JP2013517259A5 - - Google Patents
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- Publication number
- JP2013517259A5 JP2013517259A5 JP2012548460A JP2012548460A JP2013517259A5 JP 2013517259 A5 JP2013517259 A5 JP 2013517259A5 JP 2012548460 A JP2012548460 A JP 2012548460A JP 2012548460 A JP2012548460 A JP 2012548460A JP 2013517259 A5 JP2013517259 A5 JP 2013517259A5
- Authority
- JP
- Japan
- Prior art keywords
- gla
- polypeptide
- protein
- factor
- sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 17
- UHBYWPGGCSDKFX-VKHMYHEASA-N gamma-carboxy-L-glutamic acid Chemical compound OC(=O)[C@@H](N)CC(C(O)=O)C(O)=O UHBYWPGGCSDKFX-VKHMYHEASA-N 0.000 claims 8
- 229920001184 polypeptide Polymers 0.000 claims 7
- 102000004196 processed proteins & peptides Human genes 0.000 claims 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims 7
- 102000004169 proteins and genes Human genes 0.000 claims 7
- 108090000623 proteins and genes Proteins 0.000 claims 7
- 102100022641 Coagulation factor IX Human genes 0.000 claims 5
- 108010076282 Factor IX Proteins 0.000 claims 5
- 229960004222 factor ix Drugs 0.000 claims 5
- 239000000463 material Substances 0.000 claims 5
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims 3
- 229910001424 calcium ion Inorganic materials 0.000 claims 3
- UHBYWPGGCSDKFX-UHFFFAOYSA-N carboxyglutamic acid Chemical compound OC(=O)C(N)CC(C(O)=O)C(O)=O UHBYWPGGCSDKFX-UHFFFAOYSA-N 0.000 claims 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 238000004587 chromatography analysis Methods 0.000 claims 2
- 239000012149 elution buffer Substances 0.000 claims 2
- 239000006167 equilibration buffer Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 1
- 229920002684 Sepharose Polymers 0.000 claims 1
- 238000001042 affinity chromatography Methods 0.000 claims 1
- 238000005571 anion exchange chromatography Methods 0.000 claims 1
- 239000011324 bead Substances 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 238000010828 elution Methods 0.000 claims 1
- 150000002500 ions Chemical class 0.000 claims 1
- 239000011777 magnesium Substances 0.000 claims 1
- 229910052749 magnesium Inorganic materials 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 239000011534 wash buffer Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10150980.0 | 2010-01-18 | ||
| EP10150980 | 2010-01-18 | ||
| US29701110P | 2010-01-21 | 2010-01-21 | |
| US61/297,011 | 2010-01-21 | ||
| PCT/EP2011/050594 WO2011086197A1 (en) | 2010-01-18 | 2011-01-18 | Purification of blood coagulation factors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013517259A JP2013517259A (ja) | 2013-05-16 |
| JP2013517259A5 true JP2013517259A5 (https=) | 2014-03-06 |
| JP6250931B2 JP6250931B2 (ja) | 2017-12-20 |
Family
ID=42173365
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012548460A Expired - Fee Related JP6250931B2 (ja) | 2010-01-18 | 2011-01-18 | 血液凝固因子の精製 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9896677B2 (https=) |
| EP (1) | EP2526115B1 (https=) |
| JP (1) | JP6250931B2 (https=) |
| KR (1) | KR20120118028A (https=) |
| CN (1) | CN102939299B (https=) |
| BR (1) | BR112012017696A2 (https=) |
| RU (1) | RU2012133474A (https=) |
| WO (1) | WO2011086197A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2526115B1 (en) * | 2010-01-18 | 2018-08-01 | Novo Nordisk Health Care AG | Purification of blood coagulation factors |
