JP2013515739A5 - - Google Patents

Info

Publication number

JP2013515739A5

JP2013515739A5 JP2012546185A JP2012546185A JP2013515739A5 JP 2013515739 A5 JP2013515739 A5 JP 2013515739A5 JP 2012546185 A JP2012546185 A JP 2012546185A JP 2012546185 A JP2012546185 A JP 2012546185A JP 2013515739 A5 JP2013515739 A5 JP 2013515739A5

Authority

JP

Japan

Prior art keywords

composition

rhodostomin variant

subject

seq

composition according

Prior art date

2010-12-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 239000000203 mixture Substances 0.000 claims 28
• ZTYNVDHJNRIRLL-FWZKYCSMSA-N rhodostomin Chemical compound C([C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(N[C@@H]2C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CSSC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H](CC=2NC=NC=2)C(O)=O)[C@@H](C)O)=O)CSSC[C@H]2C(=O)N[C@H]3CSSC[C@@H](C(NCC(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H]2NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]4CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)CN)CSSC2)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2CCC[C@H]2C(=O)N[C@H](C(N4)=O)CSSC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC3=O)C(=O)N[C@@H](CCCCN)C(=O)N1)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=CC=C1 ZTYNVDHJNRIRLL-FWZKYCSMSA-N 0.000 claims 16
• 108010049985 rhodostomin Proteins 0.000 claims 16
• 230000033115 angiogenesis Effects 0.000 claims 7
• 208000030533 eye disease Diseases 0.000 claims 7
• 150000001413 amino acids Chemical group 0.000 claims 6
• 239000013543 active substance Substances 0.000 claims 5
• 230000002265 prevention Effects 0.000 claims 4
• 150000003839 salts Chemical class 0.000 claims 4
• 102000009027 Albumins Human genes 0.000 claims 2
• 108010088751 Albumins Proteins 0.000 claims 2
• 206010012689 Diabetic retinopathy Diseases 0.000 claims 2
• 241000220010 Rhode Species 0.000 claims 2
• 206010064930 age-related macular degeneration Diseases 0.000 claims 2
• 208000002780 macular degeneration Diseases 0.000 claims 2
• 206010063381 Polypoidal choroidal vasculopathy Diseases 0.000 claims 1
• 208000017442 Retinal disease Diseases 0.000 claims 1
• 206010038923 Retinopathy Diseases 0.000 claims 1
• 206010038933 Retinopathy of prematurity Diseases 0.000 claims 1
• 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 1
• 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 1
• 239000004037 angiogenesis inhibitor Substances 0.000 claims 1
• 230000002491 angiogenic effect Effects 0.000 claims 1
• 239000005557 antagonist Substances 0.000 claims 1
• 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
• 239000002260 anti-inflammatory agent Substances 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 239000007972 injectable composition Substances 0.000 claims 1
• 238000002347 injection Methods 0.000 claims 1
• 239000007924 injection Substances 0.000 claims 1
• 208000028867 ischemia Diseases 0.000 claims 1
• 208000001491 myopia Diseases 0.000 claims 1
• 230000004379 myopia Effects 0.000 claims 1
• 230000035755 proliferation Effects 0.000 claims 1
• 230000002207 retinal effect Effects 0.000 claims 1
• 150000003431 steroids Chemical class 0.000 claims 1
• 230000000699 topical effect Effects 0.000 claims 1