JP2013512889A5 - - Google Patents
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- Publication number
- JP2013512889A5 JP2013512889A5 JP2012541584A JP2012541584A JP2013512889A5 JP 2013512889 A5 JP2013512889 A5 JP 2013512889A5 JP 2012541584 A JP2012541584 A JP 2012541584A JP 2012541584 A JP2012541584 A JP 2012541584A JP 2013512889 A5 JP2013512889 A5 JP 2013512889A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- sheep
- difficile
- toxin
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 27
- 241001494479 Pecora Species 0.000 claims 19
- 239000003053 toxin Substances 0.000 claims 18
- 231100000765 toxin Toxicity 0.000 claims 18
- 108700012359 toxins Proteins 0.000 claims 18
- 238000000034 method Methods 0.000 claims 12
- 102000004142 Trypsin Human genes 0.000 claims 9
- 108090000317 Chymotrypsin Proteins 0.000 claims 8
- 108090000631 Trypsin Proteins 0.000 claims 8
- 229960002376 chymotrypsin Drugs 0.000 claims 8
- 230000003053 immunization Effects 0.000 claims 8
- 238000002649 immunization Methods 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 239000012588 trypsin Substances 0.000 claims 8
- 208000015181 infectious disease Diseases 0.000 claims 5
- 101000963974 Hydrophis stokesii Alpha-elapitoxin-Ast2b Proteins 0.000 claims 4
- 101000964025 Naja naja Long neurotoxin 3 Proteins 0.000 claims 4
- 101710084578 Short neurotoxin 1 Proteins 0.000 claims 4
- 101710182223 Toxin B Proteins 0.000 claims 4
- 101710182532 Toxin a Proteins 0.000 claims 4
- 230000002265 prevention Effects 0.000 claims 4
- 239000000243 solution Substances 0.000 claims 4
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical class [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims 3
- 241000193163 Clostridioides difficile Species 0.000 claims 3
- 229940069428 antacid Drugs 0.000 claims 3
- 239000003159 antacid agent Substances 0.000 claims 3
- 230000001458 anti-acid effect Effects 0.000 claims 3
- 208000028235 central diabetes insipidus Diseases 0.000 claims 3
- 230000002163 immunogen Effects 0.000 claims 3
- 108091005804 Peptidases Proteins 0.000 claims 2
- 239000004365 Protease Substances 0.000 claims 2
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 2
- 239000002671 adjuvant Substances 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 239000007853 buffer solution Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 210000004211 gastric acid Anatomy 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000007911 parenteral administration Methods 0.000 claims 2
- 230000002797 proteolythic effect Effects 0.000 claims 2
- 230000009885 systemic effect Effects 0.000 claims 2
- 229940122644 Chymotrypsin inhibitor Drugs 0.000 claims 1
- 101710137926 Chymotrypsin inhibitor Proteins 0.000 claims 1
- 229940122618 Trypsin inhibitor Drugs 0.000 claims 1
- 101710162629 Trypsin inhibitor Proteins 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 239000011324 bead Substances 0.000 claims 1
- 239000003541 chymotrypsin inhibitor Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- -1 granular matrices Substances 0.000 claims 1
- 230000016784 immunoglobulin production Effects 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- 210000001589 microsome Anatomy 0.000 claims 1
- 239000004005 microsphere Substances 0.000 claims 1
- 239000002105 nanoparticle Substances 0.000 claims 1
- 239000008188 pellet Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 230000000306 recurrent effect Effects 0.000 claims 1
- 239000002753 trypsin inhibitor Substances 0.000 claims 1
- 210000001364 upper extremity Anatomy 0.000 claims 1
- 239000003981 vehicle Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0921288.7 | 2009-12-04 | ||
| GBGB0921288.7A GB0921288D0 (en) | 2009-12-04 | 2009-12-04 | Therapies for preventing or suppressing clostridium difficile infection |
| PCT/GB2010/050288 WO2010094970A1 (en) | 2009-02-20 | 2010-02-19 | Antibodies to clostridium difficile toxins |
| GBPCT/GB2010/050288 | 2010-02-19 | ||
