JP2013513622A - 白内障及び老眼を阻害する方法 - Google Patents
白内障及び老眼を阻害する方法 Download PDFInfo
- Publication number
- JP2013513622A JP2013513622A JP2012543328A JP2012543328A JP2013513622A JP 2013513622 A JP2013513622 A JP 2013513622A JP 2012543328 A JP2012543328 A JP 2012543328A JP 2012543328 A JP2012543328 A JP 2012543328A JP 2013513622 A JP2013513622 A JP 2013513622A
- Authority
- JP
- Japan
- Prior art keywords
- crystallin
- electrostatic interaction
- eye
- interaction inhibitor
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims abstract description 48
- 208000002177 Cataract Diseases 0.000 title claims abstract description 42
- 201000010041 presbyopia Diseases 0.000 title claims abstract description 29
- 230000002401 inhibitory effect Effects 0.000 title claims abstract description 13
- 230000009881 electrostatic interaction Effects 0.000 claims abstract description 56
- 239000003112 inhibitor Substances 0.000 claims abstract description 53
- 230000015572 biosynthetic process Effects 0.000 claims abstract description 20
- 239000000243 solution Substances 0.000 claims description 41
- 239000000203 mixture Substances 0.000 claims description 36
- 150000003839 salts Chemical class 0.000 claims description 19
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 13
- 239000002608 ionic liquid Substances 0.000 claims description 11
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 11
- 150000001450 anions Chemical class 0.000 claims description 10
- 150000001768 cations Chemical class 0.000 claims description 10
- 229920001184 polypeptide Polymers 0.000 claims description 10
- 125000001931 aliphatic group Chemical group 0.000 claims description 5
- 125000004432 carbon atom Chemical group C* 0.000 claims description 5
- 229940054534 ophthalmic solution Drugs 0.000 claims description 4
- 239000002997 ophthalmic solution Substances 0.000 claims description 4
- 230000007850 degeneration Effects 0.000 claims description 3
- 229910017053 inorganic salt Inorganic materials 0.000 claims description 3
- 230000002776 aggregation Effects 0.000 abstract description 27
- 238000004220 aggregation Methods 0.000 abstract description 27
- 102000014824 Crystallins Human genes 0.000 abstract description 4
- 108010064003 Crystallins Proteins 0.000 abstract description 4
- 210000000695 crystalline len Anatomy 0.000 description 47
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 35
- 238000002296 dynamic light scattering Methods 0.000 description 32
- 108010007908 alpha-Crystallins Proteins 0.000 description 31
- 102000007362 alpha-Crystallins Human genes 0.000 description 31
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 25
- 239000002953 phosphate buffered saline Substances 0.000 description 25
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 14
- 238000005315 distribution function Methods 0.000 description 13
- 102000004169 proteins and genes Human genes 0.000 description 13
- 108090000623 proteins and genes Proteins 0.000 description 13
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 12
- 229920000642 polymer Polymers 0.000 description 12
- 208000024891 symptom Diseases 0.000 description 10
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- 230000009471 action Effects 0.000 description 9
- 108010006519 Molecular Chaperones Proteins 0.000 description 8
- 239000000872 buffer Substances 0.000 description 8
- 102000016611 Proteoglycans Human genes 0.000 description 7
- 108010067787 Proteoglycans Proteins 0.000 description 7
- 238000004458 analytical method Methods 0.000 description 7
- 239000000463 material Substances 0.000 description 7
- 239000011780 sodium chloride Substances 0.000 description 7
- 239000011550 stock solution Substances 0.000 description 7
- -1 ammonium halides Chemical class 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 6
- 230000010354 integration Effects 0.000 description 6
- 230000007246 mechanism Effects 0.000 description 5
- 239000000178 monomer Substances 0.000 description 5
- 239000000546 pharmaceutical excipient Substances 0.000 description 5
- 230000002829 reductive effect Effects 0.000 description 5
- 238000001370 static light scattering Methods 0.000 description 5
