|
CN104926815B
(zh)
|
2008-01-04 |
2017-11-03 |
英特利凯恩有限责任公司 |
某些化学实体、组合物和方法
|
|
US8193182B2
(en)
|
2008-01-04 |
2012-06-05 |
Intellikine, Inc. |
Substituted isoquinolin-1(2H)-ones, and methods of use thereof
|
|
EP2346508B1
(en)
|
2008-09-26 |
2016-08-24 |
Intellikine, LLC |
Heterocyclic kinase inhibitors
|
|
JP5789252B2
(ja)
|
2009-05-07 |
2015-10-07 |
インテリカイン, エルエルシー |
複素環式化合物およびその使用
|
|
NZ600954A
(en)
|
2009-12-22 |
2013-11-29 |
|
Isoindolinone inhibitors of phosphatidylinositol 3-kinase
|
|
WO2011146882A1
(en)
|
2010-05-21 |
2011-11-24 |
Intellikine, Inc. |
Chemical compounds, compositions and methods for kinase modulation
|
|
CN103298474B
(zh)
|
2010-11-10 |
2016-06-29 |
无限药品股份有限公司 |
杂环化合物及其用途
|
|
US8754114B2
(en)
|
2010-12-22 |
2014-06-17 |
Incyte Corporation |
Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3
|
|
AR084824A1
(es)
|
2011-01-10 |
2013-06-26 |
Intellikine Inc |
Procesos para preparar isoquinolinonas y formas solidas de isoquinolinonas
|
|
WO2013012915A1
(en)
|
2011-07-19 |
2013-01-24 |
Infinity Pharmaceuticals Inc. |
Heterocyclic compounds and uses thereof
|
|
CA2842190A1
(en)
|
2011-07-19 |
2013-01-24 |
Infinity Pharmaceuticals Inc. |
Heterocyclic compounds and uses thereof
|
|
CN103998442B
(zh)
|
2011-08-29 |
2016-09-14 |
无限药品股份有限公司 |
杂环化合物及其用途
|
|
US8940742B2
(en)
|
2012-04-10 |
2015-01-27 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
|
ES2645984T3
(es)
*
|
2012-04-25 |
2017-12-11 |
Raqualia Pharma Inc |
Derivados de pirrolopiridinona como bloqueadores de TTX-S
|
|
EP3495367B1
(en)
|
2012-06-13 |
2020-09-30 |
Incyte Holdings Corporation |
Substituted tricyclic compounds as fgfr inhibitors
|
|
US8828998B2
(en)
|
2012-06-25 |
2014-09-09 |
Infinity Pharmaceuticals, Inc. |
Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
|
|
WO2014026125A1
(en)
|
2012-08-10 |
2014-02-13 |
Incyte Corporation |
Pyrazine derivatives as fgfr inhibitors
|
|
UA110688C2
(uk)
*
|
2012-09-21 |
2016-01-25 |
Пфайзер Інк. |
Біциклічні піридинони
|
|
HRP20181367T4
(hr)
|
2012-11-01 |
2021-11-26 |
Infinity Pharmaceuticals, Inc. |
Liječenje raka korištenjem modulatora izoforme pi3 kinaze
|
|
US9266892B2
(en)
|
2012-12-19 |
2016-02-23 |
Incyte Holdings Corporation |
Fused pyrazoles as FGFR inhibitors
|
|
US9481667B2
(en)
|
2013-03-15 |
2016-11-01 |
Infinity Pharmaceuticals, Inc. |
Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
|
|
UY35464A
(es)
|
2013-03-15 |
2014-10-31 |
Araxes Pharma Llc |
Inhibidores covalentes de kras g12c.
|
|
DK2986610T5
(en)
|
2013-04-19 |
2018-12-10 |
Incyte Holdings Corp |
BICYCLIC HETEROCYCLES AS FGFR INHIBITORS
|
|
CA2925601C
(en)
*
|
2013-09-25 |
2022-11-01 |
Vertex Pharmaceuticals Incorporated |
A selective inhibitor of phosphatidylinositol 3-kinase-gamma
|
|
US9751888B2
(en)
|
2013-10-04 |
2017-09-05 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
|
MX389256B
(es)
|
2013-10-04 |
2025-03-20 |
Infinity Pharmaceuticals Inc |
Compuestos heterociclicos y usos de los mismos.