| PCT/GB2010/052035 WO2011067616A1 (en) | 2009-12-04 | 2010-12-06 | Therapies for preventing or suppressing clostridium difficile infection |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013512889A JP2013512889A (ja) | 2013-04-18 |
| JP2013512889A5 true JP2013512889A5 (cg-RX-API-DMAC7.html) | 2014-01-30 |
| JP5877161B2 JP5877161B2 (ja) | 2016-03-02 |
Family
ID=41641956
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012541584A Active JP5877161B2 (ja) | 2009-12-04 | 2010-12-06 | クロストリジウム・ディフィシル感染を予防または抑制するための治療法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8921529B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2506877B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5877161B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN102740889A (cg-RX-API-DMAC7.html) |
| BR (1) | BR112012013496A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2782639C (cg-RX-API-DMAC7.html) |
| GB (1) | GB0921288D0 (cg-RX-API-DMAC7.html) |
| MY (1) | MY158712A (cg-RX-API-DMAC7.html) |
| SG (1) | SG181127A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2011067616A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2010215275B2 (en) | 2009-02-20 | 2016-03-31 | Micropharm Limited | Antibodies to Clostridium difficile toxins |
| GB0921288D0 (en) | 2009-12-04 | 2010-01-20 | Health Prot Agency | Therapies for preventing or suppressing clostridium difficile infection |
| US9598472B2 (en) | 2010-09-03 | 2017-03-21 | Valneva Austria Gmbh | Isolated polypeptide of the toxin A and toxin B proteins of C. difficile and uses thereof |
| GB201016742D0 (en) | 2010-10-05 | 2010-11-17 | Health Prot Agency | Clostridium difficile antigens |
| BR112013027229B1 (pt) * | 2011-04-22 | 2020-10-27 | Wyeth Llc | polipeptídeo imunogênico isolado e seu uso, composição imunogênica e seu uso, célula recombinante ou progênie da mesma, e método de produção de uma toxina de clostridium difficile mutante |
| SG11201400916XA (en) | 2011-08-22 | 2014-06-27 | Cangene Corp | Clostridium difficile antibodies |
| BR112014013876A2 (pt) | 2011-12-08 | 2019-09-24 | Novartis Ag | vacina à base de toxina de clostridium difficile |
| DE102011121237A1 (de) * | 2011-12-14 | 2013-06-20 | Universitätsklinikum Hamburg-Eppendorf | Einzeldomänen-Antikörper gegen Clostridium difficile Toxin CDTa |
| AR089797A1 (es) * | 2012-01-27 | 2014-09-17 | Merck Sharp & Dohme | Vacunas contra clostridum difficile que comprenden toxinas recombinantes |
| BR122016023101B1 (pt) | 2012-10-21 | 2022-03-22 | Pfizer Inc | Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile |
| RU2015140498A (ru) | 2013-03-08 | 2017-04-13 | Сипла Лимитед | Фармацевтические композиции для ректального введения |
| EP2970400A1 (en) * | 2013-03-15 | 2016-01-20 | Sanofi Pasteur, Inc. | Toxoid, compositions and related methods |
| EP2988778A4 (en) * | 2013-04-22 | 2016-12-14 | Board Of Regents Of The Univ Of Oklahoma | CLOSTRIDIUM DIFFICILE IMPREGENT AND METHOD OF USE |
| AU2014277981B2 (en) | 2013-06-14 | 2019-06-20 | Sanofi Pasteur Inc. | Compositions and methods of immunizing against C. difficile |
| EP2957570B1 (en) | 2014-06-20 | 2019-04-17 | Immunimed Inc. | Polyclonal antibodies against clostridium difficile and uses thereof |
| US10513552B2 (en) | 2014-06-20 | 2019-12-24 | Immunimed Inc. | Use of polyclonal antibodies against clostridium difficile for treatment of inflammatory bowel disease |
| HUE038212T2 (hu) * | 2014-07-25 | 2018-10-29 | Biosynth Srl | Többszörös beépített epitópokat kifejezõ molekuláris konstrukt bázikus egységeket tartalmazó glikokonjugátum vakcinák enteropatogén baktériumok által okozott fertõzések elleni szélesspektrumú vakcina elõállításához |
| EP3121272A1 (en) * | 2015-07-24 | 2017-01-25 | Zymetech ehf. | Novel fish trypsin isoforms and their use |
| WO2017173068A1 (en) * | 2016-03-30 | 2017-10-05 | University Of Maryland, Baltimore | Microparticulate system for colonic drug delivery |
