JP2013515486A5 - - Google Patents
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- Publication number
- JP2013515486A5 JP2013515486A5 JP2012546229A JP2012546229A JP2013515486A5 JP 2013515486 A5 JP2013515486 A5 JP 2013515486A5 JP 2012546229 A JP2012546229 A JP 2012546229A JP 2012546229 A JP2012546229 A JP 2012546229A JP 2013515486 A5 JP2013515486 A5 JP 2013515486A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- antibody
- binding fragment
- ser
- gly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29009209P | 2009-12-24 | 2009-12-24 | |
| US61/290,092 | 2009-12-24 | ||
| US30635910P | 2010-02-19 | 2010-02-19 | |
| US61/306,359 | 2010-02-19 | ||
| US32831610P | 2010-04-27 | 2010-04-27 | |
| US61/328,316 | 2010-04-27 | ||
| US34927310P | 2010-05-28 | 2010-05-28 | |
| US61/349,273 | 2010-05-28 | ||
| US35612610P | 2010-06-18 | 2010-06-18 | |
| US61/356,126 | 2010-06-18 | ||
| PCT/US2010/061987 WO2011079257A2 (en) | 2009-12-24 | 2010-12-23 | Human antibodies to human angiopoietin-like protein 4 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015096446A Division JP2015145424A (ja) | 2009-12-24 | 2015-05-11 | ヒトアンギオポエチン様タンパク質４に対するヒト抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013515486A JP2013515486A (ja) | 2013-05-09 |
| JP2013515486A5 true JP2013515486A5 (https=) | 2014-02-06 |
| JP6000855B2 JP6000855B2 (ja) | 2016-10-05 |
Family
ID=43629324
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012546229A Expired - Fee Related JP6000855B2 (ja) | 2009-12-24 | 2010-12-23 | ヒトアンギオポエチン様タンパク質４に対するヒト抗体 |
| JP2015096446A Pending JP2015145424A (ja) | 2009-12-24 | 2015-05-11 | ヒトアンギオポエチン様タンパク質４に対するヒト抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015096446A Pending JP2015145424A (ja) | 2009-12-24 | 2015-05-11 | ヒトアンギオポエチン様タンパク質４に対するヒト抗体 |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US8354103B2 (https=) |
| EP (1) | EP2516466B1 (https=) |
| JP (2) | JP6000855B2 (https=) |
| KR (1) | KR101842570B1 (https=) |
| CN (1) | CN102741284A (https=) |
| AR (1) | AR079708A1 (https=) |
| AU (1) | AU2010336369C1 (https=) |
| BR (1) | BR112012017765A2 (https=) |
| CA (1) | CA2785158C (https=) |
| CY (1) | CY1118898T1 (https=) |
| DK (1) | DK2516466T3 (https=) |
| ES (1) | ES2628135T3 (https=) |
| HR (1) | HRP20170524T1 (https=) |
| HU (1) | HUE034722T2 (https=) |
| IL (1) | IL220402A (https=) |
| JO (1) | JO3274B1 (https=) |
| LT (1) | LT2516466T (https=) |
| MX (1) | MX337082B (https=) |
| NZ (1) | NZ600768A (https=) |
| PL (1) | PL2516466T3 (https=) |
| PT (1) | PT2516466T (https=) |
| RS (1) | RS56009B1 (https=) |
| RU (1) | RU2580045C2 (https=) |
| SG (1) | SG181784A1 (https=) |
| SI (1) | SI2516466T1 (https=) |
| SM (1) | SMT201700280T1 (https=) |
| TW (1) | TWI488643B (https=) |
| UY (1) | UY33144A (https=) |
| WO (1) | WO2011079257A2 (https=) |
| ZA (1) | ZA201204507B (https=) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3672B1 (ar) | 2008-12-15 | 2020-08-27 | Regeneron Pharma | أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9). |
| PL3395836T3 (pl) | 2011-01-28 | 2021-12-13 | Sanofi Biotechnology | Ludzkie przeciwciała przeciwko pcsk9 do zastosowania w sposobach leczenia konkretnych grup osobników |
| AR087305A1 (es) | 2011-07-28 | 2014-03-12 | Regeneron Pharma | Formulaciones estabilizadas que contienen anticuerpos anti-pcsk9, metodo de preparacion y kit |
| BR112014006394A2 (pt) * | 2011-09-19 | 2017-03-28 | Kymab Ltd | manipulação de diversidade genética de imunoglobulina e terapêuticos multi-anticorpos |
| WO2013155512A2 (en) * | 2012-04-13 | 2013-10-17 | The Johns Hopkins University | Treatment of ischemic retinopathies |
