JP2013512276A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013512276A5 JP2013512276A5 JP2012541614A JP2012541614A JP2013512276A5 JP 2013512276 A5 JP2013512276 A5 JP 2013512276A5 JP 2012541614 A JP2012541614 A JP 2012541614A JP 2012541614 A JP2012541614 A JP 2012541614A JP 2013512276 A5 JP2013512276 A5 JP 2013512276A5
- Authority
- JP
- Japan
- Prior art keywords
- acid
- compound
- formula
- anhydride
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CCC(*)([C@](C)(CN(C)C)[Si])c1cccc(N*)c1 Chemical compound CCC(*)([C@](C)(CN(C)C)[Si])c1cccc(N*)c1 0.000 description 2
- SCZGQTRPAVMTQE-SMDDNHRTSA-N CC[C@@]([C@@H](C)CN(C)C)(c1cccc(N)c1)O Chemical compound CC[C@@]([C@@H](C)CN(C)C)(c1cccc(N)c1)O SCZGQTRPAVMTQE-SMDDNHRTSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI2009A002110A IT1397189B1 (it) | 2009-12-01 | 2009-12-01 | Nuovo processo per la preparazione di tapentadol e suoi intermedi. |
| ITMI2009A002110 | 2009-12-01 | ||
| PCT/IB2010/055499 WO2011067714A1 (en) | 2009-12-01 | 2010-11-30 | New process for the preparation of tapentadol and intermediates thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013512276A JP2013512276A (ja) | 2013-04-11 |
| JP2013512276A5 true JP2013512276A5 (https=) | 2014-01-09 |
| JP5901534B2 JP5901534B2 (ja) | 2016-04-13 |
Family
ID=42309693
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012541614A Expired - Fee Related JP5901534B2 (ja) | 2009-12-01 | 2010-11-30 | タペンタドールおよびその中間体を調製するための新しい方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8729308B2 (https=) |
| EP (1) | EP2507203B1 (https=) |
| JP (1) | JP5901534B2 (https=) |
| KR (1) | KR101766503B1 (https=) |
| CN (1) | CN102869644B (https=) |
| BR (1) | BR112012013302A2 (https=) |
| CA (1) | CA2780842C (https=) |
| ES (1) | ES2640313T3 (https=) |
| IL (1) | IL219913A (https=) |
| IT (1) | IT1397189B1 (https=) |
| WO (1) | WO2011067714A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2674414A1 (en) | 2012-06-15 | 2013-12-18 | Siegfried AG | Method for the preparation of 1-aryl-1-alkyl-3-dialkylaminopropane compounds |
| CN102924303B (zh) * | 2012-10-31 | 2013-11-20 | 合肥市新星医药化工有限公司 | 盐酸他喷他多晶型c及其制备方法和应用 |
| US9090539B2 (en) | 2013-05-24 | 2015-07-28 | Ampac Fine Chemicals Llc | Compounds and methods for preparing substituted 3-(1-amino-2-methylpentane-3-yl)phenyl compounds |
| CN103254088B (zh) * | 2013-05-24 | 2014-08-06 | 合肥市新星医药化工有限公司 | 盐酸他喷他多晶型d及其制备方法和应用 |
| WO2015075678A1 (en) | 2013-11-21 | 2015-05-28 | Unimark Remedies Ltd. | A novel process for the preparation of 1-phenyl-3-aminopropane derivatives |
| CN104803861B (zh) * | 2014-01-27 | 2017-05-24 | 上海博邦医药科技有限公司 | 一种合成盐酸他喷他多的方法 |
| GB2539442A (en) * | 2015-06-16 | 2016-12-21 | Azad Pharmaceutical Ingredients Ag | New synthesis of tapentadol-HCI intermediates |
| SK812017A3 (sk) | 2017-08-18 | 2019-03-01 | Saneca Pharmaceuticals A. S. | Spôsob prípravy tapentadolu a jeho medziproduktov |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3824271A (en) * | 1972-07-20 | 1974-07-16 | American Cyanamid Co | 3-alkyl-3-(benzoyl)propionitriles |
| US3888901A (en) | 1972-07-20 | 1975-06-10 | American Cyanamid Co | Process of preparing 3-alkyl-3-(benzoyl)propionitriles |
| AU651373B2 (en) | 1990-07-25 | 1994-07-21 | Mobil Oil Corporation | Reactor quenching for catalytic olefin hydration in ether production |
