JP2013519722A - (r)−4−((4−((4−(テトラヒドロフラン−3−イルオキシ)ベンゾ[d]イソオキサゾール−3−イルオキシ)メチル)ピペリジン−1−イル)メチル)テトラヒドロ−2h−ピラン−4−オール、5−ht4受容体の部分アゴニスト - Google Patents
(r)−4−((4−((4−(テトラヒドロフラン−3−イルオキシ)ベンゾ[d]イソオキサゾール−3−イルオキシ)メチル)ピペリジン−1−イル)メチル)テトラヒドロ−2h−ピラン−4−オール、5−ht4受容体の部分アゴニスト Download PDFInfo
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30492110P | 2010-02-16 | 2010-02-16 | |
| US61/304,921 | 2010-02-16 | ||
| PCT/IB2011/050548 WO2011101774A1 (en) | 2010-02-16 | 2011-02-09 | (r)-4-((4-((4-(tetrahydrofuran-3-yloxy)benzo[d]isoxazol-3-yloxy)methyl)piperidin-1-yl)methyl)tetrahydro-2h-pyran-4-ol, a partial agonist of 5-ht4 receptors |
Publications (1)
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|---|---|
| JP2013519722A true JP2013519722A (ja) | 2013-05-30 |
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| JP2012553423A Withdrawn JP2013519722A (ja) | 2010-02-16 | 2011-02-09 | (r)−4−((4−((4−(テトラヒドロフラン−3−イルオキシ)ベンゾ[d]イソオキサゾール−3−イルオキシ)メチル)ピペリジン−1−イル)メチル)テトラヒドロ−2h−ピラン−4−オール、5−ht4受容体の部分アゴニスト |
Country Status (15)
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|---|---|
| US (1) | US20120041026A1 (enExample) |
| EP (1) | EP2536713A1 (enExample) |
| JP (1) | JP2013519722A (enExample) |
| KR (1) | KR20120123089A (enExample) |
| CN (1) | CN102762554A (enExample) |
| AR (1) | AR080172A1 (enExample) |
| AU (1) | AU2011216950A1 (enExample) |
| CA (1) | CA2788656A1 (enExample) |
| IN (1) | IN2012DN06631A (enExample) |
| MX (1) | MX2012008721A (enExample) |
| SG (1) | SG183111A1 (enExample) |
| TW (1) | TW201141856A (enExample) |
| UY (1) | UY33225A (enExample) |
| WO (1) | WO2011101774A1 (enExample) |
| ZA (1) | ZA201206469B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10583138B2 (en) | 2012-07-12 | 2020-03-10 | Glytech, Llc | Composition and method for treatment of depression and psychosis in humans |
| US9737531B2 (en) | 2012-07-12 | 2017-08-22 | Glytech, Llc | Composition and method for treatment of depression and psychosis in humans |
| CN103702995B (zh) * | 2011-05-18 | 2016-04-13 | 拉夸里亚创药株式会社 | 4-{[4-({[4-(2,2,2-三氟乙氧基)-1,2-苯并异噁唑-3-基]氧}甲基)哌啶-1-基]甲基}-四氢-2h-吡喃-4-羧酸的多晶型形式 |
| CA2890861C (en) * | 2012-11-21 | 2021-03-30 | Raqualia Pharma Inc. | Polymorphic forms of 4-{[4-({[4-(2,2,2-trifluoroethoxy)-1,2-benzisoxazol-3-yl]oxy}methyl)piperidin-1-yl]methyl}-tetrahydro-2h-pyran-4-carboxylic acid |
| AP2015008742A0 (en) | 2013-03-20 | 2015-09-30 | Suven Life Sciences Ltd | 5-amino quinoline-8-carboxamide derivatives as 5-ht4 receptor agonists |
| CN105873920B (zh) | 2013-12-16 | 2018-06-08 | 苏文生命科学有限公司 | 作为5-ht4受体激动剂的吲唑化合物 |
| JP6572414B2 (ja) * | 2014-05-20 | 2019-09-11 | ラクオリア創薬株式会社 | ベンズイソオキサゾール誘導体塩 |
| MX368214B (es) | 2015-02-13 | 2019-09-24 | Suven Life Sciences Ltd | Compuestos de amida como agonistas del receptor de la 5-hidroxitriptamina 4 (5-ht4). |
| CN117796401A (zh) * | 2023-12-25 | 2024-04-02 | 江苏万隆化学有限公司 | 一种含2-羟基-6-氟苯甲酸甲酯中间体抗菌剂的制备工艺 |
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| HU217425B (hu) | 1991-02-27 | 2000-01-28 | Merrell Dow Pharmaceuticals Inc. | Eljárás NMDA antagonista hatású kinolinszármazékok és ezeket tartalmazó gyógyszerkészítmények előállítására |
| US5750542A (en) * | 1993-09-28 | 1998-05-12 | Pfizer | Benzisoxazole and benzisothizole derivatives as cholinesterase inhibitors |
| NZ243065A (en) * | 1991-06-13 | 1995-07-26 | Lundbeck & Co As H | Piperidine derivatives and pharmaceutical compositions |
