JP2013519636A5 - - Google Patents

Download PDF

Info

Publication number
JP2013519636A5
JP2013519636A5 JP2012552352A JP2012552352A JP2013519636A5 JP 2013519636 A5 JP2013519636 A5 JP 2013519636A5 JP 2012552352 A JP2012552352 A JP 2012552352A JP 2012552352 A JP2012552352 A JP 2012552352A JP 2013519636 A5 JP2013519636 A5 JP 2013519636A5
Authority
JP
Japan
Prior art keywords
fviii
domain
linked
psa
fviii variant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2012552352A
Other languages
English (en)
Japanese (ja)
Other versions
JP5933457B2 (ja
JP2013519636A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2011/051723 external-priority patent/WO2011101267A1/en
Publication of JP2013519636A publication Critical patent/JP2013519636A/ja
Publication of JP2013519636A5 publication Critical patent/JP2013519636A5/ja
Application granted granted Critical
Publication of JP5933457B2 publication Critical patent/JP5933457B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2012552352A 2010-02-16 2011-02-07 コンジュゲートfviiiバリアント Expired - Fee Related JP5933457B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP10153718 2010-02-16
EP10153718.1 2010-02-16
US30560810P 2010-02-18 2010-02-18
US61/305,608 2010-02-18
PCT/EP2011/051723 WO2011101267A1 (en) 2010-02-16 2011-02-07 Conjugated fviii variants

Publications (3)

Publication Number Publication Date
JP2013519636A JP2013519636A (ja) 2013-05-30
JP2013519636A5 true JP2013519636A5 (enExample) 2014-03-27
JP5933457B2 JP5933457B2 (ja) 2016-06-08

Family

ID=42173354

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2012553254A Expired - Fee Related JP5914363B2 (ja) 2010-02-16 2011-02-02 低減されたvwf結合を有する因子viii分子
JP2012552352A Expired - Fee Related JP5933457B2 (ja) 2010-02-16 2011-02-07 コンジュゲートfviiiバリアント

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2012553254A Expired - Fee Related JP5914363B2 (ja) 2010-02-16 2011-02-02 低減されたvwf結合を有する因子viii分子

Country Status (5)

