JP2013512199A - アジルサルタン有機アミン塩、その製造方法及び使用 - Google Patents

アジルサルタン有機アミン塩、その製造方法及び使用 Download PDF

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Publication number
JP2013512199A
JP2013512199A JP2012540278A JP2012540278A JP2013512199A JP 2013512199 A JP2013512199 A JP 2013512199A JP 2012540278 A JP2012540278 A JP 2012540278A JP 2012540278 A JP2012540278 A JP 2012540278A JP 2013512199 A JP2013512199 A JP 2013512199A
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JP
Japan
Prior art keywords
azilsartanamine
salt
azilsartan
salt according
formula
Prior art date
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Pending
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JP2012540278A
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English (en)
Japanese (ja)
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JP2013512199A5 (enExample
Inventor
愛鋒 呂
宝海 楊
Original Assignee
ジエンス ハンセン ファーマセウティカル カンパニー リミテッド
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Application filed by ジエンス ハンセン ファーマセウティカル カンパニー リミテッド filed Critical ジエンス ハンセン ファーマセウティカル カンパニー リミテッド
Publication of JP2013512199A publication Critical patent/JP2013512199A/ja
Publication of JP2013512199A5 publication Critical patent/JP2013512199A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
    • C07C215/08—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with only one hydroxy group and one amino group bound to the carbon skeleton

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2012540278A 2009-11-30 2010-11-29 アジルサルタン有機アミン塩、その製造方法及び使用 Pending JP2013512199A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN200910246554 2009-11-30
CN200910246554.9 2009-11-30
PCT/CN2010/079222 WO2011063764A1 (zh) 2009-11-30 2010-11-29 阿齐沙坦有机胺盐及其制备方法和用途

Publications (2)

Publication Number Publication Date
JP2013512199A true JP2013512199A (ja) 2013-04-11
JP2013512199A5 JP2013512199A5 (enExample) 2014-12-25

Family

ID=44065877

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012540278A Pending JP2013512199A (ja) 2009-11-30 2010-11-29 アジルサルタン有機アミン塩、その製造方法及び使用

Country Status (11)

Country Link
US (1) US20120238606A1 (enExample)
EP (1) EP2508522A4 (enExample)
JP (1) JP2013512199A (enExample)
CN (1) CN102548988B (enExample)
AU (1) AU2010324249B2 (enExample)
BR (1) BR112012012484A2 (enExample)
CA (1) CA2782224A1 (enExample)
MX (1) MX2012005776A (enExample)
RU (1) RU2554947C2 (enExample)
WO (1) WO2011063764A1 (enExample)
ZA (1) ZA201202683B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015099111A1 (ja) * 2013-12-27 2015-07-02 トーアエイヨー株式会社 アンジオテンシンｉｉ受容体拮抗物質の塩

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5981940B2 (ja) * 2011-01-20 2016-08-31 ジエンス ハンセン ファーマセウティカル カンパニー リミテッド アジルサルタン有機アミン塩、その製造方法及び使用
EP2760859A1 (en) 2011-09-30 2014-08-06 Sunshine Lake Pharma Co., Ltd Crystalline forms of azilsartan and preparation and uses thereof
CN105037341B (zh) * 2014-04-04 2019-12-03 江苏豪森药业集团有限公司 阿齐沙坦醇铵晶型及其制备方法
CN105503848A (zh) * 2014-10-13 2016-04-20 江苏豪森药业集团有限公司 阿齐沙坦有机胺盐复合物及其制备方法和用途
CZ2014702A3 (cs) 2014-10-15 2016-04-27 Zentiva, K.S. Způsob přípravy vysoce čistého azilsartanu
KR102220011B1 (ko) * 2020-05-15 2021-02-25 대봉엘에스 주식회사 친환경 용매를 이용한 아질사탄의 제조방법 및 이에 관한 핵심 중간체 화합물
KR102862852B1 (ko) * 2022-09-19 2025-09-22 대봉엘에스 주식회사 안지오텐신 ⅱ 길항제로서의 아질사르탄 디시클로헥실아민 및 이를 유효성분으로 하는 심혈관질환 치료 또는 예방용 약학적 조성물

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003231636A (ja) * 2001-12-03 2003-08-19 Takeda Chem Ind Ltd インスリン抵抗性改善剤
JP2004523569A (ja) * 2001-03-08 2004-08-05 メルク　エンド　カムパニー　インコーポレーテッド 抗高血圧薬とコレステロール吸収阻害薬の併用療法
JP2008515767A (ja) * 2004-10-07 2008-05-15 武田薬品工業株式会社 代謝症候群予防治療剤

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA924666B (en) * 1991-06-27 1993-12-24 Takeda Chemical Industries Ltd Heterocyclic compounds, their production and use
TW251288B (enExample) * 1991-06-27 1995-07-11 Takeda Dharm Industry Co Ltd
EP1452176A4 (en) * 2001-12-03 2009-01-21 Takeda Pharmaceutical AGENTS FOR IMPROVING THE STATE OF RESISTANCE OF INSULIN
CN101035524A (zh) * 2004-10-07 2007-09-12 武田药品工业株式会社 预防或治疗代谢综合征的药剂
WO2006064228A2 (en) * 2004-12-17 2006-06-22 Astrazeneca Ab Thiazolopyramidine compounds for the modulation of chemokine receptor activity

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004523569A (ja) * 2001-03-08 2004-08-05 メルク　エンド　カムパニー　インコーポレーテッド 抗高血圧薬とコレステロール吸収阻害薬の併用療法
JP2003231636A (ja) * 2001-12-03 2003-08-19 Takeda Chem Ind Ltd インスリン抵抗性改善剤
JP2008515767A (ja) * 2004-10-07 2008-05-15 武田薬品工業株式会社 代謝症候群予防治療剤

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015099111A1 (ja) * 2013-12-27 2015-07-02 トーアエイヨー株式会社 アンジオテンシンｉｉ受容体拮抗物質の塩

Also Published As

Publication number Publication date
ZA201202683B (en) 2013-08-28
RU2554947C2 (ru) 2015-07-10
WO2011063764A1 (zh) 2011-06-03
EP2508522A1 (en) 2012-10-10
US20120238606A1 (en) 2012-09-20
CN102548988B (zh) 2013-10-23
RU2012124332A (ru) 2014-01-10
AU2010324249A1 (en) 2012-05-03
AU2010324249B2 (en) 2014-08-28
MX2012005776A (es) 2012-06-13
CA2782224A1 (en) 2011-06-03
BR112012012484A2 (pt) 2016-04-12
CN102548988A (zh) 2012-07-04
EP2508522A4 (en) 2013-05-08
HK1164310A1 (en) 2012-09-21

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