| US9255154B2 (en) | 2012-05-08 | 2016-02-09 | Alderbio Holdings, Llc | Anti-PCSK9 antibodies and use thereof |
| TW201823460A (zh) | 2012-05-29 | 2018-07-01 | 美商再生元醫藥公司 | 生產細胞株增強子 |
| US20150210753A1 (en) | 2012-07-26 | 2015-07-30 | Momenta Pharmaceuticals, Inc. | Glycoproteins with anti-inflammatory properties |
| TWI596115B (zh) | 2012-08-13 | 2017-08-21 | 再生元醫藥公司 | 具有ｐＨ－依賴性結合特性之抗－ＰＣＳＫ９抗體 |
| GB201301313D0 (en) * | 2013-01-25 | 2013-03-06 | Univ Singapore | Respiratory Tract Infections |
| MX2015016978A (es) | 2013-06-10 | 2016-04-25 | Merck Sharp & Dohme | Proteinas de union a antigeno neutralizantes de citomegalovirus. |
| KR101538787B1 (ko) * | 2013-06-27 | 2015-07-22 | 인하대학교 산학협력단 | 췌장염 진단용 바이오 마커 조성물 |
| MX2016006226A (es) | 2013-11-12 | 2016-09-07 | Sanofi Biotechnology | Regimenes de dosificacion para uso con inhibidores de pcsk9. |
| US11293929B2 (en) * | 2014-01-07 | 2022-04-05 | Bioatla, Inc. | Proteins targeting orthologs |
| WO2016020880A2 (en) * | 2014-08-07 | 2016-02-11 | Novartis Ag | Angiopoietin-like 4 antibodies and methods of use |
| WO2016020882A2 (en) * | 2014-08-07 | 2016-02-11 | Novartis Ag | Angiopoetin-like 4 (angptl4) antibodies and methods of use |
| US9556225B2 (en) * | 2014-10-15 | 2017-01-31 | Uniao Quimica Farmaceutica Nacional S/A | Peptide stimulator of cell survival and proliferation |
| WO2016181409A1 (en) | 2015-05-11 | 2016-11-17 | Cadila Healthcare Limited | Saroglitazar magnesium for the treatment of chylomicronemia syndrome - |
| WO2017011929A1 (zh) * | 2015-07-17 | 2017-01-26 | 北京大学第一医院 | 检测血清血管生成素样蛋白2含量的物质在制备检测肝脏炎症和纤维化程度产品中的应用 |
| TW201713690A (zh) | 2015-08-07 | 2017-04-16 | 再生元醫藥公司 | 抗ａｎｇｐｔｌ８抗體及其用途 |
| JP2018523684A (ja) | 2015-08-18 | 2018-08-23 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | リポタンパク質アフェレーシスを受けている高脂血症の患者を治療するための抗ｐｃｓｋ９阻害抗体 |
| WO2017064635A2 (en) | 2015-10-14 | 2017-04-20 | Cadila Healthcare Limited | Pyrrole compound, compositions and process for preparation thereof |
| WO2018094112A1 (en) | 2016-11-17 | 2018-05-24 | Regeneron Pharmaceuticals, Inc. | Methods of treating obesity with anti-angptl8 antibodies |
| WO2018129090A1 (en) * | 2017-01-03 | 2018-07-12 | Trellis Bioscience, Llc | Native human antibodies for immune checkpoint modulation targets tim-3 and b7-h3 |
| US20190031774A1 (en) | 2017-06-09 | 2019-01-31 | Sanofi Biotechnology | Methods for treating hyperlipidemia in diabetic patients by administering a pcsk9 inhibitor |
| EP3938405A4 (en) * | 2019-03-20 | 2022-12-28 | Javelin Oncology, Inc. | ANTI-ADAM12 ANTIBODIES AND CHIMERIC ANTIGEN RECEPTORS, AND COMPOSITIONS AND METHODS THEREOF |
| WO2021037007A1 (zh) | 2019-08-29 | 2021-03-04 | 荣昌生物制药(烟台)股份有限公司 | 抗pd-l1抗体及其应用 |
| CN115175685B (zh) * | 2019-12-09 | 2024-12-13 | 艾姆皮瑞克公司 | 用于治疗血管生成素样4(angptl4)相关疾病的寡核苷酸 |
| SG11202110145SA (en) | 2020-02-26 | 2021-10-28 | Vir Biotechnology Inc | Antibodies against sars-cov-2 and methods of using the same |
| JP2023533253A (ja) * | 2020-07-02 | 2023-08-02 | マブリティクス， インコーポレイテッド | 細胞結合タンパク質および使用の方法 |
| WO2022006555A2 (en) * | 2020-07-02 | 2022-01-06 | Gigagen, Inc. | BISPECIFIC ANTIGEN BINDING PROTEINS TARGETING PD-L1 AND TGF-β AND METHODS OF USE |
| WO2023239307A1 (en) * | 2022-06-10 | 2023-12-14 | Nanyang Technological University | Methods of treating liver fibrosis, inflammation or associated diseases using an angptl4 antagonist |
| WO2024027708A1 (zh) * | 2022-08-02 | 2024-02-08 | 诺纳生物（苏州）有限公司 | Msln抗体药物偶联物 |
| CN117535353A (zh) * | 2023-10-11 | 2024-02-09 | 首都医科大学附属北京潞河医院 | 一种糖尿病视网膜病变模型的建立方法及应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7070959B1 (en) | 1999-06-08 | 2006-07-04 | Regeneron Pharmaceuticals, Inc. | Modified chimeric polypeptides with improved pharmacokinetic properties |