| DE4426245A1 (de) * | 1994-07-23 | 1996-02-22 | Gruenenthal Gmbh | 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung |
| DE10326097A1 (de) * | 2003-06-06 | 2005-01-05 | Grünenthal GmbH | Verfahren zur Herstellung von Dimethyl-(3-aryl-butyl)-aminverbindungen |
| WO2006012283A1 (en) | 2004-06-25 | 2006-02-02 | Ranpak Corporation | Dunnage conversion machine with floating guides |
| DE102005033732B4 (de) * | 2005-05-27 | 2014-02-13 | Grünenthal GmbH | Trennung stereoisomerer N,N-Dialkylamino-2-alkyl-3-hydroxy-3-phenyl-alkane |
| TWI401237B (zh) * | 2006-07-24 | 2013-07-11 | ３-〔（１ｒ，２ｒ）-３-（二甲基氨基）-１-乙基-２-甲基丙基〕酚之製備 | |
| TWI496762B (zh) * | 2006-07-24 | 2015-08-21 | 製備（１ｒ，２ｒ）-３-（３-二甲胺基-１-乙基-２-甲基-丙基）-酚之方法 | |
| WO2008012283A1 (en) * | 2006-07-24 | 2008-01-31 | Janssen Pharmaceutica Nv | Preparation of (2r,3r)-3-(3-methoxyphenyl)-n,n,2-trimethylpentanamine |
-
2009
- 2009-12-01 IT ITMI2009A002110A patent/IT1397189B1/it active
-
2010
- 2010-11-30 ES ES10805326.5T patent/ES2640313T3/es active Active
- 2010-11-30 WO PCT/IB2010/055499 patent/WO2011067714A1/en not_active Ceased
- 2010-11-30 CN CN201080052937.3A patent/CN102869644B/zh not_active Expired - Fee Related
- 2010-11-30 EP EP10805326.5A patent/EP2507203B1/en active Active
- 2010-11-30 KR KR1020127016688A patent/KR101766503B1/ko active Active
- 2010-11-30 US US13/512,989 patent/US8729308B2/en active Active
- 2010-11-30 JP JP2012541614A patent/JP5901534B2/ja not_active Expired - Fee Related
- 2010-11-30 BR BR112012013302A patent/BR112012013302A2/pt not_active Application Discontinuation
- 2010-11-30 CA CA2780842A patent/CA2780842C/en active Active
-
2012
- 2012-05-21 IL IL219913A patent/IL219913A/en active IP Right Grant
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2013512276A5 (https=) | ||
| CN105593197B (zh) | 水解1,2,4-三卤代苯的方法 | |
| JP5901534B2 (ja) | タペンタドールおよびその中間体を調製するための新しい方法 | |
| JP2011523953A (ja) | １−（２−ハロビフェニル−４−イル）−シクロプロパンカルボン酸の誘導体を調製する方法 | |
| CN114163375B (zh) | 6,6-二甲基-3-氮杂双环[3.1.0]己烷或其衍生物的合成方法 | |
| US9056818B2 (en) | Process for the preparation of derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid | |
| JP7068467B2 (ja) | 置換フェニル酢酸誘導体の製造方法 | |
| WO2011086570A1 (en) | Process for preparation of cyanoalkylpropionate derivatives | |
| JP2005247850A5 (https=) | ||
| JP4045722B2 (ja) | アミン化合物、中間体、製造法および光学分割剤 | |
| JP5001264B2 (ja) | アダマンタン誘導体の調製方法 | |
| Baricordi et al. | A Diphenylprolinol TMS Ether/Bile Acid Organocatalytic System for the Asymmetric Domino Sulfa-Michael/Aldol Condensation Reactions of 1, 4-Dithiane-2, 5-diol and Cinnamaldehydes | |
| JP6806990B2 (ja) | α−フルオロアルデヒド類の製造方法 | |
| JP2006517202A5 (https=) | ||
| PT857713E (pt) | Processo para producao de acido 3-hidroxi-2-metilbenzoico e acido 3-acetoxi-2-metilbenzoico | |
| JP3903213B2 (ja) | ４−ビフェニリル酢酸の製造方法 | |
| JP3743867B2 (ja) | ２−フルオロシクロプロパンカルボン酸類の製造法 | |
| JP2000212110A (ja) | 光学活性α―アルキルベンジルアルコ―ル類の製造方法 | |
| JP2017105721A (ja) | １−アミノ−３，５−ジメチルアダマンタン塩酸塩を製造する方法 | |
| JP4951957B2 (ja) | フルフラール類の製造方法 | |
| JP4595178B2 (ja) | アミン化合物、中間体、製造法および光学分割剤 | |
| JP5499572B2 (ja) | ４−シアノテトラヒドロピランの製造方法 | |
| JP2014076969A (ja) | 芳香族エステル化合物の製造方法および芳香族アミド化合物の製造方法 | |
| JP2003261500A (ja) | α−アルキル−置換フェニル酢酸の製造方法 | |
| JP2002356458A (ja) | α位トリ置換酢酸の製造方法 |