- 238000013268 sustained release Methods 0.000 description 5
- 239000012730 sustained-release form Substances 0.000 description 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- 150000001413 amino acids Chemical class 0.000 description 4
- 238000009826 distribution Methods 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 239000000017 hydrogel Substances 0.000 description 4
- 239000008194 pharmaceutical composition Substances 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 230000032683 aging Effects 0.000 description 3
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 239000000499 gel Substances 0.000 description 3
- 230000005764 inhibitory process Effects 0.000 description 3
- 230000003993 interaction Effects 0.000 description 3
- 238000012544 monitoring process Methods 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- FHDQNOXQSTVAIC-UHFFFAOYSA-M 1-butyl-3-methylimidazol-3-ium;chloride Chemical compound [Cl-].CCCCN1C=C[N+](C)=C1 FHDQNOXQSTVAIC-UHFFFAOYSA-M 0.000 description 2
- ZPTRYWVRCNOTAS-UHFFFAOYSA-M 1-ethyl-3-methylimidazol-3-ium;trifluoromethanesulfonate Chemical compound CC[N+]=1C=CN(C)C=1.[O-]S(=O)(=O)C(F)(F)F ZPTRYWVRCNOTAS-UHFFFAOYSA-M 0.000 description 2
- WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-phenylethanol Chemical compound OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 description 2
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 2
- 201000004569 Blindness Diseases 0.000 description 2
- 230000005653 Brownian motion process Effects 0.000 description 2
- 229920001287 Chondroitin sulfate Polymers 0.000 description 2
- OVBJJZOQPCKUOR-UHFFFAOYSA-L EDTA disodium salt dihydrate Chemical compound O.O.[Na+].[Na+].[O-]C(=O)C[NH+](CC([O-])=O)CC[NH+](CC([O-])=O)CC([O-])=O OVBJJZOQPCKUOR-UHFFFAOYSA-L 0.000 description 2
- 206010019233 Headaches Diseases 0.000 description 2
- 102000005431 Molecular Chaperones Human genes 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 241000083513 Punctum Species 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 108010055905 alpha-Crystallin A Chain Proteins 0.000 description 2
- 108010051585 alpha-Crystallin B Chain Proteins 0.000 description 2
- 102000013640 alpha-Crystallin B Chain Human genes 0.000 description 2
- 125000000539 amino acid group Chemical group 0.000 description 2
- 238000005311 autocorrelation function Methods 0.000 description 2
- HTZCNXWZYVXIMZ-UHFFFAOYSA-M benzyl(triethyl)azanium;chloride Chemical compound [Cl-].CC[N+](CC)(CC)CC1=CC=CC=C1 HTZCNXWZYVXIMZ-UHFFFAOYSA-M 0.000 description 2
- 102000005735 beta-Crystallins Human genes 0.000 description 2
- 108010070654 beta-Crystallins Proteins 0.000 description 2
- 238000005537 brownian motion Methods 0.000 description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 description 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 2
- 238000012512 characterization method Methods 0.000 description 2
- 150000001793 charged compounds Chemical class 0.000 description 2
- 239000002738 chelating agent Substances 0.000 description 2
- OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 description 2
- 229940059329 chondroitin sulfate Drugs 0.000 description 2
- 229960004106 citric acid Drugs 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 239000008367 deionised water Substances 0.000 description 2
- 229910021641 deionized water Inorganic materials 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 238000007865 diluting Methods 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 231100000869 headache Toxicity 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 230000002452 interceptive effect Effects 0.000 description 2
- 201000004673 mature cataract Diseases 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 208000001491 myopia Diseases 0.000 description 2
- 230000036961 partial effect Effects 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 2
- 239000004926 polymethyl methacrylate Substances 0.000 description 2
- SCVFZCLFOSHCOH-UHFFFAOYSA-M potassium acetate Chemical compound [K+].CC([O-])=O SCVFZCLFOSHCOH-UHFFFAOYSA-M 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000012846 protein folding Effects 0.000 description 2
