JP2012050465A5 - - Google Patents
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- Publication number
- JP2012050465A5 JP2012050465A5 JP2011270236A JP2011270236A JP2012050465A5 JP 2012050465 A5 JP2012050465 A5 JP 2012050465A5 JP 2011270236 A JP2011270236 A JP 2011270236A JP 2011270236 A JP2011270236 A JP 2011270236A JP 2012050465 A5 JP2012050465 A5 JP 2012050465A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- inhibitor
- mammal
- dna segment
- segment encoding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 101001081555 Homo sapiens Plasma protease C1 inhibitor Proteins 0.000 claims 39
- 102000044507 human SERPING1 Human genes 0.000 claims 39
- 102000055157 Complement C1 Inhibitor Human genes 0.000 claims 16
- 108700040183 Complement C1 Inhibitor Proteins 0.000 claims 16
- 241000124008 Mammalia Species 0.000 claims 15
- 210000004216 mammary stem cell Anatomy 0.000 claims 15
- 239000008267 milk Substances 0.000 claims 14
- 210000004080 milk Anatomy 0.000 claims 14
- 235000013336 milk Nutrition 0.000 claims 14
- 210000004027 cell Anatomy 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 8
- 210000000481 breast Anatomy 0.000 claims 8
- 230000001105 regulatory effect Effects 0.000 claims 8
- 238000000034 method Methods 0.000 claims 6
- 201000007120 C1 inhibitor deficiency Diseases 0.000 claims 4
- 206010019860 Hereditary angioedema Diseases 0.000 claims 4
- 238000005342 ion exchange Methods 0.000 claims 4
- 229910021645 metal ion Inorganic materials 0.000 claims 4
- 102000003839 Human Proteins Human genes 0.000 claims 3
- 108090000144 Human Proteins Proteins 0.000 claims 3
- 238000005349 anion exchange Methods 0.000 claims 3
- 238000005341 cation exchange Methods 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 241000283973 Oryctolagus cuniculus Species 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 235000013305 food Nutrition 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 210000005075 mammary gland Anatomy 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000009261 transgenic effect Effects 0.000 claims 1
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17931000P | 2000-01-31 | 2000-01-31 | |
| US60/179,310 | 2000-01-31 | ||
| EP00200320.0 | 2000-01-31 | ||
| EP00200320 | 2000-01-31 | ||
| US18758000P | 2000-03-07 | 2000-03-07 | |
| US60/187,580 | 2000-03-07 | ||
| EP00200810.0 | 2000-03-07 | ||
| EP00200810 | 2000-03-07 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001557910A Division JP2003521914A (ja) | 2000-01-31 | 2001-01-31 | トランスジェニック哺乳動物の乳汁に産生されるｃ１インヒビター |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014075150A Division JP2014121337A (ja) | 2000-01-31 | 2014-04-01 | トランスジェニック哺乳動物の乳汁に産生されるｃ１インヒビター |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012050465A JP2012050465A (ja) | 2012-03-15 |
| JP2012050465A5 true JP2012050465A5 (https=) | 2013-07-04 |
Family
ID=27439989
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011270236A Pending JP2012050465A (ja) | 2000-01-31 | 2011-12-09 | トランスジェニック哺乳動物の乳汁に産生されるｃ１インヒビター |
| JP2014075150A Pending JP2014121337A (ja) | 2000-01-31 | 2014-04-01 | トランスジェニック哺乳動物の乳汁に産生されるｃ１インヒビター |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014075150A Pending JP2014121337A (ja) | 2000-01-31 | 2014-04-01 | トランスジェニック哺乳動物の乳汁に産生されるｃ１インヒビター |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US7067713B2 (https=) |
| JP (2) | JP2012050465A (https=) |
| BE (1) | BE2010C040I2 (https=) |
| FR (1) | FR10C0054I2 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2502539A1 (en) * | 2002-10-17 | 2004-04-29 | Pharming Intellectual Property B.V. | Protein modification |
| EP1626736B1 (en) * | 2003-05-16 | 2020-09-16 | Pharming Intellectual Property B.V. | C1 inhibitor with short half-life for transient treatment |
| EP2500031A3 (en) * | 2005-02-24 | 2012-12-26 | Joslin Diabetes Center, Inc. | Compositions and Methods for Treating Vascular Permeability |
| AU2006327989B2 (en) | 2005-12-21 | 2012-06-07 | Pharming Intellectual Property Bv | Use of C1 inhibitor for the prevention of ischemia-reperfusion injury |
| FR2901707B1 (fr) * | 2006-05-31 | 2017-09-29 | Lab Francais Du Fractionnement | Composition de facteur vii recombinant ou transgenique, chaque molecule de facteur vii possedant deux sites de n-glycosylation a motifs glycanniques definis |
| FR2904558B1 (fr) * | 2006-08-01 | 2008-10-17 | Lab Francais Du Fractionnement | "composition de facteur vii recombinant ou transgenique, presentant majoritairement des formes glycanniques biantennees, bisialylees et non fucosylees" |
