JP2012529296A5 - - Google Patents
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- JP2012529296A5 JP2012529296A5 JP2012515080A JP2012515080A JP2012529296A5 JP 2012529296 A5 JP2012529296 A5 JP 2012529296A5 JP 2012515080 A JP2012515080 A JP 2012515080A JP 2012515080 A JP2012515080 A JP 2012515080A JP 2012529296 A5 JP2012529296 A5 JP 2012529296A5
- Authority
- JP
- Japan
- Prior art keywords
- xten
- fusion protein
- seq
- sequence
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108020001507 fusion proteins Proteins 0.000 claims 63
- 102000037865 fusion proteins Human genes 0.000 claims 63
- 102000018997 Growth Hormone Human genes 0.000 claims 36
- 108010051696 Growth Hormone Proteins 0.000 claims 36
- 239000000122 growth hormone Substances 0.000 claims 36
- 150000007523 nucleic acids Chemical class 0.000 claims 20
- 150000001413 amino acids Chemical group 0.000 claims 19
- 108020004707 nucleic acids Proteins 0.000 claims 13
- 102000039446 nucleic acids Human genes 0.000 claims 13
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims 8
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 claims 8
- 230000001225 therapeutic effect Effects 0.000 claims 8
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 7
- 230000000295 complement effect Effects 0.000 claims 7
- 239000003814 drug Substances 0.000 claims 7
- 229920001184 polypeptide Polymers 0.000 claims 7
- 102000004196 processed proteins & peptides Human genes 0.000 claims 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims 7
- 210000004027 cell Anatomy 0.000 claims 6
- 210000001612 chondrocyte Anatomy 0.000 claims 4
- 230000036470 plasma concentration Effects 0.000 claims 4
- 108091033319 polynucleotide Proteins 0.000 claims 4
- 102000040430 polynucleotide Human genes 0.000 claims 4
- 239000002157 polynucleotide Substances 0.000 claims 4
- 235000018102 proteins Nutrition 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 125000000539 amino acid group Chemical group 0.000 claims 3
- 230000004927 fusion Effects 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 125000006850 spacer group Chemical group 0.000 claims 3
- 208000037415 AIDS wasting syndrome Diseases 0.000 claims 2
- 206010009900 Colitis ulcerative Diseases 0.000 claims 2
- 208000011231 Crohn disease Diseases 0.000 claims 2
- 208000001640 Fibromyalgia Diseases 0.000 claims 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- 206010056438 Growth hormone deficiency Diseases 0.000 claims 2
- 206010053759 Growth retardation Diseases 0.000 claims 2
- 208000003577 HIV wasting syndrome Diseases 0.000 claims 2
- 101001044927 Homo sapiens Insulin-like growth factor-binding protein 3 Proteins 0.000 claims 2
- 206010022489 Insulin Resistance Diseases 0.000 claims 2
- 102100022708 Insulin-like growth factor-binding protein 3 Human genes 0.000 claims 2
- 208000029725 Metabolic bone disease Diseases 0.000 claims 2
- 208000008589 Obesity Diseases 0.000 claims 2
- 208000001132 Osteoporosis Diseases 0.000 claims 2
- 201000010769 Prader-Willi syndrome Diseases 0.000 claims 2
- 208000026928 Turner syndrome Diseases 0.000 claims 2
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 230000036765 blood level Effects 0.000 claims 2
- 230000037182 bone density Effects 0.000 claims 2
- 230000008468 bone growth Effects 0.000 claims 2
- 208000020832 chronic kidney disease Diseases 0.000 claims 2
- 208000022831 chronic renal failure syndrome Diseases 0.000 claims 2
- 230000012010 growth Effects 0.000 claims 2
- 210000004349 growth plate Anatomy 0.000 claims 2
- 150000002632 lipids Chemical class 0.000 claims 2
- 238000005259 measurement Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 210000003205 muscle Anatomy 0.000 claims 2