- 230000006916 protein interaction Effects 0.000 description 2
- 230000004850 protein–protein interaction Effects 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 239000001509 sodium citrate Substances 0.000 description 2
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 2
- 235000011083 sodium citrates Nutrition 0.000 description 2
- 229940037001 sodium edetate Drugs 0.000 description 2
- 230000003068 static effect Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000012353 t test Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 239000002562 thickening agent Substances 0.000 description 2
- 239000003981 vehicle Substances 0.000 description 2
- 230000004393 visual impairment Effects 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- NAWXUBYGYWOOIX-SFHVURJKSA-N (2s)-2-[[4-[2-(2,4-diaminoquinazolin-6-yl)ethyl]benzoyl]amino]-4-methylidenepentanedioic acid Chemical compound C1=CC2=NC(N)=NC(N)=C2C=C1CCC1=CC=C(C(=O)N[C@@H](CC(=C)C(O)=O)C(O)=O)C=C1 NAWXUBYGYWOOIX-SFHVURJKSA-N 0.000 description 1
- CUCZSYMTPDSMEL-UHFFFAOYSA-M 1,3-dimethylimidazol-1-ium;methanesulfonate Chemical compound CS([O-])(=O)=O.CN1C=C[N+](C)=C1 CUCZSYMTPDSMEL-UHFFFAOYSA-M 0.000 description 1
- QPDGLRRWSBZCHP-UHFFFAOYSA-M 1-butyl-3-methylimidazol-3-ium;2,2,2-trifluoroacetate Chemical compound [O-]C(=O)C(F)(F)F.CCCC[N+]=1C=CN(C)C=1 QPDGLRRWSBZCHP-UHFFFAOYSA-M 0.000 description 1
- BSQPRRIYLXHOGO-UHFFFAOYSA-M 1-butyl-3-methylimidazol-3-ium;2-(2-methoxyethoxy)ethyl sulfate Chemical compound CCCCN1C=C[N+](C)=C1.COCCOCCOS([O-])(=O)=O BSQPRRIYLXHOGO-UHFFFAOYSA-M 0.000 description 1
- POKOASTYJWUQJG-UHFFFAOYSA-M 1-butylpyridin-1-ium;chloride Chemical compound [Cl-].CCCC[N+]1=CC=CC=C1 POKOASTYJWUQJG-UHFFFAOYSA-M 0.000 description 1
- BMQZYMYBQZGEEY-UHFFFAOYSA-M 1-ethyl-3-methylimidazolium chloride Chemical compound [Cl-].CCN1C=C[N+](C)=C1 BMQZYMYBQZGEEY-UHFFFAOYSA-M 0.000 description 1
- NKRASMXHSQKLHA-UHFFFAOYSA-M 1-hexyl-3-methylimidazolium chloride Chemical compound [Cl-].CCCCCCN1C=C[N+](C)=C1 NKRASMXHSQKLHA-UHFFFAOYSA-M 0.000 description 1
- AEQDJSLRWYMAQI-UHFFFAOYSA-N 2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline Chemical compound C1CN2CC(C(=C(OC)C=C3)OC)=C3CC2C2=C1C=C(OC)C(OC)=C2 AEQDJSLRWYMAQI-UHFFFAOYSA-N 0.000 description 1
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-M 4-hydroxybenzoate Chemical compound OC1=CC=C(C([O-])=O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-M 0.000 description 1
- SNXTZFCNWIVLKZ-UHFFFAOYSA-M 4-methylbenzenesulfonate;methyl-tris(2-methylpropyl)phosphanium Chemical compound CC1=CC=C(S([O-])(=O)=O)C=C1.CC(C)C[P+](C)(CC(C)C)CC(C)C SNXTZFCNWIVLKZ-UHFFFAOYSA-M 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 1
- USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 description 1
- 239000005695 Ammonium acetate Substances 0.000 description 1
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 206010010725 Conjunctival irritation Diseases 0.000 description 1
- 206010056476 Corneal irritation Diseases 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 description 1
- 102000011782 Keratins Human genes 0.000 description 1
- 108010076876 Keratins Proteins 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
- QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical class OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 description 1
- IVGFYNISEOBYTD-UHFFFAOYSA-M OP(O)([O-])=O.CCCC[N+]1(C)CCCC1 Chemical compound OP(O)([O-])=O.CCCC[N+]1(C)CCCC1 IVGFYNISEOBYTD-UHFFFAOYSA-M 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 102000008063 Small Heat-Shock Proteins Human genes 0.000 description 1
- 108010088928 Small Heat-Shock Proteins Proteins 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 description 1
- 239000004288 Sodium dehydroacetate Substances 0.000 description 1
- 239000004280 Sodium formate Substances 0.000 description 1
- 229920002385 Sodium hyaluronate Polymers 0.000 description 1
- 101710172711 Structural protein Proteins 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