|
|
JO3805B1
(ar)
|
2013-10-10 |
2021-01-31 |
Araxes Pharma Llc |
مثبطات كراس جي12سي
|
|
CN113616656B
(zh)
|
2014-03-19 |
2023-02-17 |
无限药品股份有限公司 |
用于治疗PI3K-γ介导的障碍的杂环化合物
|
|
WO2015160307A1
(en)
*
|
2014-04-16 |
2015-10-22 |
Nanyang Technological University |
Allenamide as an orthogonal handle for selective modification of cysteine in peptides and proteins
|
|
WO2015160975A2
(en)
|
2014-04-16 |
2015-10-22 |
Infinity Pharmaceuticals, Inc. |
Combination therapies
|
|
AU2015250610B2
(en)
*
|
2014-04-23 |
2019-02-07 |
Takeda Pharmaceutical Company Limited |
Isoindoline-1-one derivatives as cholinergic muscarinic M1 receptor positive alloesteric modulator activity for the treatment of Alzheimers disease
|
|
CN106660994A
(zh)
|
2014-06-13 |
2017-05-10 |
吉利德科学公司 |
磷脂酰肌醇3‑激酶抑制剂
|
|
AU2015274696B2
(en)
|
2014-06-13 |
2018-09-27 |
Gilead Sciences, Inc. |
Phosphatidylinositol 3-kinase inhibitors
|
|
NZ726055A
(en)
|
2014-06-13 |
2018-04-27 |
Gilead Sciences Inc |
Quinazolinone derivatives as phosphatidylinositol 3-kinase inhibitors
|
|
SG11201610095SA
(en)
|
2014-06-13 |
2016-12-29 |
Gilead Sciences Inc |
Phosphatidylinositol 3-kinase inhibitors
|
|
CA2952044C
(en)
*
|
2014-06-13 |
2019-01-29 |
Gilead Sciences, Inc. |
Phosphatidylinositol 3-kinase inhibitors
|
|
US9708348B2
(en)
|
2014-10-03 |
2017-07-18 |
Infinity Pharmaceuticals, Inc. |
Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof
|
|
US10851105B2
(en)
|
2014-10-22 |
2020-12-01 |
Incyte Corporation |
Bicyclic heterocycles as FGFR4 inhibitors
|
|
CR20170390A
(es)
|
2015-02-20 |
2017-10-23 |
Incyte Holdings Corp |
Heterociclos biciclicos como inhibidores de fgfr
|
|
WO2016134294A1
(en)
|
2015-02-20 |
2016-08-25 |
Incyte Corporation |
Bicyclic heterocycles as fgfr4 inhibitors
|
|
MA41551A
(fr)
|
2015-02-20 |
2017-12-26 |
Incyte Corp |
Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
|
|
MX382355B
(es)
|
2015-04-10 |
2025-03-13 |
Araxes Pharma Llc |
Compuestos de quinazolina sustituidos y métodos de uso de los mismos.
|
|
CA2982360A1
(en)
|
2015-04-15 |
2016-10-20 |
Liansheng Li |
Fused-tricyclic inhibitors of kras and methods of use thereof
|
|
US10144724B2
(en)
|
2015-07-22 |
2018-12-04 |
Araxes Pharma Llc |
Substituted quinazoline compounds and methods of use thereof
|
|
WO2017045955A1
(en)
*
|
2015-09-14 |
2017-03-23 |
Basf Se |
Heterobicyclic compounds
|
|
CN114230571B
(zh)
|
2015-09-14 |
2025-07-08 |
无限药品股份有限公司 |
异喹啉酮的固体形式、其制备方法、包含其的组合物及其使用方法
|
|
WO2017058807A1
(en)
|
2015-09-28 |
2017-04-06 |
Araxes Pharma Llc |
Inhibitors of kras g12c mutant proteins
|
|
US10858343B2
(en)
|
2015-09-28 |
2020-12-08 |
Araxes Pharma Llc |
Inhibitors of KRAS G12C mutant proteins
|
|
EP3356354A1
(en)
|
2015-09-28 |
2018-08-08 |
Araxes Pharma LLC |
Inhibitors of kras g12c mutant proteins
|
|
WO2017058792A1
(en)
|
2015-09-28 |
2017-04-06 |
Araxes Pharma Llc |
Inhibitors of kras g12c mutant proteins
|
|
WO2017058768A1
(en)
|
2015-09-28 |
2017-04-06 |
Araxes Pharma Llc |
Inhibitors of kras g12c mutant proteins
|
|
US10975071B2
(en)
|
2015-09-28 |
2021-04-13 |
Araxes Pharma Llc |
Inhibitors of KRAS G12C mutant proteins
|
|
WO2017058902A1
(en)
|
2015-09-28 |
2017-04-06 |
Araxes Pharma Llc |
Inhibitors of kras g12c mutant proteins
|
|
US10514986B2
(en)
|
2015-09-30 |
2019-12-24 |
Commvault Systems, Inc. |
Dynamic triggering of block-level backups based on block change thresholds and corresponding file identities in a data storage management system
|
|
SG10201912959QA
(en)
|
2015-10-21 |
2020-02-27 |
Otsuka Pharma Co Ltd |
Benzolactam compounds as protein kinase inhibitors
|
|
US20180305331A1
(en)
*
|
2015-10-22 |
2018-10-25 |
Selvita S.A. |
Pyridone derivatives and their use as kinase inhibitors
|
|
MX2018005967A
(es)
|
2015-11-16 |
2018-08-29 |
Araxes Pharma Llc |
Compuestos de quinazolina 2-sustituida que comprenden un grupo heterociclico sustituido y metodos de uso de los mismos.