| GB201701404D0 (en) * | 2017-01-27 | 2017-03-15 | Micropharm Ltd | Therapies for treating inflammatory disorders |
| GB202019817D0 (en) * | 2020-12-15 | 2021-01-27 | Univ Oxford Innovation Ltd | Ligand-binding polypeptides and uses thereof |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS608225A (ja) | 1983-06-29 | 1985-01-17 | Kowa Co | 腸管吸収医薬組成物 |
| US5601823A (en) * | 1989-10-31 | 1997-02-11 | Ophidian Pharmaceuticals, Inc. | Avian antitoxins to clostridium difficle toxin A |
| MX9701683A (es) | 1994-09-06 | 1997-06-28 | Galagen Inc | Tratamiento terapeutico de enfermedades asociadas a clostridium difficile. |
| JP2002514886A (ja) * | 1994-10-24 | 2002-05-21 | プロメガ コーポレーション | クロストリジウム・ディフィシル疾患の治療及び予防のためのワクチン及び抗トキシン |
| US6096310A (en) | 1997-04-15 | 2000-08-01 | Bier; Milan | Oral immunotherapy of bacterial overgrowth |
| EP1000155A1 (en) | 1997-06-20 | 2000-05-17 | QUEEN MARY & WESTFIELD COLLEGE | Immunogenic fragments of toxin a of clostridium difficile |
| US6969520B2 (en) | 1997-10-20 | 2005-11-29 | Acambis Inc. | Active immunization against clostridium difficile disease |
| DE69829400T2 (de) | 1997-10-20 | 2006-04-13 | Acambis, Inc., Cambridge | Passive immunisierung gegen durch clostridium difficile verursachte krankheit |
| US6074689A (en) | 1998-03-10 | 2000-06-13 | Immucell Corporation | Colonic delivery of protein or peptide compositions |
| US20020009429A1 (en) | 1999-01-29 | 2002-01-24 | Galagen, Inc. | Pharmaceutical composition comprising a selected antigen and candida species antigen and methods |
| US6673574B2 (en) | 2000-11-30 | 2004-01-06 | Unigene Laboratories Inc. | Oral delivery of peptides using enzyme-cleavable membrane translocators |
| GB0205206D0 (en) | 2002-03-06 | 2002-04-17 | Oxoid Ltd | Synthetic peptides |
| WO2004041857A2 (en) | 2002-06-17 | 2004-05-21 | Ballard Jimmy D | Mutant of clostridium difficile toxin b and methods of use |
| JP2005537244A (ja) * | 2002-06-28 | 2005-12-08 | ナステック・ファーマシューティカル・カンパニー・インコーポレーテッド | 療法化合物の粘膜搬送を増進させるための、上皮接合部接着分子の生理機能を調節する組成物および方法 |
| GB0309126D0 (en) | 2003-04-17 | 2003-05-28 | Neutec Pharma Plc | Clostridium difficile focussed antibodies |
| ES2533492T3 (es) * | 2004-02-06 | 2015-04-10 | University Of Massachusetts | Anticuerpos contra toxinas de Clostridium difficile y usos de los mismos |
| WO2005110465A2 (en) * | 2004-04-29 | 2005-11-24 | Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. | Oral formulations comprising bone morphogenetic proteins for treating metabolic bone diseases |
| CA2592015A1 (en) | 2004-12-27 | 2006-07-06 | Progenics Pharmaceuticals (Nevada), Inc. | Orally deliverable and anti-toxin antibodies and methods for making and using them |
| US7794721B2 (en) | 2006-12-13 | 2010-09-14 | Simon Michael R | Synthesis of human secretory IgM and the treatment of clostridium difficile associated diseases herewith |
| CN101363867B (zh) | 2008-05-26 | 2012-12-19 | 北京庄笛浩禾生物医学科技有限公司 | 一种艰难梭菌a、b毒素胶体金检测试纸条及其制备方法 |
| AU2010215275B2 (en) | 2009-02-20 | 2016-03-31 | Micropharm Limited | Antibodies to Clostridium difficile toxins |
| GB0921288D0 (en) | 2009-12-04 | 2010-01-20 | Health Prot Agency | Therapies for preventing or suppressing clostridium difficile infection |
-
2009
- 2009-12-04 GB GBGB0921288.7A patent/GB0921288D0/en not_active Ceased
-
2010
- 2010-12-06 CA CA2782639A patent/CA2782639C/en active Active
- 2010-12-06 US US13/513,555 patent/US8921529B2/en active Active
- 2010-12-06 EP EP10787170.9A patent/EP2506877B1/en active Active
- 2010-12-06 MY MYPI2012002466A patent/MY158712A/en unknown
- 2010-12-06 CN CN2010800537789A patent/CN102740889A/zh active Pending
- 2010-12-06 JP JP2012541584A patent/JP5877161B2/ja active Active
- 2010-12-06 SG SG2012039616A patent/SG181127A1/en unknown
- 2010-12-06 BR BR112012013496A patent/BR112012013496A2/pt not_active IP Right Cessation
- 2010-12-06 WO PCT/GB2010/052035 patent/WO2011067616A1/en not_active Ceased
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