- 206010047571 Visual impairment Diseases 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 239000008351 acetate buffer Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 229910001615 alkaline earth metal halide Inorganic materials 0.000 description 1
- 125000005210 alkyl ammonium group Chemical group 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 235000019257 ammonium acetate Nutrition 0.000 description 1
- 229940043376 ammonium acetate Drugs 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 235000011130 ammonium sulphate Nutrition 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 238000004873 anchoring Methods 0.000 description 1
- 150000001449 anionic compounds Chemical class 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000000149 argon plasma sintering Methods 0.000 description 1
- 208000003464 asthenopia Diseases 0.000 description 1
- 229960000686 benzalkonium chloride Drugs 0.000 description 1
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 description 1
- 229960001950 benzethonium chloride Drugs 0.000 description 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
- VSGNNIFQASZAOI-UHFFFAOYSA-L calcium acetate Chemical compound [Ca+2].CC([O-])=O.CC([O-])=O VSGNNIFQASZAOI-UHFFFAOYSA-L 0.000 description 1
- 239000001639 calcium acetate Substances 0.000 description 1
- 235000011092 calcium acetate Nutrition 0.000 description 1
- 229960005147 calcium acetate Drugs 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 1
- 229960001927 cetylpyridinium chloride Drugs 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 229960004926 chlorobutanol Drugs 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 229940090960 diethylenetriamine pentamethylene phosphonic acid Drugs 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- DUYCTCQXNHFCSJ-UHFFFAOYSA-N dtpmp Chemical compound OP(=O)(O)CN(CP(O)(O)=O)CCN(CP(O)(=O)O)CCN(CP(O)(O)=O)CP(O)(O)=O DUYCTCQXNHFCSJ-UHFFFAOYSA-N 0.000 description 1
- 239000008151 electrolyte solution Substances 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- AHRQMWOXLCFNAV-UHFFFAOYSA-O ethylammonium nitrate Chemical compound CC[NH3+].[O-][N+]([O-])=O AHRQMWOXLCFNAV-UHFFFAOYSA-O 0.000 description 1
- 230000004399 eye closure Effects 0.000 description 1
- 239000003885 eye ointment Substances 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 102000013069 gamma-Crystallins Human genes 0.000 description 1
- 108010079934 gamma-Crystallins Proteins 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000012456 homogeneous solution Substances 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 125000001165 hydrophobic group Chemical group 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 229910001412 inorganic anion Inorganic materials 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000001755 magnesium gluconate Substances 0.000 description 1
- 235000015778 magnesium gluconate Nutrition 0.000 description 1
- 229960003035 magnesium gluconate Drugs 0.000 description 1
- IAKLPCRFBAZVRW-XRDLMGPZSA-L magnesium;(2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanoate;hydrate Chemical compound O.[Mg+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O IAKLPCRFBAZVRW-XRDLMGPZSA-L 0.000 description 1
- 125000005397 methacrylic acid ester group Chemical group 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000004770 neurodegeneration Effects 0.000 description 1
- 208000015122 neurodegenerative disease Diseases 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 229940100655 ophthalmic gel Drugs 0.000 description 1
- 229940069265 ophthalmic ointment Drugs 0.000 description 1
- 229940100654 ophthalmic suspension Drugs 0.000 description 1
- 150000002891 organic anions Chemical class 0.000 description 1
- 150000002892 organic cations Chemical class 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 238000005191 phase separation Methods 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 229940068968 polysorbate 80 Drugs 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 235000011056 potassium acetate Nutrition 0.000 description 1
- 239000001508 potassium citrate Substances 0.000 description 1
- 229960002635 potassium citrate Drugs 0.000 description 1
- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 description 1