| US20040101920A1 (en) | 2002-11-01 | 2004-05-27 | Czeslaw Radziejewski | Modification assisted profiling (MAP) methodology |
| WO2005103081A2 (en) | 2004-04-20 | 2005-11-03 | Genmab A/S | Human monoclonal antibodies against cd20 |
| BRPI0519596B1 (pt) * | 2004-12-21 | 2022-01-18 | Astrazeneca Ab | Agente de ligação alvejado, anticorpo monoclonal que se liga a angiopoietina-2, molécula de ácido nucleico, vetor, e, uso do agente de ligação alvejado |
| JP5366406B2 (ja) | 2005-01-07 | 2013-12-11 | レキシコン ファーマシューティカルズ インコーポレーテッド | アンジオポエチン様タンパク質４（ａｎｇｐｔｌ４）に対するモノクローナル抗体 |
| DK1962895T3 (da) | 2005-12-16 | 2013-03-04 | Regeneron Pharma | TERAPEUTISK ANVENDELSE AF EN Dll4-ANTAGONIST OG EN VEGF-HÆMMER TIL HÆMNING AF TUMORVÆKST |
| AU2007227251A1 (en) * | 2006-03-20 | 2007-09-27 | Amgen Fremont, Inc. | Antibodies directed to angiopoietin-like protein 4 and uses thereof |
| ES2398076T3 (es) | 2006-06-02 | 2013-03-13 | Regeneron Pharmaceuticals, Inc. | Anticuerpos de alta afinidad contra el receptor de IL-6 humano |
| NO347649B1 (no) | 2006-12-14 | 2024-02-12 | Regeneron Pharma | Humant antistoff eller antistoff fragment som spesifikt binder human deltaliknende ligand 4 (hDII4), nukleinsyremolekyl som koder for slike og vektor og vert-vektorsystemer, samt fremgangsmåte for fremstilling, sammensetning og anvendelse. |
| JO3672B1 (ar) | 2008-12-15 | 2020-08-27 | Regeneron Pharma | أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9). |
-
2010
- 2010-12-16 JO JOP/2010/0453A patent/JO3274B1/ar active
- 2010-12-22 UY UY0001033144A patent/UY33144A/es unknown
- 2010-12-22 AR ARP100104893A patent/AR079708A1/es unknown
- 2010-12-23 EP EP10798240.7A patent/EP2516466B1/en active Active
- 2010-12-23 TW TW099145406A patent/TWI488643B/zh not_active IP Right Cessation
- 2010-12-23 CN CN2010800628627A patent/CN102741284A/zh active Pending
- 2010-12-23 SM SM20170280T patent/SMT201700280T1/it unknown
- 2010-12-23 KR KR1020127019046A patent/KR101842570B1/ko not_active Expired - Fee Related
- 2010-12-23 WO PCT/US2010/061987 patent/WO2011079257A2/en not_active Ceased
- 2010-12-23 ES ES10798240.7T patent/ES2628135T3/es active Active
- 2010-12-23 BR BR112012017765A patent/BR112012017765A2/pt not_active Application Discontinuation
- 2010-12-23 SI SI201031459A patent/SI2516466T1/sl unknown
- 2010-12-23 HU HUE10798240A patent/HUE034722T2/en unknown
- 2010-12-23 CA CA2785158A patent/CA2785158C/en active Active
- 2010-12-23 US US12/977,361 patent/US8354103B2/en active Active
- 2010-12-23 PT PT107982407T patent/PT2516466T/pt unknown
- 2010-12-23 SG SG2012044871A patent/SG181784A1/en unknown
- 2010-12-23 PL PL10798240T patent/PL2516466T3/pl unknown
- 2010-12-23 JP JP2012546229A patent/JP6000855B2/ja not_active Expired - Fee Related
- 2010-12-23 RS RS20170522A patent/RS56009B1/sr unknown
- 2010-12-23 HR HRP20170524TT patent/HRP20170524T1/hr unknown
- 2010-12-23 DK DK10798240.7T patent/DK2516466T3/en active
- 2010-12-23 NZ NZ600768A patent/NZ600768A/en not_active IP Right Cessation
- 2010-12-23 AU AU2010336369A patent/AU2010336369C1/en not_active Ceased
- 2010-12-23 LT LTEP10798240.7T patent/LT2516466T/lt unknown
- 2010-12-23 RU RU2012131547/10A patent/RU2580045C2/ru not_active IP Right Cessation
- 2010-12-23 MX MX2012007460A patent/MX337082B/es active IP Right Grant
-
2012
- 2012-06-14 IL IL220402A patent/IL220402A/en not_active IP Right Cessation
- 2012-06-19 ZA ZA2012/04507A patent/ZA201204507B/en unknown
- 2012-12-12 US US13/712,268 patent/US9120851B2/en active Active
-
2015
- 2015-05-11 JP JP2015096446A patent/JP2015145424A/ja active Pending
-
2017
- 2017-05-17 CY CY20171100521T patent/CY1118898T1/el unknown
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