| CN103539852B (zh) * | 2012-07-12 | 2015-08-12 | 上海泰龙生物医药科技有限公司 | 一种从细胞培养液中分离纯化重组人凝血八因子的方法 |
| AU2013364043B2 (en) | 2012-12-21 | 2018-01-04 | Seagen Inc. | Anti-NTB-A antibodies and related compositions and methods |
| US10643423B2 (en) | 2016-09-23 | 2020-05-05 | Sg Gaming, Inc. | System and digital table for binding a mobile device to a position at the table for transactions |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6258938B1 (en) | 1983-10-28 | 2001-07-10 | Ne Medical Center Hospital, Inc. | Method for the purification and isolation of blood clotting proteins using conformation specific antibodies |
| US4902614A (en) | 1984-12-03 | 1990-02-20 | Teijin Limited | Monoclonal antibody to human protein C |
| FR2632309B1 (fr) | 1988-06-07 | 1990-08-24 | Lille Transfusion Sanguine | Procede de purification par voie chromatographique de proteines, notamment de facteur viii, et les produits obtenus |
| US4981952A (en) | 1988-10-04 | 1991-01-01 | Eli Lilly And Company | Method for the purification of vitamin K-dependent proteins |
| ATE195877T1 (de) | 1991-03-01 | 2000-09-15 | Rhone Poulenc Rorer Int | Herstellung von faktor-ix |
| IT1262899B (it) | 1992-03-27 | 1996-07-22 | Sclavo Spa | Processo per l'isolamento di fattore ix, fattore x e fattore ii altamente purificati dal complesso protrombinico o dal plasma umano |
| DE4406515C1 (de) | 1994-02-28 | 1995-10-19 | Immuno Ag | Verfahren zur Isolierung und Reinigung Vitamin K-abhängiger Proteine |
| US6451987B1 (en) | 1999-03-15 | 2002-09-17 | Novo Nordisk A/S | Ion exchange chromatography of proteins and peptides |
| SE0000675D0 (sv) | 2000-03-02 | 2000-03-02 | Protease Ab | Monoclonal antibodies |
| RU2364626C2 (ru) | 2003-03-18 | 2009-08-20 | Ново Нордиск Хелт Кэр Аг | Способ получения, способ очистки и способ стабилизации полипептидов фактора vii, ix и x |
| ES2395544T3 (es) | 2004-12-23 | 2013-02-13 | Novo Nordisk Health Care Ag | Reducción del contenido de contaminantes proteínicos en composiciones que comprenden una proteína dependiente de la vitamina K de interés |
| EP1963506B1 (en) | 2005-12-02 | 2010-10-27 | Wake Forest University Health Sciences | Compositions and methods for increasing production of recombinant gamma-carboxylated proteins |
| WO2008104372A1 (en) | 2007-02-28 | 2008-09-04 | Baxter International Inc. | Method for the purification of recombinant blood coagulation factor ix enriched in sulfated and/or phosphorylated molecules |
| AU2009324204B2 (en) | 2008-12-02 | 2014-10-16 | Novo Nordisk Health Care Ag | Polypeptide purification |
| EP2526115B1 (en) * | 2010-01-18 | 2018-08-01 | Novo Nordisk Health Care AG | Purification of blood coagulation factors |
-
2011
- 2011-01-18 EP EP11700547.0A patent/EP2526115B1/en not_active Not-in-force
- 2011-01-18 KR KR1020127020380A patent/KR20120118028A/ko not_active Withdrawn
- 2011-01-18 JP JP2012548460A patent/JP6250931B2/ja not_active Expired - Fee Related
- 2011-01-18 CN CN201180006396.5A patent/CN102939299B/zh not_active Expired - Fee Related
- 2011-01-18 BR BR112012017696A patent/BR112012017696A2/pt not_active IP Right Cessation
- 2011-01-18 WO PCT/EP2011/050594 patent/WO2011086197A1/en not_active Ceased
- 2011-01-18 US US13/522,548 patent/US9896677B2/en active Active
- 2011-01-18 RU RU2012133474/10A patent/RU2012133474A/ru unknown
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