Country Link
US (4) US20130040888A1 (enExample)
EP (2) EP2536753B1 (enExample)
JP (2) JP5914363B2 (enExample)
CN (3) CN102770449B (enExample)
WO (2) WO2011101242A1 (enExample)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6263355A (ja) * 1985-09-13 1987-03-20 Hitachi Ltd バツテリバツクアツプramのチエツク方法
BRPI0720282B8 (pt) 2006-12-15 2021-05-25 Baxalta GmbH construção proteica, composição farmacêutica, e, kit
CA2690611C (en) 2007-06-12 2015-12-08 Novo Nordisk A/S Improved process for the production of nucleotide sugars
NZ606427A (en) 2009-02-03 2014-10-31 Amunix Operating Inc Extended recombinant polypeptides and compositions comprising same
EP2459224B1 (en) 2009-07-27 2016-06-01 Baxalta GmbH Blood coagulation protein conjugates
RU2744370C2 (ru) 2009-07-27 2021-03-05 Баксалта Инкорпорейтед Конъюгаты белков свертывания крови
US8809501B2 (en) 2009-07-27 2014-08-19 Baxter International Inc. Nucleophilic catalysts for oxime linkage
US8642737B2 (en) 2010-07-26 2014-02-04 Baxter International Inc. Nucleophilic catalysts for oxime linkage
EP3081233B1 (en) 2009-07-27 2020-12-23 Baxalta GmbH Glycopolysialylation of proteins other than blood coagulation proteins
EP2470670A4 (en) 2009-08-24 2013-07-10 Amunix Operating Inc COAGULATION FACTOR VII COMPOSITIONS AND METHODS OF PREPARATION AND USE THEREOF
US8765432B2 (en) 2009-12-18 2014-07-01 Oligasis, Llc Targeted drug phosphorylcholine polymer conjugates
GB201007356D0 (en) 2010-04-30 2010-06-16 Leverton Licence Holdings Ltd Conjugated factor VIIa
HUE049352T2 (hu) 2010-12-22 2020-09-28 Baxalta GmbH Anyagok és módszerek egy vízoldható zsírsavszármazéknak egy fehérjéhez való konjugálására
EP2804623B1 (en) * 2012-01-12 2019-08-07 Bioverativ Therapeutics Inc. Chimeric factor viii polypeptides and uses thereof
BR112014019901A8 (pt) 2012-02-15 2018-01-02 Biogen Idec Inc Proteínas de fator viii recombinante
ES2771208T3 (es) 2012-02-15 2020-07-06 Bioverativ Therapeutics Inc Composiciones de factor VIII y métodos de preparación y uso de las mismas
GB2516388A (en) * 2012-04-16 2015-01-21 Cantab Biopharmaceuticals Patents Ltd Optimised subcutaneous therapeutic agents
US10138291B2 (en) * 2012-07-11 2018-11-27 Bioverativ Therapeutics Inc. Factor VIII complex with XTEN and von Willebrand Factor protein, and uses thereof
US20150259665A1 (en) 2012-10-15 2015-09-17 Novo Nordisk Health Care Ag Factor vii conjugates
EP2796145B1 (en) * 2013-04-22 2017-11-01 CSL Ltd. A covalent complex of von willebrand factor and faktor viii linked by a disulphide bridge
EP3033097B1 (en) * 2013-08-14 2021-03-10 Bioverativ Therapeutics Inc. Factor viii-xten fusions and uses thereof
EP3041513B1 (en) 2013-09-08 2020-08-05 Kodiak Sciences Inc. Factor viii zwitterionic polymer conjugates
CN105637088A (zh) 2013-10-15 2016-06-01 诺和诺德保健股份有限公司 凝固因子vii多肽
PT3091997T (pt) 2014-01-10 2022-09-29 Bioverativ Therapeutics Inc Proteínas quiméricas de fator viii e utilizações destas
AR101060A1 (es) * 2014-02-12 2016-11-23 Novo Nordisk As Conjugados de fviii
AR099328A1 (es) * 2014-02-12 2016-07-13 Novo Nordisk As Conjugados de factor vii
AR099340A1 (es) * 2014-02-12 2016-07-13 Novo Nordisk As Conjugados del factor de coagulación ix
WO2015143512A2 (en) * 2014-03-23 2015-10-01 Advantech Bioscience Farmacêutica Ltda. Enhancement of recombinant protein expression with copper
US9840553B2 (en) 2014-06-28 2017-12-12 Kodiak Sciences Inc. Dual PDGF/VEGF antagonists
JP6516829B2 (ja) 2014-08-04 2019-05-22 シーエスエル、リミテッド 第viii因子製剤
CN107208076A (zh) 2014-10-17 2017-09-26 科达制药 丁酰胆碱酯酶两性离子聚合物缀合物
EP3042952A1 (en) * 2015-01-07 2016-07-13 CEVEC Pharmaceuticals GmbH O-glycan sialylated recombinant glycoproteins and cell lines for producing the same
BR112017018468A2 (pt) 2015-03-06 2018-04-17 Csl Behring Recombinant Facility Ag fator de von willebrand modificado com meia-vida aumentada
BR112018002150A2 (pt) 2015-08-03 2018-09-18 Bioverativ Therapeutics Inc proteínas de fusão do fator ix e métodos de fabricação e uso das mesmas
KR102799807B1 (ko) * 2015-12-30 2025-04-24 코디악 사이언시스 인코포레이티드 항체 및 이의 접합체
WO2017222330A1 (ko) * 2016-06-24 2017-12-28 재단법인 목암생명과학연구소 재조합 단쇄 fviii 및 그 화학 접합물
JP6877469B2 (ja) 2016-06-24 2021-05-26 モガム・インスティテュート・フォー・バイオメディカル・リサーチMogam Institute For Biomedical Research Fviiiおよびvwf因子を含むキメラタンパク質、ならびにそれらの使用
US12161696B2 (en) 2016-12-02 2024-12-10 Bioverativ Therapeutics Inc. Methods of treating hemophilic arthropathy using chimeric clotting factors
EP3382014A1 (en) 2017-03-29 2018-10-03 CEVEC Pharmaceuticals GmbH Recombinant glycoproteins with reduced antennary fucosylation
EP3642225A1 (en) * 2017-06-23 2020-04-29 Baxalta Incorporated Purification of factor viii subspecies
EP3441471A1 (en) 2017-08-08 2019-02-13 CEVEC Pharmaceuticals GmbH Use of constitutively active variants of growth factor receptors as selection makers for the generation of stable producer cell lines
CN112203679A (zh) 2018-03-02 2021-01-08 科达制药股份有限公司 Il-6抗体及其融合构建体和缀合物
MA53020A (fr) * 2018-05-18 2021-05-05 Zhengzhou Gensciences Inc Protéine de fusion du fviii améliorée et utilisation associée
DK3793588T3 (da) 2018-05-18 2025-06-16 Bioverativ Therapeutics Inc Fremgangsmåder til behandling af hæmofili a
JP7780341B2 (ja) 2019-07-04 2025-12-04 ツェー・エス・エル・ベーリング・レングナウ・アクチエンゲゼルシャフト 第VIII凝固因子のin vitroでの安定性を向上させるための切断型フォン・ヴィレブランド因子(VWF)
US20220281939A1 (en) 2019-08-27 2022-09-08 Tonix Pharma Limited Modified tff2 polypeptides
US11912784B2 (en) 2019-10-10 2024-02-27 Kodiak Sciences Inc. Methods of treating an eye disorder
WO2021094344A1 (en) 2019-11-11 2021-05-20 CSL Behring Lengnau AG Polypeptides for inducing tolerance to factor viii

