JP2013519636A5 - - Google Patents
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- Publication number
- JP2013519636A5 JP2013519636A5 JP2012552352A JP2012552352A JP2013519636A5 JP 2013519636 A5 JP2013519636 A5 JP 2013519636A5 JP 2012552352 A JP2012552352 A JP 2012552352A JP 2012552352 A JP2012552352 A JP 2012552352A JP 2013519636 A5 JP2013519636 A5 JP 2013519636A5
- Authority
- JP
- Japan
- Prior art keywords
- fviii
- domain
- linked
- psa
- fviii variant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10153718.1 | 2010-02-16 | ||
| EP10153718 | 2010-02-16 | ||
| US30560810P | 2010-02-18 | 2010-02-18 | |
| US61/305,608 | 2010-02-18 | ||
| PCT/EP2011/051723 WO2011101267A1 (en) | 2010-02-16 | 2011-02-07 | Conjugated fviii variants |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013519636A JP2013519636A (ja) | 2013-05-30 |
| JP2013519636A5 true JP2013519636A5 (enExample) | 2014-03-27 |
| JP5933457B2 JP5933457B2 (ja) | 2016-06-08 |
Family
ID=42173354
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012553254A Expired - Fee Related JP5914363B2 (ja) | 2010-02-16 | 2011-02-02 | 低減されたvwf結合を有する因子viii分子 |
| JP2012552352A Expired - Fee Related JP5933457B2 (ja) | 2010-02-16 | 2011-02-07 | コンジュゲートfviiiバリアント |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012553254A Expired - Fee Related JP5914363B2 (ja) | 2010-02-16 | 2011-02-02 | 低減されたvwf結合を有する因子viii分子 |
Country Status (5)
| Country | Link |
|---|---|
| US (4) | US20130040888A1 (enExample) |
| EP (2) | EP2536753B1 (enExample) |
| JP (2) | JP5914363B2 (enExample) |
| CN (3) | CN105524164A (enExample) |
| WO (2) | WO2011101242A1 (enExample) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6263355A (ja) * | 1985-09-13 | 1987-03-20 | Hitachi Ltd | バツテリバツクアツプramのチエツク方法 |
| CA2670618C (en) | 2006-12-15 | 2016-10-04 | Baxter International Inc. | Factor viia- (poly) sialic acid conjugate having prolonged in vivo half-life |
| US9493499B2 (en) | 2007-06-12 | 2016-11-15 | Novo Nordisk A/S | Process for the production of purified cytidinemonophosphate-sialic acid-polyalkylene oxide (CMP-SA-PEG) as modified nucleotide sugars via anion exchange chromatography |
| WO2010091122A1 (en) | 2009-02-03 | 2010-08-12 | Amunix, Inc. | Extended recombinant polypeptides and compositions comprising same |
| US8809501B2 (en) | 2009-07-27 | 2014-08-19 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
| US8642737B2 (en) | 2010-07-26 | 2014-02-04 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
| PL2459224T3 (pl) | 2009-07-27 | 2017-08-31 | Baxalta GmbH | Koniugaty białka związanego z krzepnięciem krwi |
| RU2533619C2 (ru) | 2009-07-27 | 2014-11-20 | Лайпоксен Текнолоджиз Лимитед | Гликополисиалирование белков, не являющихся белками свертывания крови |
| NZ598056A (en) | 2009-07-27 | 2014-01-31 | Baxter Int | Blood coagulation protein conjugates |
| EP2470559B1 (en) | 2009-08-24 | 2017-03-22 | Amunix Operating Inc. | Coagulation factor ix compositions and methods of making and using same |
| WO2011075185A1 (en) | 2009-12-18 | 2011-06-23 | Oligasis | Targeted drug phosphorylcholine polymer conjugates |
| GB201007356D0 (en) | 2010-04-30 | 2010-06-16 | Leverton Licence Holdings Ltd | Conjugated factor VIIa |
| JP6138052B2 (ja) | 2010-12-22 | 2017-05-31 | バクスアルタ ゲーエムベーハー | 水溶性脂肪酸誘導体をタンパク質に抱合させるための材料および方法 |
