JP2013514971A5 - - Google Patents
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- Publication number
- JP2013514971A5 JP2013514971A5 JP2012543843A JP2012543843A JP2013514971A5 JP 2013514971 A5 JP2013514971 A5 JP 2013514971A5 JP 2012543843 A JP2012543843 A JP 2012543843A JP 2012543843 A JP2012543843 A JP 2012543843A JP 2013514971 A5 JP2013514971 A5 JP 2013514971A5
- Authority
- JP
- Japan
- Prior art keywords
- microparticles
- implant
- poly
- lactide
- polymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000007943 implant Substances 0.000 claims 15
- 239000011859 microparticle Substances 0.000 claims 14
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims 6
- -1 copoly (ether-ester) Polymers 0.000 claims 5
- JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 claims 5
- RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 claims 4
- 239000004952 Polyamide Substances 0.000 claims 4
- 229920002988 biodegradable polymer Polymers 0.000 claims 4
- 239000004621 biodegradable polymer Substances 0.000 claims 4
- 229920001577 copolymer Polymers 0.000 claims 4
- 229920006237 degradable polymer Polymers 0.000 claims 4
- 229920002647 polyamide Polymers 0.000 claims 4
- JJTUDXZGHPGLLC-ZXZARUISSA-N (3r,6s)-3,6-dimethyl-1,4-dioxane-2,5-dione Chemical compound C[C@H]1OC(=O)[C@H](C)OC1=O JJTUDXZGHPGLLC-ZXZARUISSA-N 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 3
- 239000002726 nonnucleoside reverse transcriptase inhibitor Substances 0.000 claims 3
- 229920000642 polymer Polymers 0.000 claims 3
- ICGQLNMKJVHCIR-UHFFFAOYSA-N 1,3,2-dioxazetidin-4-one Chemical compound O=C1ONO1 ICGQLNMKJVHCIR-UHFFFAOYSA-N 0.000 claims 2
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims 2
- 229920002732 Polyanhydride Polymers 0.000 claims 2
- 229920001710 Polyorthoester Polymers 0.000 claims 2
- 239000013543 active substance Substances 0.000 claims 2
- 229920003232 aliphatic polyester Polymers 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 229920001519 homopolymer Polymers 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 229920001308 poly(aminoacid) Polymers 0.000 claims 2
- 239000002745 poly(ortho ester) Substances 0.000 claims 2
- 229920002627 poly(phosphazenes) Polymers 0.000 claims 2
- 229920001281 polyalkylene Polymers 0.000 claims 2
- 238000007920 subcutaneous administration Methods 0.000 claims 2
- UJGHGRGFKZWGMS-UHFFFAOYSA-N 1,3-dioxan-2-one Chemical compound O=C1OCCCO1.O=C1OCCCO1 UJGHGRGFKZWGMS-UHFFFAOYSA-N 0.000 claims 1
- KKGSHHDRPRINNY-UHFFFAOYSA-N 1,4-dioxan-2-one Chemical compound O=C1COCCO1.O=C1COCCO1 KKGSHHDRPRINNY-UHFFFAOYSA-N 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000010419 fine particle Substances 0.000 claims 1
- 239000000017 hydrogel Substances 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 229920000117 poly(dioxanone) Polymers 0.000 claims 1
- YIBOMRUWOWDFLG-ONEGZZNKSA-N rilpivirine Chemical compound CC1=CC(\C=C\C#N)=CC(C)=C1NC1=CC=NC(NC=2C=CC(=CC=2)C#N)=N1 YIBOMRUWOWDFLG-ONEGZZNKSA-N 0.000 claims 1
- 229960002814 rilpivirine Drugs 0.000 claims 1
- 238000013268 sustained release Methods 0.000 claims 1
- 239000012730 sustained-release form Substances 0.000 claims 1
- 230000029305 taxis Effects 0.000 claims 1
- PAPBSGBWRJIAAV-UHFFFAOYSA-N ε-Caprolactone Chemical compound O=C1CCCCCO1 PAPBSGBWRJIAAV-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28837309P | 2009-12-21 | 2009-12-21 | |
| US61/288,373 | 2009-12-21 | ||
| PCT/EP2010/070246 WO2011080141A2 (en) | 2009-12-21 | 2010-12-20 | Degradable removable implant for the sustained release of an active compound |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013514971A JP2013514971A (ja) | 2013-05-02 |
| JP2013514971A5 true JP2013514971A5 (OSRAM) | 2014-02-13 |
| JP5950825B2 JP5950825B2 (ja) | 2016-07-13 |
Family
ID=43743502
