JP2013515074A5 - - Google Patents

Download PDF

Info

Publication number
JP2013515074A5
JP2013515074A5 JP2012546137A JP2012546137A JP2013515074A5 JP 2013515074 A5 JP2013515074 A5 JP 2013515074A5 JP 2012546137 A JP2012546137 A JP 2012546137A JP 2012546137 A JP2012546137 A JP 2012546137A JP 2013515074 A5 JP2013515074 A5 JP 2013515074A5
Authority
JP
Japan
Prior art keywords
aliphatic
alkyl
hydrogen
acceptable salt
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2012546137A
Other languages
English (en)
Japanese (ja)
Other versions
JP5721187B2 (ja
JP2013515074A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2010/061484 external-priority patent/WO2011087776A1/en
Publication of JP2013515074A publication Critical patent/JP2013515074A/ja
Publication of JP2013515074A5 publication Critical patent/JP2013515074A5/ja
Application granted granted Critical
Publication of JP5721187B2 publication Critical patent/JP5721187B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2012546137A 2009-12-22 2010-12-21 ホスファチジルイノシトール3−キナーゼのイソインドリノンインヒビター Expired - Fee Related JP5721187B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US28900309P 2009-12-22 2009-12-22
US61/289,003 2009-12-22
US35063110P 2010-06-02 2010-06-02
US61/350,631 2010-06-02
US36920110P 2010-07-30 2010-07-30
US61/369,201 2010-07-30
US38758210P 2010-09-29 2010-09-29
US61/387,582 2010-09-29
PCT/US2010/061484 WO2011087776A1 (en) 2009-12-22 2010-12-21 Isoindolinone inhibitors of phosphatidylinositol 3-kinase

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015034849A Division JP6132410B2 (ja) 2009-12-22 2015-02-25 ホスファチジルイノシトール3−キナーゼのイソインドリノンインヒビター

Publications (3)

Publication Number Publication Date
JP2013515074A JP2013515074A (ja) 2013-05-02
JP2013515074A5 true JP2013515074A5 (cg-RX-API-DMAC7.html) 2014-02-13
JP5721187B2 JP5721187B2 (ja) 2015-05-20

Family

ID=43859800

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2012546137A Expired - Fee Related JP5721187B2 (ja) 2009-12-22 2010-12-21 ホスファチジルイノシトール3−キナーゼのイソインドリノンインヒビター
JP2015034849A Expired - Fee Related JP6132410B2 (ja) 2009-12-22 2015-02-25 ホスファチジルイノシトール3−キナーゼのイソインドリノンインヒビター
JP2017067536A Expired - Fee Related JP6510580B2 (ja) 2009-12-22 2017-03-30 ホスファチジルイノシトール3−キナーゼのイソインドリノンインヒビター
JP2018079069A Withdrawn JP2018131449A (ja) 2009-12-22 2018-04-17 ホスファチジルイノシトール3−キナーゼのイソインドリノンインヒビター

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2015034849A Expired - Fee Related JP6132410B2 (ja) 2009-12-22 2015-02-25 ホスファチジルイノシトール3−キナーゼのイソインドリノンインヒビター
JP2017067536A Expired - Fee Related JP6510580B2 (ja) 2009-12-22 2017-03-30 ホスファチジルイノシトール3−キナーゼのイソインドリノンインヒビター
JP2018079069A Withdrawn JP2018131449A (ja) 2009-12-22 2018-04-17 ホスファチジルイノシトール3−キナーゼのイソインドリノンインヒビター

Country Status (16)

Country Link
US (4) US20120040950A1 (cg-RX-API-DMAC7.html)
EP (3) EP2516417B1 (cg-RX-API-DMAC7.html)
JP (4) JP5721187B2 (cg-RX-API-DMAC7.html)
KR (1) KR101758046B1 (cg-RX-API-DMAC7.html)
CN (1) CN102762548B (cg-RX-API-DMAC7.html)
AU (1) AU2010341573B2 (cg-RX-API-DMAC7.html)
BR (1) BR112012018386A8 (cg-RX-API-DMAC7.html)
CA (1) CA2785499C (cg-RX-API-DMAC7.html)
CL (1) CL2012001714A1 (cg-RX-API-DMAC7.html)
ES (2) ES2842399T3 (cg-RX-API-DMAC7.html)
IL (1) IL220625A (cg-RX-API-DMAC7.html)
MX (2) MX2012007403A (cg-RX-API-DMAC7.html)
NZ (1) NZ600954A (cg-RX-API-DMAC7.html)
RU (1) RU2573569C2 (cg-RX-API-DMAC7.html)
SG (2) SG10201502073PA (cg-RX-API-DMAC7.html)
WO (1) WO2011087776A1 (cg-RX-API-DMAC7.html)

