JP2013512678A5 - - Google Patents
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- JP2013512678A5 JP2013512678A5 JP2012542240A JP2012542240A JP2013512678A5 JP 2013512678 A5 JP2013512678 A5 JP 2013512678A5 JP 2012542240 A JP2012542240 A JP 2012542240A JP 2012542240 A JP2012542240 A JP 2012542240A JP 2013512678 A5 JP2013512678 A5 JP 2013512678A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- seq
- factor viii
- amino acids
- item
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001413 amino acids Chemical class 0.000 claims description 159
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 130
- 229920001184 polypeptide Polymers 0.000 claims description 129
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 129
- 108010054218 Factor VIII Proteins 0.000 claims description 114
- 102000001690 Factor VIII Human genes 0.000 claims description 114
- 229960000301 factor viii Drugs 0.000 claims description 114
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 58
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 44
- 230000000694 effects Effects 0.000 claims description 30
- 208000032843 Hemorrhage Diseases 0.000 claims description 26
- 208000034158 bleeding Diseases 0.000 claims description 26
- 230000000740 bleeding effect Effects 0.000 claims description 26
- 238000001356 surgical procedure Methods 0.000 claims description 21
- 238000011287 therapeutic dose Methods 0.000 claims description 21
- 238000011084 recovery Methods 0.000 claims description 12
- 238000011282 treatment Methods 0.000 claims description 10
- 208000024891 symptom Diseases 0.000 claims description 9
- 208000014674 injury Diseases 0.000 claims description 5
- 238000007917 intracranial administration Methods 0.000 claims description 5
- 230000008733 trauma Effects 0.000 claims description 5
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 claims description 4
- 238000012217 deletion Methods 0.000 claims description 4
- 230000037430 deletion Effects 0.000 claims description 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 4
- 230000002265 prevention Effects 0.000 claims description 4
- 238000011321 prophylaxis Methods 0.000 claims description 4
- 208000029836 Inguinal Hernia Diseases 0.000 claims description 3
- 210000000683 abdominal cavity Anatomy 0.000 claims description 3
- 238000007428 craniotomy Methods 0.000 claims description 3
- 238000000605 extraction Methods 0.000 claims description 3
- 238000013150 knee replacement Methods 0.000 claims description 3
- 238000002271 resection Methods 0.000 claims description 3
- 238000007483 tonsillectomy Methods 0.000 claims description 3
- 102000009027 Albumins Human genes 0.000 claims description 2
- 108010088751 Albumins Proteins 0.000 claims description 2
- 102100026735 Coagulation factor VIII Human genes 0.000 claims 1
- 201000003542 Factor VIII deficiency Diseases 0.000 claims 1
- 208000009292 Hemophilia A Diseases 0.000 claims 1
- 239000000539 dimer Substances 0.000 claims 1
- 238000002297 emergency surgery Methods 0.000 claims 1
- 230000013632 homeostatic process Effects 0.000 claims 1
- 239000000178 monomer Substances 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 88
- 108010076504 Protein Sorting Signals Proteins 0.000 description 43
- 108010014173 Factor X Proteins 0.000 description 21
- 108090001015 cancer procoagulant Proteins 0.000 description 15
- 108010048049 Factor IXa Proteins 0.000 description 9
- 239000002157 polynucleotide Substances 0.000 description 8
- 102000040430 polynucleotide Human genes 0.000 description 8
- 108091033319 polynucleotide Proteins 0.000 description 8
- 210000004027 cell Anatomy 0.000 description 4
- 108090000190 Thrombin Proteins 0.000 description 3
- 102000057593 human F8 Human genes 0.000 description 3
- 229960000900 human factor viii Drugs 0.000 description 3
- 239000008194 pharmaceutical composition Substances 0.000 description 3
- 150000003904 phospholipids Chemical class 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 208000010392 Bone Fractures Diseases 0.000 description 2
- 206010072043 Central nervous system haemorrhage Diseases 0.000 description 2
- 206010017076 Fracture Diseases 0.000 description 2
- 208000012671 Gastrointestinal haemorrhages Diseases 0.000 description 2