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012543843A Active JP5950825B2 (ja) | 2009-12-21 | 2010-12-20 | 活性化合物の持続放出のための分解性の取り外し可能なインプラント |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US8784858B2 (OSRAM) |
| EP (1) | EP2515877B1 (OSRAM) |
| JP (1) | JP5950825B2 (OSRAM) |
| KR (1) | KR101798430B1 (OSRAM) |
| CN (1) | CN102740837B (OSRAM) |
| AU (1) | AU2010338425B2 (OSRAM) |
| BR (1) | BR112012015114B1 (OSRAM) |
| CA (1) | CA2784530C (OSRAM) |
| ES (1) | ES2600878T3 (OSRAM) |
| IL (1) | IL219685B (OSRAM) |
| MX (1) | MX2012007210A (OSRAM) |
| MY (1) | MY163383A (OSRAM) |
| NZ (1) | NZ600156A (OSRAM) |
| RU (1) | RU2593790C2 (OSRAM) |
| SG (1) | SG181759A1 (OSRAM) |
| UA (1) | UA112155C2 (OSRAM) |
| WO (1) | WO2011080141A2 (OSRAM) |
| ZA (1) | ZA201204583B (OSRAM) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014205252A2 (en) * | 2013-06-20 | 2014-12-24 | Mercy Medical Research Institute | Extended release drug-delivery contact lenses and methods of making |
| EP3180042B8 (en) | 2014-08-15 | 2025-03-12 | The Johns Hopkins University | Composite material for tissue restoration |
| WO2016149561A1 (en) * | 2015-03-17 | 2016-09-22 | Oak Crest Institute Of Science | Subdermal implants for the sustained delivery of water-soluble drugs |
| US11779435B2 (en) | 2015-08-26 | 2023-10-10 | Flexscrewdriver I.K.E. | Dental screwdriver |
| CN106702597B (zh) * | 2016-12-20 | 2019-06-18 | 华南理工大学 | 一种核-壳结构纳米纤维膜及其制备方法和应用 |
| BR112020000506A2 (pt) | 2017-07-11 | 2020-07-14 | Sustained Nano Systems Llc | formulações farmacêuticas hipercomprimidas |
| KR20210034544A (ko) | 2018-05-09 | 2021-03-30 | 더 존스 홉킨스 유니버시티 | 향상된 연조직 대체 및 재생을 위한 나노섬유-하이드로겔 복합재료 |
| CN112384258A (zh) | 2018-05-09 | 2021-02-19 | 约翰·霍普金斯大学 | 用于细胞和组织递送的纳米纤维-水凝胶复合物 |
| CN112423739A (zh) * | 2018-05-16 | 2021-02-26 | 斯贝洛克斯公司 | 过敏性鼻炎药物输送植入物 |
| EP3866761A4 (en) * | 2018-10-16 | 2022-08-10 | Research Triangle Institute | SUBCUTANEOUS BIODEGRADABLE RESERVOIR DEVICE |
| WO2021207329A1 (en) * | 2020-04-07 | 2021-10-14 | Research Triangle Institute | Multi-drug formulations for subcutaneous biodegradable reservoir device |
| WO2021229111A1 (es) * | 2020-05-12 | 2021-11-18 | Laboratorios Farmacéuticos Rovi, S.A. | Procedimiento para la purificación de partículas poliméricas termoplásticas biodegradables para uso médico y/o farmacéutico |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5182111A (en) * | 1987-11-17 | 1993-01-26 | Boston University Research Foundation | In vivo delivery of active factors by co-cultured cell implants |
| US5837747A (en) * | 1991-10-29 | 1998-11-17 | Vivorx, Inc. | Crosslinkable polysaccharides, polycations and lipids useful for encapsulation and drug release |
| US5651900A (en) | 1994-03-07 | 1997-07-29 | The Regents Of The University Of California | Microfabricated particle filter |
| US5645684A (en) | 1994-03-07 | 1997-07-08 | The Regents Of The University Of California | Multilayer high vertical aspect ratio thin film structures |
| US5660680A (en) | 1994-03-07 | 1997-08-26 | The Regents Of The University Of California | Method for fabrication of high vertical aspect ratio thin film structures |
| US5798042A (en) | 1994-03-07 | 1998-08-25 | Regents Of The University Of California | Microfabricated filter with specially constructed channel walls, and containment well and capsule constructed with such filters |
| WO1995024472A1 (en) | 1994-03-07 | 1995-09-14 | The Regents Of The University Of California | Microfabricated capsules for isolation of cell transplants |
| US7033603B2 (en) | 1999-08-06 | 2006-04-25 | Board Of Regents The University Of Texas | Drug releasing biodegradable fiber for delivery of therapeutics |
| WO2001010421A1 (en) | 1999-08-06 | 2001-02-15 | Board Of Regents, The University Of Texas System | Drug releasing biodegradable fiber implant |