Families Citing this family (117)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104926815B (zh) 2008-01-04 2017-11-03 英特利凯恩有限责任公司 某些化学实体、组合物和方法
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
EP2346508B1 (en) 2008-09-26 2016-08-24 Intellikine, LLC Heterocyclic kinase inhibitors
JP5789252B2 (ja) 2009-05-07 2015-10-07 インテリカイン, エルエルシー 複素環式化合物およびその使用
NZ600954A (en) 2009-12-22 2013-11-29 Isoindolinone inhibitors of phosphatidylinositol 3-kinase
WO2011146882A1 (en) 2010-05-21 2011-11-24 Intellikine, Inc. Chemical compounds, compositions and methods for kinase modulation
CN103298474B (zh) 2010-11-10 2016-06-29 无限药品股份有限公司 杂环化合物及其用途
US8754114B2 (en) 2010-12-22 2014-06-17 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3
AR084824A1 (es) 2011-01-10 2013-06-26 Intellikine Inc Procesos para preparar isoquinolinonas y formas solidas de isoquinolinonas
WO2013012915A1 (en) 2011-07-19 2013-01-24 Infinity Pharmaceuticals Inc. Heterocyclic compounds and uses thereof
CA2842190A1 (en) 2011-07-19 2013-01-24 Infinity Pharmaceuticals Inc. Heterocyclic compounds and uses thereof
CN103998442B (zh) 2011-08-29 2016-09-14 无限药品股份有限公司 杂环化合物及其用途
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
ES2645984T3 (es) * 2012-04-25 2017-12-11 Raqualia Pharma Inc Derivados de pirrolopiridinona como bloqueadores de TTX-S
EP3495367B1 (en) 2012-06-13 2020-09-30 Incyte Holdings Corporation Substituted tricyclic compounds as fgfr inhibitors
US8828998B2 (en) 2012-06-25 2014-09-09 Infinity Pharmaceuticals, Inc. Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
WO2014026125A1 (en) 2012-08-10 2014-02-13 Incyte Corporation Pyrazine derivatives as fgfr inhibitors
UA110688C2 (uk) * 2012-09-21 2016-01-25 Пфайзер Інк. Біциклічні піридинони
HRP20181367T4 (hr) 2012-11-01 2021-11-26 Infinity Pharmaceuticals, Inc. Liječenje raka korištenjem modulatora izoforme pi3 kinaze
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
US9481667B2 (en) 2013-03-15 2016-11-01 Infinity Pharmaceuticals, Inc. Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
UY35464A (es) 2013-03-15 2014-10-31 Araxes Pharma Llc Inhibidores covalentes de kras g12c.
DK2986610T5 (en) 2013-04-19 2018-12-10 Incyte Holdings Corp BICYCLIC HETEROCYCLES AS FGFR INHIBITORS
CA2925601C (en) * 2013-09-25 2022-11-01 Vertex Pharmaceuticals Incorporated A selective inhibitor of phosphatidylinositol 3-kinase-gamma
US9751888B2 (en) 2013-10-04 2017-09-05 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
MX389256B (es) 2013-10-04 2025-03-20 Infinity Pharmaceuticals Inc Compuestos heterociclicos y usos de los mismos.
JO3805B1 (ar) 2013-10-10 2021-01-31 Araxes Pharma Llc مثبطات كراس جي12سي
CN113616656B (zh) 2014-03-19 2023-02-17 无限药品股份有限公司 用于治疗PI3K-γ介导的障碍的杂环化合物
WO2015160307A1 (en) * 2014-04-16 2015-10-22 Nanyang Technological University Allenamide as an orthogonal handle for selective modification of cysteine in peptides and proteins
WO2015160975A2 (en) 2014-04-16 2015-10-22 Infinity Pharmaceuticals, Inc. Combination therapies
AU2015250610B2 (en) * 2014-04-23 2019-02-07 Takeda Pharmaceutical Company Limited Isoindoline-1-one derivatives as cholinergic muscarinic M1 receptor positive alloesteric modulator activity for the treatment of Alzheimers disease
CN106660994A (zh) 2014-06-13 2017-05-10 吉利德科学公司 磷脂酰肌醇3‑激酶抑制剂
AU2015274696B2 (en) 2014-06-13 2018-09-27 Gilead Sciences, Inc. Phosphatidylinositol 3-kinase inhibitors
NZ726055A (en) 2014-06-13 2018-04-27 Gilead Sciences Inc Quinazolinone derivatives as phosphatidylinositol 3-kinase inhibitors