| CA2149918A1 (en) * | 1992-11-23 | 1994-06-09 | Mark G. Palermo | Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds |
| IL117149A0 (en) | 1995-02-23 | 1996-06-18 | Schering Corp | Muscarinic antagonists |
| US5889006A (en) | 1995-02-23 | 1999-03-30 | Schering Corporation | Muscarinic antagonists |
| CZ292379B6 (cs) | 1995-09-29 | 2003-09-17 | Glaxo Wellcome Spa | Tetrahydrochinolinové deriváty, způsob jejich výroby a farmaceutický prostředek s jejich obsahem |
| IL126003A0 (en) | 1996-04-10 | 1999-04-11 | Hoechst Marion Roussel Inc | Spiro [cyclopent [b] indole-piperidines] and n-[phenyl-hydrazon intermediates for their preparation both being acetyl cholinesterase and mao inhibitors |
| CA2252039C (en) | 1996-04-12 | 2002-12-24 | Hoechst Marion Roussel, Inc. | Isatin derivatives as acetylcholinesterase inhibitors and analgesics |
| AU717431B2 (en) | 1996-07-01 | 2000-03-23 | Schering Corporation | Muscarinic antagonists |
| JP3390179B2 (ja) | 1996-08-15 | 2003-03-24 | シェーリング コーポレイション | エーテルムスカリン様アンタゴニスト |
| ATE309215T1 (de) | 1996-09-30 | 2005-11-15 | Aventis Pharma Inc | Nmda (n-methyl-d-aspartate) antagonists |
| AU758802B2 (en) | 1998-09-30 | 2003-03-27 | Takeda Pharmaceutical Company Limited | Drugs for improving vesical excretory strength |
| WO2002059074A1 (en) | 2001-01-26 | 2002-08-01 | Sankyo Company, Limited | Benzylamine analogue |
| CA2440284A1 (en) | 2001-03-08 | 2002-09-19 | Emory University | Ph-dependent nmda receptor antagonists |
| CA2443108A1 (en) | 2001-04-03 | 2002-10-17 | Merck & Co. Inc. | N-substituted nonaryl-heterocyclo amidyl nmda/nr2b antagonists |
| DE60228969D1 (enExample) | 2001-07-24 | 2008-10-30 | Richter Gedeon Nyrt | |
| JP3927228B2 (ja) | 2003-06-04 | 2007-06-06 | メルク エンド カムパニー インコーポレーテッド | Nmda/nr2b拮抗物質としての3−フルオロ−ピペリジン |
| GB0316094D0 (en) | 2003-07-09 | 2003-08-13 | Neuropharma Sa | Acetylcholinesterase dual inhibitors |
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| HU227119B1 (en) | 2004-07-29 | 2010-07-28 | Richter Gedeon Nyrt | Indole and benzimidazole carboxylic acid amide derivatives and pharmaceutical compositions containing them |
| HU227000B1 (en) | 2004-07-29 | 2010-04-28 | Richter Gedeon Nyrt | Nmda receptor antagonist benzoyl urea derivatives, and pharmaceutical compositions containing them |
| HUP0401522A2 (en) | 2004-07-29 | 2006-04-28 | Richter Gedeon Vegyeszet | New 4-benzylidene-piperidine derivatives, pharmaceutical compositions containing the same and process for their preparation |
| HUP0401523A3 (en) | 2004-07-29 | 2007-05-02 | Richter Gedeon Vegyeszet | Indole-2-carboxamide derivatives, pharmaceutical compositions containing them and process for producing them |
| HU226977B1 (en) | 2004-07-29 | 2010-04-28 | Richter Gedeon Nyrt | Kynurenic acid amide derivatives, pharmaceutical compositions containing them and process for producing them |
| TW200621677A (en) | 2004-09-21 | 2006-07-01 | Astellas Pharma Inc | Cyclic amine derivative or salt thereof |
| JP4824693B2 (ja) | 2004-10-15 | 2011-11-30 | ユニベルシダデ フェデラル ド リオ デ ジャネイロ | ピペリジン誘導体、それを含有する薬剤組成物、及び調製方法 |
| WO2006090224A1 (en) | 2005-02-25 | 2006-08-31 | Pfizer Japan Inc. | Benzisoxazole derivatives |
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| WO2007016357A1 (en) | 2005-07-29 | 2007-02-08 | Regents Of The University Of Minnesota | Amyloid beta receptor and uses thereof |