| US20100119512A1 (en) * | 2007-01-25 | 2010-05-13 | Joslin Diabetes Center | Methods of diagnosing, treating, and preventing increased vascular permeability |
| WO2014113712A1 (en) | 2013-01-20 | 2014-07-24 | Dyax Corp. | Evaluation and treatment of bradykinin-mediated disorders |
| EP3594231A1 (en) | 2013-02-13 | 2020-01-15 | Laboratoire Français du Fractionnement et des Biotechnologies | Highly galactosylated anti-tnf-alpha antibodies and uses thereof |
| US10034921B2 (en) | 2013-02-13 | 2018-07-31 | Laboratoire Français Du Fractionnement Et Des Biotechnologies | Proteins with modified glycosylation and methods of production thereof |
| BR112015023207A8 (pt) | 2013-03-15 | 2018-01-23 | Shire Viropharma Inc | composições de ci-inh e métodos para prevenção e tratamento de desordens associadas à deficiência de inibidor de c1 esterase. |
| CA2927695C (en) | 2013-10-21 | 2022-03-01 | Dyax Corp. | Diagnosis and treatment of autoimmune diseases |
| JP6757252B2 (ja) | 2013-10-21 | 2020-09-16 | ダイアックス コーポレーション | 血漿カリクレイン系バイオマーカーを決定するためのアッセイ |
| CN105828603A (zh) * | 2013-12-24 | 2016-08-03 | Lfb美国股份有限公司 | 肝素的转基因生产 |
| HK1250623A1 (zh) * | 2015-05-28 | 2019-01-11 | Cornell University | 腺相关病毒介导的c1ei递送作为用於血管性水肿的疗法 |
| JP6573991B2 (ja) * | 2015-05-28 | 2019-09-11 | コーネル ユニヴァーシティー | 血管性浮腫の治療としてのｃ１ｅｉのアデノ随伴ウイルス介在性送達 |
| FR3038517B1 (fr) | 2015-07-06 | 2020-02-28 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Utilisation de fragments fc modifies en immunotherapie |
| KR20240133761A (ko) | 2015-10-19 | 2024-09-04 | 다케다 파머수티컬 컴패니 리미티드 | 절단된 고분자량 키니노겐의 검출을 위한 면역검정법 |
| AU2017305856B2 (en) | 2016-08-05 | 2024-09-12 | Csl Behring Gmbh | Pharmaceutical formulations of C1 esterase inhibitor |
| BR112019023737A2 (pt) | 2017-05-16 | 2020-05-26 | Octapharma Ag | Preparação de inibidor de c1-esterase (c1-inh), kit que consiste em um primeiro receptáculo contendo a preparação de c1-inh, kit que consiste em uma seringa pré-cheia com a preparação de c1-inh, kit que consiste em um dispositivo adequado para aplicação subcutânea, tal como um injetor no corpo e uso de histidina para aumentar a biodisponibilidade de c1-inh administrado por via subcutânea |
| PL3758739T3 (pl) * | 2018-02-28 | 2024-09-16 | Pharming Intellectual Property B.V. | Leczenie i zapobieganie stanowi przedrzucawkowemu |
| EP3895726A1 (en) | 2020-04-17 | 2021-10-20 | Pharming Intellectual Property BV | Using c1 esterase inhibitor to treat viral infection-related acute respiratory distress |
| JP2024525084A (ja) | 2021-07-09 | 2024-07-09 | ファーミング・インテレクチュアル・プロパティー・ビー．ブイ． | Ｃ１エステラーゼ阻害剤によるウイルス感染関連症状の治療 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2601034B1 (fr) | 1986-07-03 | 1989-11-17 | Pasteur Institut | Inhibiteur de l'activite de la c1-esterase plasmatique (c1-inhibiteur) et d'autres enzymes proteolytiques du groupe des proteases a serine, son procede de preparation, acides nucleiques codant pour cet inhibiteur, methodes de detection d'affections correlees aux defauts dudit inhibiteur a l'aide d'anticorps ou de sondes nucleotidiques et medicaments contenant ledit inhibiteur de synthese |
| EP0497833A1 (en) | 1989-10-27 | 1992-08-12 | Stichting Centraal Laboratorium van de Bloedtransfusiedienst van het Nederlandse Rode Kruis | C1 inhibitor muteins and uses thereof |
| US5633076A (en) * | 1989-12-01 | 1997-05-27 | Pharming Bv | Method of producing a transgenic bovine or transgenic bovine embryo |
| WO1992022320A1 (en) | 1991-06-14 | 1992-12-23 | Genentech, Inc. | C1 inhibitor variants and treating inflammatory response with c1 inhibitor |
| DE4227762A1 (de) | 1992-08-24 | 1994-03-03 | Behringwerke Ag | Verwendung eines Kallikrein-Inhibitors zur Herstellung eines Arzneimittels zur Prophylaxe und Therapie bestimmter Krankheiten |
| US6713662B1 (en) | 1994-07-27 | 2004-03-30 | Pharming Intellectual Property B.V. | Production of collagen in the milk of transgenic mammals |
| GB9807464D0 (en) * | 1998-04-07 | 1998-06-10 | Pharming Bv | Purification of human acid µ-glucosidase |
| ES2299473T3 (es) * | 2000-01-31 | 2008-06-01 | Pharming Intellectual Property B.V. | Inhibidor de c1 humano producido en la leche de mamiferos transgenicos. |
-
2001
- 2001-01-31 US US10/181,704 patent/US7067713B2/en active Active
-
2005
- 2005-03-22 US US11/087,789 patent/US20050223416A1/en not_active Abandoned
-
2010
- 2010-12-08 BE BE2010C040C patent/BE2010C040I2/fr unknown
- 2010-12-16 FR FR10C0054C patent/FR10C0054I2/fr active Active
-
2011
- 2011-12-09 JP JP2011270236A patent/JP2012050465A/ja active Pending
-
2014
- 2014-04-01 JP JP2014075150A patent/JP2014121337A/ja active Pending
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