|
|
TW201726675A
(zh)
|
2015-12-23 |
2017-08-01 |
默沙東藥廠 |
M4毒蕈鹼乙醯膽鹼受體之異位調節劑6,7-二氫-5h-吡咯并[3,4-b]吡啶-5-酮
|
|
WO2017107089A1
(en)
|
2015-12-23 |
2017-06-29 |
Merck Sharp & Dohme Corp. |
3- (1h-pyrazol-4-yl) pyridineallosteric modulators of the m4 muscarinic acetylcholine receptor
|
|
WO2017107087A1
(en)
*
|
2015-12-23 |
2017-06-29 |
Merck Sharp & Dohme Corp. |
6, 7-dihydro-5h-pyrrolo [3, 4-b] pyridin-5-oneallosteric modulators of the m4 muscarinic acetylcholine receptor
|
|
KR20180117693A
(ko)
*
|
2016-03-10 |
2018-10-29 |
아스트라제네카 아베 |
포스파티딜이노시톨 3-키나제 감마의 신규 억제제
|
|
CA3013696C
(en)
|
2016-03-17 |
2024-04-16 |
F. Hoffmann-La Roche Ag |
5-ethyl-4-methyl-pyrazole-3-carboxamide derivative having activity as agonist of taar
|
|
US10759806B2
(en)
|
2016-03-17 |
2020-09-01 |
Infinity Pharmaceuticals, Inc. |
Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as PI3K kinase inhibitors
|
|
GB201604970D0
(en)
|
2016-03-23 |
2016-05-04 |
Syngenta Participations Ag |
Improvements in or relating to organic compounds
|
|
WO2017214269A1
(en)
|
2016-06-08 |
2017-12-14 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
|
CA3028718A1
(en)
|
2016-06-24 |
2017-12-28 |
Infinity Pharmaceuticals, Inc. |
Combination therapies
|
|
US10646488B2
(en)
|
2016-07-13 |
2020-05-12 |
Araxes Pharma Llc |
Conjugates of cereblon binding compounds and G12C mutant KRAS, HRAS or NRAS protein modulating compounds and methods of use thereof
|
|
CN110036010A
(zh)
|
2016-09-29 |
2019-07-19 |
亚瑞克西斯制药公司 |
Kras g12c突变蛋白的抑制剂
|
|
WO2018068017A1
(en)
*
|
2016-10-07 |
2018-04-12 |
Araxes Pharma Llc |
Heterocyclic compounds as inhibitors of ras and methods of use thereof
|
|
WO2018112843A1
(en)
|
2016-12-22 |
2018-06-28 |
Merck Sharp & Dohme Corp. |
Heteroaryl piperidine ether allosteric modulators of the m4 muscarinic acetylcholine receptor
|
|
WO2018112842A1
(en)
|
2016-12-22 |
2018-06-28 |
Merck Sharp & Dohme Corp. |
6,6-fused heteroaryl piperidine ether allosteric modulators of m4 muscarinic acetylcholine receptor
|
|
US11279689B2
(en)
|
2017-01-26 |
2022-03-22 |
Araxes Pharma Llc |
1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1 yl)prop-2-en-1-one derivatives and similar compounds as KRAS G12C modulators for treating cancer
|
|
WO2018140512A1
(en)
|
2017-01-26 |
2018-08-02 |
Araxes Pharma Llc |
Fused bicyclic benzoheteroaromatic compounds and methods of use thereof
|
|
EP3573970A1
(en)
|
2017-01-26 |
2019-12-04 |
Araxes Pharma LLC |
1-(6-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)azetidin-1-yl)prop-2-en-1-one derivatives and similar compounds as kras g12c inhibitors for the treatment of cancer