| EP2001463B1 (en) | 2006-03-20 | 2013-07-03 | Council of Scientific and Industrial Research | A pharmaceutical composition useful as acetyl cholinesterase inhibitors |
| ES2288406B1 (es) | 2006-04-20 | 2008-12-16 | Universidad De Barcelona | Compuestos inhibidores de acetilcolinesterasa para el tratamiento de la enfermedad de alzheimer. |
| WO2008074816A1 (en) | 2006-12-20 | 2008-06-26 | Solvay Pharmaceuticals B.V. | Compounds with a combination of cannabinoid-cb1 antagonism and acetylcholinesterase inhibition |
| US7605265B2 (en) | 2007-01-22 | 2009-10-20 | Biotechnology Research Corporation Ltd. | Heterodimers and methods of using them |
| PL2522668T3 (pl) | 2007-05-01 | 2015-07-31 | Concert Pharmaceuticals Inc | Związki morfinanu |
| CN101730706B (zh) | 2007-05-11 | 2015-04-15 | 生物科技研究有限公司 | 具有神经保护和增强记忆活性的受体拮抗剂 |
| MX2009014216A (es) | 2007-06-29 | 2010-07-05 | Univ Emory | Antagonistas del receptor nmda para neuroproteccion. |
| WO2009036235A2 (en) | 2007-09-12 | 2009-03-19 | Virginia Tech Intellectual Properties, Inc. | Insecticidal carbamates exhibiting species-selective inhibition of acetylcholinesterase (ache) |
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| EA014100B1 (ru) | 2008-02-21 | 2010-08-30 | Общество С Ограниченной Ответственностью "Валексфарм" | Производные 2,4-диаминопиридина, фармацевтическая композиция, лекарственное средство на их основе для лечения или предупреждения заболеваний и нарушений, вызванных гиперактивацией nmda-рецепторов и/или в качестве стимуляторов когнитивных функций и способ лечения |
| CN101440061B (zh) | 2008-04-08 | 2010-12-08 | 温州医学院 | 一类具有抑制乙酰胆碱酯酶活性的芳基吡啶酮类衍生物 |
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2011
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- 2011-02-09 CA CA2788656A patent/CA2788656A1/en not_active Abandoned
- 2011-02-09 EP EP11710564A patent/EP2536713A1/en not_active Withdrawn
- 2011-02-09 KR KR1020127021310A patent/KR20120123089A/ko not_active Ceased
- 2011-02-09 JP JP2012553423A patent/JP2013519722A/ja not_active Withdrawn
- 2011-02-09 MX MX2012008721A patent/MX2012008721A/es not_active Application Discontinuation
- 2011-02-09 SG SG2012053906A patent/SG183111A1/en unknown
- 2011-02-09 CN CN2011800099647A patent/CN102762554A/zh active Pending
- 2011-02-09 WO PCT/IB2011/050548 patent/WO2011101774A1/en not_active Ceased
- 2011-02-09 AU AU2011216950A patent/AU2011216950A1/en not_active Abandoned
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- 2011-02-15 TW TW100104942A patent/TW201141856A/zh unknown
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2012
- 2012-08-28 ZA ZA2012/06469A patent/ZA201206469B/en unknown
Also Published As
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|---|---|
| UY33225A (es) | 2011-09-30 |
| US20120041026A1 (en) | 2012-02-16 |
| AU2011216950A1 (en) | 2012-08-23 |
| CA2788656A1 (en) | 2011-08-25 |
| KR20120123089A (ko) | 2012-11-07 |
| TW201141856A (en) | 2011-12-01 |
| AR080172A1 (es) | 2012-03-21 |
| CN102762554A (zh) | 2012-10-31 |
| MX2012008721A (es) | 2012-08-17 |
| SG183111A1 (en) | 2012-09-27 |
| WO2011101774A1 (en) | 2011-08-25 |
| IN2012DN06631A (enExample) | 2015-10-23 |
| EP2536713A1 (en) | 2012-12-26 |
| ZA201206469B (en) | 2013-05-29 |
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