JP2013511280A5 - - Google Patents
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- JP2013511280A5 JP2013511280A5 JP2012540120A JP2012540120A JP2013511280A5 JP 2013511280 A5 JP2013511280 A5 JP 2013511280A5 JP 2012540120 A JP2012540120 A JP 2012540120A JP 2012540120 A JP2012540120 A JP 2012540120A JP 2013511280 A5 JP2013511280 A5 JP 2013511280A5
- Authority
- JP
- Japan
- Prior art keywords
- substitution
- variant
- bgl1
- bgl1 variant
- activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000006467 substitution reaction Methods 0.000 claims 34
- 101100437484 Arabidopsis thaliana BGLU18 gene Proteins 0.000 claims 31
- 101100342633 Bos taurus LLGL1 gene Proteins 0.000 claims 31
- 101100065855 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) EXG1 gene Proteins 0.000 claims 31
- 101100058298 Saccharomycopsis fibuligera BGL1 gene Proteins 0.000 claims 31
- 101150100570 bglA gene Proteins 0.000 claims 31
- 230000000694 effects Effects 0.000 claims 16
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 102000006995 beta-Glucosidase Human genes 0.000 claims 3
- 108010047754 beta-Glucosidase Proteins 0.000 claims 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L calcium carbonate Substances [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims 3
- 230000007062 hydrolysis Effects 0.000 claims 3
- 238000006460 hydrolysis reaction Methods 0.000 claims 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims 2
- 101710099628 Beta-glucosidase 1 Proteins 0.000 claims 2
- 239000002028 Biomass Substances 0.000 claims 2
- 241000209149 Zea Species 0.000 claims 2
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims 2
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 235000005822 corn Nutrition 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 229910021529 ammonia Inorganic materials 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 230000003301 hydrolyzing effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 239000010907 stover Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26324009P | 2009-11-20 | 2009-11-20 | |
| US61/263,240 | 2009-11-20 | ||
| PCT/US2010/057531 WO2011063308A2 (en) | 2009-11-20 | 2010-11-19 | Beta-glucosidase i variants with improved properties |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015120937A Division JP2015211678A (ja) | 2009-11-20 | 2015-06-16 | 改良された特性を有するβ−グルコシダーゼＩ変異体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013511280A JP2013511280A (ja) | 2013-04-04 |
| JP2013511280A5 true JP2013511280A5 (enExample) | 2014-01-09 |
Family
ID=43608030
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012540120A Pending JP2013511280A (ja) | 2009-11-20 | 2010-11-19 | 改良された特性を有するβ−グルコシダーゼＩ変異体 |
| JP2015120937A Withdrawn JP2015211678A (ja) | 2009-11-20 | 2015-06-16 | 改良された特性を有するβ−グルコシダーゼＩ変異体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015120937A Withdrawn JP2015211678A (ja) | 2009-11-20 | 2015-06-16 | 改良された特性を有するβ−グルコシダーゼＩ変異体 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US9447400B2 (enExample) |
