JP2013513622A - 白内障及び老眼を阻害する方法 - Google Patents

白内障及び老眼を阻害する方法 Download PDF

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JP2013513622A
JP2013513622A JP2012543328A JP2012543328A JP2013513622A JP 2013513622 A JP2013513622 A JP 2013513622A JP 2012543328 A JP2012543328 A JP 2012543328A JP 2012543328 A JP2012543328 A JP 2012543328A JP 2013513622 A JP2013513622 A JP 2013513622A
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crystallin
electrostatic interaction
eye
interaction inhibitor
solution
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JP2013513622A5 (enExample
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ミュルガッパン ミュシュクマー,
チャオヤン オウ,
デニズ シバイ,
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ユニバーシティ オブ マサチューセッツ
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/675Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/14Quaternary ammonium compounds, e.g. edrophonium, choline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4425Pyridinium derivatives, e.g. pralidoxime, pyridostigmine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/14Alkali metal chlorides; Alkaline earth metal chlorides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/10Ophthalmic agents for accommodation disorders, e.g. myopia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/12Ophthalmic agents for cataracts

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2012543328A 2009-12-14 2010-12-13 白内障及び老眼を阻害する方法 Pending JP2013513622A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US28613909P 2009-12-14 2009-12-14
US61/286,139 2009-12-14
US35016110P 2010-06-01 2010-06-01
US61/350,161 2010-06-01
PCT/US2010/060044 WO2011075430A1 (en) 2009-12-14 2010-12-13 Methods of inhibiting cataracts and presbyopia

Publications (2)

Publication Number Publication Date
JP2013513622A true JP2013513622A (ja) 2013-04-22
JP2013513622A5 JP2013513622A5 (enExample) 2013-10-17

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JP2012543328A Pending JP2013513622A (ja) 2009-12-14 2010-12-13 白内障及び老眼を阻害する方法

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US (2) US8758802B2 (enExample)
EP (1) EP2512492A1 (enExample)
JP (1) JP2013513622A (enExample)
WO (1) WO2011075430A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018526423A (ja) * 2015-09-08 2018-09-13 ビューポイント セラピューティクス, インコーポレイテッド 眼科疾患を処置するための化合物および製剤
JP2018536659A (ja) * 2015-11-13 2018-12-13 ユニバーシティ オブ マサチューセッツ 白内障および老視の抑制に用いられるpegを含有する二官能性分子

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2968239B1 (en) * 2013-03-14 2019-04-24 The University of Massachusetts Methods of inhibiting cataracts and presbyopia
WO2019210352A1 (en) 2018-05-01 2019-11-07 Jinan Cao Eye drops that cure cataracts presbyopia and

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Publication number Priority date Publication date Assignee Title
JPH0262821A (ja) * 1988-08-27 1990-03-02 Santen Pharmaceut Co Ltd 抗白内障剤
DE3906311A1 (de) * 1989-02-28 1990-08-30 Adatomed Pharma & Med Behandlungsystem zur verhinderung von nachstarbildung nach einer kataraktoperation
JPH02258727A (ja) * 1989-03-31 1990-10-19 Teijin Ltd γ―L―グルタミル―L―システインエステル誘導体を含有するリポソーム製剤
CN1093259A (zh) * 1993-04-07 1994-10-12 王慧康 用于治疗老年性白内障的药物组合物
WO1995014482A1 (en) * 1993-11-26 1995-06-01 Rensselaer Polytechnic Institute Use of lithium salts for reducing structural defects in a human lens
JPH09216826A (ja) * 1995-12-22 1997-08-19 Chemedica Sa 眼外科用のヒアルロン酸ナトリウム主薬の眼製剤
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WO2009029991A1 (en) * 2007-09-07 2009-03-12 Meat & Livestock Australia Limited Agents with angiogenic and wound healing activity

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018526423A (ja) * 2015-09-08 2018-09-13 ビューポイント セラピューティクス, インコーポレイテッド 眼科疾患を処置するための化合物および製剤
JP2018536659A (ja) * 2015-11-13 2018-12-13 ユニバーシティ オブ マサチューセッツ 白内障および老視の抑制に用いられるpegを含有する二官能性分子

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US20140274962A1 (en) 2014-09-18
US9283237B2 (en) 2016-03-15
EP2512492A1 (en) 2012-10-24
US8758802B2 (en) 2014-06-24
WO2011075430A1 (en) 2011-06-23
US20120321675A1 (en) 2012-12-20

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