SG11201610095SA (en) 2014-06-13 2016-12-29 Gilead Sciences Inc Phosphatidylinositol 3-kinase inhibitors
CA2952044C (en) * 2014-06-13 2019-01-29 Gilead Sciences, Inc. Phosphatidylinositol 3-kinase inhibitors
US9708348B2 (en) 2014-10-03 2017-07-18 Infinity Pharmaceuticals, Inc. Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
CR20170390A (es) 2015-02-20 2017-10-23 Incyte Holdings Corp Heterociclos biciclicos como inhibidores de fgfr
WO2016134294A1 (en) 2015-02-20 2016-08-25 Incyte Corporation Bicyclic heterocycles as fgfr4 inhibitors
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
MX382355B (es) 2015-04-10 2025-03-13 Araxes Pharma Llc Compuestos de quinazolina sustituidos y métodos de uso de los mismos.
CA2982360A1 (en) 2015-04-15 2016-10-20 Liansheng Li Fused-tricyclic inhibitors of kras and methods of use thereof
US10144724B2 (en) 2015-07-22 2018-12-04 Araxes Pharma Llc Substituted quinazoline compounds and methods of use thereof
WO2017045955A1 (en) * 2015-09-14 2017-03-23 Basf Se Heterobicyclic compounds
CN114230571B (zh) 2015-09-14 2025-07-08 无限药品股份有限公司 异喹啉酮的固体形式、其制备方法、包含其的组合物及其使用方法
WO2017058807A1 (en) 2015-09-28 2017-04-06 Araxes Pharma Llc Inhibitors of kras g12c mutant proteins
US10858343B2 (en) 2015-09-28 2020-12-08 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
EP3356354A1 (en) 2015-09-28 2018-08-08 Araxes Pharma LLC Inhibitors of kras g12c mutant proteins
WO2017058792A1 (en) 2015-09-28 2017-04-06 Araxes Pharma Llc Inhibitors of kras g12c mutant proteins
WO2017058768A1 (en) 2015-09-28 2017-04-06 Araxes Pharma Llc Inhibitors of kras g12c mutant proteins
US10975071B2 (en) 2015-09-28 2021-04-13 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
WO2017058902A1 (en) 2015-09-28 2017-04-06 Araxes Pharma Llc Inhibitors of kras g12c mutant proteins
US10514986B2 (en) 2015-09-30 2019-12-24 Commvault Systems, Inc. Dynamic triggering of block-level backups based on block change thresholds and corresponding file identities in a data storage management system
SG10201912959QA (en) 2015-10-21 2020-02-27 Otsuka Pharma Co Ltd Benzolactam compounds as protein kinase inhibitors
US20180305331A1 (en) * 2015-10-22 2018-10-25 Selvita S.A. Pyridone derivatives and their use as kinase inhibitors
MX2018005967A (es) 2015-11-16 2018-08-29 Araxes Pharma Llc Compuestos de quinazolina 2-sustituida que comprenden un grupo heterociclico sustituido y metodos de uso de los mismos.
TW201726675A (zh) 2015-12-23 2017-08-01 默沙東藥廠 M4毒蕈鹼乙醯膽鹼受體之異位調節劑6,7-二氫-5h-吡咯并[3,4-b]吡啶-5-酮
WO2017107089A1 (en) 2015-12-23 2017-06-29 Merck Sharp & Dohme Corp. 3- (1h-pyrazol-4-yl) pyridineallosteric modulators of the m4 muscarinic acetylcholine receptor
WO2017107087A1 (en) * 2015-12-23 2017-06-29 Merck Sharp & Dohme Corp. 6, 7-dihydro-5h-pyrrolo [3, 4-b] pyridin-5-oneallosteric modulators of the m4 muscarinic acetylcholine receptor
KR20180117693A (ko) * 2016-03-10 2018-10-29 아스트라제네카 아베 포스파티딜이노시톨 3-키나제 감마의 신규 억제제
CA3013696C (en) 2016-03-17 2024-04-16 F. Hoffmann-La Roche Ag 5-ethyl-4-methyl-pyrazole-3-carboxamide derivative having activity as agonist of taar
US10759806B2 (en) 2016-03-17 2020-09-01 Infinity Pharmaceuticals, Inc. Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as PI3K kinase inhibitors
GB201604970D0 (en) 2016-03-23 2016-05-04 Syngenta Participations Ag Improvements in or relating to organic compounds
WO2017214269A1 (en) 2016-06-08 2017-12-14 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
CA3028718A1 (en) 2016-06-24 2017-12-28 Infinity Pharmaceuticals, Inc. Combination therapies