| CA2386850C (en) | 1999-10-06 | 2010-03-30 | Piet Tom Bert Paul Wigerinck | Hexahydrofuro[2,3-b]furan-3-yl-n-{3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-benzyl-2-hydroxypropyl} carbamate as retroviral protease inhibitor |
| TW200800298A (en) | 2000-01-27 | 2008-01-01 | Zentaris Ag | Compressed microparticles for dry injection |
| US20040115268A1 (en) * | 2000-04-26 | 2004-06-17 | Control Delivery Systems, Inc. | Systemic delivery of antiviral agents |
| DE10050199A1 (de) * | 2000-10-11 | 2002-04-25 | Ethicon Gmbh | Flächiges Implantat mit im Ultraschall detektierbaren Elementen |
| AU2002305079B8 (en) * | 2001-05-11 | 2006-05-25 | Ortho-Mcneil Pharmaceutical, Inc. | Immune modulation device for use in animals |
| MY169670A (en) | 2003-09-03 | 2019-05-08 | Tibotec Pharm Ltd | Combinations of a pyrimidine containing nnrti with rt inhibitors |
| US7497855B2 (en) | 2002-09-04 | 2009-03-03 | Microchips, Inc. | Method and device for the controlled delivery of parathyroid hormone |
| US20040156878A1 (en) * | 2003-02-11 | 2004-08-12 | Alireza Rezania | Implantable medical device seeded with mammalian cells and methods of treatment |
| TWI457136B (zh) * | 2005-04-04 | 2014-10-21 | Tibotec Pharm Ltd | Ｈｉｖ-感染之預防 |
| JP2008538754A (ja) | 2005-04-11 | 2008-11-06 | ザ・ボード・オブ・トラスティーズ・オブ・ザ・レランド・スタンフォード・ジュニア・ユニバーシティ | 薬剤を含んだ所定のレイヤパターンを有する複層構造体 |
| US20060252049A1 (en) | 2005-05-04 | 2006-11-09 | Shuler Richard O | Growth-promoting and immunizing subcutaneous implant |
| US7261529B2 (en) | 2005-09-07 | 2007-08-28 | Southwest Research Institute | Apparatus for preparing biodegradable microparticle formulations containing pharmaceutically active agents |
| ME01617B (me) * | 2006-01-20 | 2014-09-20 | Janssen R&D Ireland | Dugotrajno tretiranje hiv-infekcije s tcm278 |
| US20080081064A1 (en) * | 2006-09-28 | 2008-04-03 | Surmodics, Inc. | Implantable Medical Device with Apertures for Delivery of Bioactive Agents |
| CA2692028C (en) * | 2007-06-12 | 2013-06-04 | Concert Pharmaceuticals, Inc. | Azapeptide derivatives |
| WO2009046299A2 (en) | 2007-10-04 | 2009-04-09 | Boston Scientific Scimed, Inc | Implantable drug depot for intrathecal drug delivery system for pain management |
| WO2010047819A1 (en) * | 2008-10-24 | 2010-04-29 | Concert Pharmaceuticals, Inc. | Hydroxyethylamino sulfonamide derivatives |
| JP5612602B2 (ja) | 2008-12-24 | 2014-10-22 | ヤンセン・アールアンドデイ・アイルランド | Ｈｉｖ処置用の移植可能デバイス |
-
2010
- 2010-12-20 AU AU2010338425A patent/AU2010338425B2/en active Active
- 2010-12-20 BR BR112012015114-2A patent/BR112012015114B1/pt not_active IP Right Cessation
- 2010-12-20 WO PCT/EP2010/070246 patent/WO2011080141A2/en not_active Ceased
- 2010-12-20 MX MX2012007210A patent/MX2012007210A/es active IP Right Grant
- 2010-12-20 CN CN201080058303.9A patent/CN102740837B/zh not_active Expired - Fee Related
- 2010-12-20 ES ES10803585.8T patent/ES2600878T3/es active Active
- 2010-12-20 SG SG2012044541A patent/SG181759A1/en unknown
- 2010-12-20 EP EP10803585.8A patent/EP2515877B1/en active Active
- 2010-12-20 KR KR1020127016179A patent/KR101798430B1/ko active Active
- 2010-12-20 JP JP2012543843A patent/JP5950825B2/ja active Active
- 2010-12-20 NZ NZ600156A patent/NZ600156A/en not_active IP Right Cessation
- 2010-12-20 RU RU2012131282/15A patent/RU2593790C2/ru active
- 2010-12-20 CA CA2784530A patent/CA2784530C/en active Active
- 2010-12-20 MY MYPI2012002730A patent/MY163383A/en unknown
- 2010-12-20 UA UAA201206035A patent/UA112155C2/uk unknown
- 2010-12-20 US US13/515,380 patent/US8784858B2/en active Active
-
2012
- 2012-05-09 IL IL219685A patent/IL219685B/en active IP Right Grant
- 2012-06-20 ZA ZA2012/04583A patent/ZA201204583B/en unknown
-
2014
- 2014-06-10 US US14/300,607 patent/US10744235B2/en active Active
-
2020
- 2020-06-30 US US16/917,269 patent/US11395867B2/en active Active
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