| EP (6) | EP2599862B1 (enExample) |
| JP (2) | JP2013511280A (enExample) |
| CN (2) | CN105316303B (enExample) |
| BR (1) | BR112012011711A2 (enExample) |
| CA (1) | CA2780767A1 (enExample) |
| DK (6) | DK2599864T3 (enExample) |
| IN (1) | IN2012DN03825A (enExample) |
| RU (1) | RU2012125624A (enExample) |
| WO (1) | WO2011063308A2 (enExample) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP5932648B2 (ja) | 2009-09-23 | 2016-06-15 | ダニスコ・ユーエス・インク | 新規なグリコシルヒドロラーゼ酵素及びその用途 |
| CN102740868B (zh) | 2009-11-25 | 2016-01-20 | 科德克希思公司 | 用于从纤维素生物质产生可溶性糖的重组β-葡糖苷酶变体 |
| PH12012500999A1 (en) | 2009-12-23 | 2013-02-11 | Danisco Us Inc | Methods for improving the efficiency of simultaneous saccharification and fermentation reactions |
| US10130697B2 (en) | 2010-03-23 | 2018-11-20 | Wisconsin Alumni Research Foundation (Warf) | Vaccines comprising mutant attenuated influenza viruses |
| ES2563209T3 (es) * | 2010-10-01 | 2016-03-11 | Novozymes, Inc. | Variantes de beta-glucosidasa y polinucleótidos que codifican las mismas |
| KR20130132789A (ko) * | 2010-11-05 | 2013-12-05 | 아사히 가라스 가부시키가이샤 | 스키조사카로미세스속 효모의 형질 전환체 및 그 제조 방법 |
| MX2013010512A (es) | 2011-03-17 | 2013-10-07 | Danisco Inc | Metodo para reducir la viscosidad en un proceso de sacarificacion. |
| CN102816748B (zh) * | 2011-06-09 | 2014-07-16 | 中国科学院上海生命科学研究院 | 一种新型β-葡萄糖苷酶及其编码基因和应用 |
| ES2655051T3 (es) | 2011-08-26 | 2018-02-16 | Wisconsin Alumni Research Foundation | Virus de la gripe con segmento génico PB2 mutante como vacunas vivas atenuadas |
| BR112015012968A2 (pt) | 2012-12-07 | 2017-09-12 | Danisco Us Inc | composições e métodos de uso |
| ES2521940B1 (es) | 2013-05-10 | 2015-09-09 | Abengoa Bioenergía Nuevas Tecnologías, S.A. | Variantes de beta-glucosidasa con actividad de transglicosilación reducida |
| CN105916981A (zh) | 2013-07-29 | 2016-08-31 | 丹尼斯科美国公司 | 变体酶 |
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| BR112016017502B1 (pt) * | 2014-02-26 | 2023-10-24 | Chr. Hansen A/S | Variantes de polipeptídeo de quimosina isoladas método para a produção das mesmas e método para a fabricação de um produto de alimentação humana ou animal |
| WO2015196150A2 (en) | 2014-06-20 | 2015-12-23 | Wisconsin Alumni Research Foundation (Warf) | Mutations that confer genetic stability to additional genes in influenza viruses |
| SG11201610894UA (en) | 2014-08-08 | 2017-01-27 | Xyleco Inc | Aglycosylated enzyme and uses thereof |
| US20170362621A1 (en) | 2014-12-18 | 2017-12-21 | Danisco Us Inc. | Engineered multifunctional enzymes and methods of use |
| US20180002683A1 (en) | 2014-12-18 | 2018-01-04 | Danisco Us Inc. | Engineered multifunctional enzymes and methods of use |
| CN113403357B (zh) * | 2014-12-19 | 2024-10-18 | 丹尼斯科美国公司 | 葡糖淀粉酶共混物 |
| US20180148683A1 (en) | 2015-07-07 | 2018-05-31 | Danisco Us Inc. | Induction of gene expression using a high concentration sugar mixture |
| BR112018010938A2 (pt) * | 2015-12-10 | 2018-12-04 | Dsm Ip Assets Bv | beta-glicosidase e usos da mesma |