US10646488B2 (en) 2016-07-13 2020-05-12 Araxes Pharma Llc Conjugates of cereblon binding compounds and G12C mutant KRAS, HRAS or NRAS protein modulating compounds and methods of use thereof
CN110036010A (zh) 2016-09-29 2019-07-19 亚瑞克西斯制药公司 Kras g12c突变蛋白的抑制剂
WO2018068017A1 (en) * 2016-10-07 2018-04-12 Araxes Pharma Llc Heterocyclic compounds as inhibitors of ras and methods of use thereof
WO2018112843A1 (en) 2016-12-22 2018-06-28 Merck Sharp & Dohme Corp. Heteroaryl piperidine ether allosteric modulators of the m4 muscarinic acetylcholine receptor
WO2018112842A1 (en) 2016-12-22 2018-06-28 Merck Sharp & Dohme Corp. 6,6-fused heteroaryl piperidine ether allosteric modulators of m4 muscarinic acetylcholine receptor
US11279689B2 (en) 2017-01-26 2022-03-22 Araxes Pharma Llc 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1 yl)prop-2-en-1-one derivatives and similar compounds as KRAS G12C modulators for treating cancer
WO2018140512A1 (en) 2017-01-26 2018-08-02 Araxes Pharma Llc Fused bicyclic benzoheteroaromatic compounds and methods of use thereof
EP3573970A1 (en) 2017-01-26 2019-12-04 Araxes Pharma LLC 1-(6-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)azetidin-1-yl)prop-2-en-1-one derivatives and similar compounds as kras g12c inhibitors for the treatment of cancer
EP3573964A1 (en) 2017-01-26 2019-12-04 Araxes Pharma LLC Benzothiophene and benzothiazole compounds and methods of use thereof
US11059819B2 (en) 2017-01-26 2021-07-13 Janssen Biotech, Inc. Fused hetero-hetero bicyclic compounds and methods of use thereof
GB201706327D0 (en) 2017-04-20 2017-06-07 Otsuka Pharma Co Ltd A pharmaceutical compound
CN110869357A (zh) 2017-05-25 2020-03-06 亚瑞克西斯制药公司 化合物及其用于治疗癌症的使用方法
JP2020521740A (ja) 2017-05-25 2020-07-27 アラクセス ファーマ エルエルシー 変異体kras、hrasまたはnrasの調節因子としてのキナゾリン誘導体
MX2019013954A (es) 2017-05-25 2020-08-31 Araxes Pharma Llc Inhibidores covalentes de kras.
AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
WO2018226545A1 (en) * 2017-06-09 2018-12-13 Merck Sharp & Dohme Corp. Azabicyclo[4.1.0]heptane allosteric modulators of the m4 muscarinic acetylcholine receptor
JP6647738B2 (ja) 2017-06-12 2020-02-14 矢崎総業株式会社 電池パック
WO2019000237A1 (en) 2017-06-27 2019-01-03 Merck Sharp & Dohme Corp. ALLOSTERIC MODULATORS OF 3- (1H-PYRAZOL-4-YL) PYRIDINE FROM THE M4 ACETYLCHOLINE MUSCARINIC RECEPTOR
WO2019000238A1 (en) * 2017-06-27 2019-01-03 Merck Sharp & Dohme Corp. 5- (PYRIDIN-3-YL) OXAZOLE ALLOSTERIC MODULATORS OF M4 ACETYLCHOLINE MUSCARINIC RECEPTOR
WO2019000236A1 (en) 2017-06-27 2019-01-03 Merck Sharp & Dohme Corp. ALLOSTERIC MODULATORS OF 3- (1H-PYRAZOL-4-YL) PYRIDINE FROM THE M4 ACETYLCHOLINE MUSCARINIC RECEPTOR
RU2020136310A (ru) * 2018-04-06 2022-05-06 ПРАКСИС БАЙОТЕК ЭлЭлСи Ингибиторы atf6 и их применение
US11466004B2 (en) 2018-05-04 2022-10-11 Incyte Corporation Solid forms of an FGFR inhibitor and processes for preparing the same
CN112566912A (zh) 2018-05-04 2021-03-26 因赛特公司 Fgfr抑制剂的盐
KR20210045998A (ko) 2018-08-01 2021-04-27 아락세스 파마 엘엘씨 헤테로사이클릭 스피로 화합물 및 암 치료를 위한 그의 사용 방법
WO2020102150A1 (en) 2018-11-13 2020-05-22 Incyte Corporation Heterocyclic derivatives as pi3k inhibitors
WO2020102216A1 (en) 2018-11-13 2020-05-22 Incyte Corporation Substituted heterocyclic derivatives as pi3k inhibitors
US11078204B2 (en) 2018-11-13 2021-08-03 Incyte Corporation Heterocyclic derivatives as PI3K inhibitors
WO2020185532A1 (en) 2019-03-08 2020-09-17 Incyte Corporation Methods of treating cancer with an fgfr inhibitor