- 235000011082 potassium citrates Nutrition 0.000 description 1
- OTYBMLCTZGSZBG-UHFFFAOYSA-L potassium sulfate Chemical compound [K+].[K+].[O-]S([O-])(=O)=O OTYBMLCTZGSZBG-UHFFFAOYSA-L 0.000 description 1
- 229910052939 potassium sulfate Inorganic materials 0.000 description 1
- 235000011151 potassium sulphates Nutrition 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 210000001525 retina Anatomy 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 description 1
- 235000010378 sodium ascorbate Nutrition 0.000 description 1
- 229960005055 sodium ascorbate Drugs 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 235000019259 sodium dehydroacetate Nutrition 0.000 description 1
- 229940079839 sodium dehydroacetate Drugs 0.000 description 1
- HLBBKKJFGFRGMU-UHFFFAOYSA-M sodium formate Chemical compound [Na+].[O-]C=O HLBBKKJFGFRGMU-UHFFFAOYSA-M 0.000 description 1
- 235000019254 sodium formate Nutrition 0.000 description 1
- 239000000176 sodium gluconate Substances 0.000 description 1
- 235000012207 sodium gluconate Nutrition 0.000 description 1
- 229940005574 sodium gluconate Drugs 0.000 description 1
- 229940010747 sodium hyaluronate Drugs 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- 229940074404 sodium succinate Drugs 0.000 description 1
- ZDQYSKICYIVCPN-UHFFFAOYSA-L sodium succinate (anhydrous) Chemical compound [Na+].[Na+].[O-]C(=O)CCC([O-])=O ZDQYSKICYIVCPN-UHFFFAOYSA-L 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 description 1
- DSOWAKKSGYUMTF-GZOLSCHFSA-M sodium;(1e)-1-(6-methyl-2,4-dioxopyran-3-ylidene)ethanolate Chemical compound [Na+].C\C([O-])=C1/C(=O)OC(C)=CC1=O DSOWAKKSGYUMTF-GZOLSCHFSA-M 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- RKHXQBLJXBGEKF-UHFFFAOYSA-M tetrabutylphosphanium;bromide Chemical compound [Br-].CCCC[P+](CCCC)(CCCC)CCCC RKHXQBLJXBGEKF-UHFFFAOYSA-M 0.000 description 1
- HWCKGOZZJDHMNC-UHFFFAOYSA-M tetraethylammonium bromide Chemical compound [Br-].CC[N+](CC)(CC)CC HWCKGOZZJDHMNC-UHFFFAOYSA-M 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 238000004627 transmission electron microscopy Methods 0.000 description 1
- YWYZEGXAUVWDED-UHFFFAOYSA-N triammonium citrate Chemical compound [NH4+].[NH4+].[NH4+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O YWYZEGXAUVWDED-UHFFFAOYSA-N 0.000 description 1
- 229940073585 tromethamine hydrochloride Drugs 0.000 description 1
- 210000005239 tubule Anatomy 0.000 description 1
- 208000029257 vision disease Diseases 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4425—Pyridinium derivatives, e.g. pralidoxime, pyridostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28613909P | 2009-12-14 | 2009-12-14 | |
| US61/286,139 | 2009-12-14 | ||
| US35016110P | 2010-06-01 | 2010-06-01 | |
| US61/350,161 | 2010-06-01 | ||
| PCT/US2010/060044 WO2011075430A1 (en) | 2009-12-14 | 2010-12-13 | Methods of inhibiting cataracts and presbyopia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013513622A true JP2013513622A (ja) | 2013-04-22 |
| JP2013513622A5 JP2013513622A5 (enExample) | 2013-10-17 |
Family
ID=43532783
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012543328A Pending JP2013513622A (ja) | 2009-12-14 | 2010-12-13 | 白内障及び老眼を阻害する方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US8758802B2 (enExample) |
| EP (1) | EP2512492A1 (enExample) |
| JP (1) | JP2013513622A (enExample) |
| WO (1) | WO2011075430A1 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2018526423A (ja) * | 2015-09-08 | 2018-09-13 | ビューポイント セラピューティクス, インコーポレイテッド | 眼科疾患を処置するための化合物および製剤 |
| JP2018536659A (ja) * | 2015-11-13 | 2018-12-13 | ユニバーシティ オブ マサチューセッツ | 白内障および老視の抑制に用いられるpegを含有する二官能性分子 |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2968239B1 (en) * | 2013-03-14 | 2019-04-24 | The University of Massachusetts | Methods of inhibiting cataracts and presbyopia |
| WO2019210352A1 (en) | 2018-05-01 | 2019-11-07 | Jinan Cao | Eye drops that cure cataracts presbyopia and |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0262821A (ja) * | 1988-08-27 | 1990-03-02 | Santen Pharmaceut Co Ltd | 抗白内障剤 |
| DE3906311A1 (de) * | 1989-02-28 | 1990-08-30 | Adatomed Pharma & Med | Behandlungsystem zur verhinderung von nachstarbildung nach einer kataraktoperation |
