10-05 | Joyant Pharmaceuticals, Inc. | Dimeric pyrrolidine amide-containing small molecule apoptosis promoters |
| US8202902B2 (en) | 2006-05-05 | 2012-06-19 | The Regents Of The University Of Michigan | Bivalent SMAC mimetics and the uses thereof |
| CN101535300B (zh) | 2006-05-16 | 2014-05-28 | 埃格拉医疗公司 | Iap bir域结合化合物 |
| MX2009000824A (es) | 2006-07-24 | 2009-02-04 | Tetralogic Pharmaceuticals Cor | Antagonistas dimericos de las proteinas inhibidoras de la apoptosis. |
| WO2008014240A2 (en) | 2006-07-24 | 2008-01-31 | Tetralogic Pharmaceuticals Corporation | Dimeric iap inhibitors |
| US20100143499A1 (en) | 2006-07-24 | 2010-06-10 | Tetralogic Pharmaceuticals Corporation | Dimeric iap inhibitors |
| JP5452223B2 (ja) | 2006-07-24 | 2014-03-26 | テトラロジック ファーマシューティカルズ コーポレーション | Ｉａｐ阻害剤 |
| WO2008014229A2 (en) | 2006-07-24 | 2008-01-31 | Tetralogic Pharmaceuticals Corporation | Dimeric iap inhibitors |
| US20100056495A1 (en) | 2006-07-24 | 2010-03-04 | Tetralogic Pharmaceuticals Corporation | Dimeric iap inhibitors |
| PE20110220A1 (es) | 2006-08-02 | 2011-04-11 | Novartis Ag | DERIVADOS DE 2-OXO-ETIL-AMINO-PROPIONAMIDA-PIRROLIDIN-2-IL-SUSTITUIDOS COMO INHIBIDORES DEL ENLACE DE LA PROTEINA Smac AL INHIBIDOR DE LA PROTEINA DE APOPTOSIS |
| BRPI0717411A2 (pt) | 2006-10-19 | 2013-11-12 | Novartis Ag | Uso de inibidores de iap |
| JP2010511057A (ja) | 2006-11-28 | 2010-04-08 | ノバルティス アーゲー | 急性骨髄性白血病の処置のためのｉａｐ阻害剤の使用 |
| WO2008066854A2 (en) | 2006-11-28 | 2008-06-05 | Novartis Ag | Methods and compositions for inducing apoptosis in cancer cells |
| KR101149449B1 (ko) | 2007-03-20 | 2012-05-25 | 삼성전자주식회사 | 오디오 신호의 인코딩 방법 및 장치, 그리고 오디오 신호의디코딩 방법 및 장치 |
| JP5454943B2 (ja) | 2007-04-12 | 2014-03-26 | ジョイアント ファーマスーティカルズ、インク． | 抗癌剤として有用なｓｍａｃ模倣二量体及び三量体 |
| WO2008134679A1 (en) | 2007-04-30 | 2008-11-06 | Genentech, Inc. | Inhibitors of iap |
| JP2010528587A (ja) | 2007-05-07 | 2010-08-26 | テトラロジック ファーマシューティカルズ コーポレーション | アポトーシス阻害タンパク質のアンタゴニストに対する感受性のバイオマーカーとしてＴＮＦα遺伝子の発現を用いる方法 |
| EP2205242B1 (en) | 2007-09-12 | 2015-04-15 | Genentech, Inc. | Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods of use |
| JP5348725B2 (ja) | 2007-10-25 | 2013-11-20 | ジェネンテック， インコーポレイテッド | チエノピリミジン化合物の製造方法 |
| EP2058312A1 (en) | 2007-11-09 | 2009-05-13 | Universita' degli Studi di Milano | SMAC mimetic compounds as apoptosis inducers |
| AU2009203971A1 (en) | 2008-01-11 | 2009-07-16 | Genentech, Inc. | Inhibitors of IAP |
| CA2712604A1 (en) | 2008-01-24 | 2009-07-30 | Tetralogic Pharmaceutical Corporation | Iap inhibitors |
| WO2009136290A1 (en) | 2008-05-05 | 2009-11-12 | Aegera Therapeutics, Inc. | Functionalized pyrrolidines and use thereof as iap inhibitors |
| US8168784B2 (en) | 2008-06-20 | 2012-05-01 | Abbott Laboratories | Processes to make apoptosis promoters |
| AU2009261919A1 (en) | 2008-06-27 | 2009-12-30 | Pharmascience Inc. | Bridged secondary amines and use thereof as IAP BIR domain binding compounds |