CN115677692A (zh) * 2019-04-10 2023-02-03 南京征祥医药有限公司 磷脂酰肌醇3-激酶抑制剂
CA3142712A1 (en) 2019-06-04 2020-12-10 Arcus Biosciences, Inc. 2,3,5-trisubstituted pyrazolo[1,5-a]pyrimidine compounds
US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
US12122767B2 (en) 2019-10-01 2024-10-22 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
GEAP202415945A (en) 2019-10-14 2024-04-25 Incyte Corp Bicyclic heterocycles as fgfr inhibitors
WO2021076728A1 (en) 2019-10-16 2021-04-22 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
EP4069696A1 (en) 2019-12-04 2022-10-12 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors
BR112022010664A2 (pt) 2019-12-04 2022-08-16 Incyte Corp Derivados de um inibidor de fgfr
US12012409B2 (en) 2020-01-15 2024-06-18 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
MX2022013417A (es) 2020-04-29 2022-11-14 Relay Therapeutics Inc Inhibidores de fosfatidilinositol 3 cinasa (pi3k) alfa y metodos de uso de los mismos.
WO2022105526A1 (zh) * 2020-11-20 2022-05-27 中国科学院合肥物质科学研究院 二氢异喹啉酮和异吲哚啉酮衍生物及其用途
US20240174679A1 (en) * 2021-03-17 2024-05-30 Merck Sharp & Dohme Llc Heteroaroyl amides as lrrk2 inhibitors, pharmaceutical compositions, and uses thereof
TW202304459A (zh) 2021-04-12 2023-02-01 美商英塞特公司 包含fgfr抑制劑及nectin-4靶向劑之組合療法
JP2024522189A (ja) 2021-06-09 2024-06-11 インサイト・コーポレイション Fgfr阻害剤としての三環式ヘテロ環
WO2022261159A1 (en) 2021-06-09 2022-12-15 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors
EP4426286A4 (en) * 2021-11-03 2025-12-24 Relay Therapeutics Inc Bifunctional PI3K-Alpha Inhibitors and Their Uses
CN118302427A (zh) * 2021-12-02 2024-07-05 上海翰森生物医药科技有限公司 稠环类衍生物调节剂、其制备方法和应用
KR102670554B1 (ko) * 2022-01-04 2024-05-30 주식회사 이노보테라퓨틱스 캐스파제 저해제로서의 신규한 이소인돌리논 유도체 화합물
WO2023168378A1 (en) * 2022-03-04 2023-09-07 Synnovation Therapeutics, Inc. Pi3ka inhibitors
WO2024051784A1 (zh) * 2022-09-09 2024-03-14 上海璎黎药业有限公司 一种含氮杂环化合物、其药物组合物及应用
WO2024153238A1 (zh) * 2023-01-20 2024-07-25 南京再明医药有限公司 四环化合物及其应用
WO2024251212A1 (en) * 2023-06-06 2024-12-12 Revir Therapeutics, Inc. Isoindolinone and dihydropyrrolopridinone compounds and uses thereof
WO2025179441A1 (zh) * 2024-02-27 2025-09-04 上海璎黎药业有限公司 一种三并环结构化合物、其药物组合物及应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57134467A (en) * 1981-02-13 1982-08-19 Dai Ichi Seiyaku Co Ltd Pyridine derivative and its preparation
JP2006526648A (ja) * 2003-06-02 2006-11-24 アボット・ラボラトリーズ キナーゼ阻害剤としてのイソインドリン−1−オン化合物
CA2558278A1 (en) 2004-03-05 2005-09-15 Banyu Pharmaceutical Co., Ltd. Diaryl-substituted five-membered heterocycle derivative
SE0400970D0 (sv) * 2004-04-14 2004-04-14 Astrazeneca Ab Nicotinic acetylcholine receptor ligands
TW200613272A (en) * 2004-08-13 2006-05-01 Astrazeneca Ab Isoindolone compounds and their use as metabotropic glutamate receptor potentiators
GB0504753D0 (en) 2005-03-08 2005-04-13 Astrazeneca Ab Chemical compounds
TW200728277A (en) * 2005-06-29 2007-08-01 Palau Pharma Sa Bicyclic derivatives as P38 inhibitors
TW200804281A (en) * 2006-02-16 2008-01-16 Astrazeneca Ab New metabotropic glutamate receptor-potentiating isoindolones
CN101421237A (zh) * 2006-02-16 2009-04-29 阿斯利康(瑞典)有限公司 增效亲代谢性谷氨酸受体的异吲哚酮
US8110681B2 (en) * 2006-03-17 2012-02-07 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Compounds for the treatment of spinal muscular atrophy and other uses
AU2008239596B2 (en) * 2007-04-11 2013-08-15 Exelixis, Inc. Pyrido [2,3-D] pyrimidin-7-one compounds as inhibitors of PI3K-alpha for the treatment of cancer
NZ600954A (en) 2009-12-22 2013-11-29 Isoindolinone inhibitors of phosphatidylinositol 3-kinase