|
|
EP3573964A1
(en)
|
2017-01-26 |
2019-12-04 |
Araxes Pharma LLC |
Benzothiophene and benzothiazole compounds and methods of use thereof
|
|
US11059819B2
(en)
|
2017-01-26 |
2021-07-13 |
Janssen Biotech, Inc. |
Fused hetero-hetero bicyclic compounds and methods of use thereof
|
|
GB201706327D0
(en)
|
2017-04-20 |
2017-06-07 |
Otsuka Pharma Co Ltd |
A pharmaceutical compound
|
|
CN110869357A
(zh)
|
2017-05-25 |
2020-03-06 |
亚瑞克西斯制药公司 |
化合物及其用于治疗癌症的使用方法
|
|
JP2020521740A
(ja)
|
2017-05-25 |
2020-07-27 |
アラクセス ファーマ エルエルシー |
変異体kras、hrasまたはnrasの調節因子としてのキナゾリン誘導体
|
|
MX2019013954A
(es)
|
2017-05-25 |
2020-08-31 |
Araxes Pharma Llc |
Inhibidores covalentes de kras.
|
|
AR111960A1
(es)
|
2017-05-26 |
2019-09-04 |
Incyte Corp |
Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
|
|
WO2018226545A1
(en)
*
|
2017-06-09 |
2018-12-13 |
Merck Sharp & Dohme Corp. |
Azabicyclo[4.1.0]heptane allosteric modulators of the m4 muscarinic acetylcholine receptor
|
|
JP6647738B2
(ja)
|
2017-06-12 |
2020-02-14 |
矢崎総業株式会社 |
電池パック
|
|
WO2019000237A1
(en)
|
2017-06-27 |
2019-01-03 |
Merck Sharp & Dohme Corp. |
ALLOSTERIC MODULATORS OF 3- (1H-PYRAZOL-4-YL) PYRIDINE FROM THE M4 ACETYLCHOLINE MUSCARINIC RECEPTOR
|
|
WO2019000238A1
(en)
*
|
2017-06-27 |
2019-01-03 |
Merck Sharp & Dohme Corp. |
5- (PYRIDIN-3-YL) OXAZOLE ALLOSTERIC MODULATORS OF M4 ACETYLCHOLINE MUSCARINIC RECEPTOR
|
|
WO2019000236A1
(en)
|
2017-06-27 |
2019-01-03 |
Merck Sharp & Dohme Corp. |
ALLOSTERIC MODULATORS OF 3- (1H-PYRAZOL-4-YL) PYRIDINE FROM THE M4 ACETYLCHOLINE MUSCARINIC RECEPTOR
|
|
RU2020136310A
(ru)
*
|
2018-04-06 |
2022-05-06 |
ПРАКСИС БАЙОТЕК ЭлЭлСи |
Ингибиторы atf6 и их применение
|
|
US11466004B2
(en)
|
2018-05-04 |
2022-10-11 |
Incyte Corporation |
Solid forms of an FGFR inhibitor and processes for preparing the same
|
|
CN112566912A
(zh)
|
2018-05-04 |
2021-03-26 |
因赛特公司 |
Fgfr抑制剂的盐
|
|
KR20210045998A
(ko)
|
2018-08-01 |
2021-04-27 |
아락세스 파마 엘엘씨 |
헤테로사이클릭 스피로 화합물 및 암 치료를 위한 그의 사용 방법
|
|
WO2020102150A1
(en)
|
2018-11-13 |
2020-05-22 |
Incyte Corporation |
Heterocyclic derivatives as pi3k inhibitors
|
|
WO2020102216A1
(en)
|
2018-11-13 |
2020-05-22 |
Incyte Corporation |
Substituted heterocyclic derivatives as pi3k inhibitors
|
|
US11078204B2
(en)
|
2018-11-13 |
2021-08-03 |
Incyte Corporation |
Heterocyclic derivatives as PI3K inhibitors
|
|
WO2020185532A1
(en)
|
2019-03-08 |
2020-09-17 |
Incyte Corporation |
Methods of treating cancer with an fgfr inhibitor