| RS59670B1 (sr) * | 2012-01-12 | 2020-01-31 | Bioverativ Therapeutics Inc | Himerni polipeptidi faktora viii i njihove upotrebe |
| HUE043537T2 (hu) | 2012-02-15 | 2019-08-28 | Bioverativ Therapeutics Inc | Rekombináns VIII faktor fehérjék |
| PT2814840T (pt) | 2012-02-15 | 2020-01-28 | Bioverativ Therapeutics Inc | Composições de fator viii e métodos de produção e utilização das mesmas |
| MD20140123A2 (ro) * | 2012-04-16 | 2015-04-30 | Cantab Biopharmaceuticals Patents Limited | Agenţi terapeutici optimizaţi pentru administrare subcutanată |
| RS59876B1 (sr) * | 2012-07-11 | 2020-03-31 | Bioverativ Therapeutics Inc | Kompleks faktora viii sa xten i proteinom fon vilebrandovog faktora, i njihova primena |
| JP2015533152A (ja) | 2012-10-15 | 2015-11-19 | ノヴォ・ノルディスク・ヘルス・ケア・アーゲー | 第vii因子コンジュゲート |
| DK2796145T3 (da) * | 2013-04-22 | 2018-01-29 | Csl Ltd | Et kovalent kompleks af von Willebrand-faktor og faktor VIII linket af en disulfidbro |
| TW202003554A (zh) * | 2013-08-14 | 2020-01-16 | 美商百歐維拉提夫治療公司 | 因子viii-xten融合物及其用途 |
| ES2819217T3 (es) * | 2013-09-08 | 2021-04-15 | Kodiak Sciences Inc | Conjugados de polímeros iónicos dipolares y factor VIII |
| BR112016008039A2 (pt) | 2013-10-15 | 2017-10-17 | Novo Nordisk Healthcare Ag | polipeptídeos do fator vii da coagulação |
| EP3091997B1 (en) | 2014-01-10 | 2022-07-06 | Bioverativ Therapeutics Inc. | Factor viii chimeric proteins and uses thereof |
| AR101060A1 (es) * | 2014-02-12 | 2016-11-23 | Novo Nordisk As | Conjugados de fviii |
| AR099328A1 (es) * | 2014-02-12 | 2016-07-13 | Novo Nordisk As | Conjugados de factor vii |
| AR099340A1 (es) * | 2014-02-12 | 2016-07-13 | Novo Nordisk As | Conjugados del factor de coagulación ix |
| CN106459180A (zh) * | 2014-03-23 | 2017-02-22 | 爱德技术生物科学有限公司 | 在铜使用下重组蛋白表达的增强 |
| US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
| WO2016020210A1 (en) | 2014-08-04 | 2016-02-11 | Csl Behring Gmbh | Csl behring gmbh |
| KR20210013299A (ko) | 2014-10-17 | 2021-02-03 | 코디악 사이언시스 인코포레이티드 | 부티릴콜린에스테라제 양성이온성 중합체 컨쥬게이트 |
| EP3042952A1 (en) * | 2015-01-07 | 2016-07-13 | CEVEC Pharmaceuticals GmbH | O-glycan sialylated recombinant glycoproteins and cell lines for producing the same |
| CN107406493B (zh) | 2015-03-06 | 2021-08-13 | 康诺贝林伦瑙有限公司 | 具有改善的半衰期的经修饰的血管性血友病因子 |
| JP6909203B2 (ja) | 2015-08-03 | 2021-07-28 | バイオベラティブ セラピューティクス インコーポレイテッド | 第ix因子融合タンパク質及びそれらの製造方法及び使用方法 |
| WO2017117464A1 (en) * | 2015-12-30 | 2017-07-06 | Kodiak Sciences Inc. | Antibodies and conjugates thereof |
| CN109790529A (zh) | 2016-06-24 | 2019-05-21 | 财团法人牧岩生命科学研究所 | 包含FVIII和vWF因子的嵌合蛋白及其用途 |
| CN109689683A (zh) * | 2016-06-24 | 2019-04-26 | 财团法人牧岩生命科学研究所 | 重组单链fvⅲ及其化学缀合物 |
| BR112019011115A2 (pt) | 2016-12-02 | 2019-10-01 | Bioverativ Therapeutics Inc. | métodos para tratar artropatia hemofílica usando fatores de coagulação quiméricos |
| EP3382014A1 (en) | 2017-03-29 | 2018-10-03 | CEVEC Pharmaceuticals GmbH | Recombinant glycoproteins with reduced antennary fucosylation |
| CN111183151B (zh) | 2017-06-23 | 2024-06-07 | 武田药品工业株式会社 | 因子viii亚种的纯化 |
| EP3441471A1 (en) | 2017-08-08 | 2019-02-13 | CEVEC Pharmaceuticals GmbH | Use of constitutively active variants of growth factor receptors as selection makers for the generation of stable producer cell lines |