| JPH02258727A (ja) * | 1989-03-31 | 1990-10-19 | Teijin Ltd | γ―L―グルタミル―L―システインエステル誘導体を含有するリポソーム製剤 |
| CN1093259A (zh) * | 1993-04-07 | 1994-10-12 | 王慧康 | 用于治疗老年性白内障的药物组合物 |
| WO1995014482A1 (en) * | 1993-11-26 | 1995-06-01 | Rensselaer Polytechnic Institute | Use of lithium salts for reducing structural defects in a human lens |
| JPH09216826A (ja) * | 1995-12-22 | 1997-08-19 | Chemedica Sa | 眼外科用のヒアルロン酸ナトリウム主薬の眼製剤 |
| WO2002048190A1 (en) * | 2000-12-15 | 2002-06-20 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Use of l-carnitine as stabilizing agent of proteins |
| WO2009029991A1 (en) * | 2007-09-07 | 2009-03-12 | Meat & Livestock Australia Limited | Agents with angiogenic and wound healing activity |
Family Cites Families (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4526789A (en) | 1980-02-29 | 1985-07-02 | Massachusetts Institute Of Technology | Process for preventing or reversing cataract formation |
| US4351826A (en) | 1980-02-29 | 1982-09-28 | Massachusetts Institute Of Technology | Process for preventing or reversing cataract formation using acrylamides |
| US4665089A (en) | 1985-03-21 | 1987-05-12 | Massachusetts Institute Of Technology | Process for preventing or reversing cataract formation using protein modification reagents |
| US4620979A (en) * | 1985-08-02 | 1986-11-04 | Schachar Ronald A | Ophthalmological irrigating solution containing ascorbate |
| US4771036A (en) | 1986-02-10 | 1988-09-13 | Trustees Of Columbia University In The City Of New York | Method and ophthalmic composition for the prevention and reversal of cataracts |
| US5055291A (en) | 1986-11-04 | 1991-10-08 | Baylor College Of Medicine | Compositions for preventing secondary cataracts |
| US4808182A (en) * | 1986-11-26 | 1989-02-28 | Nestle, S.A. | Deswelled, hydrogel intraocular lenses |
| US5091421A (en) | 1987-06-04 | 1992-02-25 | Massachusetts Institute Of Technology | Chemical prevention or reversal of cataract by phase separation inhibitors |
| US5338545A (en) | 1987-06-04 | 1994-08-16 | Oculon Corporation | Chemical prevention or reversal of cataract by phase separation inhibitors |
| WO1992000748A1 (en) | 1990-07-06 | 1992-01-23 | Enzon, Inc. | Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon |
| ATE138914T1 (de) | 1990-12-10 | 1996-06-15 | Bio Physio Pharmaceutical Rese | Indeno-d-pyrimidonverbindungen zur verwendung in der medizin |
| BR9306387A (pt) | 1992-05-20 | 1998-09-15 | Senju Pharma Co | Agente para tratar catarata e método para a sua preparação |
| US5663304A (en) | 1993-08-20 | 1997-09-02 | Genentech, Inc. | Refolding of misfolded insulin-like growth factor-I |
| DE69434617D1 (de) | 1993-11-19 | 2006-04-06 | Univ Sydney | Verfahren zur prophylaxe oder kontrolle des katarakts |
| US5591773A (en) | 1994-03-14 | 1997-01-07 | The Trustees Of Columbia University In The City Of New York | Inhibition of cataract formation, diseases resulting from oxidative stress, and HIV replication by caffeic acid esters |
| EP0712635B1 (en) | 1994-05-13 | 2003-05-02 | Kuraray Co., Ltd. | Medical polymer gel |
| DE69629230D1 (de) | 1995-03-24 | 2003-09-04 | Ocular Res Of Bonton Inc | Hydrogellinse mit Lipid-Vorbeschichtigung |
| JP3599848B2 (ja) | 1995-09-11 | 2004-12-08 | 株式会社メニコン | 含水性軟質眼用レンズ用材料、それからなる含水性軟質眼用レンズ用成形体、ならびにそれからなる含水性軟質眼用レンズおよびその製法 |
| EP0781777A1 (en) | 1995-12-28 | 1997-07-02 | Menicon Co., Ltd. | Silicon-containing compound and ocular lens material |
| EP0816398B1 (en) | 1996-06-28 | 2002-08-14 | Ube Industries, Ltd. | Process for producing polybutadiene |
| US5817630A (en) * | 1997-03-18 | 1998-10-06 | Austin Nutriceutical Corporation | Glutathione antioxidant eye drops |
| JPH10339857A (ja) | 1997-06-05 | 1998-12-22 | Menicon Co Ltd | 薬剤徐放性コンタクトレンズの製法およびそれによってえられた薬剤徐放性コンタクトレンズ |
| US6015787A (en) | 1997-11-04 | 2000-01-18 | New England Medical Center Hospitals, Inc. | Cell-permeable protein inhibitors of calpain |
| US6291466B1 (en) * | 1998-07-30 | 2001-09-18 | Allergan Sales, Inc. | Cholinergic agents in the treatment of presbyopia |
| EP1149909A1 (en) | 2000-04-28 | 2001-10-31 | Boehringer Mannheim Gmbh | Methods for regulating protein conformation using molecular chaperones |