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4356170A (en) 1981-05-27 1982-10-26 Canadian Patents & Development Ltd. Immunogenic polysaccharide-protein conjugates
AU2645588A (en) * 1987-12-04 1989-06-15 Scripps Clinic And Research Foundation The von willebrand factor binding domain of factor viii
US5629384A (en) 1994-05-17 1997-05-13 Consiglio Nazionale Delle Ricerche Polymers of N-acryloylmorpholine activated at one end and conjugates with bioactive materials and surfaces
US5824784A (en) 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
DE4437544A1 (de) * 1994-10-20 1996-04-25 Behringwerke Ag Einsatz von vWF-enthaltenden Konzentraten als Kombinationstherapie bei Therapie mit Antithrombotika und Fibrinolytika
US5932462A (en) 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
ATE275422T1 (de) 1998-04-28 2004-09-15 Applied Research Systems Konjugate aus polyole und beta-interferon
US6759216B1 (en) * 1998-11-06 2004-07-06 Emory University Glycosylated, low antigenicity low immunogenicity factor VIII
US7157277B2 (en) * 2001-11-28 2007-01-02 Neose Technologies, Inc. Factor VIII remodeling and glycoconjugation of Factor VIII
HK1080090B (zh) 2001-10-10 2012-12-14 诺和诺德公司 肽的重构和糖缀合的方法
MXPA04004336A (es) * 2001-11-07 2005-05-16 Nektar Therapeutics Al Corp Polimeros ramificados y sus conjugados.
WO2003062290A1 (en) 2002-01-16 2003-07-31 Biocompatibles Uk Limited Polymer conjugates
WO2005016949A2 (en) 2003-08-12 2005-02-24 Lipoxen Technologies Limited Sialic acid derivatives
CN105753968A (zh) 2004-11-12 2016-07-13 拜尔健康护理有限责任公司 Fviii的位点定向修饰
US8217154B2 (en) 2005-02-23 2012-07-10 Lipoxen Technologies Limited Activated sialic acid derivatives for protein derivatisation and conjugation
US8137928B2 (en) 2005-03-24 2012-03-20 BioGeneriX Expression of soluble, active eukaryotic glycosyltransferases in prokaryotic organisms
JP2008534559A (ja) * 2005-04-01 2008-08-28 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト 血液凝固fviii類似体
KR20080016674A (ko) 2005-06-15 2008-02-21 노보 노르디스크 헬스 케어 악티엔게젤샤프트 트랜스글루타미나제 매개 성장 호르몬 컨쥬게이션
US20070105755A1 (en) * 2005-10-26 2007-05-10 Neose Technologies, Inc. One pot desialylation and glycopegylation of therapeutic peptides
US20090048440A1 (en) 2005-11-03 2009-02-19 Neose Technologies, Inc. Nucleotide Sugar Purification Using Membranes
WO2007087711A1 (en) 2006-01-31 2007-08-09 National Research Council Of Canada Production of polysialic acid containing glyconjugates using a self-priming polysialyltransferase
US7645860B2 (en) * 2006-03-31 2010-01-12 Baxter Healthcare S.A. Factor VIII polymer conjugates
JP2009532351A (ja) 2006-03-31 2009-09-10 バクスター・インターナショナル・インコーポレイテッド ペグ化第viii因子
CN101516388B (zh) 2006-07-21 2012-10-31 诺和诺德公司 通过o-联糖基化序列的肽的糖基化
BRPI0720282B8 (pt) 2006-12-15 2021-05-25 Baxalta GmbH construção proteica, composição farmacêutica, e, kit
CN101778937A (zh) * 2007-06-04 2010-07-14 诺和诺德公司 使用n-乙酰葡糖胺转移酶的o-联糖基化
JP5356373B2 (ja) 2007-06-15 2013-12-04 ナショナル リサーチ カウンシル オブ カナダ 酵素特性を向上させたポリシアリルトランスフェラーゼの操作されたバージョン
GB2467700A (en) * 2007-11-09 2010-08-11 Baxter Int Modified recombinant Factor VIII and von Willebrand Factor and methods of use
JP5647899B2 (ja) * 2008-01-08 2015-01-07 ラツィオファルム ゲーエムベーハーratiopharm GmbH オリゴサッカリルトランスフェラーゼを使用するポリペプチドの複合糖質化
CN103497246B (zh) * 2008-02-27 2016-08-10 诺沃—诺迪斯克有限公司 缀合的因子viii分子
CA2728012C (en) 2008-06-24 2017-10-31 Csl Behring Gmbh Factor viii, von willebrand factor or complexes thereof with prolonged in vivo half-life
HUE039906T2 (hu) 2008-10-17 2019-02-28 Baxalta GmbH Alacsony fokú vízben oldható polimer tartalmú módosított vérfaktorok
EP2398822B1 (en) 2009-02-19 2013-01-02 Novo Nordisk A/S Modification of factor viii
EP2417155B1 (en) * 2009-04-06 2013-06-19 Novo Nordisk A/S Targeted delivery of factor viii proteins to platelets
CN105153313A (zh) * 2010-02-16 2015-12-16 诺沃—诺迪斯克有限公司 因子viii融合蛋白