| BR112020017872A2 (pt) | 2018-03-02 | 2020-12-22 | Kodiak Sciences Inc. | Anticorpos de il-6 e construtos de fusão e conjugados dos mesmos |
| BR112020022164A2 (pt) | 2018-05-18 | 2021-02-02 | Bioverativ Therapeutics Inc. | métodos de tratamento de hemofilia a |
| EP3816181A4 (en) | 2018-05-18 | 2022-04-20 | Zhengzhou Gensciences Inc. | Improved fviii fusion protein and use thereof |
| KR20220029733A (ko) | 2019-07-04 | 2022-03-08 | 체에스엘 베링 렝나우 아게 | 응고 인자 viii의 시험관내 안정성을 증가시키기 위한 절단된 폰 빌레브란트 인자 (vwf) |
| EP4021479A2 (en) | 2019-08-27 | 2022-07-06 | Tonix Pharma Limited | Modified tff2 polypeptides |
| CA3157509A1 (en) | 2019-10-10 | 2021-04-15 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
| JP7680442B2 (ja) | 2019-11-11 | 2025-05-20 | ツェー・エス・エル・ベーリング・レングナウ・アクチエンゲゼルシャフト | 第viii因子に対する寛容を誘導するためのポリペプチド |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4356170A (en) | 1981-05-27 | 1982-10-26 | Canadian Patents & Development Ltd. | Immunogenic polysaccharide-protein conjugates |
| AU2645588A (en) | 1987-12-04 | 1989-06-15 | Scripps Clinic And Research Foundation | The von willebrand factor binding domain of factor viii |
| US5629384A (en) | 1994-05-17 | 1997-05-13 | Consiglio Nazionale Delle Ricerche | Polymers of N-acryloylmorpholine activated at one end and conjugates with bioactive materials and surfaces |
| US5824784A (en) | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
| DE4437544A1 (de) * | 1994-10-20 | 1996-04-25 | Behringwerke Ag | Einsatz von vWF-enthaltenden Konzentraten als Kombinationstherapie bei Therapie mit Antithrombotika und Fibrinolytika |
| US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
| WO1999055377A2 (en) | 1998-04-28 | 1999-11-04 | Applied Research Systems Ars Holding N.V. | Polyol-ifn-beta conjugates |
| US6759216B1 (en) * | 1998-11-06 | 2004-07-06 | Emory University | Glycosylated, low antigenicity low immunogenicity factor VIII |
| BRPI0213207B1 (pt) | 2001-10-10 | 2021-06-15 | Novo Nordisk A/S | Processo in vitro, isento de células, para a remodelagem de um peptídeo e processos para formar um conjugado entre peptídeos e um grupo de modificação |
| US7157277B2 (en) * | 2001-11-28 | 2007-01-02 | Neose Technologies, Inc. | Factor VIII remodeling and glycoconjugation of Factor VIII |
| CA2466027C (en) * | 2001-11-07 | 2013-01-08 | Nektar Therapeutics Al, Corporation | Branched polymers and their conjugates |
| DE60315949T2 (de) | 2002-01-16 | 2008-06-12 | Biocompatibles Uk Ltd., Farnham | Polymerkonjugate |
| EP1654290B1 (en) | 2003-08-12 | 2019-03-13 | Lipoxen Technologies Limited | Sialic acid derivatives for protein derivatisation and conjugation |
| LT2371856T (lt) | 2004-11-12 | 2022-08-25 | Bayer Healthcare Llc | Fviii modifikacija, nukreipta į tam tikrą vietą |
| WO2006090119A1 (en) | 2005-02-23 | 2006-08-31 | Lipoxen Technologies Limited | Activated sialic acid derivatives for protein derivatisation and conjugation |
| EP1863921B1 (en) | 2005-03-24 | 2011-10-05 | BioGeneriX AG | Expression of soluble, active eukaryotic glycosyltransferases in prokaryotic organisms |
| EP1871801A2 (en) * | 2005-04-01 | 2008-01-02 | Novo Nordisk Health Care AG | Blood coagulation fviii analogues |