| JP2011529962A (ja) | 2008-08-02 | 2011-12-15 | ジェネンテック， インコーポレイテッド | Ｉａｐのインヒビター |
| US20120009141A1 (en) | 2008-08-07 | 2012-01-12 | Pharmascience Inc. | Functionalized pyrrolidines and use thereof as iap inhibitors |
| WO2010033531A1 (en) | 2008-09-17 | 2010-03-25 | Tetralogic Pharmaceuticals Corp. | Iap inhibitors |
| WO2010033315A1 (en) | 2008-09-22 | 2010-03-25 | Amgen Inc. | Method of treatment |
| US8283372B2 (en) | 2009-07-02 | 2012-10-09 | Tetralogic Pharmaceuticals Corp. | 2-(1H-indol-3-ylmethyl)-pyrrolidine dimer as a SMAC mimetic |
-
2011
- 2011-02-21 UY UY0001033236A patent/UY33236A/es not_active Application Discontinuation
- 2011-02-23 EP EP11705532A patent/EP2539333A1/en not_active Withdrawn
- 2011-02-23 MX MX2012009894A patent/MX2012009894A/es active IP Right Grant
- 2011-02-23 CA CA2790302A patent/CA2790302A1/en not_active Abandoned
- 2011-02-23 AR ARP110100547A patent/AR080253A1/es unknown
- 2011-02-23 JP JP2012554332A patent/JP2013520466A/ja active Pending
- 2011-02-23 BR BR112012021291A patent/BR112012021291A2/pt not_active IP Right Cessation
- 2011-02-23 WO PCT/EP2011/052662 patent/WO2011104266A1/en not_active Ceased
- 2011-02-23 KR KR1020127024875A patent/KR20130010894A/ko not_active Withdrawn
- 2011-02-23 EA EA201201177A patent/EA201201177A1/ru unknown
- 2011-02-23 US US13/033,463 patent/US8445440B2/en not_active Expired - Fee Related
- 2011-02-23 CN CN2011800177078A patent/CN102834389A/zh active Pending
- 2011-02-24 TW TW100106289A patent/TW201141846A/zh unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2013520466A5 (cg-RX-API-DMAC7.html) | ||
| US9193719B2 (en) | 1,2,4-triazol-5-ones and analogs exhibiting anti-cancer and anti-proliferative activities | |
| CN101506149B (zh) | 脯氨酰羟化酶抑制剂及使用方法 | |
| CN102725283B (zh) | 作为蛋白激酶抑制剂的化合物和组合物 | |
| ES2645947T3 (es) | Inhibidores de actividad de quinasa | |
| KR102341064B1 (ko) | 리소포스파티드산 수용체 1 (lpar1) 억제제 화합물 | |
| JP6473420B2 (ja) | 複素環スルホンアミド誘導体及びそれを含有する医薬 | |
| ES3059917T3 (en) | N-acyl-{4-[(4-aryl-phenyl)sulfonylmethyl]piperidine} compounds and their therapeutic use | |
| US20180057458A1 (en) | Lysyl oxidase-like 2 inhibitors and uses thereof | |
| JP2013121919A (ja) | 血漿カリクレイン阻害剤 | |
| CN112961104A (zh) | 用于治疗nk-1受体相关疾病的取代的4-苯基吡啶 | |
| JP2010515691A (ja) | 第Ｘａ因子阻害剤 | |
| JP2019524702A (ja) | テトラヒドロナフチルリジンペンタンアミドインテグリンアンタゴニスト | |
| JP2015536997A (ja) | カンナビノイド受容体媒介性化合物 | |
| JP2019519593A (ja) | ＭＥＫ／ＰＩ３Ｋ及びｍＴＯＲ／ＭＥＫ／ＰＩ３Ｋ生物学的経路の多官能性阻害剤、並びに同多官能性阻害剤を用いた治療方法 | |
| US20230212138A1 (en) | Phd inhibitor compounds, compositions, and their use | |
| JP2024023490A (ja) | 治療用化合物および組成物 | |
| JP2016513726A (ja) | がん細胞成長阻害剤としてのテトラヒドロイソキノリン−２−イル−（キナゾリン−４−イル）メタノン化合物 | |
| TWI912295B (zh) | Ｐｈｄ抑制劑化合物、組成物及使用方法 | |
| CN103917520A (zh) | 苯基胍衍生物 | |
| KR20260006612A (ko) | 이미다졸 함유 화합물, 이의 유도체 및 이의 용도 | |
| JP7832179B2 (ja) | Ｐｈｄ阻害剤化合物、組成物、及び使用方法 | |
| JP2026503167A (ja) | Ｇｐｒ３５モジュレーター | |
| US20250109105A1 (en) | Compositions and methods for making and using small molecules in the treatment of cancer |