Similar Documents

Publication Publication Date Title
JP2013519636A5 (enExample)
JP2013519697A5 (enExample)
JP2010215657A5 (enExample)
IN2014DN00101A (enExample)
EA201890389A3 (ru) Композиции конъюгата xten и способы их получения
JP2012255007A5 (enExample)
JP2011515499A5 (enExample)
JP2015536943A5 (enExample)
CR20110515A (es) Compuesto biocompatible y su uso
JP2015519313A5 (enExample)
JP2012508172A5 (enExample)
EA201170039A1 (ru) Полимерные частицы, нагруженные лекарственным средством, и способы их получения и применения
BR112012012210B8 (pt) conjugado de (cdp)-taxano de polímero contendo ciclodextrina, composição, composição farmacêutica, forma de dosagem, kit e uso de um conjugado de cdp-taxano
WO2010122385A8 (fr) Formulation a action rapide d'insuline
HK1205156A1 (en) Cyclodextrin-based polymers for therapeutic delivery
SG194175A1 (en) Polymer conjugated prostaglandin analogues
GB201105455D0 (en) Blends of a polylactic acid and a water soluble polymer
IN2012DN00407A (enExample)
UA101497C2 (ru) Конъюгаты фактора ix с увеличенным временем полужизни
JP2014058562A5 (enExample)
WO2012017288A3 (en) Supramolecular complexes of polyanionic polymers and spermidine in tissue maintenance and repair
MX2022003939A (es) Composicion farmaceutica de estabilidad mejorada.
CA2402421A1 (en) Clathrate complexes formed by hyaluronic acid derivatives and use thereof as pharmaceuticals
WO2018056937A3 (en) Nanofibrous adhesion barrier
JP2016529286A5 (enExample)