- 206010019196 Head injury Diseases 0.000 description 2
- 206010028024 Mouth haemorrhage Diseases 0.000 description 2
- 206010028309 Muscle haemorrhage Diseases 0.000 description 2
- 208000009613 Oral Hemorrhage Diseases 0.000 description 2
- 206010003246 arthritis Diseases 0.000 description 2
- 208000030304 gastrointestinal bleeding Diseases 0.000 description 2
- 238000007912 intraperitoneal administration Methods 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 230000003387 muscular Effects 0.000 description 2
- 210000000574 retroperitoneal space Anatomy 0.000 description 2
- 210000000115 thoracic cavity Anatomy 0.000 description 2
- 241000700605 Viruses Species 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 210000002308 embryonic cell Anatomy 0.000 description 1
- 210000001161 mammalian embryo Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
Applications Claiming Priority (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26707009P | 2009-12-06 | 2009-12-06 | |
| US61/267,070 | 2009-12-06 | ||
| US28505409P | 2009-12-09 | 2009-12-09 | |
| US61/285,054 | 2009-12-09 | ||
| US30159210P | 2010-02-04 | 2010-02-04 | |
| US61/301,592 | 2010-02-04 | ||
| US36306510P | 2010-07-09 | 2010-07-09 | |
| US61/363,065 | 2010-07-09 | ||
| US37311310P | 2010-08-12 | 2010-08-12 | |
| US61/373,113 | 2010-08-12 | ||
| US41092910P | 2010-11-07 | 2010-11-07 | |
| US61/410,929 | 2010-11-07 | ||
| US41967610P | 2010-12-03 | 2010-12-03 | |
| US61/419,676 | 2010-12-03 | ||
| PCT/US2010/059136 WO2011069164A2 (en) | 2009-12-06 | 2010-12-06 | Factor viii-fc chimeric and hybrid polypeptides, and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015012409A Division JP6062459B2 (ja) | 2009-12-06 | 2015-01-26 | 第ＶＩＩＩ−Ｆｃ因子キメラおよびハイブリッドポリペプチドならびにその使用法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013512678A JP2013512678A (ja) | 2013-04-18 |
| JP2013512678A5 true JP2013512678A5 (cg-RX-API-DMAC7.html) | 2013-12-26 |
| JP5903048B2 JP5903048B2 (ja) | 2016-04-13 |
Family
ID=44115536
Family Applications (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012542240A Active JP5903048B2 (ja) | 2009-12-06 | 2010-12-06 | 第ＶＩＩＩ−Ｆｃ因子キメラおよびハイブリッドポリペプチドならびにその使用法 |
| JP2015012409A Active JP6062459B2 (ja) | 2009-12-06 | 2015-01-26 | 第ＶＩＩＩ−Ｆｃ因子キメラおよびハイブリッドポリペプチドならびにその使用法 |
| JP2016209535A Active JP6385410B2 (ja) | 2009-12-06 | 2016-10-26 | 第ＶＩＩＩ−Ｆｃ因子キメラおよびハイブリッドポリペプチドならびにその使用法 |
| JP2017220060A Active JP6641340B2 (ja) | 2009-12-06 | 2017-11-15 | 第ＶＩＩＩ−Ｆｃ因子キメラおよびハイブリッドポリペプチドならびにその使用法 |
| JP2019202433A Withdrawn JP2020019821A (ja) | 2009-12-06 | 2019-11-07 | 第ＶＩＩＩ−Ｆｃ因子キメラおよびハイブリッドポリペプチドならびにその使用法 |
| JP2022020759A Active JP7244688B2 (ja) | 2009-12-06 | 2022-02-14 | 第ＶＩＩＩ－Ｆｃ因子キメラおよびハイブリッドポリペプチドならびにその使用法 |
| JP2023036392A Pending JP2023071969A (ja) | 2009-12-06 | 2023-03-09 | 第ＶＩＩＩ－Ｆｃ因子キメラおよびハイブリッドポリペプチドならびにその使用法 |
| JP2025037046A Pending JP2025083451A (ja) | 2009-12-06 | 2025-03-10 | 第ＶＩＩＩ－Ｆｃ因子キメラおよびハイブリッドポリペプチドならびにその使用法 |
Family Applications After (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015012409A Active JP6062459B2 (ja) | 2009-12-06 | 2015-01-26 | 第ＶＩＩＩ−Ｆｃ因子キメラおよびハイブリッドポリペプチドならびにその使用法 |
| JP2016209535A Active JP6385410B2 (ja) | 2009-12-06 | 2016-10-26 | 第ＶＩＩＩ−Ｆｃ因子キメラおよびハイブリッドポリペプチドならびにその使用法 |
| JP2017220060A Active JP6641340B2 (ja) | 2009-12-06 | 2017-11-15 | 第ＶＩＩＩ−Ｆｃ因子キメラおよびハイブリッドポリペプチドならびにその使用法 |
| JP2019202433A Withdrawn JP2020019821A (ja) | 2009-12-06 | 2019-11-07 | 第ＶＩＩＩ−Ｆｃ因子キメラおよびハイブリッドポリペプチドならびにその使用法 |
| JP2022020759A Active JP7244688B2 (ja) | 2009-12-06 | 2022-02-14 | 第ＶＩＩＩ－Ｆｃ因子キメラおよびハイブリッドポリペプチドならびにその使用法 |
| JP2023036392A Pending JP2023071969A (ja) | 2009-12-06 | 2023-03-09 | 第ＶＩＩＩ－Ｆｃ因子キメラおよびハイブリッドポリペプチドならびにその使用法 |
| JP2025037046A Pending JP2025083451A (ja) | 2009-12-06 | 2025-03-10 | 第ＶＩＩＩ－Ｆｃ因子キメラおよびハイブリッドポリペプチドならびにその使用法 |
Country Status (30)
Families Citing this family (87)
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| PE20251064A1 (es) * | 2022-04-28 | 2025-04-09 | Biocad Joint Stock Co | Acido nucleico aislado que codifica una proteina de fusion basada en fviii-bdd y en un peptido senal heterologo, y uso de la misma |
| CN114989307B (zh) * | 2022-05-11 | 2023-08-01 | 华兰生物工程股份有限公司 | 一种重组人凝血因子Ⅷ-Fc融合蛋白及制备方法 |
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