Similar Documents

Publication Publication Date Title
JP2013515074A5 (cg-RX-API-DMAC7.html)
RU2012131416A (ru) Ингибиторы фосфатидилинозитол-3-киназы на основе изоиндолинона
JP6936823B2 (ja) 抗癌活性及び抗増殖活性を呈する2−アミノピリミジン−6−オン及び類似体
KR101585848B1 (ko) 관절염의 치료 방법
AU2014233414B2 (en) N-acyl-N'-(pyridin-2-yl) ureas and analogs exhibiting anti-cancer and anti-proliferative activities
CN112424181B (zh) 作为sting调节剂的取代的缩合噻吩
TW202019900A (zh) Ptpn11抑制劑
JP2018505898A5 (cg-RX-API-DMAC7.html)
JP2016513661A5 (cg-RX-API-DMAC7.html)
WO2017040993A4 (en) Small molecule inhibitors of dyrk1a and uses thereof
JP7244504B2 (ja) PI3K-γ阻害剤としての三級ヒドロキシ基で置換された縮合イミダゾール誘導体
JP2010513532A (ja) スフィンゴシン−1−ホスフェート受容体作働薬および拮抗薬化合物
JP2014037426A5 (cg-RX-API-DMAC7.html)
JP2016539927A (ja) Jak1選択的阻害剤とその使用
JPWO2021013735A5 (cg-RX-API-DMAC7.html)
JP2009537461A5 (cg-RX-API-DMAC7.html)
JP2016527217A5 (cg-RX-API-DMAC7.html)
KR20170081204A (ko) 제약 화합물
JP2017533968A5 (cg-RX-API-DMAC7.html)
JP2014500295A5 (cg-RX-API-DMAC7.html)
JP2014502641A5 (cg-RX-API-DMAC7.html)
JP2024519487A (ja) Nav1.8阻害薬としてのアリール 3-オキソピペラジンカルボキサミド類及びヘテロアリール 3-オキソピペラジンカルボキサミド類
JP2021509113A (ja) キナーゼ阻害剤としての複素環式アミド
JP2011518168A5 (cg-RX-API-DMAC7.html)
JP2017511339A5 (cg-RX-API-DMAC7.html)