|
|
CN115677692A
(zh)
*
|
2019-04-10 |
2023-02-03 |
南京征祥医药有限公司 |
磷脂酰肌醇3-激酶抑制剂
|
|
CA3142712A1
(en)
|
2019-06-04 |
2020-12-10 |
Arcus Biosciences, Inc. |
2,3,5-trisubstituted pyrazolo[1,5-a]pyrimidine compounds
|
|
US11591329B2
(en)
|
2019-07-09 |
2023-02-28 |
Incyte Corporation |
Bicyclic heterocycles as FGFR inhibitors
|
|
US12122767B2
(en)
|
2019-10-01 |
2024-10-22 |
Incyte Corporation |
Bicyclic heterocycles as FGFR inhibitors
|
|
GEAP202415945A
(en)
|
2019-10-14 |
2024-04-25 |
Incyte Corp |
Bicyclic heterocycles as fgfr inhibitors
|
|
WO2021076728A1
(en)
|
2019-10-16 |
2021-04-22 |
Incyte Corporation |
Bicyclic heterocycles as fgfr inhibitors
|
|
EP4069696A1
(en)
|
2019-12-04 |
2022-10-12 |
Incyte Corporation |
Tricyclic heterocycles as fgfr inhibitors
|
|
BR112022010664A2
(pt)
|
2019-12-04 |
2022-08-16 |
Incyte Corp |
Derivados de um inibidor de fgfr
|
|
US12012409B2
(en)
|
2020-01-15 |
2024-06-18 |
Incyte Corporation |
Bicyclic heterocycles as FGFR inhibitors
|
|
MX2022013417A
(es)
|
2020-04-29 |
2022-11-14 |
Relay Therapeutics Inc |
Inhibidores de fosfatidilinositol 3 cinasa (pi3k) alfa y metodos de uso de los mismos.
|
|
WO2022105526A1
(zh)
*
|
2020-11-20 |
2022-05-27 |
中国科学院合肥物质科学研究院 |
二氢异喹啉酮和异吲哚啉酮衍生物及其用途
|
|
US20240174679A1
(en)
*
|
2021-03-17 |
2024-05-30 |
Merck Sharp & Dohme Llc |
Heteroaroyl amides as lrrk2 inhibitors, pharmaceutical compositions, and uses thereof
|
|
TW202304459A
(zh)
|
2021-04-12 |
2023-02-01 |
美商英塞特公司 |
包含fgfr抑制劑及nectin-4靶向劑之組合療法
|
|
JP2024522189A
(ja)
|
2021-06-09 |
2024-06-11 |
インサイト・コーポレイション |
Fgfr阻害剤としての三環式ヘテロ環
|
|
WO2022261159A1
(en)
|
2021-06-09 |
2022-12-15 |
Incyte Corporation |
Tricyclic heterocycles as fgfr inhibitors
|
|
EP4426286A4
(en)
*
|
2021-11-03 |
2025-12-24 |
Relay Therapeutics Inc |
Bifunctional PI3K-Alpha Inhibitors and Their Uses
|
|
CN118302427A
(zh)
*
|
2021-12-02 |
2024-07-05 |
上海翰森生物医药科技有限公司 |
稠环类衍生物调节剂、其制备方法和应用
|
|
KR102670554B1
(ko)
*
|
2022-01-04 |
2024-05-30 |
주식회사 이노보테라퓨틱스 |
캐스파제 저해제로서의 신규한 이소인돌리논 유도체 화합물
|
|
WO2023168378A1
(en)
*
|
2022-03-04 |
2023-09-07 |
Synnovation Therapeutics, Inc. |
Pi3ka inhibitors
|
|
WO2024051784A1
(zh)
*
|
2022-09-09 |
2024-03-14 |
上海璎黎药业有限公司 |
一种含氮杂环化合物、其药物组合物及应用
|
|
WO2024153238A1
(zh)
*
|
2023-01-20 |
2024-07-25 |
南京再明医药有限公司 |
四环化合物及其应用
|
|
WO2024251212A1
(en)
*
|
2023-06-06 |
2024-12-12 |
Revir Therapeutics, Inc. |
Isoindolinone and dihydropyrrolopridinone compounds and uses thereof
|
|
WO2025179441A1
(zh)
*
|
2024-02-27 |
2025-09-04 |
上海璎黎药业有限公司 |
一种三并环结构化合物、其药物组合物及应用
|