| US6103756A (en) | 1999-08-11 | 2000-08-15 | Vitacost Inc. | Ocular orally ingested composition for prevention and treatment of individuals |
| CA2389917A1 (en) | 1999-11-04 | 2001-05-10 | Kazunori Kataoka | A polymer micelle as monolayer or layer-laminated surface |
| US6835394B1 (en) | 1999-12-14 | 2004-12-28 | The Trustees Of The University Of Pennsylvania | Polymersomes and related encapsulating membranes |
| US7977385B2 (en) * | 2000-03-02 | 2011-07-12 | Numoda Biotechnologies, Inc. | Agents for corneal or intrastromal administration to treat or prevent disorders of the eye |
| US6958224B2 (en) | 2001-03-28 | 2005-10-25 | Council Of Scientific And Industrial Research | Chimeric protein α BNAC crystallin with extraordinarily high chaperone-like activity and a method related to the use thereof |
| US20030020870A1 (en) | 2001-06-27 | 2003-01-30 | Zms, Llc | Biomedical molding materials from semi-solid precursors |
| US20050260259A1 (en) | 2004-04-23 | 2005-11-24 | Bolotin Elijah M | Compositions for treatment with glucagon-like peptide, and methods of making and using the same |
| JP2004161731A (ja) | 2002-09-25 | 2004-06-10 | Nof Corp | 生体関連物質用固定化剤 |
| CN1471924A (zh) * | 2003-07-09 | 2004-02-04 | 吕家昌 | 一种有助于老花眼视力恢复的药液 |
| CN1621091A (zh) | 2003-11-28 | 2005-06-01 | 付经国 | 聚乙二醇化轮状病毒体肠靶向制剂及其合成方法 |
| US7887847B2 (en) | 2004-05-08 | 2011-02-15 | Paul Jr Edward L | Nutritional supplement for treatment of ocular diseases |
| WO2005117987A1 (en) * | 2004-06-01 | 2005-12-15 | Glazier Alan N | Antibody conjugates targeting to ocular proteins |
| US6945971B1 (en) | 2004-07-19 | 2005-09-20 | Gwon Arlene E | Controlled ocular lens regeneration |
| WO2006052821A2 (en) | 2004-11-04 | 2006-05-18 | University Of Washington | Compositions and methods for treatment of protein misfolding and protein aggregation diseases |
| US7741311B2 (en) | 2005-01-03 | 2010-06-22 | Shaker Mousa | Composition and method for treating occlusive vascular diseases, nerve regeneration, and wound healing |
| CN1660920A (zh) | 2005-02-01 | 2005-08-31 | 华东理工大学 | 末端连接ω-氨基酸的聚乙二醇酸或活性酯及制法和应用 |
| DE102005041570A1 (de) | 2005-09-01 | 2007-03-22 | Celares Gmbh | Hoch verzweigte Reagenzien zur Modifaktion von Biopharmazeutika, deren Herstellung und Anwendung |
| US7832875B2 (en) * | 2005-09-29 | 2010-11-16 | Virtek Vision International Inc. | Modulated diode pumped microchip laser projector |
| US20070275098A1 (en) * | 2006-05-19 | 2007-11-29 | T.R.P. Company, Inc, A Nevada Corporation | Formulation and methodology for the treatment for eye impairment symptoms |
| WO2008145721A2 (en) | 2007-06-01 | 2008-12-04 | Novo Nordisk A/S | N-terminal modification of polypeptides for protection against degradation by aminopeptidases |
| EP2213303A4 (en) * | 2007-10-19 | 2011-12-28 | R Tech Ueno Ltd | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF CATARACT |
| KR20100000203A (ko) | 2008-06-24 | 2010-01-06 | 인하대학교 산학협력단 | 금나노입자를 이용한 표적지향형 항암약물전달체 |
| KR20110028636A (ko) * | 2008-06-30 | 2011-03-21 | 존슨 앤드 존슨 비젼 케어, 인코포레이티드 | 눈의 알러지의 치료에 사용되는 방법 및 안과용 장치 |
| US9040723B2 (en) | 2008-07-14 | 2015-05-26 | Biocon Limited | Method of synthesizing a substantially monodispersed mixture of oligomers |
| WO2010065024A1 (en) | 2008-12-05 | 2010-06-10 | Kador Peter F | Topical treatment of cataracts in dogs |
| WO2010130638A1 (en) | 2009-05-14 | 2010-11-18 | Evotec Ag | Sulfonamide compounds, pharmaceutical compositions and uses thereof |
| CN102634492B (zh) | 2011-02-14 | 2015-06-10 | 重庆富进生物医药有限公司 | 聚乙二醇化犬源尿酸氧化酶类似物及其制备方法和应用 |
| JP5881262B2 (ja) | 2011-03-31 | 2016-03-09 | ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド | 質量分析計を較正するための、組成物、方法およびキット |
| CN102579353B (zh) | 2012-03-30 | 2013-12-04 | 吉林大学 | 叶酸靶向的抗癌药物peg修饰的脂质体及制备方法 |
-
2010
- 2010-12-13 EP EP10795541A patent/EP2512492A1/en not_active Ceased
- 2010-12-13 JP JP2012543328A patent/JP2013513622A/ja active Pending
- 2010-12-13 US US13/514,185 patent/US8758802B2/en active Active
- 2010-12-13 WO PCT/US2010/060044 patent/WO2011075430A1/en not_active Ceased
-
2014
- 2014-05-09 US US14/274,139 patent/US9283237B2/en active Active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0262821A (ja) * | 1988-08-27 | 1990-03-02 | Santen Pharmaceut Co Ltd | 抗白内障剤 |