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| BR112018011097A2 (pt) * | 2015-12-10 | 2018-12-04 | Dsm Ip Assets Bv | beta-glicosidase e usos da mesma |
| CN109477074B (zh) | 2016-02-19 | 2023-01-24 | 威斯康星旧生研究基金会 | 用于疫苗开发的改进的乙型流感病毒复制 |
| EP3336180A1 (en) | 2016-07-04 | 2018-06-20 | Evonik Degussa GmbH | Mutant alkb gene |
| WO2018053058A1 (en) | 2016-09-14 | 2018-03-22 | Danisco Us Inc. | Lignocellulosic biomass fermentation-based processes |
| KR102593668B1 (ko) | 2016-10-04 | 2023-10-24 | 다니스코 유에스 인크. | 유도 기질 부재 하의 사상 진균 세포에서의 단백질 생산 |
| WO2018106656A1 (en) | 2016-12-06 | 2018-06-14 | Danisco Us Inc | Truncated lpmo enzymes and use thereof |
| EP4644560A3 (en) | 2016-12-21 | 2026-04-08 | International N&H Denmark ApS | Methods of using thermostable serine proteases |
| EP3592429A1 (en) | 2017-03-06 | 2020-01-15 | DuPont Nutrition Biosciences ApS | Novel fungal fucosidases and their use in preventing and/or treating a pathogenic infection in an animal |
| BR112019023923A2 (pt) * | 2017-05-16 | 2020-08-18 | The Curators Of The University Of Missouri | complexo de enzima imobilizada, aparelho biorreator, métodos para conversão enzimática de um substrato a um produto desejado, para produzir um complexo de enzima imobilizada e para usar um biorreator, biorreator, sistema de biorreator multienzimático de fluxo contínuo, sistema de biorreator, aparelhos de conversão de grupo sanguíneo de fluxo contínuo e de reator de múltiplas enzimas de distribuição de fármaco, e, sistema para cicatrização de ferida |
| WO2019074828A1 (en) | 2017-10-09 | 2019-04-18 | Danisco Us Inc | CELLOBIOSE DEHYDROGENASE VARIANTS AND METHODS OF USE |
| JP7051491B2 (ja) * | 2018-02-26 | 2022-04-11 | 花王株式会社 | 変異β－グルコシダーゼ |
| CA3093378A1 (en) | 2018-03-09 | 2019-09-12 | Danisco Us Inc | Glucoamylases and methods of use thereof |
| EP3818165A2 (en) | 2018-07-04 | 2021-05-12 | Danisco US Inc. | Glucoamylases and methods of use, thereof |
| JP7783047B2 (ja) | 2018-08-07 | 2025-12-09 | ウィスコンシン アルムニ リサーチ ファンデイション | 組換えの生物学的に封じ込められたフィロウイルスワクチン |
| EP3840780A1 (en) | 2018-08-20 | 2021-06-30 | Wisconsin Alumni Research Foundation | Vectors for eliciting immune responses to non-dominant epitopes in the hemagglutinin (ha) protein |
| EP3877519B1 (en) | 2018-11-09 | 2026-03-11 | Ginkgo Bioworks, Inc. | Biosynthesis of mogrosides |
| JP7569523B2 (ja) | 2018-11-20 | 2024-10-18 | インターナショナル エヌアンドエイチ デンマーク エーピーエス | 改変ロバスト高Ｔｍ－フィターゼ分岐群ポリペプチド及びその断片 |
| WO2020167432A2 (en) * | 2019-01-23 | 2020-08-20 | Yoshihiro Kawaoka | Mutations that confer genetic stability to additional genes in influenza viruses |
| WO2020163804A1 (en) | 2019-02-08 | 2020-08-13 | Wisconsin Alumni Research Foundation (Warf) | Humanized cell line |
| CN114929269A (zh) | 2019-05-01 | 2022-08-19 | 威斯康星校友研究基金会(Warf) | 用于疫苗开发的改进的流感病毒复制 |
| JP7627911B2 (ja) | 2019-08-27 | 2025-02-07 | ウィスコンシン アルムニ リサーチ ファンデイション | 卵内複製のための安定化されたｈａを持つ組換えインフルエンザウイルス |
