JP2013513610A5 - - Google Patents

Info

Publication number

JP2013513610A5

JP2013513610A5 JP2012543222A JP2012543222A JP2013513610A5 JP 2013513610 A5 JP2013513610 A5 JP 2013513610A5 JP 2012543222 A JP2012543222 A JP 2012543222A JP 2012543222 A JP2012543222 A JP 2012543222A JP 2013513610 A5 JP2013513610 A5 JP 2013513610A5

Authority

JP

Japan

Prior art keywords

photodynamic therapy

nanoparticles

photosensitizer

diseases

pharmaceutical formulation

Prior art date

2010-12-08

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 239000002105 nanoparticle Substances 0.000 claims 10
• 238000002428 photodynamic therapy Methods 0.000 claims 10
• 239000008194 pharmaceutical composition Substances 0.000 claims 6
• 239000003504 photosensitizing agent Substances 0.000 claims 6
• 239000003795 chemical substances by application Substances 0.000 claims 5
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
• XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical group CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 3
• 239000007864 aqueous solution Substances 0.000 claims 3
• 201000010099 disease Diseases 0.000 claims 3
• 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims 3
• 229920002451 polyvinyl alcohol Polymers 0.000 claims 3
• 239000003381 stabilizer Substances 0.000 claims 3
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 229940079593 drug Drugs 0.000 claims 2
• 238000009472 formulation Methods 0.000 claims 2
• JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 2
• 239000000203 mixture Substances 0.000 claims 2
• 239000003960 organic solvent Substances 0.000 claims 2
• 239000002245 particle Substances 0.000 claims 2
• 238000002360 preparation method Methods 0.000 claims 2
• 230000000087 stabilizing effect Effects 0.000 claims 2
• 125000001424 substituent group Chemical group 0.000 claims 2
• HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims 1
• HORNXRXVQWOLPJ-UHFFFAOYSA-N 3-chlorophenol Chemical compound OC1=CC=CC(Cl)=C1 HORNXRXVQWOLPJ-UHFFFAOYSA-N 0.000 claims 1
• FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 1
• FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
• FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 1
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
• AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Natural products OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims 1
• 102000008100 Human Serum Albumin Human genes 0.000 claims 1
• 108091006905 Human Serum Albumin Proteins 0.000 claims 1
• 229930195725 Mannitol Natural products 0.000 claims 1
• LYPFDBRUNKHDGX-SOGSVHMOSA-N N1C2=CC=C1\C(=C1\C=CC(=N1)\C(=C1\C=C/C(/N1)=C(/C1=N/C(/CC1)=C2/C1=CC(O)=CC=C1)C1=CC(O)=CC=C1)\C1=CC(O)=CC=C1)C1=CC(O)=CC=C1 Chemical group N1C2=CC=C1\C(=C1\C=CC(=N1)\C(=C1\C=C/C(/N1)=C(/C1=N/C(/CC1)=C2/C1=CC(O)=CC=C1)C1=CC(O)=CC=C1)\C1=CC(O)=CC=C1)C1=CC(O)=CC=C1 LYPFDBRUNKHDGX-SOGSVHMOSA-N 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 108010038807 Oligopeptides Proteins 0.000 claims 1
• 102000015636 Oligopeptides Human genes 0.000 claims 1
• RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims 1
• 239000002202 Polyethylene glycol Substances 0.000 claims 1
• CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 1
• 229930006000 Sucrose Natural products 0.000 claims 1
• HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims 1
• 208000012931 Urologic disease Diseases 0.000 claims 1
• 230000000274 adsorptive effect Effects 0.000 claims 1
• HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims 1
• 150000004036 bacteriochlorins Chemical class 0.000 claims 1
• WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 1
• 125000000837 carbohydrate group Chemical group 0.000 claims 1
• SURLGNKAQXKNSP-DBLYXWCISA-N chlorin Chemical compound C\1=C/2\N/C(=C\C3=N/C(=C\C=4NC(/C=C\5/C=CC/1=N/5)=CC=4)/C=C3)/CC\2 SURLGNKAQXKNSP-DBLYXWCISA-N 0.000 claims 1
• 229920001577 copolymer Polymers 0.000 claims 1
• 238000001914 filtration Methods 0.000 claims 1
• 238000007710 freezing Methods 0.000 claims 1
• 239000008103 glucose Substances 0.000 claims 1
• 125000003827 glycol group Chemical group 0.000 claims 1
• 230000002209 hydrophobic effect Effects 0.000 claims 1
• 208000027866 inflammatory disease Diseases 0.000 claims 1
• 238000010253 intravenous injection Methods 0.000 claims 1
• 235000014655 lactic acid Nutrition 0.000 claims 1
• 239000004310 lactic acid Substances 0.000 claims 1
• 239000003446 ligand Substances 0.000 claims 1
• 239000000594 mannitol Substances 0.000 claims 1
• 235000010355 mannitol Nutrition 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 239000007908 nanoemulsion Substances 0.000 claims 1
• 230000001613 neoplastic effect Effects 0.000 claims 1
• 239000000825 pharmaceutical preparation Substances 0.000 claims 1
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
• 229960000502 poloxamer Drugs 0.000 claims 1
• 229920001983 poloxamer Polymers 0.000 claims 1
• 229920001223 polyethylene glycol Polymers 0.000 claims 1
• 229950008882 polysorbate Drugs 0.000 claims 1
• 229920000136 polysorbate Polymers 0.000 claims 1
• 150000004032 porphyrins Chemical class 0.000 claims 1
• 108090000765 processed proteins & peptides Proteins 0.000 claims 1
• 208000017520 skin disease Diseases 0.000 claims 1
• 239000000243 solution Substances 0.000 claims 1
• 239000000600 sorbitol Substances 0.000 claims 1
• 239000005720 sucrose Substances 0.000 claims 1
• 230000008685 targeting Effects 0.000 claims 1
• 229960002197 temoporfin Drugs 0.000 claims 1
• 208000014001 urinary system disease Diseases 0.000 claims 1
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1