| EP1893239A2 (en) | 2005-06-15 | 2008-03-05 | Novo Nordisk Health Care AG | Transglutaminase mediated conjugation of growth hormone |
| US20070105755A1 (en) * | 2005-10-26 | 2007-05-10 | Neose Technologies, Inc. | One pot desialylation and glycopegylation of therapeutic peptides |
| WO2007056191A2 (en) | 2005-11-03 | 2007-05-18 | Neose Technologies, Inc. | Nucleotide sugar purification using membranes |
| EP1981977B1 (en) | 2006-01-31 | 2015-12-23 | National Research Council Of Canada | Production of polysialic acid containing glyconjugates using a self-priming polysialyltransferase |
| CA2647314A1 (en) | 2006-03-31 | 2007-11-08 | Baxter International Inc. | Pegylated factor viii |
| US7645860B2 (en) | 2006-03-31 | 2010-01-12 | Baxter Healthcare S.A. | Factor VIII polymer conjugates |
| WO2008011633A2 (en) * | 2006-07-21 | 2008-01-24 | Neose Technologies, Inc. | Glycosylation of peptides via o-linked glycosylation sequences |
| CA2670618C (en) | 2006-12-15 | 2016-10-04 | Baxter International Inc. | Factor viia- (poly) sialic acid conjugate having prolonged in vivo half-life |
| CN101778937A (zh) * | 2007-06-04 | 2010-07-14 | 诺和诺德公司 | 使用n-乙酰葡糖胺转移酶的o-联糖基化 |
| WO2008151448A1 (en) | 2007-06-15 | 2008-12-18 | National Research Council Of Canada | Engineered versions of polysialyltransferases with enhanced enzymatic properties |
| WO2009062100A1 (en) | 2007-11-09 | 2009-05-14 | Baxter International Inc. | Modified recombinant factor viii and von willebrand factor and methods of use |
| CN102037004A (zh) | 2008-01-08 | 2011-04-27 | 生物种属学股份公司 | 使用寡糖基转移酶的多肽的糖缀合 |
| CN101965200B (zh) * | 2008-02-27 | 2013-06-19 | 诺沃-诺迪斯克有限公司 | 缀合的因子ⅷ分子 |
| PL2291523T3 (pl) | 2008-06-24 | 2015-05-29 | Csl Behring Gmbh | Czynnik VIII, czynnik von Willebranda lub ich kompleksy o wydłużonym okresie półtrwania in vivo |
| KR101929641B1 (ko) | 2008-10-17 | 2018-12-14 | 박스알타 인코퍼레이티드 | 낮은 수준의 수용성 중합체를 포함하는 개질된 혈액 인자 |
| CN102333788A (zh) | 2009-02-19 | 2012-01-25 | 诺沃—诺迪斯克有限公司 | 因子viii的修饰 |
| ES2427627T3 (es) * | 2009-04-06 | 2013-10-31 | Novo Nordisk A/S | Entrega dirigida de proteínas de Factor VIII a plaquetas |
| US9493543B2 (en) * | 2010-02-16 | 2016-11-15 | Novo Nordisk A/S | Factor VIII fusion protein |
-
2011
- 2011-02-02 US US13/574,142 patent/US20130040888A1/en not_active Abandoned
- 2011-02-02 WO PCT/EP2011/051438 patent/WO2011101242A1/en not_active Ceased
- 2011-02-02 CN CN201610048268.1A patent/CN105524164A/zh not_active Withdrawn
- 2011-02-02 JP JP2012553254A patent/JP5914363B2/ja not_active Expired - Fee Related
- 2011-02-02 CN CN201180009856.XA patent/CN102770449B/zh not_active Expired - Fee Related
- 2011-02-02 EP EP11701527.1A patent/EP2536753B1/en not_active Not-in-force
- 2011-02-07 CN CN201180009852.1A patent/CN102884077B/zh not_active Expired - Fee Related
- 2011-02-07 WO PCT/EP2011/051723 patent/WO2011101267A1/en not_active Ceased
- 2011-02-07 EP EP11717973A patent/EP2536755A1/en not_active Withdrawn
- 2011-02-07 JP JP2012552352A patent/JP5933457B2/ja not_active Expired - Fee Related
- 2011-02-07 US US13/577,310 patent/US9018166B2/en not_active Expired - Fee Related
-
2015
- 2015-09-11 US US14/851,395 patent/US20150376262A1/en not_active Abandoned
-
2016
- 2016-10-07 US US15/288,248 patent/US20170020992A1/en not_active Abandoned
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