| EP4093415A1 (en) | 2020-01-24 | 2022-11-30 | Wisconsin Alumni Research Foundation (WARF) | Recombinant influenza viruses with stabilized na |
| WO2021173974A1 (en) | 2020-02-28 | 2021-09-02 | Dupont Nutrition Biosciences Aps | Feed compositions |
| US12290562B2 (en) | 2020-03-25 | 2025-05-06 | Wisconsin Alumni Research Foundation (Warf) | Recombinant multivalent influenza viruses |
| CN115478060B (zh) * | 2021-06-16 | 2023-11-28 | 弈柯莱生物科技(集团)股份有限公司 | 一种糖基转移酶及其应用 |
| CN113842454B (zh) * | 2021-09-30 | 2026-01-30 | 中国人民解放军空军军医大学 | 一种基于vsv载体的htnv疫苗及其制备方法和应用 |
| EP4416280A1 (en) | 2021-10-15 | 2024-08-21 | Danisco Us Inc | Glucoamylase variants and methods for use thereof |
| MX2024005861A (es) | 2021-11-17 | 2024-08-06 | Int N&H Denmark Aps | Modificación enzimática mejorada de galactolípidos en los alimentos. |
| CN116426506B (zh) * | 2023-03-10 | 2024-01-30 | 云南师范大学 | 低温活性提高的β-木糖苷酶突变体D259G及其应用 |
| CN118006590B (zh) * | 2024-02-23 | 2024-12-27 | 南京师范大学常州合成生物学产业研究院有限公司 | 一种Microbacterium dextranolyticumβ-葡萄糖苷酶的突变体及方法和应用 |
| CN118956830B (zh) * | 2024-09-27 | 2025-09-09 | 安徽大学 | 一种β-葡萄糖苷酶突变体及其在水解丙二酰染料木苷中的应用 |
| CN118853624B (zh) * | 2024-09-29 | 2025-04-25 | 青岛奔月生物技术有限公司 | 催化莱鲍迪苷d生产莱鲍迪苷m的葡萄糖基转移酶突变体及其应用 |
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-
2010
- 2010-11-19 EP EP12199329.9A patent/EP2599862B1/en not_active Not-in-force
- 2010-11-19 DK DK12199332.3T patent/DK2599864T3/da active
- 2010-11-19 JP JP2012540120A patent/JP2013511280A/ja active Pending
- 2010-11-19 EP EP12199332.3A patent/EP2599864B1/en not_active Not-in-force
- 2010-11-19 EP EP12199328.1A patent/EP2602317B1/en not_active Not-in-force
- 2010-11-19 DK DK10782511.9T patent/DK2501806T3/da active
- 2010-11-19 EP EP10782511.9A patent/EP2501806B1/en not_active Not-in-force
- 2010-11-19 CN CN201510672711.8A patent/CN105316303B/zh not_active Expired - Fee Related
- 2010-11-19 DK DK12199329.9T patent/DK2599862T3/da active
- 2010-11-19 CN CN201080061975.5A patent/CN102844429B/zh not_active Expired - Fee Related
- 2010-11-19 EP EP12199327.3A patent/EP2599861B1/en not_active Not-in-force
- 2010-11-19 BR BR112012011711A patent/BR112012011711A2/pt not_active IP Right Cessation
- 2010-11-19 US US13/510,902 patent/US9447400B2/en not_active Expired - Fee Related
- 2010-11-19 WO PCT/US2010/057531 patent/WO2011063308A2/en not_active Ceased
- 2010-11-19 EP EP12199330.7A patent/EP2599863B1/en not_active Not-in-force
- 2010-11-19 DK DK12199328.1T patent/DK2602317T3/da active
- 2010-11-19 IN IN3825DEN2012 patent/IN2012DN03825A/en unknown
- 2010-11-19 DK DK12199330.7T patent/DK2599863T3/da active
- 2010-11-19 DK DK12199327.3T patent/DK2599861T3/da active
- 2010-11-19 CA CA2780767A patent/CA2780767A1/en not_active Abandoned
- 2010-11-19 RU RU2012125624/10A patent/RU2012125624A/ru not_active Application Discontinuation
-
2015
- 2015-06-16 JP JP2015120937A patent/JP2015211678A/ja not_active Withdrawn
-
2016
- 2016-08-29 US US15/250,626 patent/US20170145396A1/en not_active Abandoned
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