| DE3906311A1 (de) * | 1989-02-28 | 1990-08-30 | Adatomed Pharma & Med | Behandlungsystem zur verhinderung von nachstarbildung nach einer kataraktoperation |
| JPH02258727A (ja) * | 1989-03-31 | 1990-10-19 | Teijin Ltd | γ―L―グルタミル―L―システインエステル誘導体を含有するリポソーム製剤 |
| CN1093259A (zh) * | 1993-04-07 | 1994-10-12 | 王慧康 | 用于治疗老年性白内障的药物组合物 |
| WO1995014482A1 (en) * | 1993-11-26 | 1995-06-01 | Rensselaer Polytechnic Institute | Use of lithium salts for reducing structural defects in a human lens |
| JPH09216826A (ja) * | 1995-12-22 | 1997-08-19 | Chemedica Sa | 眼外科用のヒアルロン酸ナトリウム主薬の眼製剤 |
| WO2002048190A1 (en) * | 2000-12-15 | 2002-06-20 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Use of l-carnitine as stabilizing agent of proteins |
| WO2009029991A1 (en) * | 2007-09-07 | 2009-03-12 | Meat & Livestock Australia Limited | Agents with angiogenic and wound healing activity |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2018526423A (ja) * | 2015-09-08 | 2018-09-13 | ビューポイント セラピューティクス, インコーポレイテッド | 眼科疾患を処置するための化合物および製剤 |
| JP2018536659A (ja) * | 2015-11-13 | 2018-12-13 | ユニバーシティ オブ マサチューセッツ | 白内障および老視の抑制に用いられるpegを含有する二官能性分子 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20140274962A1 (en) | 2014-09-18 |
| US9283237B2 (en) | 2016-03-15 |
| EP2512492A1 (en) | 2012-10-24 |
| US8758802B2 (en) | 2014-06-24 |
| WO2011075430A1 (en) | 2011-06-23 |
| US20120321675A1 (en) | 2012-12-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Vandamme et al. | Poly (amidoamine) dendrimers as ophthalmic vehicles for ocular delivery of pilocarpine nitrate and tropicamide | |
| Coursey et al. | Dexamethasone nanowafer as an effective therapy for dry eye disease | |
| Sechoy et al. | A new long acting ophthalmic formulation of carteolol containing alginic acid | |
| Al-Saedi et al. | Dry eye disease: present challenges in the management and future trends | |
| JP2019535657A (ja) | 人工涙液、コンタクトレンズ及び薬剤担体組成物並びにその使用方法 | |
| JP2021138760A (ja) | セチリジンの眼科用製剤および使用方法 | |
| US10413529B2 (en) | Methods of inhibiting cataracts and presbyopia | |
| JP2009501726A (ja) | 眼科学的活性剤の製剤とその投与の方法 | |
| Rupenthal et al. | Comparison of ion-activated in situ gelling systems for ocular drug delivery. Part 2: Precorneal retention and in vivo pharmacodynamic study | |
| JPWO2008001872A1 (ja) | アルギン酸又はその塩を含有する眼科用組成物 | |
| EA013931B1 (ru) | Способ лечения глазных расстройств | |
| US9283237B2 (en) | Methods of inhibiting presbyopia | |
| Balla et al. | Understanding dexamethasone kinetics in the rabbit tear fluid: Drug release and clearance from solution, suspension and hydrogel formulations | |
| Wang et al. | Tacrolimus-loaded cationic nanoemulsion in-situ gel system: in-vitro characterization and performance in a dry-eye rabbit model | |
| JP2023530188A (ja) | 高分子量ヒアルロン酸の眼科用薬物輸送ビヒクルとしての使用 | |
| RU2710366C1 (ru) | Термочувствительная гелеобразующая искусственная слеза | |
| Shetty et al. | A study on stability and in vivo drug release of naphazoline and antazoline in situ gelling system for ocular delivery | |
| BUCOLO et al. | Pharmacological profile of a new topical pilocarpine formulation | |
| Tuft et al. | Medical management of dry eye disease | |
| Simroth‐Loch et al. | Ophthalmic dosage forms | |
| Kanclerz et al. | Tear film stability in patients with symptoms of dry eye after instillation of dual polymer hydroxypropyl guar/sodium hyaluronate vs single polymer sodium hyaluronate | |
| RU2806029C2 (ru) | Композиции, обеспечивающие повышенный комфорт для глаз | |
| EP4454639A1 (en) | Ophthalmic composition comprising carbomer and taurine | |
| KR20200044847A (ko) | 개선된 눈 편안함을 제공하는 조성물 | |
| CN102274172A (zh) | 滴眼液 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20130830 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20130830 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20140826 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20141126 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20141203 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20141216 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20150310 |