- 201000006938 muscular dystrophy Diseases 0.000 claims 2
- 208000031225 myocardial ischemia Diseases 0.000 claims 2
- 235000020824 obesity Nutrition 0.000 claims 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 2
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- 102100020948 Growth hormone receptor Human genes 0.000 claims 1
- 102000002265 Human Growth Hormone Human genes 0.000 claims 1
- 108010000521 Human Growth Hormone Proteins 0.000 claims 1
- 239000000854 Human Growth Hormone Substances 0.000 claims 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- 108010068542 Somatotropin Receptors Proteins 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 1
- 239000004473 Threonine Substances 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 235000004279 alanine Nutrition 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 210000000805 cytoplasm Anatomy 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000001747 exhibiting effect Effects 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 235000013922 glutamic acid Nutrition 0.000 claims 1
- 239000004220 glutamic acid Substances 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 210000001236 prokaryotic cell Anatomy 0.000 claims 1
- 230000002035 prolonged effect Effects 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18511209P | 2009-06-08 | 2009-06-08 | |
| US61/185,112 | 2009-06-08 | ||
| US23683609P | 2009-08-25 | 2009-08-25 | |
| US61/236,836 | 2009-08-25 | ||
| US28095509P | 2009-11-10 | 2009-11-10 | |
| US61/280,955 | 2009-11-10 | ||
| USPCT/US2010/023106 | 2010-02-03 | ||
| US12/699,761 | 2010-02-03 | ||
| PCT/US2010/023106 WO2010091122A1 (en) | 2009-02-03 | 2010-02-03 | Extended recombinant polypeptides and compositions comprising same |
| US12/699,761 US8673860B2 (en) | 2009-02-03 | 2010-02-03 | Extended recombinant polypeptides and compositions comprising same |
| PCT/US2010/037849 WO2010144502A2 (en) | 2009-06-08 | 2010-06-08 | Growth hormone polypeptides and methods of making and using same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015068675A Division JP2015124222A (ja) | 2009-06-08 | 2015-03-30 | 成長ホルモンポリペプチド並びにその作成及び使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012529296A JP2012529296A (ja) | 2012-11-22 |
| JP2012529296A5 true JP2012529296A5 (cg-RX-API-DMAC7.html) | 2013-08-15 |
| JP5805634B2 JP5805634B2 (ja) | 2015-11-04 |
Family
ID=43309446
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012515080A Expired - Fee Related JP5805634B2 (ja) | 2009-06-08 | 2010-06-08 | 成長ホルモンポリペプチド並びにその作成及び使用方法 |
| JP2015068675A Withdrawn JP2015124222A (ja) | 2009-06-08 | 2015-03-30 | 成長ホルモンポリペプチド並びにその作成及び使用方法 |
| JP2016151272A Withdrawn JP2016185171A (ja) | 2009-06-08 | 2016-08-01 | 成長ホルモンポリペプチド並びにその作成及び使用方法 |
| JP2017181582A Expired - Fee Related JP6543668B2 (ja) | 2009-06-08 | 2017-09-21 | 成長ホルモンポリペプチド並びにその作成及び使用方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015068675A Withdrawn JP2015124222A (ja) | 2009-06-08 | 2015-03-30 | 成長ホルモンポリペプチド並びにその作成及び使用方法 |
| JP2016151272A Withdrawn JP2016185171A (ja) | 2009-06-08 | 2016-08-01 | 成長ホルモンポリペプチド並びにその作成及び使用方法 |
| JP2017181582A Expired - Fee Related JP6543668B2 (ja) | 2009-06-08 | 2017-09-21 | 成長ホルモンポリペプチド並びにその作成及び使用方法 |
Country Status (26)
Families Citing this family (62)
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2010
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- 2010-06-08 NO NO10786725A patent/NO2440241T3/no unknown
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- 2010-06-08 PE PE2011002057A patent/PE20121539A1/es active IP Right Grant
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